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Aliases for OR4D10 Gene

Aliases for OR4D10 Gene

  • Olfactory Receptor, Family 4, Subfamily D, Member 10 2 3
  • Olfactory Receptor OR11-251 3 4
  • OR4D10P 3 4
  • Olfactory Receptor, Family 4, Subfamily D, Member 10 Pseudogene 3
  • Seven Transmembrane Helix Receptor 3
  • OR11-251 3
  • OST711 3

External Ids for OR4D10 Gene

Previous HGNC Symbols for OR4D10 Gene

  • OR4D10P

Previous GeneCards Identifiers for OR4D10 Gene

  • GC11P059021
  • GC11P059001
  • GC11P059244

Summaries for OR4D10 Gene

Entrez Gene Summary for OR4D10 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4D10 Gene

OR4D10 (Olfactory Receptor, Family 4, Subfamily D, Member 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4D9.

UniProtKB/Swiss-Prot for OR4D10 Gene

  • Odorant receptor.

Gene Wiki entry for OR4D10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4D10 Gene

Genomics for OR4D10 Gene

Regulatory Elements for OR4D10 Gene

Genomic Location for OR4D10 Gene

Chromosome:
11
Start:
59,477,373 bp from pter
End:
59,478,396 bp from pter
Size:
1,024 bases
Orientation:
Plus strand

Genomic View for OR4D10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4D10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4D10 Gene

Proteins for OR4D10 Gene

  • Protein details for OR4D10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGI6-OR4DA_HUMAN
    Recommended name:
    Olfactory receptor 4D10
    Protein Accession:
    Q8NGI6
    Secondary Accessions:
    • B2RNH6

    Protein attributes for OR4D10 Gene

    Size:
    311 amino acids
    Molecular mass:
    35300 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4D10 Gene

Proteomics data for OR4D10 Gene at MOPED

Post-translational modifications for OR4D10 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4D10 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4D10 Gene

Domains & Families for OR4D10 Gene

Gene Families for OR4D10 Gene

Protein Domains for OR4D10 Gene

Suggested Antigen Peptide Sequences for OR4D10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGI6

UniProtKB/Swiss-Prot:

OR4DA_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4D10: view

Function for OR4D10 Gene

Molecular function for OR4D10 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4D10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4D10: view

Phenotypes for OR4D10 Gene

genes like me logo Genes that share phenotypes with OR4D10: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4D10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4D10 Gene

Localization for OR4D10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4D10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4D10 Gene COMPARTMENTS Subcellular localization image for OR4D10 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4D10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4D10: view

Pathways & Interactions for OR4D10 Gene

genes like me logo Genes that share pathways with OR4D10: view

Pathways by source for OR4D10 Gene

Interacting Proteins for OR4D10 Gene

Gene Ontology (GO) - Biological Process for OR4D10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4D10: view

No data available for SIGNOR curated interactions for OR4D10 Gene

Drugs & Compounds for OR4D10 Gene

No Compound Related Data Available

Transcripts for OR4D10 Gene

mRNA/cDNA for OR4D10 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4D10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4D10 Gene

No ASD Table

Relevant External Links for OR4D10 Gene

GeneLoc Exon Structure for
OR4D10
ECgene alternative splicing isoforms for
OR4D10

Expression for OR4D10 Gene

mRNA expression in normal human tissues for OR4D10 Gene

Protein differential expression in normal tissues from HIPED for OR4D10 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR4D10 Gene



SOURCE GeneReport for Unigene cluster for OR4D10 Gene Hs.553756

genes like me logo Genes that share expression patterns with OR4D10: view

Protein tissue co-expression partners for OR4D10 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR4D10 Gene

Orthologs for OR4D10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4D10 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC483451 35
  • 87.35 (n)
  • 89.07 (a)
OR4D10 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1424 35
  • 84.87 (n)
  • 85.53 (a)
Olfr1424 16
Olfr1424 36
  • 83 (a)
OneToMany
Olfr1425 36
  • 86 (a)
OneToMany
Olfr1426 36
  • 85 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC735830 35
  • 98.93 (n)
  • 97.75 (a)
OR4D10 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
-- 36
  • 77 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
Species with no ortholog for OR4D10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4D10 Gene

ENSEMBL:
Gene Tree for OR4D10 (if available)
TreeFam:
Gene Tree for OR4D10 (if available)

Paralogs for OR4D10 Gene

(437) SIMAP similar genes for OR4D10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4D10: view

Variants for OR4D10 Gene

Sequence variations from dbSNP and Humsavar for OR4D10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7108052 -- 59,475,503(+) ACAGC(A/G)CTATA upstream-variant-2KB
rs17153810 -- 59,477,135(+) AAATT(A/G)AATAT upstream-variant-2KB
rs59180472 -- 59,476,548(+) GCTAA(-/T)TTTTT upstream-variant-2KB
rs60607993 -- 59,476,923(+) AAAAA(-/TA)ACTGA upstream-variant-2KB
rs73482815 -- 59,476,845(+) TGGGG(A/G)AAAAA upstream-variant-2KB

Variation tolerance for OR4D10 Gene

Residual Variation Intolerance Score: 59.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.07; 75.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4D10 Gene

HapMap Linkage Disequilibrium report
OR4D10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR4D10 Gene

Disorders for OR4D10 Gene

Relevant External Links for OR4D10

Genetic Association Database (GAD)
OR4D10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4D10
genes like me logo Genes that share disorders with OR4D10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4D10 Gene

Publications for OR4D10 Gene

  1. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta K.L. … Murabito J.M. (BMC Med. Genet. 2007) 67
  2. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 67
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Population differences in the human functional olfactory repertoire. (PMID: 12644552) Gilad Y. … Lancet D. (Mol. Biol. Evol. 2003) 67

Products for OR4D10 Gene

Sources for OR4D10 Gene

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