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Aliases for OR4K3 Gene

Aliases for OR4K3 Gene

  • Olfactory Receptor Family 4 Subfamily K Member 3 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 4, Subfamily K, Member 3 Pseudogene 2 3
  • Olfactory Receptor OR14-14 3 4
  • OR4K3P 3 4
  • Olfactory Receptor, Family 4, Subfamily K, Member 3 (Gene/Pseudogene) 2
  • Olfactory Receptor 4K3 3
  • OR14-10 3

External Ids for OR4K3 Gene

Previous HGNC Symbols for OR4K3 Gene

  • OR4K3P

Previous GeneCards Identifiers for OR4K3 Gene

  • GC14U990423
  • GC14M019406
  • GC14M020337

Summaries for OR4K3 Gene

Entrez Gene Summary for OR4K3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR4K3 Gene

OR4K3 (Olfactory Receptor Family 4 Subfamily K Member 3 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR4K3 Gene

  • Odorant receptor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4K3 Gene

Genomics for OR4K3 Gene

Genomic Location for OR4K3 Gene

Chromosome:
14
Start:
19,867,997 bp from pter
End:
19,869,343 bp from pter
Size:
1,347 bases
Orientation:
Minus strand

Genomic View for OR4K3 Gene

Genes around OR4K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4K3 Gene

No data available for Regulatory Elements for OR4K3 Gene

Proteins for OR4K3 Gene

  • Protein details for OR4K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R72-OR4K3_HUMAN
    Recommended name:
    Olfactory receptor 4K3
    Protein Accession:
    Q96R72
    Secondary Accessions:
    • Q6IFA4

    Protein attributes for OR4K3 Gene

    Size:
    315 amino acids
    Molecular mass:
    35408 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04756.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR4K3 Gene

Post-translational modifications for OR4K3 Gene

  • Glycosylation at posLast=55
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4K3 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for OR4K3 Gene

Domains & Families for OR4K3 Gene

Gene Families for OR4K3 Gene

Protein Domains for OR4K3 Gene

Suggested Antigen Peptide Sequences for OR4K3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96R72

UniProtKB/Swiss-Prot:

OR4K3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4K3: view

Function for OR4K3 Gene

Molecular function for OR4K3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4K3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4K3 Gene

Localization for OR4K3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4K3 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR4K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4K3: view

No data available for Subcellular locations from COMPARTMENTS for OR4K3 Gene

Pathways & Interactions for OR4K3 Gene

genes like me logo Genes that share pathways with OR4K3: view

Pathways by source for OR4K3 Gene

Interacting Proteins for OR4K3 Gene

Selected Interacting proteins: Q96R72-OR4K3_HUMAN for OR4K3 Gene via IID

Symbol External ID(s) Details
ESR2

Gene Ontology (GO) - Biological Process for OR4K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4K3: view

No data available for SIGNOR curated interactions for OR4K3 Gene

Transcripts for OR4K3 Gene

mRNA/cDNA for OR4K3 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4K3 Gene

No ASD Table

Relevant External Links for OR4K3 Gene

GeneLoc Exon Structure for
OR4K3
ECgene alternative splicing isoforms for
OR4K3

Expression for OR4K3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4K3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4K3 Gene:

OR4K3
genes like me logo Genes that share expression patterns with OR4K3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4K3 Gene

Orthologs for OR4K3 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for OR4K3 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Or4k46-ps 55 Olfr1296-ps1
  • chr2:111,593,079-111,594,011
Species where no ortholog for OR4K3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4K3 Gene

ENSEMBL:
Gene Tree for OR4K3 (if available)
TreeFam:
Gene Tree for OR4K3 (if available)

Paralogs for OR4K3 Gene

(457) SIMAP similar genes for OR4K3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4K3: view

No data available for Paralogs for OR4K3 Gene

Variants for OR4K3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR4K3 Gene

OR4K3_HUMAN-Q96R72
A single nucleotide deletion at position Met-205 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Sequence variations from dbSNP and Humsavar for OR4K3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs143385785 -- 19,871,223(+) TGCTC(A/G/T)TAAAT upstream-variant-2KB
rs185687456 -- 19,869,873(+) ACATG(A/C/T)GCCTG upstream-variant-2KB
rs559603124 -- 19,869,803(+) CGAGA(A/C/T)GAGCC upstream-variant-2KB
rs758976117 -- 19,868,372(+) ACACA(A/C/T)AAATG nc-transcript-variant, reference, missense

Relevant External Links for OR4K3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4K3

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR4K3 Gene

Disorders for OR4K3 Gene

No disorders were found for OR4K3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for OR4K3 Gene

Publications for OR4K3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64
  3. Different noses for different people. (PMID: 12730696) Menashe I. … Gilad Y. (Nat. Genet. 2003) 3 4 64
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64

Products for OR4K3 Gene

Sources for OR4K3 Gene

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