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Aliases for OR4C45 Gene

Aliases for OR4C45 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 45 (Gene/Pseudogene) 2 3
  • Olfactory Receptor, Family 4, Subfamily C, Member 45 2
  • Olfactory Receptor Family 4 Subfamily C Member 45 5

External Ids for OR4C45 Gene

Previous GeneCards Identifiers for OR4C45 Gene

  • GC11U900137
  • GC11P050020
  • GC11M048366
  • GC11P049771
  • GC11P9I0191

Summaries for OR4C45 Gene

Entrez Gene Summary for OR4C45 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C45 Gene

OR4C45 (Olfactory Receptor Family 4 Subfamily C Member 45 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4C46.

UniProtKB/Swiss-Prot for OR4C45 Gene

  • Odorant receptor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C45 Gene

Genomics for OR4C45 Gene

Regulatory Elements for OR4C45 Gene


Genomic Location for OR4C45 Gene

Chromosome:
11
Start:
50,032,874 bp from pter
End:
50,033,794 bp from pter
Size:
921 bases
Orientation:
Plus strand

Genomic View for OR4C45 Gene

Genes around OR4C45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C45 Gene

Proteins for OR4C45 Gene

  • Protein details for OR4C45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMZ5-O4C45_HUMAN
    Recommended name:
    Olfactory receptor 4C45
    Protein Accession:
    A6NMZ5

    Protein attributes for OR4C45 Gene

    Size:
    311 amino acids
    Molecular mass:
    35341 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C45 Gene

Post-translational modifications for OR4C45 Gene

No Post-translational modifications

Other Protein References for OR4C45 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C45 Gene

Domains & Families for OR4C45 Gene

Gene Families for OR4C45 Gene

Protein Domains for OR4C45 Gene

Suggested Antigen Peptide Sequences for OR4C45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMZ5

UniProtKB/Swiss-Prot:

O4C45_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C45: view

Function for OR4C45 Gene

Molecular function for OR4C45 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C45: view

Phenotypes for OR4C45 Gene

genes like me logo Genes that share phenotypes with OR4C45: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C45 Gene

Localization for OR4C45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C45 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR4C45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4C45: view

No data available for Subcellular locations from COMPARTMENTS for OR4C45 Gene

Pathways & Interactions for OR4C45 Gene

genes like me logo Genes that share pathways with OR4C45: view

Pathways by source for OR4C45 Gene

Interacting Proteins for OR4C45 Gene

Gene Ontology (GO) - Biological Process for OR4C45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C45: view

No data available for SIGNOR curated interactions for OR4C45 Gene

Drugs & Compounds for OR4C45 Gene

No Compound Related Data Available

Transcripts for OR4C45 Gene

mRNA/cDNA for OR4C45 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C45 Gene

No ASD Table

Relevant External Links for OR4C45 Gene

GeneLoc Exon Structure for
OR4C45
ECgene alternative splicing isoforms for
OR4C45

Expression for OR4C45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4C45 Gene

mRNA expression in normal human tissues for OR4C45 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4C45 Gene:

OR4C45

SOURCE GeneReport for Unigene cluster for OR4C45 Gene:

Hs.554533
genes like me logo Genes that share expression patterns with OR4C45: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4C45 Gene

Orthologs for OR4C45 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100614455 34
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia LOC483599 34
  • 84.31 (n)
rat
(Rattus norvegicus)
Mammalia Olr728 34
  • 81.15 (n)
mouse
(Mus musculus)
Mammalia Or4c52 55 Olfr1263 34 16
  • 80.66 (n)
Or4c126 55 Olfr1261
  • chr2:89,993,395-89,994,312
Or4c127 55 Olfr1262
  • chr2:90,002,408-90,003,319
Species where no ortholog for OR4C45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C45 Gene

ENSEMBL:
Gene Tree for OR4C45 (if available)
TreeFam:
Gene Tree for OR4C45 (if available)

Paralogs for OR4C45 Gene

(425) SIMAP similar genes for OR4C45 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4C45: view

Variants for OR4C45 Gene

Sequence variations from dbSNP and Humsavar for OR4C45 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11606669 -- 50,031,717(+) TGTGG(G/T)TACAT upstream-variant-2KB
rs35974149 -- 50,031,179(+) CCGGG(-/G)TCAGT upstream-variant-2KB
rs36140616 -- 50,033,131(+) ACACC(-/C)ATATC reference, frameshift-variant
rs397806275 -- 50,031,777(+) AAAAT(A/G)TCTTA upstream-variant-2KB
rs397826261 -- 50,033,053(+) TCCTA(G/T)TTATC reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for OR4C45 Gene

Variant ID Type Subtype PubMed ID
dgv1128n100 CNV gain 25217958
dgv1134n100 CNV gain 25217958
dgv1813n54 CNV gain 21841781
dgv1814n54 CNV gain 21841781
dgv352e212 CNV gain 25503493
esv33425 CNV gain 17666407
esv34613 CNV gain 17911159
esv3626326 CNV gain 21293372
esv3626329 CNV gain 21293372
esv3892002 CNV gain 25118596
esv3892003 CNV gain 25118596
nsv1048074 CNV gain 25217958
nsv428254 CNV loss 18775914
nsv467876 CNV gain 19166990
nsv511004 OTHER complex 20534489
nsv983017 CNV duplication 23825009

Relevant External Links for OR4C45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4C45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for OR4C45 Gene

Disorders for OR4C45 Gene

Relevant External Links for OR4C45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4C45

No disorders were found for OR4C45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C45 Gene

Publications for OR4C45 Gene

  1. Genetic predictors of fibrin D-dimer levels in healthy adults. (PMID: 21502573) Smith N.L. … Hayward C. (Circulation 2011) 3 64
  2. Extensive copy-number variation of the human olfactory receptor gene family. (PMID: 18674749) Young J.M. … Trask B.J. (Am. J. Hum. Genet. 2008) 3 64
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for OR4C45 Gene

Sources for OR4C45 Gene

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