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Aliases for OR4K1 Gene

Aliases for OR4K1 Gene

  • Olfactory Receptor, Family 4, Subfamily K, Member 1 2 3
  • Olfactory Receptor OR14-19 3 4
  • Olfactory Receptor 4K1 3
  • OR14-19 3

External Ids for OR4K1 Gene

Previous GeneCards Identifiers for OR4K1 Gene

  • GC14U990425
  • GC14P019473
  • GC14P020403

Summaries for OR4K1 Gene

Entrez Gene Summary for OR4K1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4K1 Gene

OR4K1 (Olfactory Receptor, Family 4, Subfamily K, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4F4.

UniProtKB/Swiss-Prot for OR4K1 Gene

  • Odorant receptor.

Gene Wiki entry for OR4K1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4K1 Gene

Genomics for OR4K1 Gene

Regulatory Elements for OR4K1 Gene

Genomic Location for OR4K1 Gene

Start:
19,935,608 bp from pter
End:
19,936,683 bp from pter
Size:
1,076 bases
Orientation:
Plus strand

Genomic View for OR4K1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4K1 Gene

Proteins for OR4K1 Gene

  • Protein details for OR4K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGD4-OR4K1_HUMAN
    Recommended name:
    Olfactory receptor 4K1
    Protein Accession:
    Q8NGD4
    Secondary Accessions:
    • B9EKV9
    • Q8NGD6
    • Q96R73

    Protein attributes for OR4K1 Gene

    Size:
    311 amino acids
    Molecular mass:
    35201 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4K1 Gene

Proteomics data for OR4K1 Gene at MOPED

Post-translational modifications for OR4K1 Gene

Other Protein References for OR4K1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4K1 Gene

Domains for OR4K1 Gene

Gene Families for OR4K1 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4K1 Gene

Suggested Antigen Peptide Sequences for OR4K1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGD4

UniProtKB/Swiss-Prot:

OR4K1_HUMAN :
  • Q8NGD4
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4K1: view

Function for OR4K1 Gene

Molecular function for OR4K1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4K1: view

Phenotypes for OR4K1 Gene

GenomeRNAi human phenotypes for OR4K1:
genes like me logo Genes that share phenotypes with OR4K1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4K1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4K1 Gene

Localization for OR4K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4K1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4K1 Gene COMPARTMENTS Subcellular localization image for OR4K1 gene
Compartment Confidence
plasma membrane 5
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for OR4K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4K1: view

Pathways for OR4K1 Gene

genes like me logo Genes that share pathways with OR4K1: view

Pathways by source for OR4K1 Gene

Interacting Proteins for OR4K1 Gene

Gene Ontology (GO) - Biological Process for OR4K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4K1: view

Transcripts for OR4K1 Gene

mRNA/cDNA for OR4K1 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4K1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR4K1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4K1 Gene

No ASD Table

Relevant External Links for OR4K1 Gene

GeneLoc Exon Structure for
OR4K1
ECgene alternative splicing isoforms for
OR4K1

Expression for OR4K1 Gene

mRNA expression in normal human tissues for OR4K1 Gene

mRNA differential expression in normal tissues according to GTEx for OR4K1 Gene

This gene is overexpressed in Testis (27.8), Brain - Caudate (basal ganglia) (6.7), Bladder (6.4), Brain - Cortex (6.1), and Cervix - Ectocervix (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR4K1 Gene

SOURCE GeneReport for Unigene cluster for OR4K1 Gene Hs.554584

genes like me logo Genes that share expressions with OR4K1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR4K1 Gene

Orthologs for OR4K1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4K1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473309 35
  • 98.5 (n)
  • 97.11 (a)
OR4K1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR4K1 36
  • 68 (a)
OneToOne
OR4K14 35
  • 67.32 (n)
  • 69.51 (a)
dog
(Canis familiaris)
Mammalia LOC100687258 35
  • 88.53 (n)
  • 91.32 (a)
OR4K1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr728 35
  • 83.39 (n)
  • 85.85 (a)
Olfr728 16
Olfr728 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR4K1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1629 35
  • 83.17 (n)
  • 84.57 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
Species with no ortholog for OR4K1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4K1 Gene

ENSEMBL:
Gene Tree for OR4K1 (if available)
TreeFam:
Gene Tree for OR4K1 (if available)

Paralogs for OR4K1 Gene

Selected SIMAP similar genes for OR4K1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4K1 Gene

genes like me logo Genes that share paralogs with OR4K1: view

Variants for OR4K1 Gene

Sequence variations from dbSNP and Humsavar for OR4K1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2635552 -- 19,934,774(+) CAAGC(A/G)ATTCT upstream-variant-2KB
rs2792142 -- 19,937,078(-) AAAAT(A/G)TATAA downstream-variant-500B
rs2792143 -- 19,936,896(-) GTAAC(A/G)TGAAT downstream-variant-500B
rs2792144 -- 19,936,715(-) AAAAA(A/G)CCAAT downstream-variant-500B
rs2792145 -- 19,936,608(-) CGTAA(C/T)GATCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OR4K1 Gene

Variant ID Type Subtype PubMed ID
esv23873 CNV Gain+Loss 19812545
esv33527 CNV Gain+Loss 17666407
nsv819711 CNV Loss 19587683
nsv9117 CNV Gain+Loss 18304495
dgv45e180 CNV Loss 20482838
nsv901117 CNV Gain 21882294
dgv599e1 CNV Complex 17122850
nsv428292 CNV Gain+Loss 18775914
dgv1811n71 CNV Gain 21882294
dgv601e1 CNV Complex 17122850
dgv1814n71 CNV Gain 21882294
dgv1819n71 CNV Gain 21882294
dgv1826n71 CNV Gain 21882294
dgv602e1 CNV Complex 17122850
dgv603e1 CNV Complex 17122850
dgv1831n71 CNV Gain+Loss 21882294
dgv1834n71 CNV Gain 21882294
nsv901299 CNV Gain 21882294
nsv511546 CNV Gain 21212237
esv1002355 CNV Loss 20482838
dgv361n67 CNV Gain 20364138
nsv442679 CNV CNV 18776908
esv2421752 OTHER Complex 20811451
nsv514728 CNV Gain 21397061
dgv79e55 CNV Loss 17911159
dgv80e55 CNV Gain 17911159
dgv81e55 CNV Gain 17911159
esv2751268 CNV Gain 17911159
dgv1838n71 CNV Gain 21882294
dgv1839n71 CNV Gain 21882294
nsv832735 CNV Gain 17160897
dgv604e1 CNV Complex 17122850
dgv82e55 CNV Gain 17911159
esv34243 CNV Loss 17911159
dgv1841n71 CNV Loss 21882294
dgv1842n71 CNV Gain 21882294
nsv901404 CNV Loss 21882294
dgv605e1 CNV Complex 17122850
essv15197 CNV CNV 17122850
dgv1843n71 CNV Gain 21882294
dgv1844n71 CNV Gain 21882294
nsv517699 CNV Gain+Loss 19592680
nsv520814 CNV Loss 19592680
dgv1845n71 CNV Loss 21882294
nsv901446 CNV Loss 21882294
dgv1847n71 CNV Gain 21882294
nsv832737 CNV Gain 17160897
nsv469855 CNV Loss 16826518
dgv1848n71 CNV Gain 21882294
dgv606e1 CNV Complex 17122850
dgv1849n71 CNV Gain 21882294
dgv1850n71 CNV Gain 21882294
nsv901461 CNV Loss 21882294

Relevant External Links for OR4K1 Gene

HapMap Linkage Disequilibrium report
OR4K1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4K1 Gene

Disorders for OR4K1 Gene

No disorders were found for OR4K1 Gene.

No data available for UniProtKB/Swiss-Prot for OR4K1 Gene

Publications for OR4K1 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR4K1 Gene

Sources for OR4K1 Gene

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