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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR4E2 Gene

protein-coding   GIFtS: 45
GCID: GC14P022133

Olfactory Receptor, Family 4, Subfamily E, Member 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 4, Subfamily E, Member 21 2
Olfactory Receptor OR14-422 3
OR14-422
Olfactory Receptor 4E22

External Ids:    HGNC: 82971   Entrez Gene: 266862   Ensembl: ENSG000002219777   UniProtKB: Q8NGC23   

Export aliases for OR4E2 gene to outside databases

Previous GC identifers: GC14U990090 GC14P021203


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR4E2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4E2 Gene: 
OR4E2 (olfactory receptor, family 4, subfamily E, member 2) is a protein-coding gene. Diseases associated with OR4E2 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4D11.

UniProtKB/Swiss-Prot: OR4E2_HUMAN, Q8NGC2
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4E2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR4E2 gene promoter:
         E2F-3a   E2F-4   E2F-5   CUTL1   E2F-2   AREB6   E2F-1   E2F   HFH-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR4E2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR4E2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR4E2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

OR4E2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4E2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P022133:  view genomic region     (about GC identifiers)

Start:
22,133,297 bp from pter      End:
22,134,235 bp from pter
Size:
939 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OR4E2_HUMAN, Q8NGC2 (See protein sequence)
Recommended Name: Olfactory receptor 4E2  
Size: 313 amino acids; 35466 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6IET6 Q96R62

Explore the universe of human proteins at neXtProt for OR4E2: NX_Q8NGC2

Explore proteomics data for OR4E2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NGC2

  • HORDE protein sequence for OR4E2
    OR4E2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR4E2 Protein Expression
    REFSEQ proteins: NP_001001912.1  
    ENSEMBL proteins: 
     ENSP00000386195  
    Reactome Protein details: Q8NGC2
    Human Recombinant Protein Products for OR4E2: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OR4E2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    OR4E2 for ontologies           About GeneDecksing



    OR4E2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGC2

    ProtoNet protein and cluster: Q8NGC2

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR4E2_HUMAN, Q8NGC2
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR4E2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR4E2_HUMAN, Q8NGC2
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR4E2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OR4E2:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OR4E2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR4E2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for OR4E2
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR4E2):
        Olfactory transduction


    OR4E2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR4E2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/273 Interacting proteins for OR4E2 (ENSP000003861954) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10G3ENSP000003024374STRING: ENSP00000302437
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR4E2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR4E2

    Search CenterWatch for drugs/clinical trials and news about OR4E2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR4E2 gene: 
    NM_001001912.1  

    Unigene Cluster for OR4E2:

    Olfactory receptor, family 4, subfamily E, member 2
    Hs.547982
    Unigene Representative Sequence: NM_001001912
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000408935(uc010tmd.2)
    miRNA
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    Inhib. RNA
    Products:
         
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4E2
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR4E2

    Additional mRNA sequence: AY726598.1 

    1 DOTS entry:

    DT.120771451 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR4E2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCAGCTCA
    OR4E2 Expression
    About this image


    See OR4E2 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.547982
        SABiosciences Custom PCR Arrays for OR4E2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4E2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OR4E2 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr15091 , 5 olfactory receptor 15091, 5 86.17(n)1
    85.95(a)1
      14 (26.95 cM)5
    572711  NM_020514.21  NP_065260.21 
     524503935 
    lizard
    (Anolis carolinensis)
    Reptilia OR4E26
    Uncharacterized protein
    59(a)
    1 ↔ 1
    GL343466.1(534859-535803)


    ENSEMBL Gene Tree for OR4E2 (if available)
    TreeFam Gene Tree for OR4E2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR4E2 gene
    OR4D112  OR4D22  OR4D52  OR4N22  OR4N52  OR4D62  OR4M12  OR4Q22  
    OR4N42  OR4D102  OR4M22  OR4D12  OR4D92  OR4Q32  
    18/447 SIMAP similar genes for OR4E2 using alignment to 1 protein entry:     OR4E2_HUMAN(see all similar genes):
    OR4K2    OR4S2    OR4E1    OR4K14    OR4K15    OR4Q3
    OR4B1    OR4K17    OR4N5    OR4C3    OR4D1    OR4D5
    OR4K3    OR4L1    OR4Q2    OR4A15    OR4C11    OR4C13

    OR4E2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for OR4E2
    PGOHUM00000247740 PGOHUM00000261870 PGOHUM00000244966


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/104 SNPs in OR4E2 are shown (see all 104)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844855211,2
    --22131413(+) TTAGTC/TTGGGC 1 -- us2k10--------
    rs287009501,2
    C--22131620(+) CCTGGG/AAGGCG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1892349081,2
    --22131625(+) GAGGCA/GGAGCT 1 -- us2k10--------
    rs1445537351,2
    C--22131694(+) TCTCG-/AAAAAA 1 -- us2k10--------
    rs756460751,2
    C--22131701(+) AAAAAA/TATTTT 1 -- us2k10--------
    rs124324131,2
    C,H--22131702(+) AAAAAT/ATTTTT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs128890351,2
    C,A--22131703(+) aaaaaA/TTTTTT 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1411220431,2
    --22131768(+) GTCAAA/GGACCA 1 -- us2k10--------
    rs1820258441,2
    --22131900(+) TTTAAG/TTTCAT 1 -- us2k10--------
    rs1469680291,2
    --22131934(+) TTTTGC/TTACAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR4E2 ( 22133297 - 22134235 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OR4E2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422459CNV Duplication17116639
    nsv901479CNV Gain21882294
    nsv456147CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OR4E2:    About MalaCards
    neuronitis    


    OR4E2 for disorders           About GeneDecksing


    Export disorders for OR4E2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR4E2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR4E2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
    3. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    4. Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones. (PubMed id 9110172)1 Boysen C.... Hood L. (1997)
    5. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PubMed id 8188290)1 Koop B.F.... Hood L. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26686 HGNC: 8297 Ensembl:ENSG00000221977 euGenes: HUgn26686 ECgene: OR4E2 Kegg: 26686
    H-InvDB: OR4E2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR4E2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4E2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR4E2 gene:
    Search GeneIP for patents involving OR4E2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Regulatory tfbs in OR4E2 promoter
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     Proteins for OR4E2
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     Search ThermoFisher Antibodies for OR4E2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4E2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for OR4E2
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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