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Aliases for OR4F17 Gene

Aliases for OR4F17 Gene

  • Olfactory Receptor Family 4 Subfamily F Member 17 2 3 5
  • Olfactory Receptor 4F11 3 4
  • Olfactory Receptor 4F18 3 4
  • Olfactory Receptor 4F19 3 4
  • OR4F11P 3 4
  • OR4F18 3 4
  • OR4F19 3 4
  • Olfactory Receptor, Family 4, Subfamily F, Member 11 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily F, Member 17 2
  • Olfactory Receptor, Family 4, Subfamily F, Member 19 3
  • Olfactory Receptor 4F17 3

External Ids for OR4F17 Gene

Previous HGNC Symbols for OR4F17 Gene

  • OR4F19
  • OR4F11P
  • OR4F18

Previous GeneCards Identifiers for OR4F17 Gene

  • GC16U990216
  • GC19U900464
  • GC19P000063
  • GC19P000064

Summaries for OR4F17 Gene

Entrez Gene Summary for OR4F17 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F17 Gene

OR4F17 (Olfactory Receptor Family 4 Subfamily F Member 17) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F4.

UniProtKB/Swiss-Prot for OR4F17 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4F17 Gene

Genomics for OR4F17 Gene

Regulatory Elements for OR4F17 Gene


Genomic Location for OR4F17 Gene

Chromosome:
19
Start:
107,152 bp from pter
End:
111,696 bp from pter
Size:
4,545 bases
Orientation:
Plus strand

Genomic View for OR4F17 Gene

Genes around OR4F17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4F17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4F17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F17 Gene

Proteins for OR4F17 Gene

  • Protein details for OR4F17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGA8-O4F17_HUMAN
    Recommended name:
    Olfactory receptor 4F17
    Protein Accession:
    Q8NGA8
    Secondary Accessions:
    • B2RNE8

    Protein attributes for OR4F17 Gene

    Size:
    305 amino acids
    Molecular mass:
    34212 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F17 Gene

Post-translational modifications for OR4F17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR4F17 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F17 Gene

Domains & Families for OR4F17 Gene

Gene Families for OR4F17 Gene

Protein Domains for OR4F17 Gene

Suggested Antigen Peptide Sequences for OR4F17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGA8

UniProtKB/Swiss-Prot:

O4F17_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F17: view

Function for OR4F17 Gene

Molecular function for OR4F17 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F17: view
genes like me logo Genes that share phenotypes with OR4F17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4F17 Gene

Localization for OR4F17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F17 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4F17 Gene COMPARTMENTS Subcellular localization image for OR4F17 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4F17: view

Pathways & Interactions for OR4F17 Gene

genes like me logo Genes that share pathways with OR4F17: view

Pathways by source for OR4F17 Gene

Gene Ontology (GO) - Biological Process for OR4F17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4F17: view

No data available for SIGNOR curated interactions for OR4F17 Gene

Drugs & Compounds for OR4F17 Gene

No Compound Related Data Available

Transcripts for OR4F17 Gene

mRNA/cDNA for OR4F17 Gene

(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F17 Gene

No ASD Table

Relevant External Links for OR4F17 Gene

GeneLoc Exon Structure for
OR4F17
ECgene alternative splicing isoforms for
OR4F17

Expression for OR4F17 Gene

mRNA expression in normal human tissues for OR4F17 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4F17 Gene:

OR4F17

SOURCE GeneReport for Unigene cluster for OR4F17 Gene:

Hs.572591
genes like me logo Genes that share expression patterns with OR4F17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR4F17 Gene

Orthologs for OR4F17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC785647 34
  • 88.34 (n)
  • 85.15 (a)
-- 35
  • 78 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC100608733 34
  • 99.45 (n)
  • 98.36 (a)
-- 35
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr765 34
  • 83.39 (n)
  • 82.84 (a)
dog
(Canis familiaris)
Mammalia -- 35
  • 58 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 59 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr1289 35
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
OneToMany
Species where no ortholog for OR4F17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4F17 Gene

ENSEMBL:
Gene Tree for OR4F17 (if available)
TreeFam:
Gene Tree for OR4F17 (if available)

Paralogs for OR4F17 Gene

(445) SIMAP similar genes for OR4F17 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR4F17: view

Variants for OR4F17 Gene

Sequence variations from dbSNP and Humsavar for OR4F17 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10543188 -- 107,954(+) ATATA(-/TATTT)TATTA intron-variant
rs3855807 -- 108,239(-) TATTC(A/T)TGGAA intron-variant
rs11384287 -- 107,893(+) TATAT(-/A)AATAT intron-variant
rs11384288 -- 108,055(+) TTATA(-/T)AAATA intron-variant
rs11669393 -- 107,866(+) atatt(A/T)tatta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR4F17 Gene

Variant ID Type Subtype PubMed ID
dgv1959e59 CNV duplication 20981092
dgv1962e59 CNV duplication 20981092
dgv3419n100 CNV gain 25217958
esv22059 CNV gain+loss 19812545
esv2763195 CNV gain 21179565
nsv1076459 CNV duplication 25765185
nsv1128774 CNV duplication 24896259
nsv1141324 CNV duplication 24896259
nsv1148371 CNV duplication 26484159
nsv471407 CNV gain 19718026
nsv471520 CNV gain 19718026
nsv577974 CNV gain 21841781
nsv577975 CNV gain 21841781
nsv820962 CNV duplication 20802225
nsv953935 CNV duplication 24416366
nsv9651 CNV gain+loss 18304495

Variation tolerance for OR4F17 Gene

Gene Damage Index Score: 0.91; 18.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4F17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4F17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4F17 Gene

Disorders for OR4F17 Gene

Relevant External Links for OR4F17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4F17

No disorders were found for OR4F17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4F17 Gene

Publications for OR4F17 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65
  3. Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non- homologous chromosomes. (PMID: 11689483) Mefford H.C. … Trask B.J. (Hum. Mol. Genet. 2001) 3 65
  4. Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location. (PMID: 11689484) Linardopoulou E. … Trask B.J. (Hum. Mol. Genet. 2001) 3 65
  5. Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes. (PMID: 9384599) Trask B.J. … van den Engh G. (Hum. Mol. Genet. 1998) 3 65

Products for OR4F17 Gene

Sources for OR4F17 Gene

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