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Aliases for OR4F6 Gene

Aliases for OR4F6 Gene

  • Olfactory Receptor Family 4 Subfamily F Member 6 2 3 5
  • Olfactory Receptor, Family 4, Subfamily F, Member 12 2 3
  • Olfactory Receptor, Family 4, Subfamily F, Member 6 2 3
  • Olfactory Receptor OR15-15 3 4
  • Olfactory Receptor 4F12 3 4
  • OR4F12 3 4
  • OR15-15 3

External Ids for OR4F6 Gene

Previous HGNC Symbols for OR4F6 Gene

  • OR4F12

Previous GeneCards Identifiers for OR4F6 Gene

  • GC15U990132
  • GC15P100082
  • GC15P100163
  • GC15P102345

Summaries for OR4F6 Gene

Entrez Gene Summary for OR4F6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F6 Gene

OR4F6 (Olfactory Receptor Family 4 Subfamily F Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F5.

UniProtKB/Swiss-Prot for OR4F6 Gene

  • Odorant receptor.

Gene Wiki entry for OR4F6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4F6 Gene

Genomics for OR4F6 Gene

Regulatory Elements for OR4F6 Gene

Genomic Location for OR4F6 Gene

Chromosome:
15
Start:
101,805,699 bp from pter
End:
101,806,686 bp from pter
Size:
988 bases
Orientation:
Plus strand

Genomic View for OR4F6 Gene

Genes around OR4F6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4F6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4F6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F6 Gene

Proteins for OR4F6 Gene

  • Protein details for OR4F6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGB9-OR4F6_HUMAN
    Recommended name:
    Olfactory receptor 4F6
    Protein Accession:
    Q8NGB9
    Secondary Accessions:
    • B9EH28
    • Q6IF95

    Protein attributes for OR4F6 Gene

    Size:
    312 amino acids
    Molecular mass:
    35355 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F6 Gene

Proteomics data for OR4F6 Gene at MOPED

Post-translational modifications for OR4F6 Gene

Other Protein References for OR4F6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F6 Gene

Domains & Families for OR4F6 Gene

Gene Families for OR4F6 Gene

Protein Domains for OR4F6 Gene

Suggested Antigen Peptide Sequences for OR4F6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGB9

UniProtKB/Swiss-Prot:

OR4F6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F6: view

Function for OR4F6 Gene

Molecular function for OR4F6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F6: view
genes like me logo Genes that share phenotypes with OR4F6: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4F6 Gene

Localization for OR4F6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4F6 Gene COMPARTMENTS Subcellular localization image for OR4F6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR4F6: view

Pathways & Interactions for OR4F6 Gene

genes like me logo Genes that share pathways with OR4F6: view

Pathways by source for OR4F6 Gene

Interacting Proteins for OR4F6 Gene

Gene Ontology (GO) - Biological Process for OR4F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4F6: view

No data available for SIGNOR curated interactions for OR4F6 Gene

Drugs & Compounds for OR4F6 Gene

No Compound Related Data Available

Transcripts for OR4F6 Gene

mRNA/cDNA for OR4F6 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F6 Gene

No ASD Table

Relevant External Links for OR4F6 Gene

GeneLoc Exon Structure for
OR4F6
ECgene alternative splicing isoforms for
OR4F6

Expression for OR4F6 Gene

mRNA expression in normal human tissues for OR4F6 Gene

SOURCE GeneReport for Unigene cluster for OR4F6 Gene Hs.553399

genes like me logo Genes that share expression patterns with OR4F6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR4F6 Gene

Orthologs for OR4F6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC504344 35
  • 78.14 (n)
  • 76.53 (a)
-- 36
  • 71 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr1310 35
  • 82.74 (n)
  • 85.21 (a)
Olfr1310 16
Olfr1310 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC467782 35
  • 99.25 (n)
  • 99.04 (a)
OR4F6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr783 35
  • 82.1 (n)
  • 84.24 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
Species with no ortholog for OR4F6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4F6 Gene

ENSEMBL:
Gene Tree for OR4F6 (if available)
TreeFam:
Gene Tree for OR4F6 (if available)

Paralogs for OR4F6 Gene

(431) SIMAP similar genes for OR4F6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4F6: view

Variants for OR4F6 Gene

Sequence variations from dbSNP and Humsavar for OR4F6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs401632 -- 101,805,827(+) TATGT(A/G)TCAAG reference, synonymous-codon
rs3934044 -- 101,804,368(+) CATTT(C/T)TGTTG upstream-variant-2KB
rs7169656 -- 101,806,884(+) TATAT(A/G)TAATG downstream-variant-500B
rs10713522 -- 101,804,181(+) AATTT(-/G)GGGAG upstream-variant-2KB
rs12900177 -- 101,805,296(+) GGTAT(C/G)AAAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4F6 Gene

Variant ID Type Subtype PubMed ID
dgv113e55 CNV Gain 17911159
dgv2454n71 CNV Gain 21882294
nsv482948 CNV Complex 15286789
nsv904619 CNV Gain 21882294
dgv788e1 CNV Complex 17122850
nsv469708 CNV Gain 16826518
esv2751291 CNV Gain 17911159
nsv904620 CNV Loss 21882294
nsv469527 CNV Complex 16826518
nsv524612 CNV Loss 19592680
nsv519940 CNV Gain 19592680
nsv904621 CNV Gain 21882294

Variation tolerance for OR4F6 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4F6 Gene

HapMap Linkage Disequilibrium report
OR4F6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4F6 Gene

Disorders for OR4F6 Gene

Relevant External Links for OR4F6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4F6

No disorders were found for OR4F6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4F6 Gene

Publications for OR4F6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. (PMID: 12507995) Brock C. … NA1rnberg B. (J. Cell Biol. 2003) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits. (PMID: 10358071) Krugmann S. … Braselmann S. (J. Biol. Chem. 1999) 3
  5. Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus. (PMID: 10488142) Metjian A. … Abrams C.S. (J. Biol. Chem. 1999) 3

Products for OR4F6 Gene

Sources for OR4F6 Gene

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