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Aliases for OR4C6 Gene

Aliases for OR4C6 Gene

  • Olfactory Receptor, Family 4, Subfamily C, Member 6 2 3
  • Olfactory Receptor OR11-138 3 4
  • Olfactory Receptor 4C6 3
  • OR11-138 3

External Ids for OR4C6 Gene

Summaries for OR4C6 Gene

Entrez Gene Summary for OR4C6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C6 Gene

OR4C6 (Olfactory Receptor, Family 4, Subfamily C, Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot for OR4C6 Gene

  • Odorant receptor.

Gene Wiki entry for OR4C6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C6 Gene

Genomics for OR4C6 Gene

Genomic Location for OR4C6 Gene

Start:
55,665,167 bp from pter
End:
55,666,096 bp from pter
Size:
930 bases
Orientation:
Plus strand

Genomic View for OR4C6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4C6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C6 Gene

Regulatory Elements for OR4C6 Gene

Proteins for OR4C6 Gene

  • Protein details for OR4C6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH72-OR4C6_HUMAN
    Recommended name:
    Olfactory receptor 4C6
    Protein Accession:
    Q8NH72
    Secondary Accessions:
    • B2RP11
    • Q6IFD2

    Protein attributes for OR4C6 Gene

    Size:
    309 amino acids
    Molecular mass:
    34558 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C6 Gene

Proteomics data for OR4C6 Gene at MOPED

Post-translational modifications for OR4C6 Gene

Other Protein References for OR4C6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR4C6 Gene

Domains for OR4C6 Gene

Gene Families for OR4C6 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4C6 Gene

UniProtKB/Swiss-Prot:

OR4C6_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NH72
genes like me logo Genes that share domains with OR4C6: view

Function for OR4C6 Gene

Molecular function for OR4C6 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4C6 Gene

Localization for OR4C6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4C6 Gene COMPARTMENTS Subcellular localization image for OR4C6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4C6: view

Pathways for OR4C6 Gene

genes like me logo Genes that share pathways with OR4C6: view

Pathways by source for OR4C6 Gene

Interacting Proteins for OR4C6 Gene

Gene Ontology (GO) - Biological Process for OR4C6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C6: view

Transcripts for OR4C6 Gene

mRNA/cDNA for OR4C6 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4C6 Gene

Olfactory receptor, family 4, subfamily C, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C6 Gene

No ASD Table

Relevant External Links for OR4C6 Gene

GeneLoc Exon Structure for
OR4C6
ECgene alternative splicing isoforms for
OR4C6

Expression for OR4C6 Gene

mRNA expression in normal human tissues for OR4C6 Gene

mRNA differential expression in normal tissues according to GTEx for OR4C6 Gene

This gene is overexpressed in Minor Salivary Gland (11.6), Spleen (6.4), Cervix - Ectocervix (6.0), and Testis (4.6).

SOURCE GeneReport for Unigene cluster for OR4C6 Gene Hs.511921

genes like me logo Genes that share expressions with OR4C6: view

Orthologs for OR4C6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466887 36
  • 98.6 (n)
  • 97.73 (a)
OR4C6 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 70 (a)
OneToMany
-- 37
  • 68 (a)
OneToMany
OR4C6 36
  • 77.16 (n)
  • 67.86 (a)
dog
(Canis familiaris)
Mammalia LOC491531 36
  • 84.63 (n)
  • 81.17 (a)
OR4C6 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1189 37
  • 77 (a)
OneToMany
Olfr1230 36
  • 78.37 (n)
  • 77.15 (a)
Olfr1230 37
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia OR4C6 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 62 (a)
OneToMany
-- 37
  • 61 (a)
OneToMany
-- 37
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr693 36
  • 77.26 (n)
  • 76.16 (a)
Species with no ortholog for OR4C6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C6 Gene

ENSEMBL:
Gene Tree for OR4C6 (if available)
TreeFam:
Gene Tree for OR4C6 (if available)

Paralogs for OR4C6 Gene

Selected SIMAP similar genes for OR4C6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4C6 Gene

genes like me logo Genes that share paralogs with OR4C6: view

Variants for OR4C6 Gene

Sequence variations from dbSNP and Humsavar for OR4C6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs295604 -- 55,663,222(+) GAAGT(A/G)AGTGG upstream-variant-2KB
rs295605 -- 55,663,998(+) TAACT(C/T)CCCTG upstream-variant-2KB
rs10897138 -- 55,664,421(+) CTGAA(C/T)AATGA upstream-variant-2KB
rs11230590 -- 55,663,700(+) GGATT(G/T)TTGCA upstream-variant-2KB
rs11230593 -- 55,664,020(+) ATTCT(C/T)CTCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4C6 Gene

Variant ID Type Subtype PubMed ID
esv2751030 CNV Gain 17911159
nsv524091 CNV Gain 19592680
nsv821668 CNV Loss 15273396
dgv376e1 CNV Complex 17122850
esv782 CNV CNV 17122850
dgv12n68 CNV Loss 17160897
dgv377e1 CNV Complex 17122850
nsv428256 CNV Loss 18775914
dgv4e49 CNV Loss 18971310
dgv378e1 CNV Complex 17122850
dgv143n27 CNV Loss 19166990
nsv517440 CNV Gain+Loss 19592680
nsv323 CNV Loss 18451855
nsv71 CNV Loss 15895083
nsv437717 CNV Loss 16327808
nsv469957 CNV Gain 18288195
nsv818824 CNV Gain 17921354
dgv144n27 CNV Gain 19166990
dgv145n27 CNV Loss 19166990
dgv146n27 CNV Gain 19166990
nsv508632 CNV Loss 20534489
dgv211e199 CNV Deletion 23128226
nsv443003 CNV Complex 18674749
dgv12n47 CNV Loss 21111241
esv22842 CNV Gain+Loss 19812545
dgv217n67 CNV Loss 20364138
nsv8827 CNV Gain+Loss 18304495
esv33874 CNV Gain 17666407
dgv6n14 CNV Loss 18776910
esv2421634 CNV Deletion 20811451
esv29944 CNV Loss 18421352
nsv469958 CNV Loss 18288195
dgv10n64 CNV Loss 17921354
dgv11n64 CNV Gain+Loss 17921354
dgv381e1 CNV Complex 17122850
dgv382e1 CNV Complex 17122850
nsv442617 CNV CNV 18776908
dgv50e55 CNV Loss 17911159
dgv5e49 CNV Loss 18971310
dgv13n68 CNV Loss 17160897
dgv148n27 CNV Loss 19166990
nsv514622 CNV Loss 21397061
dgv149n27 CNV Loss 19166990
nsv468563 CNV Loss 19166990
dgv212e199 CNV Deletion 23128226
dgv6e49 CNV Loss 18971310
dgv12n64 CNV Loss 17921354
nsv499760 OTHER Inversion 21111241
nsv7218 OTHER Inversion 18451855
dgv213e199 CNV Deletion 23128226

Relevant External Links for OR4C6 Gene

HapMap Linkage Disequilibrium report
OR4C6

Disorders for OR4C6 Gene

Relevant External Links for OR4C6

Human Genome Epidemiology (HuGE) Navigator
OR4C6
genes like me logo Genes that share disorders with OR4C6: view

No data available for UniProtKB/Swiss-Prot for OR4C6 Gene

Publications for OR4C6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR4C6 Gene

Sources for OR4C6 Gene

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