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OR4K14 Gene

protein-coding   GIFtS: 45
GCID: GC14M020482

Olfactory Receptor, Family 4, Subfamily K, Member 14

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 4, Subfamily K, Member 141 2
Olfactory Receptor OR14-222 3
OR14-182
OR14-222
Olfactory Receptor 4K142
Olfactory Receptor OR14-18 Pseudogene2

External Ids:    HGNC: 153521   Entrez Gene: 1227402   Ensembl: ENSG000001694847   UniProtKB: Q8NGD53   

Export aliases for OR4K14 gene to outside databases

Previous GC identifers: GC14U990441 GC14M018474 GC14M019552


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR4K14 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4K14 Gene:
OR4K14 (olfactory receptor, family 4, subfamily K, member 14) is a protein-coding gene. Diseases associated with OR4K14 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4L1.

UniProtKB/Swiss-Prot: OR4KE_HUMAN, Q8NGD5
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4K14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR4K14 gene promoter:
         SRF   GR   TBP   FOXF2   Tal-1   SRF (504 AA)   E47   C/EBPalpha   CHOP-10   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR4K14 promoter sequence
   Search Chromatin IP Primers for OR4K14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4K14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

OR4K14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4K14 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M020482:  view genomic region     (about GC identifiers)

Start:
20,482,423 bp from pter      End:
20,483,352 bp from pter
Size:
930 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR4KE_HUMAN, Q8NGD5 (See protein sequence)
Recommended Name: Olfactory receptor 4K14  
Size: 310 amino acids; 35053 Da
Secondary accessions: Q6IEU1 Q96R71

Explore the universe of human proteins at neXtProt for OR4K14: NX_Q8NGD5

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR4K14
    REFSEQ proteins: NP_001004712.1  
    ENSEMBL proteins: 
     ENSP00000305011  
    Reactome Protein details: Q8NGD5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGD5

    ProtoNet protein and cluster: Q8NGD5

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR4KE_HUMAN, Q8NGD5
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR4K14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR4KE_HUMAN, Q8NGD5
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR4K14 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR4KE_HUMAN, Q8NGD5: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR4K14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR4K14 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR4K14
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR4K14):
        Olfactory transduction


    OR4K14 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR4K14
    Interactions:

        Search GeneGlobe Interaction Network for OR4K14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR4K14 (ENSP000003050114) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR2A2ENSP000003862094STRING: ENSP00000386209
    OR2V2ENSP000003321854STRING: ENSP00000332185
    OR4K1ENSP000002856004STRING: ENSP00000285600
    OR4K13ENSP000003193224STRING: ENSP00000319322
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR4K14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR4K14 (OR4KE)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR4K14 gene: 
    NM_001004712.1  

    Unigene Cluster for OR4K14:

    Olfactory receptor, family 4, subfamily K, member 14
    Hs.626814
    Unigene Representative Sequence: NM_001004712
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000305045(uc010tky.2)
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    1 AceView cDNA sequence:

    NM_001004712 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR4K14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAGTGACGC
    OR4K14 Expression
    About this image

    OR4K14 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.626814
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR4K14 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia OR4K141 cOR11G6 olfactory receptor family 11 subfamily G-like 85.71(n)
    85.71(a)
      481180  XM_847588.2  XP_852681.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    48(a)
    1 → many
    GL343220.1(928034-929008)


    ENSEMBL Gene Tree for OR4K14 (if available)
    TreeFam Gene Tree for OR4K14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR4K14 gene
    OR4L12  OR4F162  OR4K12  OR4K52  OR4F172  OR4F52  OR4F42  OR4K132  
    OR4K152  OR4F212  OR4F62  OR4F152  OR4F32  OR4K22  OR4K172  OR4F292  
    Selected SIMAP similar genes for OR4K14 using alignment to 1 protein entry:     OR4KE_HUMAN(see all similar genes):
    OR4K15    OR4K3    OR4F17    OR4F4    OR4F5    OR4K13
    OR4K17    OR4K2    OR4K5    OR4Q3    OR4E2    OR4F6
    OR4K1    OR4L1    OR4E1    OR4M1    OR4N5    OR4D1

    OR4K14 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR4K14
    PGOHUM00000248037


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR4K14 (see all 124)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018523051,2
    C--20481994(+) GAAAT-/AACACTAT 1 -- ds50010--------
    rs128881611,2
    H--20482037(+) CTGAAT/CATATA 1 -- ds50014Minor allele frequency- C:0.00NS EA 398
    rs1893421151,2
    --20482052(+) TATATC/TGTTTC 1 -- ds50010--------
    rs286028601,2
    C--20482053(+) ATATCG/ATTTCT 1 -- ds50015Minor allele frequency- A:0.33NA WA 244
    rs284470921,2
    C--20482064(+) CTGAAC/TAAATA 1 -- ds50015Minor allele frequency- T:0.38NA WA 244
    rs1178863071,2
    C,F--20482120(+) TGTACG/ATATAT 1 -- ds50011Minor allele frequency- A:0.06NA 120
    rs2001127501,2
    --20482155(+) CAAAA-/ATATATA 1 -- ds50010--------
    rs777591231,2
    C,F--20482330(+) TGTAGT/AGTCAG 1 -- ds50013Minor allele frequency- A:0.11WA CSA 122
    rs1491494801,2
    C,F--20482425(+) TCATTG/TAAAAG 2 K Q mis11Minor allele frequency- T:0.00NA 4492
    rs1817535581,2
    C--20482440(+) CCGTCA/GGTTTT 2 R * stg10--------

    HapMap Linkage Disequilibrium report for OR4K14 ( 20482423 - 20483352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR4K14 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674194CNV Deletion23128226
    esv34243CNV Loss17911159
    nsv525754CNV Loss19592680
    nsv469855CNV Loss16826518
    dgv81e55CNV Gain17911159
    nsv901299CNV Gain21882294
    dgv80e55CNV Gain17911159
    nsv832737CNV Gain17160897
    esv2751268CNV Gain17911159
    nsv428292CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR4K14:    
    About MalaCards
    neuronitis


    OR4K14 for disorders           About GeneDecksing


    Export disorders for OR4K14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR4K14 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR4K14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 122740 HGNC: 15352 AceView: OR4K14 Ensembl:ENSG00000169484 euGenes: HUgn122740
    ECgene: OR4K14 Kegg: 122740 H-InvDB: OR4K14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR4K14 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4K14 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR4K14 gene:
    Search GeneIP for patents involving OR4K14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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