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Aliases for OR4E2 Gene

Aliases for OR4E2 Gene

  • Olfactory Receptor Family 4 Subfamily E Member 2 2 3 5
  • Olfactory Receptor, Family 4, Subfamily E, Member 2 2 3
  • Olfactory Receptor OR14-42 3 4
  • OR14-42 3

External Ids for OR4E2 Gene

Previous GeneCards Identifiers for OR4E2 Gene

  • GC14U990090
  • GC14P021203
  • GC14P022133

Summaries for OR4E2 Gene

Entrez Gene Summary for OR4E2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4E2 Gene

OR4E2 (Olfactory Receptor Family 4 Subfamily E Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4Q3.

UniProtKB/Swiss-Prot for OR4E2 Gene

  • Odorant receptor.

Gene Wiki entry for OR4E2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4E2 Gene

Genomics for OR4E2 Gene

Regulatory Elements for OR4E2 Gene

Enhancers for OR4E2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR4E2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4E2 Gene

21,665,083 bp from pter
21,666,024 bp from pter
942 bases
Plus strand

Genomic View for OR4E2 Gene

Genes around OR4E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4E2 Gene

Proteins for OR4E2 Gene

  • Protein details for OR4E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4E2
    Protein Accession:
    Secondary Accessions:
    • Q6IET6
    • Q96R62

    Protein attributes for OR4E2 Gene

    313 amino acids
    Molecular mass:
    35466 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4E2 Gene

Proteomics data for OR4E2 Gene at MOPED

Post-translational modifications for OR4E2 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4E2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4E2 Gene

Domains & Families for OR4E2 Gene

Gene Families for OR4E2 Gene

Protein Domains for OR4E2 Gene

Suggested Antigen Peptide Sequences for OR4E2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4E2: view

Function for OR4E2 Gene

Molecular function for OR4E2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR4E2: view
genes like me logo Genes that share phenotypes with OR4E2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4E2 Gene

Localization for OR4E2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4E2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR4E2 Gene COMPARTMENTS Subcellular localization image for OR4E2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR4E2: view

Pathways & Interactions for OR4E2 Gene

genes like me logo Genes that share pathways with OR4E2: view

Pathways by source for OR4E2 Gene

Interacting Proteins for OR4E2 Gene

Gene Ontology (GO) - Biological Process for OR4E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4E2: view

No data available for SIGNOR curated interactions for OR4E2 Gene

Drugs & Compounds for OR4E2 Gene

No Compound Related Data Available

Transcripts for OR4E2 Gene

mRNA/cDNA for OR4E2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4E2 Gene

No ASD Table

Relevant External Links for OR4E2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4E2 Gene

mRNA expression in normal human tissues for OR4E2 Gene

SOURCE GeneReport for Unigene cluster for OR4E2 Gene Hs.547982

genes like me logo Genes that share expression patterns with OR4E2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR4E2 Gene

Orthologs for OR4E2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4E2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR4E2 35
  • 89.03 (n)
  • 86.26 (a)
OR4E2 36
  • 86 (a)
(Mus musculus)
Mammalia Olfr1509 35
  • 86.17 (n)
  • 85.95 (a)
Olfr1509 16
Olfr1509 36
  • 85 (a)
(Pan troglodytes)
Mammalia LOC467386 35
  • 99.04 (n)
  • 98.08 (a)
OR4E2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Olr1643 35
  • 86.27 (n)
  • 86.27 (a)
(Canis familiaris)
Mammalia OR4E2 36
  • 83 (a)
(Monodelphis domestica)
Mammalia OR4E2 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia OR4E2 36
  • 67 (a)
(Anolis carolinensis)
Reptilia OR4E2 36
  • 59 (a)
Species with no ortholog for OR4E2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4E2 Gene

Gene Tree for OR4E2 (if available)
Gene Tree for OR4E2 (if available)

Paralogs for OR4E2 Gene

(447) SIMAP similar genes for OR4E2 Gene using alignment to 1 proteins: Pseudogenes for OR4E2 Gene

genes like me logo Genes that share paralogs with OR4E2: view

Variants for OR4E2 Gene

Sequence variations from dbSNP and Humsavar for OR4E2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2874103 - 21,665,434(+) TCATT(A/G)TGGCG reference, missense
rs970382 - 21,665,783(+) GCGCC(A/G)GAAAG reference, missense
rs10138803 -- 21,664,654(+) GTGCA(G/T)CAGAC upstream-variant-2KB
rs10146244 -- 21,664,108(+) tttgg(G/T)tatat upstream-variant-2KB
rs10146733 -- 21,664,593(+) TGGTC(A/G)GAGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4E2 Gene

Variant ID Type Subtype PubMed ID
esv2422459 CNV Duplication 17116639
nsv456147 CNV Gain 19166990
nsv901479 CNV Gain 21882294

Variation tolerance for OR4E2 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.18; 75.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR4E2 Gene

Disorders for OR4E2 Gene

Relevant External Links for OR4E2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR4E2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4E2 Gene

Publications for OR4E2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  3. Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones. (PMID: 9110172) Boysen C. … Hood L. (Genome Res. 1997) 3
  4. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 3

Products for OR4E2 Gene

Sources for OR4E2 Gene