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OR4F6 Gene

protein-coding   GIFtS: 42
GCID: GC15P102345

Olfactory Receptor, Family 4, Subfamily F, Member 6

(Previous names: olfactory receptor, family 4, subfamily F, member 12)
(Previous symbol: OR4F12)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 4, Subfamily F, Member 61 2     Olfactory Receptor OR15-152 3
OR4F121 2 3     OR15-152
Olfactory Receptor, Family 4, Subfamily F, Member 121 2     Olfactory Receptor 4F62
Olfactory Receptor 4F122 3     

External Ids:    HGNC: 153721   Entrez Gene: 3906482   Ensembl: ENSG000001841407   UniProtKB: Q8NGB93   

Export aliases for OR4F6 gene to outside databases

Previous GC identifers: GC15U990132 GC15P100082 GC15P100163


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR4F6 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4F6 Gene:
OR4F6 (olfactory receptor, family 4, subfamily F, member 6) is a protein-coding gene. Diseases associated with OR4F6 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4L1.

UniProtKB/Swiss-Prot: OR4F6_HUMAN, Q8NGB9
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4F6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR4F6 gene promoter:
         FOXO3   FOXO3b   Evi-1   FOXL1   AREB6   c-Rel   S8   FOXJ2 (long isoform)   FOXO3a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR4F6 promoter sequence
   Search Chromatin IP Primers for OR4F6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4F6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

OR4F6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4F6 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P102345:  view genomic region     (about GC identifiers)

Start:
102,345,923 bp from pter      End:
102,346,858 bp from pter
Size:
936 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OR4F6_HUMAN, Q8NGB9 (See protein sequence)
Recommended Name: Olfactory receptor 4F6  
Size: 312 amino acids; 35355 Da
Secondary accessions: B9EH28 Q6IF95

Explore the universe of human proteins at neXtProt for OR4F6: NX_Q8NGB9

Explore proteomics data for OR4F6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR4F6

    See OR4F6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005326.1  
    ENSEMBL proteins: 
     ENSP00000327525  
    Reactome Protein details: Q8NGB9

    OR4F6 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGB9

    ProtoNet protein and cluster: Q8NGB9

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR4F6_HUMAN, Q8NGB9
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR4F6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR4F6_HUMAN, Q8NGB9
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR4F6 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR4F6_HUMAN, Q8NGB9: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR4F6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR4F6 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR4F6
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR4F6):
        Olfactory transduction


    OR4F6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR4F6
    Interactions:

        Search GeneGlobe Interaction Network for OR4F6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR4F6 (ENSP000003275254) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10A4ENSP000003691574STRING: ENSP00000369157
    OR10J5ENSP000003344414STRING: ENSP00000334441
    OR4E2ENSP000003861954STRING: ENSP00000386195
    OR5AR1ENSP000003026394STRING: ENSP00000302639
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR4F6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR4F6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR4F6 gene: 
    NM_001005326.1  

    Unigene Cluster for OR4F6:

    Olfactory receptor, family 4, subfamily F, member 6
    Hs.553399
    Unigene Representative Sequence: BC137002
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328882(uc010utr.2)
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat OR4F6
      QuantiFast Probe-based Assays in human, mouse, rat OR4F6

    Additional mRNA sequence: 

    BC137002.1 BC137003.1 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR4F6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR4F6 Expression
    About this image

    OR4F6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR4F6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553399
        Custom PCR Arrays for OR4F6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4F6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR4F6 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr13115
    Olfr13101
    olfactory receptor 13115
    olfactory receptor 13101
    82.74(n)1
    85.21(a)1
      2 (56.75 cM)5
    2584411  NM_146449.11  NP_666660.11 
     1120209145 


    ENSEMBL Gene Tree for OR4F6 (if available)
    TreeFam Gene Tree for OR4F6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR4F6 gene
    OR4L12  OR4F162  OR4K12  OR4K52  OR4K142  OR4F172  OR4F52  OR4F42  
    OR4K132  OR4K152  OR4F212  OR4F152  OR4F32  OR4K22  OR4K172  OR4F292  
    Selected SIMAP similar genes for OR4F6 using alignment to 1 protein entry:     OR4F6_HUMAN(see all similar genes):
    OR4F15    OR4F16    OR4F21    OR4F29    OR4F3    OR4K15
    OR4F5    OR4K2    OR4K3    OR4F17    OR4F4    OR4K14
    OR4K17    OR4K5    OR4K1    OR4K13    FKSG35    OR4Q3

    OR4F6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR4F6 (see all 95)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459460151,2
    C--102343986(+) CAGACA/GTGTTG 1 -- us2k10--------
    rs620270421,2
    C,F--102344003(+) GGTCTC/TCAGGC 1 -- us2k18Minor allele frequency- T:0.16NA WA CSA EA 368
    rs771655051,2
    --102344021(+) AAAGTC/TGGAGT 1 -- us2k10--------
    rs1830270891,2
    --102344094(+) TTTTGG/TTATGT 1 -- us2k10--------
    rs1432502731,2
    --102344136(+) AGATCA/GTCACA 1 -- us2k10--------
    rs1876068811,2
    --102344313(+) AAAGTC/TTCATT 1 -- us2k10--------
    rs1467027941,2
    --102344325(+) AGGTCA/TTAACA 1 -- us2k10--------
    rs1396889781,2
    --102344327(+) GTCATA/TACAAC 1 -- us2k10--------
    rs107135221,2
    C--102344384(+) AATTT-/GGGGAG 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1998201761,2
    C--102344384(+) AATTTG/TGGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR4F6 ( 102345923 - 102346858 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR4F6 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904620CNV Loss21882294
    nsv524612CNV Loss19592680
    esv2751291CNV Gain17911159
    nsv519940CNV Gain19592680
    nsv904621CNV Gain21882294
    nsv904619CNV Gain21882294
    nsv469708CNV Gain16826518
    dgv113e55CNV Gain17911159
    dgv2454n71CNV Gain21882294
    dgv788e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR4F6:    
    About MalaCards
    neuronitis


    OR4F6 for disorders           About GeneDecksing


    Export disorders for OR4F6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR4F6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR4F6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. (PubMed id 12507995)1 Brock C....NA1rnberg B. (J. Cell Biol. 2003)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus. (PubMed id 10488142)1 Metjian A....Abrams C.S. (J. Biol. Chem. 1999)
    6. Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits. (PubMed id 10358071)1 Krugmann S....Braselmann S. (J. Biol. Chem. 1999)
    7. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390648 HGNC: 15372 Ensembl:ENSG00000184140 euGenes: HUgn390648 ECgene: OR4F6 Kegg: 390648
    H-InvDB: OR4F6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR4F6 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4F6 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR4F6 gene:
    Search GeneIP for patents involving OR4F6

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     OriGene Antibodies for OR4F6   OriGene RNAi products in human, mouse, rat for OR4F6  
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     Block miRNA regulation of human, mouse, rat OR4F6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR4F6
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