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Aliases for OR4D1 Gene

Aliases for OR4D1 Gene

  • Olfactory Receptor Family 4 Subfamily D Member 1 2 3 5
  • Olfactory Receptor, Family 4, Subfamily D, Member 1 2 3
  • Olfactory Receptor TPCR16 3 4
  • Olfactory Receptor 4D3 3 4
  • OR4D3 3 4
  • Olfactory Receptor, Family 4, Subfamily D, Member 4 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily D, Member 3 3
  • Olfactory Receptor OR17-23 Pseudogene 3
  • Seven Transmembrane Helix Receptor 3
  • OR17-23 3
  • OR4D4P 3
  • TPCR16 3

External Ids for OR4D1 Gene

Previous HGNC Symbols for OR4D1 Gene

  • OR4D3

Previous GeneCards Identifiers for OR4D1 Gene

  • GC17P055976
  • GC17M058713
  • GC17P056539
  • GC17P056707
  • GC17P053552
  • GC17P053588
  • GC17P056232

Summaries for OR4D1 Gene

Entrez Gene Summary for OR4D1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4D1 Gene

OR4D1 (Olfactory Receptor Family 4 Subfamily D Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4Q3.

UniProtKB/Swiss-Prot for OR4D1 Gene

  • Odorant receptor.

Gene Wiki entry for OR4D1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4D1 Gene

Genomics for OR4D1 Gene

Regulatory Elements for OR4D1 Gene

Enhancers for OR4D1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR4D1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4D1 Gene

58,155,133 bp from pter
58,156,156 bp from pter
1,024 bases
Plus strand

Genomic View for OR4D1 Gene

Genes around OR4D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4D1 Gene

Proteins for OR4D1 Gene

  • Protein details for OR4D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4D1
    Protein Accession:
    Secondary Accessions:
    • B2RN14
    • Q8NGB1
    • Q96R76

    Protein attributes for OR4D1 Gene

    310 amino acids
    Molecular mass:
    35240 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4D1 Gene

Proteomics data for OR4D1 Gene at MOPED

Post-translational modifications for OR4D1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4D1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

  • Abcam antibodies for OR4D1
  • Santa Cruz Biotechnology (SCBT) Antibodies for OR4D1

No data available for DME Specific Peptides for OR4D1 Gene

Domains & Families for OR4D1 Gene

Gene Families for OR4D1 Gene

Protein Domains for OR4D1 Gene

Suggested Antigen Peptide Sequences for OR4D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4D1: view

Function for OR4D1 Gene

Molecular function for OR4D1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 4,subfamily D,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR4D1: view
genes like me logo Genes that share phenotypes with OR4D1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4D1 Gene

Localization for OR4D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4D1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR4D1 Gene COMPARTMENTS Subcellular localization image for OR4D1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,NAS 9119360
genes like me logo Genes that share ontologies with OR4D1: view

Pathways & Interactions for OR4D1 Gene

genes like me logo Genes that share pathways with OR4D1: view

Pathways by source for OR4D1 Gene

Interacting Proteins for OR4D1 Gene

Gene Ontology (GO) - Biological Process for OR4D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 9119360
genes like me logo Genes that share ontologies with OR4D1: view

No data available for SIGNOR curated interactions for OR4D1 Gene

Drugs & Compounds for OR4D1 Gene

No Compound Related Data Available

Transcripts for OR4D1 Gene

mRNA/cDNA for OR4D1 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4D1 Gene

No ASD Table

Relevant External Links for OR4D1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4D1 Gene

mRNA expression in normal human tissues for OR4D1 Gene

Protein differential expression in normal tissues from HIPED for OR4D1 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR4D1 Gene

SOURCE GeneReport for Unigene cluster for OR4D1 Gene Hs.531188

genes like me logo Genes that share expression patterns with OR4D1: view

Protein tissue co-expression partners for OR4D1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR4D1 Gene

Orthologs for OR4D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4D1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC788693 35
  • 86.77 (n)
  • 84.84 (a)
-- 36
  • 79 (a)
-- 36
  • 85 (a)
-- 36
  • 83 (a)
-- 36
  • 83 (a)
(Canis familiaris)
Mammalia OR4D1 35
  • 87.31 (n)
  • 88.39 (a)
OR4D1 36
  • 89 (a)
(Mus musculus)
Mammalia Olfr464 35
  • 84.3 (n)
  • 85.81 (a)
Olfr464 16
Olfr464 36
  • 85 (a)
(Pan troglodytes)
Mammalia LOC468418 35
  • 99.46 (n)
  • 100 (a)
OR4D1 36
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
-- 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
-- 36
  • 68 (a)
-- 36
  • 68 (a)
-- 36
  • 69 (a)
-- 36
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
-- 36
  • 56 (a)
Species with no ortholog for OR4D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4D1 Gene

Gene Tree for OR4D1 (if available)
Gene Tree for OR4D1 (if available)

Paralogs for OR4D1 Gene

(443) SIMAP similar genes for OR4D1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4D1: view

Variants for OR4D1 Gene

Sequence variations from dbSNP and Humsavar for OR4D1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_057546 -
VAR_060479 -
rs1075009 -- 58,153,502(+) CCCTC(A/G)TAAGT upstream-variant-2KB
rs3030795 -- 58,154,286(+) ttttt(-/TT)AAACA upstream-variant-2KB
rs8071251 -- 58,154,954(+) GGGAA(A/G)TAAGT upstream-variant-2KB

Variation tolerance for OR4D1 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.67; 86.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for OR4D1 Gene

Disorders for OR4D1 Gene

Relevant External Links for OR4D1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR4D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4D1 Gene

Publications for OR4D1 Gene

  1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P. … Parmentier M. (Genomics 1997) 2 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR4D1 Gene

Sources for OR4D1 Gene