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Aliases for OR4K13 Gene

Aliases for OR4K13 Gene

  • Olfactory Receptor Family 4 Subfamily K Member 13 2 3 5
  • Olfactory Receptor OR14-27 3 4
  • Olfactory Receptor, Family 4, Subfamily K, Member 13 2
  • Olfactory Receptor 4K13 3
  • OR14-27 3

External Ids for OR4K13 Gene

Previous GeneCards Identifiers for OR4K13 Gene

  • GC14U990442
  • GC14M018493
  • GC14M019571
  • GC14M020502

Summaries for OR4K13 Gene

Entrez Gene Summary for OR4K13 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4K13 Gene

OR4K13 (Olfactory Receptor Family 4 Subfamily K Member 13) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4K14.

UniProtKB/Swiss-Prot for OR4K13 Gene

  • Odorant receptor.

Gene Wiki entry for OR4K13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4K13 Gene

Genomics for OR4K13 Gene

Regulatory Elements for OR4K13 Gene

Enhancers for OR4K13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G020071 0.3 FANTOM5 2.7 -37.0 -37009 0.2 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR4K13 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4K13 Gene

Chromosome:
14
Start:
20,033,844 bp from pter
End:
20,034,760 bp from pter
Size:
917 bases
Orientation:
Minus strand

Genomic View for OR4K13 Gene

Genes around OR4K13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4K13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4K13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4K13 Gene

Proteins for OR4K13 Gene

  • Protein details for OR4K13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH42-OR4KD_HUMAN
    Recommended name:
    Olfactory receptor 4K13
    Protein Accession:
    Q8NH42
    Secondary Accessions:
    • Q6IF13

    Protein attributes for OR4K13 Gene

    Size:
    304 amino acids
    Molecular mass:
    34261 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4K13 Gene

Post-translational modifications for OR4K13 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4K13 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4K13 Gene

Domains & Families for OR4K13 Gene

Gene Families for OR4K13 Gene

Protein Domains for OR4K13 Gene

Suggested Antigen Peptide Sequences for OR4K13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH42

UniProtKB/Swiss-Prot:

OR4KD_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4K13: view

Function for OR4K13 Gene

Molecular function for OR4K13 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4K13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4K13: view
genes like me logo Genes that share phenotypes with OR4K13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4K13 Gene

Localization for OR4K13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4K13 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4K13 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4K13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4K13: view

Pathways & Interactions for OR4K13 Gene

genes like me logo Genes that share pathways with OR4K13: view

Pathways by source for OR4K13 Gene

Interacting Proteins for OR4K13 Gene

Gene Ontology (GO) - Biological Process for OR4K13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4K13: view

No data available for SIGNOR curated interactions for OR4K13 Gene

Drugs & Compounds for OR4K13 Gene

No Compound Related Data Available

Transcripts for OR4K13 Gene

mRNA/cDNA for OR4K13 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4K13 Gene

No ASD Table

Relevant External Links for OR4K13 Gene

GeneLoc Exon Structure for
OR4K13
ECgene alternative splicing isoforms for
OR4K13

Expression for OR4K13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4K13 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4K13 Gene:

OR4K13

SOURCE GeneReport for Unigene cluster for OR4K13 Gene:

Hs.553573
genes like me logo Genes that share expression patterns with OR4K13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4K13 Gene

Orthologs for OR4K13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4K13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473313 34
  • 99.56 (n)
OR4K13 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR4K13 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR4K13 34
  • 84.44 (n)
-- 35
  • 61 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia OR4K13 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr731 35
  • 56 (a)
ManyToMany
Or4k45 55 Olfr1295
  • chr2:111,564,507-111,565,442
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
OneToMany
Species where no ortholog for OR4K13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4K13 Gene

ENSEMBL:
Gene Tree for OR4K13 (if available)
TreeFam:
Gene Tree for OR4K13 (if available)

Paralogs for OR4K13 Gene

(446) SIMAP similar genes for OR4K13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4K13: view

Variants for OR4K13 Gene

Sequence variations from dbSNP and Humsavar for OR4K13 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000031384 -- 20,035,081(+) AAGCT(A/G)CTCAC upstream-variant-2KB
rs1000490138 -- 20,036,391(+) CTCCA(C/T)ATCTG upstream-variant-2KB
rs1001180230 -- 20,034,548(+) GATCA(C/T)ATCAA reference, missense
rs1008146021 -- 20,035,541(+) CACAT(A/C)AAATA upstream-variant-2KB
rs1008196930 -- 20,035,276(+) AAAAT(A/G)CATCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4K13 Gene

Variant ID Type Subtype PubMed ID
dgv3532n54 CNV loss 21841781
dgv81e55 CNV gain 17911159
esv2751268 CNV gain 17911159
esv2759971 CNV gain+loss 17122850
esv34243 CNV loss 17911159
nsv428292 CNV gain+loss 18775914
nsv469855 CNV loss 16826518
nsv832737 CNV gain 17160897
nsv832738 CNV loss 17160897

Variation tolerance for OR4K13 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4K13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4K13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4K13 Gene

Disorders for OR4K13 Gene

Relevant External Links for OR4K13

Genetic Association Database (GAD)
OR4K13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4K13

No disorders were found for OR4K13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4K13 Gene

Publications for OR4K13 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64

Products for OR4K13 Gene

Sources for OR4K13 Gene

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