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Aliases for OR4F21 Gene

Aliases for OR4F21 Gene

  • Olfactory Receptor Family 4 Subfamily F Member 21 2 3 5
  • OR4F21P 3 4
  • Olfactory Receptor, Family 4, Subfamily F, Member 21 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily F, Member 21 2

External Ids for OR4F21 Gene

Previous HGNC Symbols for OR4F21 Gene

  • OR4F21P

Previous GeneCards Identifiers for OR4F21 Gene

  • GC08M000107
  • GC08M000018

Summaries for OR4F21 Gene

Entrez Gene Summary for OR4F21 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F21 Gene

OR4F21 (Olfactory Receptor Family 4 Subfamily F Member 21) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F5.

UniProtKB/Swiss-Prot for OR4F21 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4F21 Gene

Genomics for OR4F21 Gene

Regulatory Elements for OR4F21 Gene

Enhancers for OR4F21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR4F21 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4F21 Gene

Chromosome:
8
Start:
166,049 bp from pter
End:
167,043 bp from pter
Size:
995 bases
Orientation:
Minus strand

Genomic View for OR4F21 Gene

Genes around OR4F21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4F21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4F21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F21 Gene

Proteins for OR4F21 Gene

  • Protein details for OR4F21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95013-O4F21_HUMAN
    Recommended name:
    Olfactory receptor 4F21
    Protein Accession:
    O95013
    Secondary Accessions:
    • A6NIU1

    Protein attributes for OR4F21 Gene

    Size:
    312 amino acids
    Molecular mass:
    35094 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F21 Gene

Proteomics data for OR4F21 Gene at MOPED

Post-translational modifications for OR4F21 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4F21 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F21 Gene

Domains & Families for OR4F21 Gene

Gene Families for OR4F21 Gene

Protein Domains for OR4F21 Gene

Suggested Antigen Peptide Sequences for OR4F21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95013

UniProtKB/Swiss-Prot:

O4F21_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F21: view

Function for OR4F21 Gene

Molecular function for OR4F21 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F21: view
genes like me logo Genes that share phenotypes with OR4F21: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4F21 Gene

Localization for OR4F21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F21 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4F21 Gene COMPARTMENTS Subcellular localization image for OR4F21 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR4F21: view

Pathways & Interactions for OR4F21 Gene

genes like me logo Genes that share pathways with OR4F21: view

Pathways by source for OR4F21 Gene

Interacting Proteins for OR4F21 Gene

Gene Ontology (GO) - Biological Process for OR4F21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4F21: view

No data available for SIGNOR curated interactions for OR4F21 Gene

Drugs & Compounds for OR4F21 Gene

No Compound Related Data Available

Transcripts for OR4F21 Gene

mRNA/cDNA for OR4F21 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F21 Gene

No ASD Table

Relevant External Links for OR4F21 Gene

GeneLoc Exon Structure for
OR4F21
ECgene alternative splicing isoforms for
OR4F21

Expression for OR4F21 Gene

mRNA expression in normal human tissues for OR4F21 Gene

SOURCE GeneReport for Unigene cluster for OR4F21 Gene Hs.690459

genes like me logo Genes that share expression patterns with OR4F21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR4F21 Gene

Orthologs for OR4F21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC788764 35
  • 77.06 (n)
  • 71.1 (a)
-- 36
  • 90 (a)
ManyToMany
-- 36
  • 88 (a)
ManyToMany
-- 36
  • 88 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia cOR4F25 35
  • 77.99 (n)
  • 72.76 (a)
-- 36
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr1303 35
  • 82.05 (n)
  • 81.41 (a)
Olfr1303 36
  • 81 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC744286 35
  • 99.25 (n)
  • 98.07 (a)
-- 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr774 35
  • 82.37 (n)
  • 82.37 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
Species with no ortholog for OR4F21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4F21 Gene

ENSEMBL:
Gene Tree for OR4F21 (if available)
TreeFam:
Gene Tree for OR4F21 (if available)

Paralogs for OR4F21 Gene

(439) SIMAP similar genes for OR4F21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4F21: view

Variants for OR4F21 Gene

Sequence variations from dbSNP and Humsavar for OR4F21 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs112889880 -- 167,229(+) GATTT(A/C)AACCC upstream-variant-2KB
rs183788954 -- 167,997(+) CACCC(C/T)TTTAA upstream-variant-2KB
rs192639556 -- 166,895(+) AATGA(A/G)GATGT reference, missense
rs199977572 -- 166,096(+) AGATC(C/T)TCTTG reference, missense
rs200017570 -- 166,596(+) AGAAA(C/T)GAAAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR4F21 Gene

Variant ID Type Subtype PubMed ID
nsv471521 CNV Duplication 19718026
esv26079 CNV Gain+Loss 19812545
nsv8253 CNV Gain+Loss 18304495
nsv831205 CNV Loss 17160897
nsv428193 CNV Gain+Loss 18775914
dgv2168e1 CNV Complex 17122850
dgv2169e1 CNV Complex 17122850
nsv820991 CNV Deletion 20802225
nsv515053 CNV Complex 21397061

Variation tolerance for OR4F21 Gene

Gene Damage Index Score: 0.70; 14.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4F21 Gene

HapMap Linkage Disequilibrium report
OR4F21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4F21 Gene

Disorders for OR4F21 Gene

Relevant External Links for OR4F21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4F21

No disorders were found for OR4F21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4F21 Gene

Publications for OR4F21 Gene

  1. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 67

Products for OR4F21 Gene

Sources for OR4F21 Gene

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