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Aliases for OR4C46 Gene

Aliases for OR4C46 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 46 2 3 5
  • Olfactory Receptor, Family 4, Subfamily C, Member 46 2

External Ids for OR4C46 Gene

Previous GeneCards Identifiers for OR4C46 Gene

  • GC11P051524
  • GC11P051371

Summaries for OR4C46 Gene

Entrez Gene Summary for OR4C46 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C46 Gene

OR4C46 (Olfactory Receptor Family 4 Subfamily C Member 46) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot for OR4C46 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C46 Gene

Genomics for OR4C46 Gene

Regulatory Elements for OR4C46 Gene

Genomic Location for OR4C46 Gene

54,603,069 bp from pter
54,603,998 bp from pter
930 bases
Minus strand

Genomic View for OR4C46 Gene

Genes around OR4C46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C46 Gene

Proteins for OR4C46 Gene

  • Protein details for OR4C46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4C46
    Protein Accession:

    Protein attributes for OR4C46 Gene

    309 amino acids
    Molecular mass:
    34533 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C46 Gene

Proteomics data for OR4C46 Gene at MOPED

Post-translational modifications for OR4C46 Gene

  • Glycosylation at Asn 6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C46 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C46 Gene

Domains & Families for OR4C46 Gene

Gene Families for OR4C46 Gene

Protein Domains for OR4C46 Gene

Suggested Antigen Peptide Sequences for OR4C46 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C46: view

Function for OR4C46 Gene

Molecular function for OR4C46 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C46: view

Phenotypes for OR4C46 Gene

GenomeRNAi human phenotypes for OR4C46:
genes like me logo Genes that share phenotypes with OR4C46: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C46 Gene

Localization for OR4C46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C46 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR4C46 Gene COMPARTMENTS Subcellular localization image for OR4C46 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR4C46: view

Pathways & Interactions for OR4C46 Gene

genes like me logo Genes that share pathways with OR4C46: view

Pathways by source for OR4C46 Gene

Interacting Proteins for OR4C46 Gene

Gene Ontology (GO) - Biological Process for OR4C46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C46: view

No data available for SIGNOR curated interactions for OR4C46 Gene

Drugs & Compounds for OR4C46 Gene

No Compound Related Data Available

Transcripts for OR4C46 Gene

mRNA/cDNA for OR4C46 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C46 Gene

No ASD Table

Relevant External Links for OR4C46 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4C46 Gene

mRNA expression in normal human tissues for OR4C46 Gene

SOURCE GeneReport for Unigene cluster for OR4C46 Gene Hs.553564

genes like me logo Genes that share expression patterns with OR4C46: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR4C46 Gene

Orthologs for OR4C46 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C46 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR4C46 35
  • 85.57 (n)
  • 82.95 (a)
-- 36
  • 78 (a)
-- 36
  • 80 (a)
-- 36
  • 77 (a)
(Canis familiaris)
Mammalia cOR4C43 35
  • 86.84 (n)
  • 86.41 (a)
-- 36
  • 85 (a)
(Mus musculus)
Mammalia Olfr1258 35
  • 82.13 (n)
  • 84.54 (a)
Olfr1258 16
Olfr1204 36
  • 77 (a)
Olfr1257 36
  • 79 (a)
Olfr1258 36
  • 83 (a)
(Rattus norvegicus)
Mammalia LOC100909996 35
  • 81.25 (n)
  • 83.22 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
-- 36
  • 79 (a)
-- 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
Species with no ortholog for OR4C46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C46 Gene

Gene Tree for OR4C46 (if available)
Gene Tree for OR4C46 (if available)

Paralogs for OR4C46 Gene

Paralogs for OR4C46 Gene

(443) SIMAP similar genes for OR4C46 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4C46: view

Variants for OR4C46 Gene

Sequence variations from dbSNP and Humsavar for OR4C46 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11246607 - 54,603,280(-) TGTCT(C/T)CCACA reference, missense
rs11246608 - 54,603,244(-) GCCCT(A/G)CATAT reference, missense
rs11246609 - 54,603,136(-) CTTGA(A/G)GAATG reference, missense
rs61890416 -- 54,605,697(-) ACTTG(A/G)TGGGG upstream-variant-2KB
rs61890417 -- 54,604,167(-) AAGTA(A/T)TCTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4C46 Gene

Variant ID Type Subtype PubMed ID
nsv516340 CNV Gain+Loss 19592680
nsv897582 CNV Gain 21882294
esv2751029 CNV Gain 17911159
dgv142n27 CNV Gain 19166990
nsv832151 CNV Loss 17160897

Variation tolerance for OR4C46 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.31; 99.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR4C46 Gene

Disorders for OR4C46 Gene

Relevant External Links for OR4C46

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR4C46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C46 Gene

Publications for OR4C46 Gene

  1. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3 67
  2. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PMID: 21822266) Xu B. … Karayiorgou M. (Nat. Genet. 2011) 3

Products for OR4C46 Gene

Sources for OR4C46 Gene