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Aliases for OR4F6 Gene

Aliases for OR4F6 Gene

  • Olfactory Receptor, Family 4, Subfamily F, Member 6 2 3
  • Olfactory Receptor, Family 4, Subfamily F, Member 12 2 3
  • Olfactory Receptor OR15-15 3 4
  • Olfactory Receptor 4F12 3 4
  • OR4F12 3 4
  • Olfactory Receptor 4F6 3
  • OR15-15 3

External Ids for OR4F6 Gene

Previous HGNC Symbols for OR4F6 Gene

  • OR4F12

Previous GeneCards Identifiers for OR4F6 Gene

  • GC15U990132
  • GC15P100082
  • GC15P100163
  • GC15P102345

Summaries for OR4F6 Gene

Entrez Gene Summary for OR4F6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F6 Gene

OR4F6 (Olfactory Receptor, Family 4, Subfamily F, Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4F4.

UniProtKB/Swiss-Prot for OR4F6 Gene

  • Odorant receptor.

Gene Wiki entry for OR4F6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4F6 Gene

Genomics for OR4F6 Gene

Regulatory Elements for OR4F6 Gene

Genomic Location for OR4F6 Gene

101,805,699 bp from pter
101,806,686 bp from pter
988 bases
Plus strand

Genomic View for OR4F6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4F6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F6 Gene

Proteins for OR4F6 Gene

  • Protein details for OR4F6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4F6
    Protein Accession:
    Secondary Accessions:
    • B9EH28
    • Q6IF95

    Protein attributes for OR4F6 Gene

    312 amino acids
    Molecular mass:
    35355 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F6 Gene

Proteomics data for OR4F6 Gene at MOPED

Post-translational modifications for OR4F6 Gene

Other Protein References for OR4F6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F6 Gene

Domains for OR4F6 Gene

Gene Families for OR4F6 Gene

  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4F6 Gene

Suggested Antigen Peptide Sequences for OR4F6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8NGB9
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F6: view

Function for OR4F6 Gene

Molecular function for OR4F6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4F6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4F6 Gene

Localization for OR4F6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR4F6 Gene COMPARTMENTS Subcellular localization image for OR4F6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4F6: view

Pathways for OR4F6 Gene

genes like me logo Genes that share pathways with OR4F6: view

Pathways by source for OR4F6 Gene

Interacting Proteins for OR4F6 Gene

Gene Ontology (GO) - Biological Process for OR4F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4F6: view

Transcripts for OR4F6 Gene

mRNA/cDNA for OR4F6 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4F6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F6 Gene

No ASD Table

Relevant External Links for OR4F6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4F6 Gene

mRNA expression in normal human tissues for OR4F6 Gene

SOURCE GeneReport for Unigene cluster for OR4F6 Gene Hs.553399

genes like me logo Genes that share expressions with OR4F6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR4F6 Gene

Orthologs for OR4F6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC504344 35
  • 78.14 (n)
  • 76.53 (a)
-- 36
  • 71 (a)
(Mus musculus)
Mammalia Olfr1310 35
  • 82.74 (n)
  • 85.21 (a)
Olfr1311 16
Olfr1310 36
  • 85 (a)
(Pan troglodytes)
Mammalia LOC467782 35
  • 99.25 (n)
  • 99.04 (a)
OR4F6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Olr783 35
  • 82.1 (n)
  • 84.24 (a)
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
Species with no ortholog for OR4F6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4F6 Gene

Gene Tree for OR4F6 (if available)
Gene Tree for OR4F6 (if available)

Paralogs for OR4F6 Gene

Selected SIMAP similar genes for OR4F6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4F6: view

Variants for OR4F6 Gene

Sequence variations from dbSNP and Humsavar for OR4F6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs401632 -- 101,805,827(+) TATGT(A/G)TCAAG synonymous-codon, reference
rs3934044 -- 101,804,368(+) CATTT(C/T)TGTTG upstream-variant-2KB
rs4965937 -- 101,804,580(+) TTTTT(C/T)CCTTT upstream-variant-2KB
rs7169656 -- 101,806,884(+) TATAT(A/G)TAATG downstream-variant-500B
rs10713522 -- 101,804,181(+) AATTT(-/G)GGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4F6 Gene

Variant ID Type Subtype PubMed ID
dgv113e55 CNV Gain 17911159
dgv2454n71 CNV Gain 21882294
nsv482948 CNV Complex 15286789
nsv904619 CNV Gain 21882294
dgv788e1 CNV Complex 17122850
nsv469708 CNV Gain 16826518
esv2751291 CNV Gain 17911159
nsv904620 CNV Loss 21882294
nsv469527 CNV Complex 16826518
nsv524612 CNV Loss 19592680
nsv519940 CNV Gain 19592680
nsv904621 CNV Gain 21882294

Relevant External Links for OR4F6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4F6 Gene

Disorders for OR4F6 Gene

No disorders were found for OR4F6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR4F6 Gene

Publications for OR4F6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits. (PMID: 10358071) Krugmann S. … Braselmann S. (J. Biol. Chem. 1999) 3
  4. Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus. (PMID: 10488142) Metjian A. … Abrams C.S. (J. Biol. Chem. 1999) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR4F6 Gene

Sources for OR4F6 Gene

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