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Aliases for OR4F21 Gene

Aliases for OR4F21 Gene

  • Olfactory Receptor, Family 4, Subfamily F, Member 21 2 3
  • OR4F21P 3 4
  • Olfactory Receptor, Family 4, Subfamily F, Member 21 Pseudogene 3
  • Olfactory Receptor 4F21 3

External Ids for OR4F21 Gene

Previous HGNC Symbols for OR4F21 Gene

  • OR4F21P

Previous GeneCards Identifiers for OR4F21 Gene

  • GC08M000107
  • GC08M000018

Summaries for OR4F21 Gene

Entrez Gene Summary for OR4F21 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F21 Gene

OR4F21 (Olfactory Receptor, Family 4, Subfamily F, Member 21) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4F4.

UniProtKB/Swiss-Prot for OR4F21 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4F21 Gene

Genomics for OR4F21 Gene

Regulatory Elements for OR4F21 Gene

Genomic Location for OR4F21 Gene

Start:
166,049 bp from pter
End:
167,043 bp from pter
Size:
995 bases
Orientation:
Minus strand

Genomic View for OR4F21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4F21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F21 Gene

Proteins for OR4F21 Gene

  • Protein details for OR4F21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95013-O4F21_HUMAN
    Recommended name:
    Olfactory receptor 4F21
    Protein Accession:
    O95013
    Secondary Accessions:
    • A6NIU1

    Protein attributes for OR4F21 Gene

    Size:
    312 amino acids
    Molecular mass:
    35094 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F21 Gene

Proteomics data for OR4F21 Gene at MOPED

Post-translational modifications for OR4F21 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4F21 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F21 Gene

Domains for OR4F21 Gene

Gene Families for OR4F21 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4F21 Gene

Suggested Antigen Peptide Sequences for OR4F21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95013

UniProtKB/Swiss-Prot:

O4F21_HUMAN :
  • O95013
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F21: view

Function for OR4F21 Gene

Molecular function for OR4F21 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F21: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4F21 Gene

Localization for OR4F21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F21 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4F21 Gene COMPARTMENTS Subcellular localization image for OR4F21 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4F21: view

Pathways for OR4F21 Gene

SuperPathways for OR4F21 Gene

Superpath Contained pathways
1 Olfactory Signaling Pathway
genes like me logo Genes that share pathways with OR4F21: view

Pathways by source for OR4F21 Gene

1 KEGG pathway for OR4F21 Gene

Interacting Proteins for OR4F21 Gene

Gene Ontology (GO) - Biological Process for OR4F21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4F21: view

Transcripts for OR4F21 Gene

mRNA/cDNA for OR4F21 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4F21

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR4F21
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F21 Gene

No ASD Table

Relevant External Links for OR4F21 Gene

GeneLoc Exon Structure for
OR4F21
ECgene alternative splicing isoforms for
OR4F21

Expression for OR4F21 Gene

mRNA expression in normal human tissues for OR4F21 Gene

SOURCE GeneReport for Unigene cluster for OR4F21 Gene Hs.690459

genes like me logo Genes that share expressions with OR4F21: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR4F21 Gene

Orthologs for OR4F21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
LOC744286 35
  • 99.25 (n)
  • 98.07 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 90 (a)
ManyToMany
-- 36
  • 88 (a)
ManyToMany
-- 36
  • 88 (a)
ManyToMany
LOC788764 35
  • 77.06 (n)
  • 71.1 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 91 (a)
OneToMany
cOR4F25 35
  • 77.99 (n)
  • 72.76 (a)
mouse
(Mus musculus)
Mammalia Olfr1303 35
  • 82.05 (n)
  • 81.41 (a)
Olfr1303 36
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr774 35
  • 82.37 (n)
  • 82.37 (a)
Species with no ortholog for OR4F21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4F21 Gene

ENSEMBL:
Gene Tree for OR4F21 (if available)
TreeFam:
Gene Tree for OR4F21 (if available)

Paralogs for OR4F21 Gene

Selected SIMAP similar genes for OR4F21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4F21: view

Variants for OR4F21 Gene

Sequence variations from dbSNP and Humsavar for OR4F21 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs112889880 -- 167,229(+) GATTT(A/C)AACCC upstream-variant-2KB
rs181224565 -- 168,153(+) ATTAA(C/T)AAGTG upstream-variant-2KB
rs183788954 -- 167,997(+) CACCC(C/T)TTTAA upstream-variant-2KB
rs188500417 -- 168,013(+) CAGTA(C/T)CTCCT upstream-variant-2KB
rs192639556 -- 166,895(+) AATGA(A/G)GATGT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for OR4F21 Gene

Variant ID Type Subtype PubMed ID
nsv471521 CNV Duplication 19718026
esv26079 CNV Gain+Loss 19812545
nsv8253 CNV Gain+Loss 18304495
nsv831205 CNV Loss 17160897
nsv428193 CNV Gain+Loss 18775914
dgv2168e1 CNV Complex 17122850
dgv2169e1 CNV Complex 17122850
nsv820991 CNV Deletion 20802225
nsv515053 CNV Complex 21397061

Relevant External Links for OR4F21 Gene

HapMap Linkage Disequilibrium report
OR4F21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4F21 Gene

Disorders for OR4F21 Gene

No disorders were found for OR4F21 Gene.

No data available for UniProtKB/Swiss-Prot for OR4F21 Gene

Publications for OR4F21 Gene

  1. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4

Products for OR4F21 Gene

Sources for OR4F21 Gene

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