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Aliases for OR4D10 Gene

Aliases for OR4D10 Gene

  • Olfactory Receptor Family 4 Subfamily D Member 10 2 3 5
  • Olfactory Receptor OR11-251 3 4
  • OR4D10P 3 4
  • Olfactory Receptor, Family 4, Subfamily D, Member 10 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily D, Member 10 2
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor 4D10 3
  • OR11-251 3
  • OST711 3

External Ids for OR4D10 Gene

Previous HGNC Symbols for OR4D10 Gene

  • OR4D10P

Previous GeneCards Identifiers for OR4D10 Gene

  • GC11P059021
  • GC11P059001
  • GC11P059244

Summaries for OR4D10 Gene

Entrez Gene Summary for OR4D10 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4D10 Gene

OR4D10 (Olfactory Receptor Family 4 Subfamily D Member 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4D11.

UniProtKB/Swiss-Prot for OR4D10 Gene

  • Odorant receptor.

Gene Wiki entry for OR4D10 Gene

Additional gene information for OR4D10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4D10 Gene

Genomics for OR4D10 Gene

Regulatory Elements for OR4D10 Gene

Enhancers for OR4D10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H059536 1.5 Ensembl ENCODE dbSUPER 10.6 +64.3 64290 1 HDGF PKNOX1 ATF1 ARNT SIN3A YY1 TCF12 ZNF121 GATA2 ELK1 OR4D9 OR4D10 OR5A2 OR4D6 OR5AN1 STX3 LOC102723575 GC11P059550
GH11H059510 1.1 FANTOM5 Ensembl ENCODE 11 +37.8 37786 1 ETV1 STAT2 CEBPB MAFG CEBPG NFE2 EMSY OR4D6 OR4D10 OR5A1 OR5A2 PATL1 MPEG1 STX3 OR4D9 OR4D11
GH11H059266 0.5 FANTOM5 dbSUPER 3.4 -206.6 -206636 0 OR4D10 OR4D9 OR4D6 OR10V1 OR5A1 GC11M059264 ENSG00000214797
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR4D10 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4D10 Gene

Chromosome:
11
Start:
59,473,315 bp from pter
End:
59,479,361 bp from pter
Size:
6,047 bases
Orientation:
Plus strand

Genomic View for OR4D10 Gene

Genes around OR4D10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4D10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4D10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4D10 Gene

Proteins for OR4D10 Gene

  • Protein details for OR4D10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGI6-OR4DA_HUMAN
    Recommended name:
    Olfactory receptor 4D10
    Protein Accession:
    Q8NGI6
    Secondary Accessions:
    • B2RNH6

    Protein attributes for OR4D10 Gene

    Size:
    311 amino acids
    Molecular mass:
    35300 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4D10 Gene

Post-translational modifications for OR4D10 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4D10 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4D10 Gene

Domains & Families for OR4D10 Gene

Gene Families for OR4D10 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4D10 Gene

Suggested Antigen Peptide Sequences for OR4D10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGI6

UniProtKB/Swiss-Prot:

OR4DA_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4D10: view

Function for OR4D10 Gene

Molecular function for OR4D10 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4D10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4D10: view
genes like me logo Genes that share phenotypes with OR4D10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR4D10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4D10 Gene

Localization for OR4D10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4D10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4D10 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4D10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4D10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4D10 Gene

Pathways & Interactions for OR4D10 Gene

genes like me logo Genes that share pathways with OR4D10: view

Pathways by source for OR4D10 Gene

Interacting Proteins for OR4D10 Gene

Gene Ontology (GO) - Biological Process for OR4D10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4D10: view

No data available for SIGNOR curated interactions for OR4D10 Gene

Drugs & Compounds for OR4D10 Gene

No Compound Related Data Available

Transcripts for OR4D10 Gene

mRNA/cDNA for OR4D10 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR4D10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR4D10 Gene

No ASD Table

Relevant External Links for OR4D10 Gene

GeneLoc Exon Structure for
OR4D10
ECgene alternative splicing isoforms for
OR4D10

Expression for OR4D10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4D10 Gene

Protein differential expression in normal tissues from HIPED for OR4D10 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR4D10 Gene



Protein tissue co-expression partners for OR4D10 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4D10 Gene:

OR4D10

SOURCE GeneReport for Unigene cluster for OR4D10 Gene:

Hs.553756
genes like me logo Genes that share expression patterns with OR4D10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4D10 Gene

Orthologs for OR4D10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4D10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC735830 33
  • 98.93 (n)
OR4D10 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR4D10 34
  • 89 (a)
OneToOne
LOC483451 33
  • 87.35 (n)
mouse
(Mus musculus)
Mammalia Or4d10 52 Olfr1425 34
  • 86 (a)
OneToMany
Or4d10c 52 Olfr1426 34
  • 85 (a)
OneToMany
Or4d10b 52 Olfr1424 33 16 34
  • 84.87 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 83 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 77 (a)
ManyToMany
-- 34
  • 77 (a)
ManyToMany
-- 34
  • 76 (a)
ManyToMany
-- 34
  • 76 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
ManyToMany
-- 34
  • 68 (a)
ManyToMany
-- 34
  • 67 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
ManyToMany
-- 34
  • 51 (a)
ManyToMany
Species where no ortholog for OR4D10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4D10 Gene

ENSEMBL:
Gene Tree for OR4D10 (if available)
TreeFam:
Gene Tree for OR4D10 (if available)

Paralogs for OR4D10 Gene

(437) SIMAP similar genes for OR4D10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4D10: view

Variants for OR4D10 Gene

Sequence variations from dbSNP and Humsavar for OR4D10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000691216 -- 59,476,486(+) AGTGA(A/T)CCTCC upstream-variant-2KB
rs1000721831 -- 59,476,219(+) CGCTC(C/T)CCAGC upstream-variant-2KB
rs1001267711 -- 59,477,335(+) CTGCA(A/C)TGCAT upstream-variant-2KB
rs1002939514 -- 59,475,752(+) AATCC(A/T)ACATT upstream-variant-2KB
rs1002970679 -- 59,475,451(+) CCTCT(A/C)GGAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4D10 Gene

Variant ID Type Subtype PubMed ID
esv3626537 CNV loss 21293372
nsv983027 CNV duplication 23825009

Variation tolerance for OR4D10 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.07; 75.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4D10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4D10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4D10 Gene

Disorders for OR4D10 Gene

Relevant External Links for OR4D10

Genetic Association Database (GAD)
OR4D10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4D10

No disorders were found for OR4D10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4D10 Gene

Publications for OR4D10 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta KL … Murabito JM (BMC medical genetics 2007) 45 60
  3. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan RS … Benjamin EJ (BMC medical genetics 2007) 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Population differences in the human functional olfactory repertoire. (PMID: 12644552) Gilad Y … Lancet D (Molecular biology and evolution 2003) 3 60

Products for OR4D10 Gene

Sources for OR4D10 Gene

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