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Aliases for OR4L1 Gene

Aliases for OR4L1 Gene

  • Olfactory Receptor, Family 4, Subfamily L, Member 1 2 3
  • Olfactory Receptor OR14-28 3 4
  • Olfactory Receptor 4L2 3 4
  • OR4L2P 3 4
  • Olfactory Receptor, Family 4, Subfamily L, Member 2 Pseudogene 3
  • Olfactory Receptor 4L1 3
  • OR14-28 3

External Ids for OR4L1 Gene

Previous HGNC Symbols for OR4L1 Gene

  • OR4L2P

Previous GeneCards Identifiers for OR4L1 Gene

  • GC14U990437
  • GC14P018519
  • GC14P019598
  • GC14P020530

Summaries for OR4L1 Gene

Entrez Gene Summary for OR4L1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4L1 Gene

OR4L1 (Olfactory Receptor, Family 4, Subfamily L, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4F4.

UniProtKB/Swiss-Prot for OR4L1 Gene

  • Odorant receptor.

Gene Wiki entry for OR4L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4L1 Gene

Genomics for OR4L1 Gene

Regulatory Elements for OR4L1 Gene

Genomic Location for OR4L1 Gene

Start:
20,060,045 bp from pter
End:
20,060,983 bp from pter
Size:
939 bases
Orientation:
Plus strand

Genomic View for OR4L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4L1 Gene

Proteins for OR4L1 Gene

  • Protein details for OR4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH43-OR4L1_HUMAN
    Recommended name:
    Olfactory receptor 4L1
    Protein Accession:
    Q8NH43
    Secondary Accessions:
    • Q6IEZ5

    Protein attributes for OR4L1 Gene

    Size:
    312 amino acids
    Molecular mass:
    35264 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4L1 Gene

Proteomics data for OR4L1 Gene at MOPED

Post-translational modifications for OR4L1 Gene

  • Glycosylation at Asn5 and Asn268
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4L1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4L1 Gene

Domains for OR4L1 Gene

Gene Families for OR4L1 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4L1 Gene

Suggested Antigen Peptide Sequences for OR4L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH43

UniProtKB/Swiss-Prot:

OR4L1_HUMAN :
  • Q8NH43
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4L1: view

Function for OR4L1 Gene

Molecular function for OR4L1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4L1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4L1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4L1 Gene

Localization for OR4L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4L1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4L1 Gene COMPARTMENTS Subcellular localization image for OR4L1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4L1: view

Pathways for OR4L1 Gene

genes like me logo Genes that share pathways with OR4L1: view

Pathways by source for OR4L1 Gene

Interacting Proteins for OR4L1 Gene

Gene Ontology (GO) - Biological Process for OR4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4L1: view

Transcripts for OR4L1 Gene

mRNA/cDNA for OR4L1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4L1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR4L1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4L1 Gene

No ASD Table

Relevant External Links for OR4L1 Gene

GeneLoc Exon Structure for
OR4L1
ECgene alternative splicing isoforms for
OR4L1

Expression for OR4L1 Gene

mRNA expression in normal human tissues for OR4L1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR4L1 Gene

SOURCE GeneReport for Unigene cluster for OR4L1 Gene Hs.553574

genes like me logo Genes that share expressions with OR4L1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR4L1 Gene

Orthologs for OR4L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473314 35
  • 99.04 (n)
  • 98.56 (a)
cow
(Bos Taurus)
Mammalia LOC787134 35
  • 83.98 (n)
  • 80.32 (a)
OR4L1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100682714 35
  • 85.58 (n)
  • 80.45 (a)
OR4L1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr723 35
  • 82.52 (n)
  • 80.13 (a)
Olfr723 16
Olfr723 36
  • 80 (a)
OneToMany
Olfr724 36
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia OR4L1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1625 35
  • 82.3 (n)
  • 80.13 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
OneToMany
Species with no ortholog for OR4L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4L1 Gene

ENSEMBL:
Gene Tree for OR4L1 (if available)
TreeFam:
Gene Tree for OR4L1 (if available)

Paralogs for OR4L1 Gene

Selected SIMAP similar genes for OR4L1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4L1 Gene

genes like me logo Genes that share paralogs with OR4L1: view

Variants for OR4L1 Gene

Sequence variations from dbSNP and Humsavar for OR4L1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs995725 -- 20,061,356(+) TCATG(A/T)ACAAG downstream-variant-500B
rs1958714 -- 20,059,776(+) GATCC(A/G)TTGAT upstream-variant-2KB
rs1958715 - 20,060,048(+) AAATG(A/G)ATCTT missense, reference
rs1958716 - 20,060,162(+) CTGTG(A/G)TGGGA reference, missense
rs1958717 -- 20,060,203(+) AGGTC(A/G)ACCCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR4L1 Gene

Variant ID Type Subtype PubMed ID
dgv599e1 CNV Complex 17122850
nsv428292 CNV Gain+Loss 18775914
dgv601e1 CNV Complex 17122850
dgv603e1 CNV Complex 17122850
nsv901299 CNV Gain 21882294
dgv81e55 CNV Gain 17911159
esv2751268 CNV Gain 17911159
nsv832738 CNV Loss 17160897
nsv9118 CNV Gain 18304495
essv8070 CNV CNV 17122850
esv259730 OTHER Complex 20981092
esv2421843 CNV Duplication 20811451
nsv818997 CNV Gain 17921354
dgv122n21 CNV Gain 19592680
nsv514729 CNV Complex 21397061
nsv442326 CNV CNV 18776908
nsv1202 CNV Loss 18451855
esv22236 CNV Loss 19812545
nsv818998 CNV Gain 17921354
nsv826866 CNV Loss 20364138

Relevant External Links for OR4L1 Gene

HapMap Linkage Disequilibrium report
OR4L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4L1 Gene

Disorders for OR4L1 Gene

No disorders were found for OR4L1 Gene.

No data available for UniProtKB/Swiss-Prot for OR4L1 Gene

Publications for OR4L1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for OR4L1 Gene

Sources for OR4L1 Gene

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