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Aliases for OR4D6 Gene

Aliases for OR4D6 Gene

  • Olfactory Receptor, Family 4, Subfamily D, Member 6 2 3
  • Olfactory Receptor OR11-250 3 4
  • Olfactory Receptor 4D6 3
  • OR11-250 3

External Ids for OR4D6 Gene

Previous GeneCards Identifiers for OR4D6 Gene

  • GC11U990538
  • GC11P059000
  • GC11P058981
  • GC11P059224

Summaries for OR4D6 Gene

Entrez Gene Summary for OR4D6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4D6 Gene

OR4D6 (Olfactory Receptor, Family 4, Subfamily D, Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4D9.

UniProtKB/Swiss-Prot for OR4D6 Gene

  • Odorant receptor.

Gene Wiki entry for OR4D6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4D6 Gene

Genomics for OR4D6 Gene

Regulatory Elements for OR4D6 Gene

Genomic Location for OR4D6 Gene

Start:
59,456,938 bp from pter
End:
59,457,991 bp from pter
Size:
1,054 bases
Orientation:
Plus strand

Genomic View for OR4D6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4D6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4D6 Gene

Proteins for OR4D6 Gene

  • Protein details for OR4D6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGJ1-OR4D6_HUMAN
    Recommended name:
    Olfactory receptor 4D6
    Protein Accession:
    Q8NGJ1
    Secondary Accessions:
    • B2RNP7
    • Q6IFF5
    • Q96R74

    Protein attributes for OR4D6 Gene

    Size:
    314 amino acids
    Molecular mass:
    35954 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4D6 Gene

Proteomics data for OR4D6 Gene at MOPED

Post-translational modifications for OR4D6 Gene

Other Protein References for OR4D6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4D6 Gene

Domains for OR4D6 Gene

Gene Families for OR4D6 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4D6 Gene

Suggested Antigen Peptide Sequences for OR4D6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGJ1

UniProtKB/Swiss-Prot:

OR4D6_HUMAN :
  • Q8NGJ1
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4D6: view

Function for OR4D6 Gene

Molecular function for OR4D6 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4D6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4D6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4D6 Gene

Localization for OR4D6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4D6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4D6 Gene COMPARTMENTS Subcellular localization image for OR4D6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4D6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4D6: view

Pathways for OR4D6 Gene

genes like me logo Genes that share pathways with OR4D6: view

Pathways by source for OR4D6 Gene

Gene Ontology (GO) - Biological Process for OR4D6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4D6: view

Transcripts for OR4D6 Gene

mRNA/cDNA for OR4D6 Gene

(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4D6 Gene

No ASD Table

Relevant External Links for OR4D6 Gene

GeneLoc Exon Structure for
OR4D6
ECgene alternative splicing isoforms for
OR4D6

Expression for OR4D6 Gene

mRNA expression in normal human tissues for OR4D6 Gene

SOURCE GeneReport for Unigene cluster for OR4D6 Gene Hs.553650

genes like me logo Genes that share expressions with OR4D6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR4D6 Gene

Orthologs for OR4D6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4D6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466613 35
  • 98.62 (n)
  • 96.5 (a)
OR4D6 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR4D6 35
  • 85.26 (n)
  • 83.01 (a)
OR4D6 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100856774 35
  • 87.96 (n)
  • 88.06 (a)
OR4D6 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1428 35
  • 83.97 (n)
  • 88.22 (a)
Olfr1428 16
Olfr1428 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR4D6 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr325 35
  • 84.82 (n)
  • 87.9 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
Species with no ortholog for OR4D6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4D6 Gene

ENSEMBL:
Gene Tree for OR4D6 (if available)
TreeFam:
Gene Tree for OR4D6 (if available)

Paralogs for OR4D6 Gene

Selected SIMAP similar genes for OR4D6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4D6: view

Variants for OR4D6 Gene

Sequence variations from dbSNP and Humsavar for OR4D6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1453541 - 59,457,748(-) GCGTC(A/G)TGAAG missense, reference
rs1453542 - 59,457,412(-) CACCA(C/G)TCACC missense, reference
rs1453543 - 59,457,247(-) TGCAG(C/T)CATTG reference, missense
rs1453544 - 59,457,135(-) GTACA(C/T)AGGAG reference, missense
rs1453545 -- 59,455,915(-) TTACC(A/G)GAATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4D6 Gene

Variant ID Type Subtype PubMed ID
nsv825934 CNV Loss 20364138

Relevant External Links for OR4D6 Gene

HapMap Linkage Disequilibrium report
OR4D6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4D6 Gene

Disorders for OR4D6 Gene

No disorders were found for OR4D6 Gene.

No data available for UniProtKB/Swiss-Prot for OR4D6 Gene

Publications for OR4D6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Identification of regions associated with variation in sensitivity to food-related odors in the human genome. (PMID: 23910658) McRae J.F. … Newcomb R.D. (Curr. Biol. 2013) 3

Products for OR4D6 Gene

Sources for OR4D6 Gene

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