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Aliases for OR4M2 Gene

Aliases for OR4M2 Gene

  • Olfactory Receptor Family 4 Subfamily M Member 2 2 3 5
  • Olfactory Receptor, Family 4, Subfamily M, Member 2 2 3
  • Olfactory Receptor OR15-3 3 4
  • OR15-3 3

External Ids for OR4M2 Gene

Previous GeneCards Identifiers for OR4M2 Gene

  • GC15U990131
  • GC15P019867
  • GC15P019869
  • GC15P022368

Summaries for OR4M2 Gene

Entrez Gene Summary for OR4M2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4M2 Gene

OR4M2 (Olfactory Receptor Family 4 Subfamily M Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4Q3.

UniProtKB/Swiss-Prot for OR4M2 Gene

  • Odorant receptor.

Gene Wiki entry for OR4M2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4M2 Gene

Genomics for OR4M2 Gene

Regulatory Elements for OR4M2 Gene

Genomic Location for OR4M2 Gene

Chromosome:
15
Start:
22,080,527 bp from pter
End:
22,081,659 bp from pter
Size:
1,133 bases
Orientation:
Plus strand

Genomic View for OR4M2 Gene

Genes around OR4M2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4M2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4M2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4M2 Gene

Proteins for OR4M2 Gene

  • Protein details for OR4M2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGB6-OR4M2_HUMAN
    Recommended name:
    Olfactory receptor 4M2
    Protein Accession:
    Q8NGB6
    Secondary Accessions:
    • B9EH16
    • Q6IEY2

    Protein attributes for OR4M2 Gene

    Size:
    313 amino acids
    Molecular mass:
    35416 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4M2 Gene

Proteomics data for OR4M2 Gene at MOPED

Post-translational modifications for OR4M2 Gene

Other Protein References for OR4M2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4M2 Gene

Domains & Families for OR4M2 Gene

Gene Families for OR4M2 Gene

Protein Domains for OR4M2 Gene

Suggested Antigen Peptide Sequences for OR4M2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGB6

UniProtKB/Swiss-Prot:

OR4M2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4M2: view

Function for OR4M2 Gene

Molecular function for OR4M2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR4M2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4M2 Gene

Localization for OR4M2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4M2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4M2 Gene COMPARTMENTS Subcellular localization image for OR4M2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR4M2: view

Pathways & Interactions for OR4M2 Gene

genes like me logo Genes that share pathways with OR4M2: view

Pathways by source for OR4M2 Gene

Interacting Proteins for OR4M2 Gene

Gene Ontology (GO) - Biological Process for OR4M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4M2: view

No data available for SIGNOR curated interactions for OR4M2 Gene

Drugs & Compounds for OR4M2 Gene

No Compound Related Data Available

Transcripts for OR4M2 Gene

mRNA/cDNA for OR4M2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for OR4M2 Gene

No ASD Table

Relevant External Links for OR4M2 Gene

GeneLoc Exon Structure for
OR4M2
ECgene alternative splicing isoforms for
OR4M2

Expression for OR4M2 Gene

mRNA expression in normal human tissues for OR4M2 Gene

mRNA differential expression in normal tissues according to GTEx for OR4M2 Gene

This gene is overexpressed in Testis (x49.4).

SOURCE GeneReport for Unigene cluster for OR4M2 Gene Hs.729625

genes like me logo Genes that share expression patterns with OR4M2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR4M2 Gene

Orthologs for OR4M2 Gene

Evolution for OR4M2 Gene

ENSEMBL:
Gene Tree for OR4M2 (if available)
TreeFam:
Gene Tree for OR4M2 (if available)

No data available for Orthologs for OR4M2 Gene

Paralogs for OR4M2 Gene

(433) SIMAP similar genes for OR4M2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4M2: view

Variants for OR4M2 Gene

Sequence variations from dbSNP and Humsavar for OR4M2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_047831 -
VAR_047832 -
VAR_047833 -
VAR_047834 -
VAR_047835 -

Structural Variations from Database of Genomic Variants (DGV) for OR4M2 Gene

Variant ID Type Subtype PubMed ID
dgv668e1 CNV Complex 17122850
dgv669e1 CNV Complex 17122850
nsv428296 CNV Gain+Loss 18775914
dgv92e55 CNV Gain 17911159
dgv93e55 CNV Gain 17911159
dgv96e55 CNV Loss 17911159
nsv9179 CNV Gain+Loss 18304495
dgv2081n71 CNV Gain 21882294
nsv7260 OTHER Inversion 18451855
nsv821678 CNV Loss 15273396
dgv678e1 CNV Complex 17122850
dgv679e1 CNV Complex 17122850
esv33051 CNV Gain+Loss 17666407
nsv819770 CNV Gain 19587683
dgv1n1 OTHER Inversion 15895083
esv1004259 OTHER Inversion 20482838
dgv44n16 CNV Insertion 17901297
dgv2108n71 CNV Gain 21882294
dgv2109n71 CNV Gain+Loss 21882294
dgv2110n71 CNV Gain 21882294
dgv684e1 CNV Complex 17122850
esv2751489 CNV Gain 17911159
dgv686e1 CNV Complex 17122850
dgv97e55 CNV Loss 17911159
dgv98e55 CNV Gain 17911159
esv34233 CNV Loss 17911159
dgv2148n71 CNV Gain 21882294
dgv2158n71 CNV Gain 21882294
nsv817667 CNV Gain 17921354
dgv2168n71 CNV Gain 21882294
dgv691e1 CNV Complex 17122850
essv13315 CNV CNV 17122850
esv2751492 CNV Gain 17911159
dgv2175n71 CNV Gain 21882294
dgv2183n71 CNV Gain 21882294
esv29701 CNV Gain+Loss 19812545
dgv7n31 CNV Duplication 19718026
dgv422n67 CNV Gain 20364138
dgv2188n71 CNV Loss 21882294
dgv9n14 CNV Loss 18776910
dgv2189n71 CNV Gain 21882294
dgv10n14 CNV Loss 18776910
dgv11n14 CNV Gain 18776910
dgv2190n71 CNV Gain 21882294
dgv2192n71 CNV Gain 21882294
dgv2193n71 CNV Gain+Loss 21882294
dgv2194n71 CNV Loss 21882294
dgv2195n71 CNV Gain+Loss 21882294
dgv2196n71 CNV Loss 21882294
dgv2197n71 CNV Gain 21882294
dgv2198n71 CNV Gain+Loss 21882294
dgv2199n71 CNV Gain+Loss 21882294
dgv2200n71 CNV Gain 21882294
nsv510653 CNV Loss 20534489
nsv511041 OTHER Inversion 20534489
dgv2201n71 CNV Gain+Loss 21882294
nsv819100 CNV Gain 19587683
dgv692e1 CNV Complex 17122850
dgv2202n71 CNV Loss 21882294
dgv693e1 CNV Complex 17122850
nsv903325 CNV Gain 21882294
nsv903327 CNV Gain+Loss 21882294
essv10128 CNV CNV 17122850
dgv2204n71 CNV Gain 21882294
nsv442688 CNV CNV 18776908
nsv514767 CNV Complex 21397061
dgv2205n71 CNV Gain 21882294
dgv2206n71 CNV Gain 21882294
dgv2207n71 CNV Gain 21882294
nsv469630 CNV Gain 16826518
dgv2209n71 CNV Gain 21882294
dgv99e55 CNV Gain 17911159
dgv100e55 CNV Loss 17911159
dgv101e55 CNV Loss 17911159
dgv2210n71 CNV Loss 21882294
nsv903377 CNV Loss 21882294
dgv2211n71 CNV Gain 21882294
nsv903387 CNV Gain 21882294
dgv2212n71 CNV Loss 21882294
nsv1458 CNV Loss 18451855
dgv2213n71 CNV Loss 21882294
nsv832918 CNV Gain+Loss 17160897
nsv817668 CNV Gain+Loss 17921354
dgv2214n71 CNV Gain 21882294
dgv2215n71 CNV Gain+Loss 21882294
dgv2216n71 CNV Gain 21882294
dgv2217n71 CNV Gain 21882294

Variation tolerance for OR4M2 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4M2 Gene

HapMap Linkage Disequilibrium report
OR4M2
Human Gene Mutation Database (HGMD)
OR4M2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4M2 Gene

Disorders for OR4M2 Gene

Relevant External Links for OR4M2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4M2

No disorders were found for OR4M2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4M2 Gene

Publications for OR4M2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR4M2 Gene

Sources for OR4M2 Gene

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