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Aliases for OR4C46 Gene

Aliases for OR4C46 Gene

  • Olfactory Receptor, Family 4, Subfamily C, Member 46 2 3

External Ids for OR4C46 Gene

Previous GeneCards Identifiers for OR4C46 Gene

  • GC11P051524
  • GC11P051371

Summaries for OR4C46 Gene

Entrez Gene Summary for OR4C46 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C46 Gene

OR4C46 (Olfactory Receptor, Family 4, Subfamily C, Member 46) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot for OR4C46 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C46 Gene

Genomics for OR4C46 Gene

Regulatory Elements for OR4C46 Gene

Genomic Location for OR4C46 Gene

Start:
54,603,069 bp from pter
End:
54,603,998 bp from pter
Size:
930 bases
Orientation:
Minus strand

Genomic View for OR4C46 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4C46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C46 Gene

Proteins for OR4C46 Gene

  • Protein details for OR4C46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHA9-O4C46_HUMAN
    Recommended name:
    Olfactory receptor 4C46
    Protein Accession:
    A6NHA9
    Secondary Accessions:

    Protein attributes for OR4C46 Gene

    Size:
    309 amino acids
    Molecular mass:
    34533 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C46 Gene

Proteomics data for OR4C46 Gene at MOPED

Post-translational modifications for OR4C46 Gene

  • Glycosylation at Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C46 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C46 Gene

Domains for OR4C46 Gene

Gene Families for OR4C46 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4C46 Gene

Suggested Antigen Peptide Sequences for OR4C46 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NHA9

UniProtKB/Swiss-Prot:

O4C46_HUMAN :
  • A6NHA9
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C46: view

Function for OR4C46 Gene

Molecular function for OR4C46 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C46: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4C46

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4C46 Gene

Localization for OR4C46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C46 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4C46 Gene COMPARTMENTS Subcellular localization image for OR4C46 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4C46: view

Pathways for OR4C46 Gene

genes like me logo Genes that share pathways with OR4C46: view

Pathways by source for OR4C46 Gene

Interacting Proteins for OR4C46 Gene

Gene Ontology (GO) - Biological Process for OR4C46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C46: view

Transcripts for OR4C46 Gene

mRNA/cDNA for OR4C46 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4C46

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C46 Gene

No ASD Table

Relevant External Links for OR4C46 Gene

GeneLoc Exon Structure for
OR4C46
ECgene alternative splicing isoforms for
OR4C46

Expression for OR4C46 Gene

mRNA expression in normal human tissues for OR4C46 Gene

SOURCE GeneReport for Unigene cluster for OR4C46 Gene Hs.553564

genes like me logo Genes that share expressions with OR4C46: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR4C46 Gene

Orthologs for OR4C46 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C46 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR4C46 35
  • 85.57 (n)
  • 82.95 (a)
-- 36
  • 78 (a)
ManyToMany
-- 36
  • 80 (a)
ManyToMany
-- 36
  • 77 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia cOR4C43 35
  • 86.84 (n)
  • 86.41 (a)
-- 36
  • 85 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr1258 35
  • 82.13 (n)
  • 84.54 (a)
Olfr1258 16
Olfr1204 36
  • 77 (a)
ManyToMany
Olfr1257 36
  • 79 (a)
ManyToMany
Olfr1258 36
  • 83 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100909996 35
  • 81.25 (n)
  • 83.22 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
ManyToMany
Species with no ortholog for OR4C46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C46 Gene

ENSEMBL:
Gene Tree for OR4C46 (if available)
TreeFam:
Gene Tree for OR4C46 (if available)

Paralogs for OR4C46 Gene

Selected SIMAP similar genes for OR4C46 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4C46: view

Variants for OR4C46 Gene

Sequence variations from dbSNP and Humsavar for OR4C46 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4581427 -- 54,605,428(-) ATGAG(C/T)TCAGA upstream-variant-2KB
rs10794396 -- 54,604,298(-) GCTAC(C/T)GTGTA upstream-variant-2KB
rs11246604 -- 54,605,960(-) ATCTC(C/T)GCCTC upstream-variant-2KB
rs11246605 -- 54,604,469(-) TACTA(C/G)TGGGA upstream-variant-2KB
rs11246606 -- 54,603,820(-) CCTTT(C/T)CCTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR4C46 Gene

Variant ID Type Subtype PubMed ID
nsv516340 CNV Gain+Loss 19592680
nsv897582 CNV Gain 21882294
esv2751029 CNV Gain 17911159
dgv142n27 CNV Gain 19166990
nsv832151 CNV Loss 17160897

Relevant External Links for OR4C46 Gene

HapMap Linkage Disequilibrium report
OR4C46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C46 Gene

Disorders for OR4C46 Gene

Relevant External Links for OR4C46

Genetic Association Database (GAD)
OR4C46

No disorders were found for OR4C46 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OR4C46 Gene

Publications for OR4C46 Gene

  1. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PMID: 21822266) Xu B. … Karayiorgou M. (Nat. Genet. 2011) 3
  2. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for OR4C46 Gene

Sources for OR4C46 Gene

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