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Aliases for OR4E1 Gene

Aliases for OR4E1 Gene

  • Olfactory Receptor Family 4 Subfamily E Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 4, Subfamily E, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR14-43 3 4
  • OR4E1P 3 4
  • Olfactory Receptor, Family 4, Subfamily E, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor 4E1 3

External Ids for OR4E1 Gene

Previous HGNC Symbols for OR4E1 Gene

  • OR4E1P

Previous GeneCards Identifiers for OR4E1 Gene

  • GC14M021207
  • GC14M022139
  • GC14M022141

Summaries for OR4E1 Gene

Entrez Gene Summary for OR4E1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4E1 Gene

OR4E1 (Olfactory Receptor Family 4 Subfamily E Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR4E1 Gene

  • Odorant receptor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4E1 Gene

Genomics for OR4E1 Gene

Regulatory Elements for OR4E1 Gene

Enhancers for OR4E1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G021668 0.5 ENCODE 0.7 +2.4 2433 0.2 FOXA2 JUN ZNF629 ZEB2 OR10G2 METTL17 OR4E1 GC14M021667 GC14M021665
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR4E1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4E1 Gene

Chromosome:
14
Start:
21,669,891 bp from pter
End:
21,671,035 bp from pter
Size:
1,145 bases
Orientation:
Minus strand

Genomic View for OR4E1 Gene

Genes around OR4E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4E1 Gene

Proteins for OR4E1 Gene

  • Protein details for OR4E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C645-OR4E1_HUMAN
    Recommended name:
    Olfactory receptor 4E1
    Protein Accession:
    P0C645

    Protein attributes for OR4E1 Gene

    Size:
    316 amino acids
    Molecular mass:
    D Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4E1 Gene

Post-translational modifications for OR4E1 Gene

Other Protein References for OR4E1 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for OR4E1 Gene

Domains & Families for OR4E1 Gene

Gene Families for OR4E1 Gene

Protein Domains for OR4E1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for OR4E1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C645

UniProtKB/Swiss-Prot:

OR4E1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4E1: view

Function for OR4E1 Gene

Molecular function for OR4E1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4E1: view

Phenotypes for OR4E1 Gene

GenomeRNAi human phenotypes for OR4E1:
genes like me logo Genes that share phenotypes with OR4E1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4E1 Gene

Localization for OR4E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4E1 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR4E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4E1: view

No data available for Subcellular locations from COMPARTMENTS for OR4E1 Gene

Pathways & Interactions for OR4E1 Gene

genes like me logo Genes that share pathways with OR4E1: view

Pathways by source for OR4E1 Gene

Interacting Proteins for OR4E1 Gene

Gene Ontology (GO) - Biological Process for OR4E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4E1: view

No data available for SIGNOR curated interactions for OR4E1 Gene

Transcripts for OR4E1 Gene

mRNA/cDNA for OR4E1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4E1 Gene

No ASD Table

Relevant External Links for OR4E1 Gene

GeneLoc Exon Structure for
OR4E1
ECgene alternative splicing isoforms for
OR4E1

Expression for OR4E1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4E1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4E1 Gene:

OR4E1
genes like me logo Genes that share expression patterns with OR4E1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4E1 Gene

Orthologs for OR4E1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for OR4E1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Or4e1 55 Olfr1508
  • chr14:52,463,078-52,464,007
Or4e5 55 Olfr1507
  • chr14:52,490,024-52,490,962
Species where no ortholog for OR4E1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4E1 Gene

ENSEMBL:
Gene Tree for OR4E1 (if available)
TreeFam:
Gene Tree for OR4E1 (if available)

Paralogs for OR4E1 Gene

(451) SIMAP similar genes for OR4E1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4E1: view

No data available for Paralogs for OR4E1 Gene

Variants for OR4E1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR4E1 Gene

OR4E1_HUMAN-P0C645
A double nucleotide deletion at position Pro-197 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Sequence variations from dbSNP and Humsavar for OR4E1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000850434 -- 21,670,478(+) CTGTC(C/T)AGAGG reference, stop-gained
rs1003031047 -- 21,669,487(+) CACTT(C/T)ATCTG downstream-variant-500B
rs1003080504 -- 21,669,791(+) GAATT(A/T)AGTAA downstream-variant-500B
rs1004527556 -- 21,669,964(+) CACCA(C/T)GTATC utr-variant-3-prime
rs1004991804 -- 21,670,108(+) AACAC(A/C)GATAC reference, synonymous-codon

Relevant External Links for OR4E1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4E1

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR4E1 Gene

Disorders for OR4E1 Gene

Relevant External Links for OR4E1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4E1

No disorders were found for OR4E1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4E1 Gene

Publications for OR4E1 Gene

  1. Genetic elucidation of human hyperosmia to isovaleric acid. (PMID: 17973576) Menashe I. … Lancet D. (PLoS Biol. 2007) 3 4 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  4. Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones. (PMID: 9110172) Boysen C. … Hood L. (Genome Res. 1997) 3 64
  5. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 3 64

Products for OR4E1 Gene

Sources for OR4E1 Gene

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