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OR4F4 Gene

protein-coding   GIFtS: 44
GCID: GC15M102462

Olfactory Receptor, Family 4, Subfamily F, Member 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 4, Subfamily F, Member 41 2     OR4F172
Olfactory Receptor OR19-32 3     OR4F182
HS14a-1-A2 3     Olfactory Receptor 4F42
OLA-75012     Olfactory Receptor, Family 4, Subfamily F, Member 182

External Ids:    HGNC: 83011   Entrez Gene: 266822   Ensembl: ENSG000001776937   UniProtKB: Q96R693   

Export aliases for OR4F4 gene to outside databases

Previous GC identifers: GC02U990131 GC15U900440 GC19P000062 GC15M100279


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR4F4 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4F4 Gene:
OR4F4 (olfactory receptor, family 4, subfamily F, member 4) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4L1.

UniProtKB/Swiss-Prot: OR4F4_HUMAN, Q96R69
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4F4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR4F4 gene promoter:
         RORalpha1   SRY   POU2F1   AML1a   POU2F1a   Sox9   CUTL1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR4F4 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4F4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

OR4F4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4F4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M102462:  view genomic region     (about GC identifiers)

Start:
102,462,348 bp from pter      End:
102,463,262 bp from pter
Size:
915 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: OR4F4_HUMAN, Q96R69 (See protein sequence)
Recommended Name: Olfactory receptor 4F4  
Size: 305 amino acids; 34259 Da
Secondary accessions: B2RNI5 Q6IFN9

Explore the universe of human proteins at neXtProt for OR4F4: NX_Q96R69

Explore proteomics data for OR4F4 at MOPED

HORDE protein sequence for OR4F4

See OR4F4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001004195.2  
ENSEMBL proteins: 
 ENSP00000317482  
Reactome Protein details: Q96R69

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR4: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q96R69

ProtoNet protein and cluster: Q96R69

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR4F4_HUMAN, Q96R69
Similarity: Belongs to the G-protein coupled receptor 1 family


Find genes that share domains with OR4F4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: OR4F4_HUMAN, Q96R69
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
Find genes that share ontologies with OR4F4           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
OR4F4_HUMAN, Q96R69: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR4F4 About    
See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90


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Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for OR4F4
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR4F4):
    Olfactory transduction

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Interactions:

    Search GeneGlobe Interaction Network for OR4F4

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for OR4F4 (ENSP000003174824) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ADRBK2ENSP000003175784STRING: ENSP00000317578
ARRB2ENSP000002692604STRING: ENSP00000269260
GNALENSP000003340514STRING: ENSP00000334051
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for OR4F4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for OR4F4 gene: 
NM_001004195.2  

Unigene Cluster for OR4F4:

Olfactory receptor, family 4, subfamily F, member 4
Hs.554420
Unigene Representative Sequence: BC136907
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000326183(uc002cdf.1)
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Additional mRNA sequence: 

AY972817.1 AY972819.1 BC136907.1 BC136908.1 

2 DOTS entries:

DT.121488925  DT.121017885 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR4F4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGACGGCAA
OR4F4 Expression
About this image

OR4F4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OR4F4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.554420
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for OR4F4 (if available)
TreeFam Gene Tree for OR4F4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR4F4 gene
OR4F171 2  OR4F51 2  OR4L12  OR4F162  OR4K12  OR4K52  OR4K142  OR4K132  
OR4K152  OR4F212  OR4F62  OR4F152  OR4F32  OR4K22  OR4K172  OR4F292  
Selected SIMAP similar genes for OR4F4 using alignment to 1 protein entry:     OR4F4_HUMAN(see all similar genes):
OR4F17    OR4F5    OR4K14    OR4K15    OR4K3    OR4K5
OR4K13    OR4F15    OR4K17    OR4K2    OR4F21    OR4K1
OR4Q3    OR4N2    OR4F3    OR4F16    OR4F29    OR4F6

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3 Pseudogenes.org Pseudogenes for OR4F4
PGOHUM00000246951 PGOHUM00000234459 PGOHUM00000244551


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR4F4 (see all 41)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1476944711,2
C--102462043(+) TCTACG/TAAACT 1 -- ds50010--------
rs49654121,2
C,F,H--102462051(+) ACTTAG/AGATCA 1 -- ds50017Minor allele frequency- A:0.07NS EA NA WA 656
rs1479748481,2
F--102462343(+) ATAAGA/TTCTAA 1 -- ds50011Minor allele frequency- T:0.00NA 4170
rs1407408481,2
C,F--102462351(+) TAAAAC/GTTTAC 2 N K mis11Minor allele frequency- G:0.00NA 4338
rs1500917101,2
C,F--102462424(+) GTGTGA/G/TATATA 3 Y S F mis12NA EU 5597
rs2019549551,2
--102462456(+) ATCACA/GGAATA 2 S syn10--------
rs765979421,2
C,F--102462585(+) TTGGAC/TGACTT 2 S syn12Minor allele frequency- T:0.03NA EU 5327
rs2006672061,2
C,F--102462857(+) AATGCC/TGACAC 2 S G mis11Minor allele frequency- T:0.03EU 500
rs1999326861,2
--102462925(+) TGTCAA/CAGCCC 2 C F mis10--------
rs2019778331,2
F--102463219(+) GGAGTT/CCCTGA 2 /E /G mis11Minor allele frequency- C:0.01EU 423

HapMap Linkage Disequilibrium report for OR4F4 ( 102462348 - 102463262 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for OR4F4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv820527CNV Duplication20802225
nsv471523CNV Duplication19718026
nsv511553CNV Loss21212237
esv27561CNV Gain19812545
dgv453n67CNV Gain20364138
nsv904619CNV Gain21882294
nsv904622CNV Gain21882294
nsv9315CNV Gain+Loss18304495

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OR4F4 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR4F4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
  3. Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes. (PubMed id 9384599)1, 2 Trask B.J.... van den Engh G. (Hum. Mol. Genet. 1998)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non- homologous chromosomes. (PubMed id 11689483)1 Mefford H.C.... Trask B.J. (Hum. Mol. Genet. 2001)
  7. Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location. (PubMed id 11689484)1 Linardopoulou E.... Trask B.J. (Hum. Mol. Genet. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26682 HGNC: 8301 Ensembl:ENSG00000177693 euGenes: HUgn26682 ECgene: OR4F4 Kegg: 26682
H-InvDB: OR4F4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR4F4 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR4F4 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR4F4 gene:
Search GeneIP for patents involving OR4F4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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 Block miRNA regulation of human, mouse, rat OR4F4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR4F4
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4F4 Predesigned siRNA for gene silencing in human, mouse, rat OR4F4
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 Custom PCR Arrays for OR4F4 Search Chromatin IP Primers for OR4F4
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 GenScript Custom Purified and Recombinant Proteins Services for OR4F4 GenScript cDNA clones with any tag delivered in your preferred vector for OR4F4
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 Browse ESI BIO Cell Lines and PureStem Progenitors for OR4F4
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4F4
 Browse SwitchGear 3'UTR luciferase reporter plasmids for OR4F4
 SwitchGear Promoter luciferase reporter plasmids for OR4F4
 Search ThermoFisher Antibodies for OR4F4
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4F4
 Browse compounds at ApexBio
 Search Addgene for plasmids for OR4F4
  Search eBioscience for proteins for OR4F4
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 genOway: Develop your customized and physiologically relevant rodent model for OR4F4
 antibodies-online antibodies for OR4F4 (15 products)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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