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OR4F17 Gene

protein-coding   GIFtS: 41
GCID: GC19P000107

Olfactory Receptor, Family 4, Subfamily F, Member 17


(Previous symbols: OR4F19, OR4F11P, OR4F18)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 4, Subfamily F, Member 171 2     Olfactory Receptor 4F182 3
OR4F11P1 2 3     Olfactory Receptor 4F192 3
OR4F181 2 3     Olfactory Receptor 4F172
OR4F191 2 3     Olfactory Receptor, Family 4, Subfamily F, Member 11 Pseudogene2
Olfactory Receptor 4F112 3     Olfactory Receptor, Family 4, Subfamily F, Member 192

External Ids:    HGNC: 153811   Entrez Gene: 810992   Ensembl: ENSG000001766957   UniProtKB: Q8NGA83   

Export aliases for OR4F17 gene to outside databases

Previous GC identifers: GC16U990216 GC19U900464 GC19P000063 GC19P000064


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR4F17 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4F17 Gene:
OR4F17 (olfactory receptor, family 4, subfamily F, member 17) is a protein-coding gene. Diseases associated with OR4F17 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4L1.

UniProtKB/Swiss-Prot: O4F17_HUMAN, Q8NGA8
Function: Odorant receptor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR4F17 gene promoter:
         SRY   AML1a   AP-1   Sox9   CUTL1   RSRFC4   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR4F17 promoter sequence
   Search Chromatin IP Primers for OR4F17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4F17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

OR4F17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4F17 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000107:  view genomic region     (about GC identifiers)

Start:
110,679 bp from pter      End:
111,593 bp from pter
Size:
915 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: O4F17_HUMAN, Q8NGA8 (See protein sequence)
Recommended Name: Olfactory receptor 4F17  
Size: 305 amino acids; 34212 Da
Secondary accessions: B2RNE8

Explore the universe of human proteins at neXtProt for OR4F17: NX_Q8NGA8

Explore proteomics data for OR4F17 at MOPED

HORDE protein sequence for OR4F17

See OR4F17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001005240.1  
ENSEMBL proteins: 
 ENSP00000467301   ENSP00000315047  
Reactome Protein details: Q8NGA8

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR4: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGA8

ProtoNet protein and cluster: Q8NGA8

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O4F17_HUMAN, Q8NGA8
Similarity: Belongs to the G-protein coupled receptor 1 family


OR4F17 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: O4F17_HUMAN, Q8NGA8
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR4F17 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
O4F17_HUMAN, Q8NGA8: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

OR4F17 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR4F17 About    
See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for OR4F17
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR4F17):
    Olfactory transduction


OR4F17 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR4F17
Interactions:

    Search GeneGlobe Interaction Network for OR4F17

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for OR4F17 (ENSP000003150474) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ADRBK2ENSP000003175784STRING: ENSP00000317578
ARRB2ENSP000002692604STRING: ENSP00000269260
GNALENSP000003340514STRING: ENSP00000334051
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR4F17 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for OR4F17 (O4F17)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for OR4F17 gene: 
NM_001005240.1  

Unigene Cluster for OR4F17:

Olfactory receptor, family 4, subfamily F, member 17
Hs.572591
Unigene Representative Sequence: BC136867
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000585993 ENST00000318050(uc002loc.1)
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Additional mRNA sequence: 

AY972818.1 BC136848.1 BC136867.1 

1 DOTS entry:

DT.121488925 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR4F17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
OR4F17 Expression
About this image

OR4F17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OR4F17 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.572591
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4F17

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for OR4F17 (if available)
TreeFam Gene Tree for OR4F17 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR4F17 gene
OR4F41 2  OR4F51 2  OR4L12  OR4F162  OR4K12  OR4K52  OR4K142  OR4K132  
OR4K152  OR4F212  OR4F62  OR4F152  OR4F32  OR4K22  OR4K172  OR4F292  
Selected SIMAP similar genes for OR4F17 using alignment to 2 protein entries:     O4F17_HUMAN (see all proteins) (see all similar genes):
OR4F4    OR4F5    OR4K14    OR4K15    OR4K3    OR4K5
OR4K13    OR4F15    OR4K1    OR4K17    OR4K2    OR4F21
OR4Q3    OR4F3    OR4F16    OR4F29    OR4F6    OR4N5

OR4F17 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR4F17 (see all 16)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs744335191,2
C--109894(-) TAATAA/GCTGCA 1 -- us2k10--------
rs746129851,2
C--110494(+) ATGATC/TTTGTT 1 -- us2k10--------
rs1454559371,2
F--110708(+) GGTCTC/GTCTGA 2 L syn11Minor allele frequency- G:0.00NA 4552
rs1488368831,2
C,F--110783(+) GGAAAC/ACTTCT 2 /K /N mis11Minor allele frequency- A:0.00NA 4538
rs2014383381,2
F--110893(+) AGCCCC/GCAAGA 2 P R mis11Minor allele frequency- G:0.00EU 1133
rs2003929751,2
F--111520(+) ATACAC/TACTGA 2 T I mis11Minor allele frequency- T:0.01EU 753
rs3764249941,2
----110687(+) GTGACA/TGAATT 2 T syn10--------
rs3678003211,2
----110761(+) ATTCTA/GTGGAG 2 Y C mis10--------
rs2003586271,2
----110859(+) TCTCAC/TTCATT 2 L F mis11Minor allele frequency- T:0.00EU 1291
rs3721219561,2
----110660(+) TCAACA/GAGTGA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OR4F17 ( 110679 - 111593 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for OR4F17:    About this table    
Variant IDTypeSubtypePubMed ID
nsv471407CNV Duplication19718026
nsv820962CNV Duplication20802225
nsv471520CNV Duplication19718026
nsv910070CNV Gain21882294
nsv9651CNV Gain+Loss18304495
esv22059CNV Gain+Loss19812545

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for OR4F17:    
About MalaCards
neuronitis


OR4F17 for disorders           About GeneDecksing


Export disorders for OR4F17 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OR4F17 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR4F17)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non- homologous chromosomes. (PubMed id 11689483)1 Mefford H.C.... Trask B.J. (Hum. Mol. Genet. 2001)
  4. Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location. (PubMed id 11689484)1 Linardopoulou E.... Trask B.J. (Hum. Mol. Genet. 2001)
  5. Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes. (PubMed id 9384599)1 Trask B.J.... van den Engh G. (Hum. Mol. Genet. 1998)
  6. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 81099 HGNC: 15381 Ensembl:ENSG00000176695 euGenes: HUgn81099 ECgene: OR4F17 Kegg: 81099
H-InvDB: OR4F17

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR4F17 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR4F17 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR4F17 gene:
Search GeneIP for patents involving OR4F17

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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