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Aliases for OR4F4 Gene

Aliases for OR4F4 Gene

  • Olfactory Receptor, Family 4, Subfamily F, Member 4 2 3
  • Olfactory Receptor OR19-3 3 4
  • HS14a-1-A 3 4
  • Olfactory Receptor, Family 4, Subfamily F, Member 18 3
  • Olfactory Receptor 4F4 3
  • OLA-7501 3
  • OR4F18 3
  • OR4F17 3

External Ids for OR4F4 Gene

Previous GeneCards Identifiers for OR4F4 Gene

  • GC02U990131
  • GC15U900440
  • GC19P000062
  • GC15M100279
  • GC15M102462

Summaries for OR4F4 Gene

Entrez Gene Summary for OR4F4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F4 Gene

OR4F4 (Olfactory Receptor, Family 4, Subfamily F, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4F5.

UniProtKB/Swiss-Prot for OR4F4 Gene

  • Odorant receptor.

Gene Wiki entry for OR4F4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4F4 Gene

Genomics for OR4F4 Gene

Regulatory Elements for OR4F4 Gene

Genomic Location for OR4F4 Gene

Start:
101,922,042 bp from pter
End:
101,923,095 bp from pter
Size:
1,054 bases
Orientation:
Minus strand

Genomic View for OR4F4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4F4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F4 Gene

Proteins for OR4F4 Gene

  • Protein details for OR4F4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R69-OR4F4_HUMAN
    Recommended name:
    Olfactory receptor 4F4
    Protein Accession:
    Q96R69
    Secondary Accessions:
    • B2RNI5
    • Q6IFN9

    Protein attributes for OR4F4 Gene

    Size:
    305 amino acids
    Molecular mass:
    34259 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F4 Gene

Proteomics data for OR4F4 Gene at MOPED

Post-translational modifications for OR4F4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR4F4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F4 Gene

Domains for OR4F4 Gene

Gene Families for OR4F4 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4F4 Gene

Suggested Antigen Peptide Sequences for OR4F4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96R69

UniProtKB/Swiss-Prot:

OR4F4_HUMAN :
  • Q96R69
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F4: view

Function for OR4F4 Gene

Molecular function for OR4F4 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4F4 Gene

Localization for OR4F4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4F4 Gene COMPARTMENTS Subcellular localization image for OR4F4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4F4: view

Pathways for OR4F4 Gene

genes like me logo Genes that share pathways with OR4F4: view

Pathways by source for OR4F4 Gene

Interacting Proteins for OR4F4 Gene

Gene Ontology (GO) - Biological Process for OR4F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4F4: view

Transcripts for OR4F4 Gene

mRNA/cDNA for OR4F4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F4 Gene

No ASD Table

Relevant External Links for OR4F4 Gene

GeneLoc Exon Structure for
OR4F4
ECgene alternative splicing isoforms for
OR4F4

Expression for OR4F4 Gene

mRNA expression in normal human tissues for OR4F4 Gene

SOURCE GeneReport for Unigene cluster for OR4F4 Gene Hs.554420

genes like me logo Genes that share expressions with OR4F4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR4F4 Gene

Orthologs for OR4F4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100608733 35
  • 99.56 (n)
  • 98.68 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 78 (a)
OneToMany
LOC785647 35
  • 88.45 (n)
  • 85.48 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 54 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr1289 36
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr765 35
  • 83.5 (n)
  • 83.17 (a)
Species with no ortholog for OR4F4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4F4 Gene

ENSEMBL:
Gene Tree for OR4F4 (if available)
TreeFam:
Gene Tree for OR4F4 (if available)

Paralogs for OR4F4 Gene

Selected SIMAP similar genes for OR4F4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4F4 Gene

genes like me logo Genes that share paralogs with OR4F4: view

Variants for OR4F4 Gene

Sequence variations from dbSNP and Humsavar for OR4F4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1167335 -- 101,924,174(-) TTCTC(C/T)CTTTT upstream-variant-2KB
rs1419821 -- 101,922,399(-) AGCAT(C/T)GCCCT missense, reference
rs1419827 -- 101,924,491(-) ATTAC(A/C)GTGCT upstream-variant-2KB
rs2531264 -- 101,924,315(-) AAAGT(A/G)GAATT upstream-variant-2KB
rs4965412 -- 101,921,848(+) ACTTA(A/G)GATCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR4F4 Gene

Variant ID Type Subtype PubMed ID
nsv904619 CNV Gain 21882294
esv27561 CNV Gain 19812545
nsv904622 CNV Gain 21882294
nsv9315 CNV Gain+Loss 18304495
nsv471523 CNV Duplication 19718026
nsv511553 CNV Loss 21212237
nsv820527 CNV Duplication 20802225
dgv453n67 CNV Gain 20364138

Relevant External Links for OR4F4 Gene

HapMap Linkage Disequilibrium report
OR4F4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4F4 Gene

Disorders for OR4F4 Gene

No disorders were found for OR4F4 Gene.

No data available for UniProtKB/Swiss-Prot for OR4F4 Gene

Publications for OR4F4 Gene

  1. Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes. (PMID: 9384599) Trask B.J. … van den Engh G. (Hum. Mol. Genet. 1998) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR4F4 Gene

Sources for OR4F4 Gene

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