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Aliases for OR4L1 Gene

Aliases for OR4L1 Gene

  • Olfactory Receptor Family 4 Subfamily L Member 1 2 3 5
  • Olfactory Receptor OR14-28 3 4
  • Olfactory Receptor 4L2 3 4
  • OR4L2P 3 4
  • Olfactory Receptor, Family 4, Subfamily L, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily L, Member 1 2
  • Olfactory Receptor 4L1 3
  • OR14-28 3

External Ids for OR4L1 Gene

Previous HGNC Symbols for OR4L1 Gene

  • OR4L2P

Previous GeneCards Identifiers for OR4L1 Gene

  • GC14U990437
  • GC14P018519
  • GC14P019598
  • GC14P020530

Summaries for OR4L1 Gene

Entrez Gene Summary for OR4L1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4L1 Gene

OR4L1 (Olfactory Receptor Family 4 Subfamily L Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4K13.

UniProtKB/Swiss-Prot for OR4L1 Gene

  • Odorant receptor.

Gene Wiki entry for OR4L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4L1 Gene

Genomics for OR4L1 Gene

Regulatory Elements for OR4L1 Gene

Enhancers for OR4L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F020071 0.3 FANTOM5 9.4 +11.7 11724 0.2 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
GH14F020486 1.4 FANTOM5 Ensembl ENCODE 1.8 +429.5 429490 5.5 HDGF PKNOX1 TBL1XR1 RAD21 RARA ETV6 CREM EGR2 CEBPB ELF1 PNP TMEM55B APEX1 OSGEP TEP1 RNA5SP382 OR4L1 ENSG00000258908 RNASE10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR4L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4L1 Gene

Chromosome:
14
Start:
20,060,045 bp from pter
End:
20,060,983 bp from pter
Size:
939 bases
Orientation:
Plus strand

Genomic View for OR4L1 Gene

Genes around OR4L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4L1 Gene

Proteins for OR4L1 Gene

  • Protein details for OR4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH43-OR4L1_HUMAN
    Recommended name:
    Olfactory receptor 4L1
    Protein Accession:
    Q8NH43
    Secondary Accessions:
    • Q6IEZ5

    Protein attributes for OR4L1 Gene

    Size:
    312 amino acids
    Molecular mass:
    35264 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4L1 Gene

Post-translational modifications for OR4L1 Gene

  • Glycosylation at Asn 5 and Asn 268
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4L1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4L1 Gene

Domains & Families for OR4L1 Gene

Gene Families for OR4L1 Gene

Protein Domains for OR4L1 Gene

Suggested Antigen Peptide Sequences for OR4L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH43

UniProtKB/Swiss-Prot:

OR4L1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4L1: view

Function for OR4L1 Gene

Molecular function for OR4L1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4L1: view

Phenotypes for OR4L1 Gene

genes like me logo Genes that share phenotypes with OR4L1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4L1 Gene

Localization for OR4L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4L1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4L1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4L1: view

Pathways & Interactions for OR4L1 Gene

genes like me logo Genes that share pathways with OR4L1: view

Pathways by source for OR4L1 Gene

Gene Ontology (GO) - Biological Process for OR4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4L1: view

No data available for SIGNOR curated interactions for OR4L1 Gene

Transcripts for OR4L1 Gene

mRNA/cDNA for OR4L1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4L1 Gene

No ASD Table

Relevant External Links for OR4L1 Gene

GeneLoc Exon Structure for
OR4L1
ECgene alternative splicing isoforms for
OR4L1

Expression for OR4L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4L1 Gene

Protein differential expression in normal tissues from HIPED for OR4L1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR4L1 Gene



Protein tissue co-expression partners for OR4L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4L1 Gene:

OR4L1

SOURCE GeneReport for Unigene cluster for OR4L1 Gene:

Hs.553574
genes like me logo Genes that share expression patterns with OR4L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR4L1 Gene

Orthologs for OR4L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473314 34
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia LOC100682714 34
  • 85.58 (n)
OR4L1 35
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC787134 34
  • 83.98 (n)
OR4L1 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or4l1 55 Olfr723 34 35
  • 82.52 (n)
Or4l15 55 Olfr724 16 35
  • 79 (a)
rat
(Rattus norvegicus)
Mammalia Olr1625 34
  • 82.3 (n)
oppossum
(Monodelphis domestica)
Mammalia OR4L1 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 43 (a)
OneToMany
Species where no ortholog for OR4L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4L1 Gene

ENSEMBL:
Gene Tree for OR4L1 (if available)
TreeFam:
Gene Tree for OR4L1 (if available)

Paralogs for OR4L1 Gene

(445) SIMAP similar genes for OR4L1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4L1 Gene

genes like me logo Genes that share paralogs with OR4L1: view

Variants for OR4L1 Gene

Sequence variations from dbSNP and Humsavar for OR4L1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10130629 -- 20,060,368(+) TTTGG(A/G)GGTGC reference, synonymous-codon
rs10139558 -- 20,060,149(+) ATCTA(C/T)GGTGC reference, synonymous-codon
rs10139756 -- 20,060,322(+) CATCT(C/T)TGTGT reference, missense
rs10146710 -- 20,059,993(+) TATTT(C/T)TTAAT upstream-variant-2KB
rs111380756 -- 20,061,206(+) TATTG(A/T)GGATT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR4L1 Gene

Variant ID Type Subtype PubMed ID
nsv952809 CNV duplication 24416366
nsv9118 CNV gain 18304495
nsv832738 CNV loss 17160897
nsv826866 CNV loss 20364138
nsv818998 CNV gain 17921354
nsv818997 CNV gain 17921354
nsv514729 CNV gain 21397061
nsv442326 CNV gain 18776908
nsv428292 CNV gain+loss 18775914
nsv1202 CNV deletion 18451855
nsv1043905 CNV gain 25217958
esv3633674 CNV gain 21293372
esv3580929 CNV loss 25503493
esv3302756 CNV tandem duplication 20981092
esv2760354 CNV gain 21179565
esv2759971 CNV gain+loss 17122850
esv2751268 CNV gain 17911159
esv2421843 CNV duplication 20811451
esv22236 CNV loss 19812545
dgv81e55 CNV gain 17911159
dgv3532n54 CNV loss 21841781
dgv1796n100 CNV gain 25217958
dgv122n21 CNV gain 19592680

Variation tolerance for OR4L1 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.62; 99.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4L1 Gene

Disorders for OR4L1 Gene

Relevant External Links for OR4L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4L1

No disorders were found for OR4L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4L1 Gene

Publications for OR4L1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64

Products for OR4L1 Gene

Sources for OR4L1 Gene

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