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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR4D1 Gene

protein-coding   GIFtS: 49
GCID: GC17P056232

Olfactory Receptor, Family 4, Subfamily D, Member 1


(Previous symbol: OR4D3)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 4, Subfamily D, Member 11 2     TPCR162
OR4D31 2 3     Olfactory Receptor 4D12
Olfactory Receptor 4D32 3     Olfactory Receptor OR17-23 Pseudogene2
Olfactory Receptor TPCR162 3     Olfactory Receptor, Family 4, Subfamily D, Member 32
OR17-232     Olfactory Receptor, Family 4, Subfamily D, Member 4 Pseudogene2
OR4D4P2     Seven Transmembrane Helix Receptor2

External Ids:    HGNC: 82931   Entrez Gene: 266892   Ensembl: ENSG000001411947   UniProtKB: Q156153   

Export aliases for OR4D1 gene to outside databases

Previous GC identifers: GC17P055976 GC17M058713 GC17P056539 GC17P056707 GC17P053552 GC17P053588


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR4D1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4D1 Gene: 
OR4D1 (olfactory receptor, family 4, subfamily D, member 1) is a protein-coding gene. Diseases associated with OR4D1 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4D11.

UniProtKB/Swiss-Prot: OR4D1_HUMAN, Q15615
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4D1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR4D1 gene promoter:
         STAT5B   HEN1   AhR   Spz1   p53   Brachyury   STAT5A   Arnt   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for OR4D1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR4D1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

OR4D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4D1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P056232:  view genomic region     (about GC identifiers)

Start:
56,232,515 bp from pter      End:
56,233,444 bp from pter
Size:
930 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OR4D1_HUMAN, Q15615 (See protein sequence)
Recommended Name: Olfactory receptor 4D1  
Size: 310 amino acids; 35240 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2RN14 Q8NGB1 Q96R76

Explore the universe of human proteins at neXtProt for OR4D1: NX_Q15615

Explore proteomics data for OR4D1 at MOPED 

HORDE protein sequence for OR4D1
OR4D1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

OR4D1 Protein Expression

REFSEQ proteins: NP_036506.1  
ENSEMBL proteins: 
 ENSP00000365451  
Reactome Protein details: Q15615
Human Recombinant Protein Products for OR4D1: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane NAS9119360

OR4D1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
OR4: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q15615

ProtoNet protein and cluster: Q15615

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR4D1_HUMAN, Q15615
Similarity: Belongs to the G-protein coupled receptor 1 family


OR4D1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: OR4D1_HUMAN, Q15615
Function: Odorant receptor (Potential)

     Genatlas biochemistry entry for OR4D1:
olfactory receptor,family 4,subfamily D,member 1,G protein coupled receptor superfamily

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity NAS9119360
     
OR4D1 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR4D1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory transduction
Olfactory Signaling Pathway0.81
Olfactory transduction0.81
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4        Reactome Pathways for OR4D1
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR4D1):
    Olfactory transduction


OR4D1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR4D1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for OR4D1 (ENSP000003654514) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ADRBK2ENSP000003175784STRING: ENSP00000317578
ARRB2ENSP000002692604STRING: ENSP00000269260
GNALENSP000003340514STRING: ENSP00000334051
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0007608sensory perception of smell NAS9119360
GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS9119360

OR4D1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR4D1

Search CenterWatch for drugs/clinical trials and news about OR4D1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR4D1 gene: 
NM_012374.1  

Unigene Cluster for OR4D1:

Olfactory receptor, family 4, subfamily D, member 1
Hs.531188
Unigene Representative Sequence: BC136595
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000268912(uc010wno.2)
miRNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR4D1

Additional mRNA sequence: 

BC136589.1 BC136595.1 X89670.1 

1 DOTS entry:

DT.75133116 

2 AceView cDNA sequences:

NM_012374 X89670 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR4D1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGGAGATTAG
OR4D1 Expression
About this image


See OR4D1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR4D1

SOURCE GeneReport for Unigene cluster: Hs.531188
    SABiosciences Custom PCR Arrays for OR4D1
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR4D1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4D1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for OR4D1 gene from 1/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr4641 , 5 olfactory receptor 4641, 5 84.57(n)1
86.08(a)1
  11 (52.29 cM)5
2584071  NM_146412.21  NP_666524.21 
 879139635 


ENSEMBL Gene Tree for OR4D1 (if available)
TreeFam Gene Tree for OR4D1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR4D1 gene
OR4D112  OR4D22  OR4D52  OR4N22  OR4N52  OR4D62  OR4M12  OR4Q22  
OR4N42  OR4D102  OR4M22  OR4D92  OR4Q32  OR4E22  
18/444 SIMAP similar genes for OR4D1 using alignment to 1 protein entry:     OR4D1_HUMAN(see all similar genes):
OR4D2    OR4D9    OR4D10    OR4D11    OR4D6    OR4D5
OR4K13    OR4Q3    OR4C46    OR4K3    OR4Q2    OR4C13
OR4C3    OR4E1    OR4E2    OR4F17    OR4F4    OR4F5

OR4D1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/26 SNPs in OR4D1 are shown (see all 26)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0575464
----see VAR_0575462 R Q mis40--------
VAR_0604794
----see VAR_0604792 L I mis40--------
rs1411492491,2
--56230760(+) AAACAA/CAGCAC 1 -- us2k10--------
rs1922644551,2
--56230795(+) ACAAAC/TATCTG 1 -- us2k10--------
rs1179611941,2
C,F--56230818(+) AATTTT/GATGTG 1 -- us2k11Minor allele frequency- G:0.03NA 120
rs10750091,2
C,F,H--56230863(+) CCCTCA/GTAAGT 1 -- us2k127Minor allele frequency- N:0.00EA NA NS WA CSA 2562
rs777199641,2
F--56231116(+) TTTAAC/TACCAA 1 -- us2k11Minor allele frequency- T:0.01NA 120
rs99085111,2
C,F,A,H--56231150(+) AATGTA/CTTCTA 1 -- us2k112Minor allele frequency- C:0.41NA WA CSA EA 375
rs1839938121,2
--56231389(+) GTTGCC/GCAGGC 1 -- us2k10--------
rs1447693081,2
C--56231584(+) CCAAAG/TTAGTG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OR4D1 ( 56232515 - 56233444 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for OR4D1: --
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for OR4D1:    About MalaCards
neuronitis    


OR4D1 for disorders           About GeneDecksing

Genetic Association Database (GAD): OR4D1
Human Genome Epidemiology (HuGE) Navigator: OR4D1 (1 document)

Export disorders for OR4D1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR4D1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR4D1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PubMed id 9119360)1, 2, 3 Vanderhaeghen P....Parmentier M. (1997)
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  3. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  6. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 26689 HGNC: 8293 AceView: OR4D1 Ensembl:ENSG00000141194 euGenes: HUgn26689
ECgene: OR4D1 Kegg: 26689 H-InvDB: OR4D1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR4D1 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR4D1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR4D1 gene:
Search GeneIP for patents involving OR4D1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Proteins for OR4D1
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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