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Aliases for OR4K14 Gene

Aliases for OR4K14 Gene

  • Olfactory Receptor, Family 4, Subfamily K, Member 14 2 3
  • Olfactory Receptor OR14-22 3 4
  • Olfactory Receptor OR14-18 Pseudogene 3
  • Olfactory Receptor 4K14 3
  • OR14-18 3
  • OR14-22 3

External Ids for OR4K14 Gene

Summaries for OR4K14 Gene

Entrez Gene Summary for OR4K14 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4K14 Gene

OR4K14 (Olfactory Receptor, Family 4, Subfamily K, Member 14) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4F4.

UniProtKB/Swiss-Prot for OR4K14 Gene

  • Odorant receptor.

Gene Wiki entry for OR4K14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4K14 Gene

Genomics for OR4K14 Gene

Genomic Location for OR4K14 Gene

Start:
20,014,260 bp from pter
End:
20,015,193 bp from pter
Size:
934 bases
Orientation:
Minus strand

Genomic View for OR4K14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4K14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4K14 Gene

Regulatory Elements for OR4K14 Gene

Proteins for OR4K14 Gene

  • Protein details for OR4K14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGD5-OR4KE_HUMAN
    Recommended name:
    Olfactory receptor 4K14
    Protein Accession:
    Q8NGD5
    Secondary Accessions:
    • Q6IEU1
    • Q96R71

    Protein attributes for OR4K14 Gene

    Size:
    310 amino acids
    Molecular mass:
    35053 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4K14 Gene

Proteomics data for OR4K14 Gene at MOPED

Post-translational modifications for OR4K14 Gene

Other Protein References for OR4K14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR4K14 Gene

Domains for OR4K14 Gene

Gene Families for OR4K14 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4K14 Gene

UniProtKB/Swiss-Prot:

OR4KE_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGD5
genes like me logo Genes that share domains with OR4K14: view

Function for OR4K14 Gene

Molecular function for OR4K14 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4K14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4K14: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4K14 Gene

Localization for OR4K14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4K14 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4K14 Gene COMPARTMENTS Subcellular localization image for OR4K14 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4K14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4K14: view

Pathways for OR4K14 Gene

genes like me logo Genes that share pathways with OR4K14: view

Pathways by source for OR4K14 Gene

Interacting Proteins for OR4K14 Gene

Gene Ontology (GO) - Biological Process for OR4K14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4K14: view

Transcripts for OR4K14 Gene

mRNA/cDNA for OR4K14 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4K14 Gene

No ASD Table

Relevant External Links for OR4K14 Gene

GeneLoc Exon Structure for
OR4K14
ECgene alternative splicing isoforms for
OR4K14

Expression for OR4K14 Gene

mRNA expression in normal human tissues for OR4K14 Gene

SOURCE GeneReport for Unigene cluster for OR4K14 Gene Hs.626814

genes like me logo Genes that share expressions with OR4K14: view

Orthologs for OR4K14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4K14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473312 36
  • 99.5 (n)
  • 99.01 (a)
OR4K14 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC787150 36
  • 88.17 (n)
  • 85.81 (a)
OR4K14 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 61 (a)
ManyToMany
OR4K14 36
  • 85.71 (n)
  • 85.71 (a)
oppossum
(Monodelphis domestica)
Mammalia OR4K14 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 48 (a)
OneToMany
Species with no ortholog for OR4K14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4K14 Gene

ENSEMBL:
Gene Tree for OR4K14 (if available)
TreeFam:
Gene Tree for OR4K14 (if available)

Paralogs for OR4K14 Gene

Selected SIMAP similar genes for OR4K14 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4K14 Gene

genes like me logo Genes that share paralogs with OR4K14: view

Variants for OR4K14 Gene

Sequence variations from dbSNP and Humsavar for OR4K14 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1953997 -- 20,015,485(-) TAATC(C/G)CAATG upstream-variant-2KB
rs1953998 -- 20,015,468(-) AATAG(A/G)TCACT upstream-variant-2KB
rs2039862 -- 20,013,913(-) ATGTC(A/T)TTTAT downstream-variant-500B
rs2039866 -- 20,017,005(-) TTAAC(G/T)GGAAA upstream-variant-2KB
rs4981697 -- 20,016,858(+) TTCTT(C/T)ATAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4K14 Gene

Variant ID Type Subtype PubMed ID
dgv599e1 CNV Complex 17122850
nsv428292 CNV Gain+Loss 18775914
dgv601e1 CNV Complex 17122850
dgv603e1 CNV Complex 17122850
nsv901299 CNV Gain 21882294
dgv80e55 CNV Gain 17911159
dgv81e55 CNV Gain 17911159
esv2751268 CNV Gain 17911159
esv34243 CNV Loss 17911159
essv15197 CNV CNV 17122850
nsv832737 CNV Gain 17160897
nsv469855 CNV Loss 16826518
esv2674194 CNV Deletion 23128226
nsv525754 CNV Loss 19592680

Relevant External Links for OR4K14 Gene

HapMap Linkage Disequilibrium report
OR4K14

Disorders for OR4K14 Gene

No disorders were found for OR4K14 Gene.

No data available for UniProtKB/Swiss-Prot for OR4K14 Gene

Publications for OR4K14 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for OR4K14 Gene

Sources for OR4K14 Gene

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