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Aliases for OR4D1 Gene

Aliases for OR4D1 Gene

  • Olfactory Receptor, Family 4, Subfamily D, Member 1 2 3
  • Olfactory Receptor TPCR16 3 4
  • Olfactory Receptor 4D3 3 4
  • OR4D3 3 4
  • Olfactory Receptor, Family 4, Subfamily D, Member 4 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily D, Member 3 3
  • Olfactory Receptor OR17-23 Pseudogene 3
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor 4D1 3
  • OR17-23 3
  • OR4D4P 3
  • TPCR16 3

External Ids for OR4D1 Gene

Previous HGNC Symbols for OR4D1 Gene

  • OR4D3

Previous GeneCards Identifiers for OR4D1 Gene

  • GC17P055976
  • GC17M058713
  • GC17P056539
  • GC17P056707
  • GC17P053552
  • GC17P053588
  • GC17P056232

Summaries for OR4D1 Gene

Entrez Gene Summary for OR4D1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4D1 Gene

OR4D1 (Olfactory Receptor, Family 4, Subfamily D, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4D9.

UniProtKB/Swiss-Prot for OR4D1 Gene

  • Odorant receptor.

Gene Wiki entry for OR4D1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4D1 Gene

Genomics for OR4D1 Gene

Regulatory Elements for OR4D1 Gene

Genomic Location for OR4D1 Gene

Start:
58,155,133 bp from pter
End:
58,156,156 bp from pter
Size:
1,024 bases
Orientation:
Plus strand

Genomic View for OR4D1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4D1 Gene

Proteins for OR4D1 Gene

  • Protein details for OR4D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15615-OR4D1_HUMAN
    Recommended name:
    Olfactory receptor 4D1
    Protein Accession:
    Q15615
    Secondary Accessions:
    • B2RN14
    • Q8NGB1
    • Q96R76

    Protein attributes for OR4D1 Gene

    Size:
    310 amino acids
    Molecular mass:
    35240 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4D1 Gene

Proteomics data for OR4D1 Gene at MOPED

Post-translational modifications for OR4D1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4D1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4D1 Gene

Domains for OR4D1 Gene

Gene Families for OR4D1 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4D1 Gene

Suggested Antigen Peptide Sequences for OR4D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15615

UniProtKB/Swiss-Prot:

OR4D1_HUMAN :
  • Q15615
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4D1: view

Function for OR4D1 Gene

Molecular function for OR4D1 Gene

GENATLAS Biochemistry: olfactory receptor,family 4,subfamily D,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
genes like me logo Genes that share ontologies with OR4D1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4D1 Gene

Localization for OR4D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4D1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4D1 Gene COMPARTMENTS Subcellular localization image for OR4D1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 9119360
genes like me logo Genes that share ontologies with OR4D1: view

Pathways for OR4D1 Gene

genes like me logo Genes that share pathways with OR4D1: view

Pathways by source for OR4D1 Gene

Interacting Proteins for OR4D1 Gene

Gene Ontology (GO) - Biological Process for OR4D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 9119360
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 9119360
genes like me logo Genes that share ontologies with OR4D1: view

Transcripts for OR4D1 Gene

mRNA/cDNA for OR4D1 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4D1 Gene

No ASD Table

Relevant External Links for OR4D1 Gene

GeneLoc Exon Structure for
OR4D1
ECgene alternative splicing isoforms for
OR4D1

Expression for OR4D1 Gene

mRNA expression in normal human tissues for OR4D1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR4D1 Gene

SOURCE GeneReport for Unigene cluster for OR4D1 Gene Hs.531188

genes like me logo Genes that share expressions with OR4D1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR4D1 Gene

Orthologs for OR4D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC468418 35
  • 99.46 (n)
  • 100 (a)
OR4D1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
LOC788693 35
  • 86.77 (n)
  • 84.84 (a)
dog
(Canis familiaris)
Mammalia OR4D1 35
  • 87.31 (n)
  • 88.39 (a)
OR4D1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr464 35
  • 84.3 (n)
  • 85.81 (a)
Olfr464 16
Olfr464 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
Species with no ortholog for OR4D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4D1 Gene

ENSEMBL:
Gene Tree for OR4D1 (if available)
TreeFam:
Gene Tree for OR4D1 (if available)

Paralogs for OR4D1 Gene

Selected SIMAP similar genes for OR4D1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4D1: view

Variants for OR4D1 Gene

Sequence variations from dbSNP and Humsavar for OR4D1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1075009 -- 58,153,502(+) CCCTC(A/G)TAAGT upstream-variant-2KB
rs3030795 -- 58,154,286(+) ttttt(-/TT)AAACA upstream-variant-2KB
rs8071251 -- 58,154,954(+) GGGAA(A/G)TAAGT upstream-variant-2KB
rs9908511 -- 58,153,789(+) AATGT(A/C)TTCTA upstream-variant-2KB
rs77719964 -- 58,153,755(+) TTTAA(C/T)ACCAA upstream-variant-2KB

Relevant External Links for OR4D1 Gene

HapMap Linkage Disequilibrium report
OR4D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR4D1 Gene

Disorders for OR4D1 Gene

Relevant External Links for OR4D1

Genetic Association Database (GAD)
OR4D1
Human Genome Epidemiology (HuGE) Navigator
OR4D1
genes like me logo Genes that share disorders with OR4D1: view

No data available for UniProtKB/Swiss-Prot for OR4D1 Gene

Publications for OR4D1 Gene

  1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P. … Parmentier M. (Genomics 1997) 2 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4

Products for OR4D1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate OR4D1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for OR4D1
    • Block miRNA regulation of OR4D1 using miScript Target Protectors

    Sources for OR4D1 Gene

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