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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR4F3 Gene

protein-coding   GIFtS: 44
GCID: GC05P180794

Olfactory Receptor, Family 4, Subfamily F, Member 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 4, Subfamily F, Member 31 2
Olfactory Receptor OR1-12 3
Olfactory Receptor 4F3/4F16/4F292
Olfactory Receptor OR7-212

External Ids:    HGNC: 83001   Entrez Gene: 266832   Ensembl: ENSG000002301787   UniProtKB: Q6IEY13   

Export aliases for OR4F3 gene to outside databases

Previous GC identifers: GC08U990096 GC01P000410 GC05P180726


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR4F3 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4F3 Gene: 
OR4F3 (olfactory receptor, family 4, subfamily F, member 3) is a protein-coding gene. Diseases associated with OR4F3 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. An important paralog of this gene is OR4L1.

UniProtKB/Swiss-Prot: OR4F3_HUMAN, Q6IEY1
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4F3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR4F3 gene promoter:
         HOXA9B   SRF   SRF (504 AA)   HTF   POU3F1   E4BP4   Meis-1b   FOXL1   Pax-4a   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for OR4F3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR4F3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

OR4F3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4F3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P180794:  view genomic region     (about GC identifiers)

Start:
180,794,288 bp from pter      End:
180,795,223 bp from pter
Size:
936 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: OR4F3_HUMAN, Q6IEY1 (See protein sequence)
Recommended Name: Olfactory receptor 4F3/4F16/4F29  
Size: 312 amino acids; 35074 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2RPQ6

Explore the universe of human proteins at neXtProt for OR4F3: NX_Q6IEY1

Explore proteomics data for OR4F3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6IEY1

  • HORDE protein sequence for OR4F3
    OR4F3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR4F3 Protein Expression
    REFSEQ proteins: NP_001005224.1  
    ENSEMBL proteins: 
     ENSP00000394282  
    Reactome Protein details: Q6IEY1
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0016021integral to membrane ----

    OR4F3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q6IEY1

    ProtoNet protein and cluster: Q6IEY1

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR4F3_HUMAN, Q6IEY1
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR4F3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR4F3_HUMAN, Q6IEY1
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004984olfactory receptor activity ----
         
    OR4F3 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR4F3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for OR4F3
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR4F3):
        Olfactory transduction


    OR4F3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR4F3

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR4F3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR4F3

    Search CenterWatch for drugs/clinical trials and news about OR4F3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for OR4F3 gene: 
    NM_001005224.1  

    Unigene Cluster for OR4F3:

    Olfactory receptor, family 4, subfamily F, member 3
    Hs.722724
    Unigene Representative Sequence: NM_001005221
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000456475(uc011dhm.2)
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    2 DOTS entries:

    DT.120860007  DT.121347918 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR4F3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTGTATA
    OR4F3 Expression
    About this image


    See OR4F3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OR4F3

    SOURCE GeneReport for Unigene cluster: Hs.722724
        SABiosciences Custom PCR Arrays for OR4F3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4F3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR4F3 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr13161 olfactory receptor 1316 75.85(n)
    74.36(a)
      258737  NM_146742.1  NP_666953.1 


    ENSEMBL Gene Tree for OR4F3 (if available)
    TreeFam Gene Tree for OR4F3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR4F3 gene
    OR4F161 2  OR4F291 2  OR4F211 2  OR4L12  OR4K12  OR4K52  OR4K142  OR4F42  
    OR4F52  OR4F172  OR4K132  OR4K152  OR4F62  OR4F152  OR4K22  OR4K172  
    18/439 SIMAP similar genes for OR4F3 using alignment to 2 protein entries:     OR4F3_HUMAN (see all proteins) (see all similar genes):
    OR4F16    OR4F21    OR4F29    OR4F15    OR4F6    OR4F5
    OR4K17    OR4F17    OR4F4    OR4K3    OR4K1    OR4K13
    OR4K2    OR4K5    OR4K15    OR4K14    OR4N2    OR4D1

    OR4F3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for OR4F3 (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv820415CNV Deletion20802225
    nsv471442CNV Duplication19718026
    nsv471518CNV Duplication19718026
    nsv471522CNV Duplication19718026
    dgv1e24CNV Loss17666407
    nsv830758CNV Loss17160897
    dgv2n14CNV Gain18776910
    nsv870793CNV Gain21882294
    dgv2n71CNV Gain21882294
    nsv871459CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OR4F3:    About MalaCards
    neuronitis    


    OR4F3 for disorders           About GeneDecksing


    Export disorders for OR4F3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR4F3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR4F3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26683 HGNC: 8300 Ensembl:ENSG00000230178 euGenes: HUgn26683 ECgene: OR4F3 Kegg: 26683
    H-InvDB: OR4F3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR4F3 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4F3 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR4F3 gene:
    Search GeneIP for patents involving OR4F3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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