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OR4D11 Gene

protein-coding   GIFtS: 44
GCID: GC11P059271

Olfactory Receptor, Family 4, Subfamily D, Member 11


(Previous symbol: OR4D11P)
  Search for OR4D11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 4, Subfamily D, Member 111 2
OR4D11P1 2 3
Olfactory Receptor 4D112
Olfactory Receptor OR11-252 Pseudogene2
Olfactory Receptor, Family 4, Subfamily D, Member 11 Pseudogene2

External Ids:    HGNC: 151741   Entrez Gene: 2199862   Ensembl: ENSG000001762007   UniProtKB: Q8NGI43   

Export aliases for OR4D11 gene to outside databases

Previous GC identifers: GC11P059047 GC11P059027


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR4D11 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4D11 Gene:
OR4D11 (olfactory receptor, family 4, subfamily D, member 11) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4D2.

UniProtKB/Swiss-Prot: OR4DB_HUMAN, Q8NGI4
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4D11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR4D11 gene promoter:
         AP-1   AML1a   Nkx2-5   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   GATA-2   CHOP-10   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR4D11 promoter sequence
   Search Chromatin IP Primers for OR4D11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4D11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

OR4D11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4D11 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P059271:  view genomic region     (about GC identifiers)

Start:
59,271,049 bp from pter      End:
59,271,981 bp from pter
Size:
933 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR4DB_HUMAN, Q8NGI4 (See protein sequence)
Recommended Name: Olfactory receptor 4D11  
Size: 311 amino acids; 34969 Da

Explore the universe of human proteins at neXtProt for OR4D11: NX_Q8NGI4

Explore proteomics data for OR4D11 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR4D11

    See OR4D11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004706.1  
    ENSEMBL proteins: 
     ENSP00000320077  
    Reactome Protein details: Q8NGI4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGI4

    ProtoNet protein and cluster: Q8NGI4

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR4DB_HUMAN, Q8NGI4
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR4D11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR4DB_HUMAN, Q8NGI4
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR4D11           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR4DB_HUMAN, Q8NGI4: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR4D11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR4D11 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR4D11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR4D11
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR4D11):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR4D11
    Interactions:

        Search GeneGlobe Interaction Network for OR4D11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR4D11 (ENSP000003200774) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10AD1ENSP000003086894STRING: ENSP00000308689
    OR10P1ENSP000003080824STRING: ENSP00000308082
    OR10W1ENSP000003785164STRING: ENSP00000378516
    OR11G2ENSP000003499304STRING: ENSP00000349930
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR4D11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR4D11 (OR4DB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR4D11 gene: 
    NM_001004706.1  

    Unigene Cluster for OR4D11:

    Olfactory receptor, family 4, subfamily D, member 11
    Hs.553651
    Unigene Representative Sequence: NM_001004706
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000313253(uc001noa.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR4D11

    1 AceView cDNA sequence:

    NM_001004706 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR4D11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGACTGA
    OR4D11 Expression
    About this image

    OR4D11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR4D11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553651
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR4D11 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr14231 , 5 olfactory receptor 14231, 5 86.24(n)1
    87.74(a)1
      19 (8.58 cM)5
    2586751  NM_146680.11  NP_666891.11 
     120358085 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    53(a)
    49(a)
    many ↔ many
    many ↔ many
    GL343253.1(913291-914226)
    GL343253.1(906794-907735)


    ENSEMBL Gene Tree for OR4D11 (if available)
    TreeFam Gene Tree for OR4D11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR4D11 gene
    OR4D22  OR4D52  OR4N22  OR4N52  OR4D62  OR4M12  OR4Q22  OR4N42  
    OR4D102  OR4M22  OR4D12  OR4D92  OR4Q32  OR4E22  
    Selected SIMAP similar genes for OR4D11 using alignment to 1 protein entry:     OR4DB_HUMAN(see all similar genes):
    OR4D9    OR4D10    OR4D1    OR4D2    OR4D6    OR4Q2
    OR4Q3    OR4D5    OR4K13    OR4C3    OR4F17    OR4F4
    OR4F5    OR4A47    OR4C13    OR4K15    OR4K3    OR4N5

    Find genes that share paralogs with OR4D11           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for OR4D11
    PGOHUM00000242750


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR4D11 (see all 108)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831176741,2
    --59269052(+) AGAATC/TGCTTG 1 -- us2k10--------
    rs1876185451,2
    --59269078(+) GGTTGC/TTGTGA 1 -- us2k10--------
    rs71224611,2
    C,F,H--59269253(+) cattcT/Cagtga 1 -- us2k117Minor allele frequency- C:0.01NS EA NA WA CSA 796
    rs1165747091,2
    F--59269459(+) TTGTCC/ATTGTT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1409485991,2
    C--59269492(+) ATACTA/GTTGAA 1 -- us2k10--------
    rs1930740511,2
    --59269628(+) TAACCC/TAAATG 1 -- us2k10--------
    rs112299771,2
    C,F,A,H--59269716(+) AACAAC/TGGATG 1 -- us2k1 tfbs317Minor allele frequency- T:0.36NS EA NA WA CSA 791
    rs1502624481,2
    C--59269733(+) ATGGTA/TGAAAG 1 -- us2k10--------
    rs1172013571,2
    F--59269796(+) TAGAAA/GATACA 1 -- us2k11Minor allele frequency- G:0.04EA 120
    rs1479529341,2
    C--59269801(+) AATACA/CAACTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR4D11 ( 59271049 - 59271981 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OR4D11: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR4D11
    DNA2.0 Custom Variant and Variant Library Synthesis for OR4D11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR4D11 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR4D11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1 Fuchs T.... Shamir R. (Genomics 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219986 HGNC: 15174 AceView: OR4D11 Ensembl:ENSG00000176200 euGenes: HUgn219986
    ECgene: OR4D11 Kegg: 219986 H-InvDB: OR4D11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR4D11 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4D11 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR4D11 gene:
    Search GeneIP for patents involving OR4D11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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