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Aliases for OR4K5 Gene

Aliases for OR4K5 Gene

  • Olfactory Receptor, Family 4, Subfamily K, Member 5 2 3
  • Olfactory Receptor OR14-16 3 4
  • Olfactory Receptor 4K5 3
  • OR14-16 3

External Ids for OR4K5 Gene

Previous GeneCards Identifiers for OR4K5 Gene

  • GC14U990416
  • GC14P019459
  • GC14P020388

Summaries for OR4K5 Gene

Entrez Gene Summary for OR4K5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4K5 Gene

OR4K5 (Olfactory Receptor, Family 4, Subfamily K, Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4F4.

UniProtKB/Swiss-Prot for OR4K5 Gene

  • Odorant receptor.

Gene Wiki entry for OR4K5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4K5 Gene

Genomics for OR4K5 Gene

Regulatory Elements for OR4K5 Gene

Genomic Location for OR4K5 Gene

Start:
19,920,582 bp from pter
End:
19,921,659 bp from pter
Size:
1,078 bases
Orientation:
Plus strand

Genomic View for OR4K5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4K5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4K5 Gene

Proteins for OR4K5 Gene

  • Protein details for OR4K5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGD3-OR4K5_HUMAN
    Recommended name:
    Olfactory receptor 4K5
    Protein Accession:
    Q8NGD3
    Secondary Accessions:
    • Q6IFA7

    Protein attributes for OR4K5 Gene

    Size:
    323 amino acids
    Molecular mass:
    36258 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4K5 Gene

Proteomics data for OR4K5 Gene at MOPED

Post-translational modifications for OR4K5 Gene

Other Protein References for OR4K5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4K5 Gene

Domains for OR4K5 Gene

Gene Families for OR4K5 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4K5 Gene

Suggested Antigen Peptide Sequences for OR4K5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NGD3

UniProtKB/Swiss-Prot:

OR4K5_HUMAN :
  • Q8NGD3
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4K5: view

Function for OR4K5 Gene

Molecular function for OR4K5 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4K5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4K5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4K5 Gene

Localization for OR4K5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4K5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4K5 Gene COMPARTMENTS Subcellular localization image for OR4K5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4K5: view

Pathways for OR4K5 Gene

genes like me logo Genes that share pathways with OR4K5: view

Pathways by source for OR4K5 Gene

Interacting Proteins for OR4K5 Gene

Gene Ontology (GO) - Biological Process for OR4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4K5: view

Transcripts for OR4K5 Gene

mRNA/cDNA for OR4K5 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4K5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR4K5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4K5 Gene

No ASD Table

Relevant External Links for OR4K5 Gene

GeneLoc Exon Structure for
OR4K5
ECgene alternative splicing isoforms for
OR4K5

Expression for OR4K5 Gene

mRNA expression in normal human tissues for OR4K5 Gene

SOURCE GeneReport for Unigene cluster for OR4K5 Gene Hs.554585

genes like me logo Genes that share expressions with OR4K5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR4K5 Gene

Orthologs for OR4K5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4K5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR4K5 35
  • 87.41 (n)
  • 87.62 (a)
OR4K5 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
LOC100856122 35
  • 87.41 (n)
  • 86.69 (a)
mouse
(Mus musculus)
Mammalia Olfr729 35
  • 82.46 (n)
  • 82.04 (a)
Olfr729 16
Olfr729 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1630 35
  • 82.76 (n)
  • 81.82 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
Species with no ortholog for OR4K5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4K5 Gene

ENSEMBL:
Gene Tree for OR4K5 (if available)
TreeFam:
Gene Tree for OR4K5 (if available)

Paralogs for OR4K5 Gene

Selected SIMAP similar genes for OR4K5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR4K5: view

Variants for OR4K5 Gene

Sequence variations from dbSNP and Humsavar for OR4K5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1686588 -- 19,921,715(-) CCTAG(A/C)AAAAG downstream-variant-500B
rs1686589 -- 19,919,923(-) CCTTC(A/G)TGCTC upstream-variant-2KB
rs1686590 -- 19,919,398(-) AAGAG(A/G)CCTGA upstream-variant-2KB
rs1686591 -- 19,918,855(-) ATATA(A/G)TGAAT upstream-variant-2KB
rs1780878 -- 19,920,105(-) GGCCA(A/G)TTATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4K5 Gene

Variant ID Type Subtype PubMed ID
esv23873 CNV Gain+Loss 19812545
esv33527 CNV Gain+Loss 17666407
nsv819711 CNV Loss 19587683
nsv9117 CNV Gain+Loss 18304495
dgv45e180 CNV Loss 20482838
nsv901117 CNV Gain 21882294
dgv599e1 CNV Complex 17122850
nsv428292 CNV Gain+Loss 18775914
dgv1811n71 CNV Gain 21882294
dgv601e1 CNV Complex 17122850
dgv1814n71 CNV Gain 21882294
dgv1819n71 CNV Gain 21882294
nsv901168 CNV Gain+Loss 21882294
nsv901192 CNV Loss 21882294
dgv1826n71 CNV Gain 21882294
dgv602e1 CNV Complex 17122850
dgv603e1 CNV Complex 17122850
dgv1831n71 CNV Gain+Loss 21882294
dgv1833n71 CNV Loss 21882294
dgv1834n71 CNV Gain 21882294
nsv901299 CNV Gain 21882294
nsv511546 CNV Gain 21212237
esv1002355 CNV Loss 20482838
nsv821676 CNV Gain 15273396
dgv361n67 CNV Gain 20364138
nsv442679 CNV CNV 18776908
esv2421752 OTHER Complex 20811451
nsv514728 CNV Gain 21397061
dgv79e55 CNV Loss 17911159
dgv80e55 CNV Gain 17911159
dgv81e55 CNV Gain 17911159
esv2751268 CNV Gain 17911159
dgv1838n71 CNV Gain 21882294
dgv1839n71 CNV Gain 21882294
nsv832735 CNV Gain 17160897
dgv604e1 CNV Complex 17122850
dgv82e55 CNV Gain 17911159
esv34243 CNV Loss 17911159
dgv1841n71 CNV Loss 21882294
dgv1842n71 CNV Gain 21882294
nsv901404 CNV Loss 21882294
dgv605e1 CNV Complex 17122850
essv15197 CNV CNV 17122850
dgv1843n71 CNV Gain 21882294
dgv1844n71 CNV Gain 21882294
nsv517699 CNV Gain+Loss 19592680
nsv520814 CNV Loss 19592680
dgv1845n71 CNV Loss 21882294
esv2603885 CNV Gain 19546169
dgv1846n71 CNV Gain 21882294
nsv901446 CNV Loss 21882294
dgv1847n71 CNV Gain 21882294
nsv832737 CNV Gain 17160897
nsv469855 CNV Loss 16826518
dgv1848n71 CNV Gain 21882294
dgv606e1 CNV Complex 17122850
dgv1849n71 CNV Gain 21882294
nsv471372 CNV Duplication 19718026

Relevant External Links for OR4K5 Gene

HapMap Linkage Disequilibrium report
OR4K5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4K5 Gene

Disorders for OR4K5 Gene

Relevant External Links for OR4K5

Genetic Association Database (GAD)
OR4K5
Human Genome Epidemiology (HuGE) Navigator
OR4K5
genes like me logo Genes that share disorders with OR4K5: view

No data available for UniProtKB/Swiss-Prot for OR4K5 Gene

Publications for OR4K5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR4K5 Gene

Sources for OR4K5 Gene

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