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Aliases for OR4C45 Gene

Aliases for OR4C45 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 45 2 3 5
  • Olfactory Receptor, Family 4, Subfamily C, Member 45 2

External Ids for OR4C45 Gene

Previous GeneCards Identifiers for OR4C45 Gene

  • GC11U900137
  • GC11P050020
  • GC11M048366
  • GC11P049771
  • GC11P9I0191

Summaries for OR4C45 Gene

Entrez Gene Summary for OR4C45 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C45 Gene

OR4C45 (Olfactory Receptor Family 4 Subfamily C Member 45) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR4C45 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C45 Gene

Genomics for OR4C45 Gene

Regulatory Elements for OR4C45 Gene

Genomic Location for OR4C45 Gene

50,032,874 bp from pter
50,033,794 bp from pter
921 bases
Plus strand

Genomic View for OR4C45 Gene

Genes around OR4C45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C45 Gene

Proteins for OR4C45 Gene

  • Protein details for OR4C45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4C45
    Protein Accession:

    Protein attributes for OR4C45 Gene

    311 amino acids
    Molecular mass:
    35341 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C45 Gene

Proteomics data for OR4C45 Gene at MOPED

Post-translational modifications for OR4C45 Gene

No Post-translational modifications

Other Protein References for OR4C45 Gene

REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C45 Gene

Domains & Families for OR4C45 Gene

Gene Families for OR4C45 Gene

Protein Domains for OR4C45 Gene

Suggested Antigen Peptide Sequences for OR4C45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C45: view

Function for OR4C45 Gene

Molecular function for OR4C45 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR4C45 Gene

GenomeRNAi human phenotypes for OR4C45:
genes like me logo Genes that share phenotypes with OR4C45: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C45 Gene

Localization for OR4C45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C45 Gene

Cell membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for OR4C45 Gene

Pathways & Interactions for OR4C45 Gene

genes like me logo Genes that share pathways with OR4C45: view

Pathways by source for OR4C45 Gene

Interacting Proteins for OR4C45 Gene

Gene Ontology (GO) - Biological Process for OR4C45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with OR4C45: view

No data available for SIGNOR curated interactions for OR4C45 Gene

Drugs & Compounds for OR4C45 Gene

No Compound Related Data Available

Transcripts for OR4C45 Gene

mRNA/cDNA for OR4C45 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C45 Gene

No ASD Table

Relevant External Links for OR4C45 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4C45 Gene

mRNA expression in normal human tissues for OR4C45 Gene

mRNA expression in normal human tissues for OR4C45 Gene

SOURCE GeneReport for Unigene cluster for OR4C45 Gene Hs.554533

genes like me logo Genes that share expression patterns with OR4C45: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR4C45 Gene

Orthologs for OR4C45 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C45 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC483599 35
  • 84.31 (n)
  • 81.7 (a)
(Mus musculus)
Mammalia Olfr1263 35
  • 80.66 (n)
  • 77.38 (a)
Olfr1263 16
(Pan troglodytes)
Mammalia LOC100614455 35
  • 99.13 (n)
  • 98.04 (a)
(Rattus norvegicus)
Mammalia Olr728 35
  • 81.15 (n)
  • 77.12 (a)
Species with no ortholog for OR4C45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C45 Gene

Gene Tree for OR4C45 (if available)
Gene Tree for OR4C45 (if available)

Paralogs for OR4C45 Gene

(425) SIMAP similar genes for OR4C45 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4C45: view

No data available for Paralogs for OR4C45 Gene

Variants for OR4C45 Gene

Sequence variations from dbSNP and Humsavar for OR4C45 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11606669 -- 50,031,717(+) TGTGG(G/T)TACAT upstream-variant-2KB
rs397806275 -- 50,031,777(+) AAAAT(A/G)TCTTA upstream-variant-2KB
rs752003360 -- 50,033,053(+) TCCTA(G/T)TTATC reference, stop-gained
rs764730757 -- 50,032,079(+) TAATC(C/T)GGTGT upstream-variant-2KB
rs770153123 -- 50,034,066(+) aactg(G/T)attat downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR4C45 Gene

Variant ID Type Subtype PubMed ID
dgv1091n71 CNV Gain 21882294
nsv467871 CNV Gain 19166990
nsv428253 CNV Loss 18775914
nsv467873 CNV Loss 19166990
nsv469953 CNV Loss 18288195
dgv366e1 CNV Complex 17122850
esv542 CNV CNV 17122850
dgv1092n71 CNV Loss 21882294
nsv897333 CNV Gain 21882294
dgv48e55 CNV Loss 17911159
nsv318 CNV Insertion 18451855
esv2588801 CNV Deletion 19546169
nsv435627 CNV Deletion 17901297
nsv512225 CNV Loss 21212237
esv2744454 CNV Deletion 23290073
esv6757 CNV Loss 19470904
nsv39760 CNV Loss 16902084

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for OR4C45 Gene

Disorders for OR4C45 Gene

Relevant External Links for OR4C45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR4C45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C45 Gene

Publications for OR4C45 Gene

  1. Genetic predictors of fibrin D-dimer levels in healthy adults. (PMID: 21502573) Smith N.L. … Hayward C. (Circulation 2011) 3 67
  2. Extensive copy-number variation of the human olfactory receptor gene family. (PMID: 18674749) Young J.M. … Trask B.J. (Am. J. Hum. Genet. 2008) 3

Products for OR4C45 Gene

Sources for OR4C45 Gene