Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR4C45 Gene

Aliases for OR4C45 Gene

  • Olfactory Receptor, Family 4, Subfamily C, Member 45 2 3

External Ids for OR4C45 Gene

Previous GeneCards Identifiers for OR4C45 Gene

  • GC11U900137
  • GC11P050020
  • GC11M048366
  • GC11P049771
  • GC11P9I0191

Summaries for OR4C45 Gene

Entrez Gene Summary for OR4C45 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C45 Gene

OR4C45 (Olfactory Receptor, Family 4, Subfamily C, Member 45) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR4C45 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C45 Gene

Genomics for OR4C45 Gene

Regulatory Elements for OR4C45 Gene

Genomic Location for OR4C45 Gene

Start:
50,032,874 bp from pter
End:
50,033,794 bp from pter
Size:
921 bases
Orientation:
Plus strand

Genomic View for OR4C45 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4C45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C45 Gene

Proteins for OR4C45 Gene

  • Protein details for OR4C45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMZ5-O4C45_HUMAN
    Recommended name:
    Olfactory receptor 4C45
    Protein Accession:
    A6NMZ5
    Secondary Accessions:

    Protein attributes for OR4C45 Gene

    Size:
    311 amino acids
    Molecular mass:
    35341 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C45 Gene

Proteomics data for OR4C45 Gene at MOPED

Post-translational modifications for OR4C45 Gene

No Post-translational modifications

Other Protein References for OR4C45 Gene

Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR4C45 Gene

Domains for OR4C45 Gene

Gene Families for OR4C45 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4C45 Gene

Suggested Antigen Peptide Sequences for OR4C45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMZ5

UniProtKB/Swiss-Prot:

O4C45_HUMAN :
  • A6NMZ5
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C45: view

Function for OR4C45 Gene

Molecular function for OR4C45 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C45: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4C45 Gene

Localization for OR4C45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C45 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4C45 Gene COMPARTMENTS Subcellular localization image for OR4C45 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4C45: view

Pathways for OR4C45 Gene

genes like me logo Genes that share pathways with OR4C45: view

Pathways by source for OR4C45 Gene

Interacting Proteins for OR4C45 Gene

Gene Ontology (GO) - Biological Process for OR4C45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C45: view

Transcripts for OR4C45 Gene

mRNA/cDNA for OR4C45 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C45 Gene

No ASD Table

Relevant External Links for OR4C45 Gene

GeneLoc Exon Structure for
OR4C45
ECgene alternative splicing isoforms for
OR4C45

Expression for OR4C45 Gene

mRNA expression in normal human tissues for OR4C45 Gene

mRNA expression in normal human tissues for OR4C45 Gene

SOURCE GeneReport for Unigene cluster for OR4C45 Gene Hs.554533

genes like me logo Genes that share expressions with OR4C45: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR4C45 Gene

Orthologs for OR4C45 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100614455 35
  • 99.13 (n)
  • 98.04 (a)
dog
(Canis familiaris)
Mammalia LOC483599 35
  • 84.31 (n)
  • 81.7 (a)
mouse
(Mus musculus)
Mammalia Olfr1263 35
  • 80.66 (n)
  • 77.38 (a)
rat
(Rattus norvegicus)
Mammalia Olr728 35
  • 81.15 (n)
  • 77.12 (a)
Species with no ortholog for OR4C45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C45 Gene

ENSEMBL:
Gene Tree for OR4C45 (if available)
TreeFam:
Gene Tree for OR4C45 (if available)

Paralogs for OR4C45 Gene

Selected SIMAP similar genes for OR4C45 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4C45: view

No data available for Paralogs for OR4C45 Gene

Variants for OR4C45 Gene

Sequence variations from dbSNP and Humsavar for OR4C45 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs11606669 -- 50,031,717(+) TGTGG(G/T)TACAT upstream-variant-2KB
rs35974149 -- 50,031,179(+) CCGGG(-/G)TCAGT upstream-variant-2KB
rs397806275 -- 50,031,777(+) AAAAT(A/G)TCTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4C45 Gene

Variant ID Type Subtype PubMed ID
dgv1091n71 CNV Gain 21882294
nsv467871 CNV Gain 19166990
nsv428253 CNV Loss 18775914
nsv467873 CNV Loss 19166990
nsv469953 CNV Loss 18288195
dgv366e1 CNV Complex 17122850
esv542 CNV CNV 17122850
dgv1092n71 CNV Loss 21882294
nsv897333 CNV Gain 21882294
dgv48e55 CNV Loss 17911159
nsv318 CNV Insertion 18451855
esv2588801 CNV Deletion 19546169
nsv435627 CNV Deletion 17901297
nsv512225 CNV Loss 21212237
esv2744454 CNV Deletion 23290073
esv6757 CNV Loss 19470904
nsv39760 CNV Loss 16902084

Relevant External Links for OR4C45 Gene

HapMap Linkage Disequilibrium report
OR4C45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C45 Gene

Disorders for OR4C45 Gene

No disorders were found for OR4C45 Gene.

No data available for UniProtKB/Swiss-Prot for OR4C45 Gene

Publications for OR4C45 Gene

  1. Extensive copy-number variation of the human olfactory receptor gene family. (PMID: 18674749) Young J.M. … Trask B.J. (Am. J. Hum. Genet. 2008) 3
  2. Genetic predictors of fibrin D-dimer levels in healthy adults. (PMID: 21502573) Smith N.L. … Hayward C. (Circulation 2011) 3
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for OR4C45 Gene

Sources for OR4C45 Gene

Back to Top

Content