OR4F16 Gene
protein-coding GIFtS: 43
GCID: GC01M000622
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|
olfactory receptor, family 4, subfamily F, member 16
| |
Aliases
for OR4F16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 4, Subfamily F, Member 161 2 | | Olfactory Receptor 4F3/4F16/4F292 | | Olfactory Receptor OR1-12 3 | | Olfactory Receptor OR4F162 | | OR1-12 | | Olfactory Receptor OR7-212 | | OR7-212 | | |
Export aliases for OR4F16 gene to outside databasesPrevious GC identifers: GC06U990266 GC08M000108 GC01M000662 GC01M000611 GC05P180727 |
Summaries
for OR4F16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR4F16:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR4F3_HUMAN, Q6IEY1Function: Odorant receptor (Potential)
Gene Wiki entry for OR4F16
|
Genomic Views
for OR4F16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018922.1 NT_004350.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR4F16 gene promoter:
HOXA9B SRF SRF (504 AA) HTF POU3F1 E4BP4 Meis-1b FOXL1 Pax-4a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR4F16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR4F16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33OR4F16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M000622: view genomic region
(about GC identifiers)
Start:
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621,099 bp from pter |
End:
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622,034 bp from pter |
Size:
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936 bases |
Orientation:
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minus strand |
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Proteins
for OR4F16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR4F3_HUMAN, Q6IEY1 (See
protein sequence)Recommended Name: Olfactory receptor 4F3/4F16/4F29 Size: 312 amino acids; 35074 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2RPQ6Explore the universe of human proteins at neXtProt for OR4F16: NX_Q6IEY1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6IEY1
HORDE protein sequence for OR4F16
OR4F16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001005277.1
ENSEMBL proteins: ENSP00000329982 Reactome Protein details: Q6IEY1
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
-- | -- | | GO:0016021 | integral to membrane |
-- | -- |
OR4F16 for ontologies About GeneDecksing
OR4F16 Antibody Products:
Assay Products for OR4F16: |
Protein
Domains /
Families
for OR4F16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR4F16 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6IEY1ProtoNet protein and cluster: Q6IEY1 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR4F3_HUMAN, Q6IEY1Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR4F16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OR4F3_HUMAN, Q6IEY1Function: Odorant receptor (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR4F16 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR4F16
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for OR4F16 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR4F16 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4F16 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
-- | -- | | GO:0004984 | olfactory receptor activity |
-- | -- |
OR4F16 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR4F16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR4F16
1 
Kegg Pathway (Kegg details for OR4F16):
OR4F16 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR4F16
|
Drugs & Compounds
for OR4F16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR4F16
Search CenterWatch for drugs/clinical trials and news about OR4F16 / OR4F3
|
Transcripts
for OR4F16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR4F16 gene: NM_001005277.1 Unigene Cluster for OR4F16: Olfactory receptor, family 4, subfamily F, member 16 Hs.632360 Unigene Representative Sequence: NM_0010052771 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000332831(uc010nxv.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR4F16 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR4F16
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR4F16 (NM_001005277) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR4F16 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR4F16 |
2 DOTS entries: DT.120860007 DT.121347918
GeneLoc Exon Structure
|
Expression
for OR4F16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR4F16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OR4F16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR4F16
SOURCE GeneReport for Unigene cluster: Hs.632360
SABiosciences Custom PCR Arrays for OR4F16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR4F16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat OR4F16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR4F16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR4F16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4F16 |
Orthologs
for OR4F16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR4F16 gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
42(a) |
1 → many |
GL343220.1(928034-929008) |
ENSEMBL Gene Tree for OR4F16 (if available)
TreeFam Gene Tree for OR4F16 (if available) |
Paralogs
for OR4F16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR4F16 gene
- OR4F291 2 OR4F31 2 OR4F211 2 OR4K52 OR4F52 OR4F42 OR4F172 OR4K152
- OR4K132 OR4F152 OR4F62 OR4K22 OR4L12 OR4K12 OR4K142 OR4K172
18/439 SIMAP similar genes for OR4F16 using alignment to 1 protein entry: OR4F3_HUMAN(see all similar genes):OR4F21 OR4F3 OR4F15 OR4F6 OR4F5 OR4K17
OR4F17 OR4F4 OR4K3 OR4K1 OR4K13 OR4K2
OR4K5 OR4K14 OR4K15 OR4N2 OR4D1 OR4D11
OR4F16 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for OR4F16
PGOHUM00000247295 PGOHUM00000243853
|
Genomic Variants
for OR4F16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR4F16 ( 621099 - 622034 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 22 variations for OR4F16
15/22 CNVs (see all 22): 81175 32766 37560 37559 68764 4191 81176 37598 69571 3274 4189 69275 37599 69577 31594 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for OR4F16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR4F16 for disorders About GeneDecksing
1  disease for OR4F16: About MalaCardsneuronitis
Export disorders for OR4F16 gene to outside databases
|
Publications
for OR4F16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR4F16 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR4F16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for OR4F16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR4F16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR4F16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR4F16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR4F16 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR4F16 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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| | |
About This Section
| Patent Information for OR4F16 gene:
Search GeneIP for patents involving OR4F16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR4F16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR4F16 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR4F16 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR4F16 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR4F16 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR4F16 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR4F16 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 | | | OR4F16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4F16 |
|  |  |  | | | | Search ThermoFisher Antibodies for OR4F16 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR4F16 |
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