OR4D2 Gene
protein-coding GIFtS: 47
GCID: GC17P056246
|
|
olfactory receptor, family 4, subfamily D, member 2
| |
Aliases
for OR4D2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 4, Subfamily D, Member 21 2 | | OR17-242 | | Olfactory Receptor OR17-242 3 | | G-Protein Coupled Membrane Protein2 | | B-Lymphocyte Membrane Protein BC20092 3 | | Olfactory Receptor 4D22 | | BC20092 | | |
Export aliases for OR4D2 gene to outside databasesPrevious GC identifers: GC17U990167 GC17P056722 GC17P053601 |
Summaries
for OR4D2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR4D2:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR4D2_HUMAN, P58180Function: Odorant receptor (Potential)
Gene Wiki entry for OR4D2
|
Genomic Views
for OR4D2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR4D2 gene promoter:
p53 AP-1 NRSF form 1 Olf-1 NRSF form 2 GATA-1 PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR4D2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR4D2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q22 HGNC chromosome: 17OR4D2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P056246: view genomic region
(about GC identifiers)
Start:
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56,247,017 bp from pter |
End:
|
56,247,937 bp from pter |
Size:
|
921 bases |
Orientation:
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plus strand |
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Proteins
for OR4D2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR4D2_HUMAN, P58180 (See
protein sequence)Recommended Name: Olfactory receptor 4D2 Size: 307 amino acids; 34958 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6IFN8 Q96R75Explore the universe of human proteins at neXtProt for OR4D2: NX_P58180
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P58180
HORDE protein sequence for OR4D2
OR4D2 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001004707.1
ENSEMBL proteins: ENSP00000441354 Reactome Protein details: P58180
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR4D2 for ontologies About GeneDecksing
OR4D2 Antibody Products:
Assay Products for OR4D2: |
Protein
Domains /
Families
for OR4D2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR4D2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P58180ProtoNet protein and cluster: P58180 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR4D2_HUMAN, P58180Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR4D2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OR4D2_HUMAN, P58180Function: Odorant receptor (Potential) Genatlas biochemistry entry for OR4D2:olfactory receptor,family 4,subfamily D,member 2,G protein coupled receptor superfamily
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR4D2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR4D2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR4D2 (NM_001004707) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR4D2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4D2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR4D2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for OR4D2:
|
Pathways & Interactions
for OR4D2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR4D2
1 
Kegg Pathway (Kegg details for OR4D2):
OR4D2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR4D2
|
Drugs & Compounds
for OR4D2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
OR4D2 for compounds About GeneDecksing
 Browse Tocris compounds for OR4D2
7 Novoseek chemical compound relationships for OR4D2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gdp |
62.1 |
2 |
1577001 (1), 8832375 (1) |
| guanosine 5'-o-(3-thiotriphosphate) |
60.1 |
5 |
1470218 (1), 1577001 (1), 7635969 (1) |
| gtp |
50.9 |
4 |
1470218 (1), 1577001 (1), 8832375 (1), 7635969 (1) |
| cyclic amp |
44.4 |
3 |
10063486 (1), 2282476 (1) |
| magnesium |
9.25 |
2 |
7547178 (1), 9832186 (1) |
| lipid |
0 |
1 |
9326617 (1) |
| calcium |
0 |
5 |
10822321 (1), 15649140 (1), 11224000 (1), 15067332 (1) |
Search CenterWatch for drugs/clinical trials and news about OR4D2
|
Transcripts
for OR4D2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR4D2 gene: NM_001004707.3 Unigene Cluster for OR4D2: Olfactory receptor, family 4, subfamily D, member 2 Hs.446879 Unigene Representative Sequence: NM_0010047071 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000545221(uc010wnp.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR4D2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR4D2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR4D2 (NM_001004707) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR4D2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4D2 |
2 AceView cDNA sequences: NM_001004707 AF303373
GeneLoc Exon Structure
|
Expression
for OR4D2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR4D2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGCAGCAG
About this image
Genevestigator expression for OR4D2
SOURCE GeneReport for Unigene cluster: Hs.446879
SABiosciences Custom PCR Arrays for OR4D2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR4D2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR4D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR4D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR4D2 |
Orthologs
for OR4D2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR4D2 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for OR4D2 (if available)
TreeFam Gene Tree for OR4D2 (if available) |
Paralogs
for OR4D2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR4D2 gene
- OR4D112 OR4D52 OR4N22 OR4N52 OR4D62 OR4M12 OR4N42 OR4D102
- OR4D12 OR4M22 OR4Q32 OR4D92
18/440 SIMAP similar genes for OR4D2 using alignment to 1 protein entry: OR4D2_HUMAN(see all similar genes):OR4D1 OR4D10 OR4D11 OR4D9 OR4D6 OR4Q3
OR4D5 OR4F17 OR4F4 OR4F5 OR4K13 OR4N5
OR4A15 OR4C3 OR4K2 OR4K3 OR4Q2 OR4S1
OR4D2 for paralogs About GeneDecksing
|
Genomic Variants
for OR4D2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR4D2 ( 56247017 - 56247937 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR4D2: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for OR4D2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR4D2 for disorders About GeneDecksing
12  diseases for OR4D2: About MalaCardspre-eclampsia bipolar affective disorder essential hypertension neuronitis
eclampsia hypertension pertussis lung carcinoma
breast cancer cerebritis carcinoma leukemia
1 Novoseek disease relationship for OR4D2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| essential hypertension |
32.3 |
1 |
9832186 (1) |
Export disorders for OR4D2 gene to outside databases
|
Publications
for OR4D2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR4D2 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with OR4D2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Magnetic bead isolation of neutrophil plasma membranes and quantification of membrane-associated guanine nucleotide binding proteins. (PubMed id 14751252)9 Chang P.S....Omann G.M. (2004)
- Role of lipid polymorphism in G protein-membrane interactions: nonlamellar-prone phospholipids and peripheral protein binding to membranes. (PubMed id 9326617)9 Escriba P.V....Garcia-Sevilla J.A. (1997)
- Antibodies as probes of G-protein receptor-effector c oupling and of G-protein membrane attachment. (PubMed id 2175191)9 Spiegel A.M....Unson C.G. (1990)
- Structural basis of GDP release and gating in G prote in coupled Fe2+ transport. (PubMed id 19629046)9 Guilfoyle A....Jormakka M. (2009)
- Neurosteroids as endogenous inhibitors of neuronal cell apoptosis in aging. (PubMed id 17192562)9 Charalampopoulos I....Gravanis A. (2006)
- Functional role of lipid rafts in CD20 activity? (PubMed id 15649140)9 Janas E....Malhotra R. (2005)
|
External Searches for OR4D2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR4D2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR4D2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR4D2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR4D2 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR4D2 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
|
| | |
About This Section
| Patent Information for OR4D2 gene:
Search GeneIP for patents involving OR4D2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR4D2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR4D2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR4D2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR4D2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR4D2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR4D2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR4D2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR4D2 | | OriGene Custom Protein Services for OR4D2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR4D2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR4D2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR4D2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR4D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR4D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR4D2 |
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 |  |  |  | |
| | | | Search Tocris compounds for OR4D2 |
| |  |  |  |  | | | | |
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 | | | OR4D2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for OR4D2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4D2 |
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