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Aliases for OR4C3 Gene

Aliases for OR4C3 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 3 2 3 5
  • Olfactory Receptor OR11-98 3 4
  • Olfactory Receptor, Family 4, Subfamily C, Member 3 2
  • Olfactory Receptor 4C3 3
  • OR11-98 3

External Ids for OR4C3 Gene

Previous GeneCards Identifiers for OR4C3 Gene

  • GC16U990205
  • GC11P048311
  • GC11P048300

Summaries for OR4C3 Gene

Entrez Gene Summary for OR4C3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C3 Gene

OR4C3 (Olfactory Receptor Family 4 Subfamily C Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4C12.

UniProtKB/Swiss-Prot for OR4C3 Gene

  • Odorant receptor.

Gene Wiki entry for OR4C3 Gene

Additional gene information for OR4C3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C3 Gene

Genomics for OR4C3 Gene

Regulatory Elements for OR4C3 Gene

Enhancers for OR4C3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H047869 1.2 FANTOM5 ENCODE dbSUPER 6.3 -455.1 -455116 0 TBP PKNOX1 STAT1 JUN FEZF1 EP300 PRDM6 JUND POLR2A NR2C2 OR4C3 OR4B1 OR4S1 PTPRJ OR4X2 NUP160 GC11M054682
GH11H048103 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.8 -217.7 -217696 7 HDGF PKNOX1 ARNT SIN3A FEZF1 BRCA1 ZNF2 YY1 ELK1 ZNF143 NUP160 OR4S1 PTPRJ-AS1 PTPRJ OR4B1 PACSIN3 ACP2 MADD C1QTNF4 OR4X2
GH11H048266 0.3 FANTOM5 14.1 -58.1 -58135 0 OR4B1 OR4S1 OR4X2 OR4C3 OR4X1
GH11H047912 2 FANTOM5 Ensembl ENCODE dbSUPER 1.5 -406.1 -406088 13 PKNOX1 FOXA2 SIN3A FEZF1 ZNF766 ZNF143 FOS DEK NFYC REST NUP160 FNBP4 ENSG00000270060 ENSG00000200090 DDB2 ARFGAP2 KBTBD4 PTPRJ C1QTNF4 MADD
GH11H048173 0.3 FANTOM5 6.1 -152.8 -152827 0 OR4S1 OR4C3 OR4X2 OR4B1 OR4X1 PIR60737
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR4C3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4C3 Gene

Chromosome:
11
Start:
48,324,920 bp from pter
End:
48,328,471 bp from pter
Size:
3,552 bases
Orientation:
Plus strand

Genomic View for OR4C3 Gene

Genes around OR4C3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C3 Gene

Proteins for OR4C3 Gene

  • Protein details for OR4C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH37-OR4C3_HUMAN
    Recommended name:
    Olfactory receptor 4C3
    Protein Accession:
    Q8NH37
    Secondary Accessions:
    • B2RNF2
    • Q6IFB3

    Protein attributes for OR4C3 Gene

    Size:
    302 amino acids
    Molecular mass:
    33726 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI36854.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI36855.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05803.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=DAA04747.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW67868.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR4C3 Gene

Post-translational modifications for OR4C3 Gene

  • Glycosylation at posLast=66
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C3 Gene

Domains & Families for OR4C3 Gene

Gene Families for OR4C3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4C3 Gene

Suggested Antigen Peptide Sequences for OR4C3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH37

UniProtKB/Swiss-Prot:

OR4C3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C3: view

Function for OR4C3 Gene

Molecular function for OR4C3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4C3 Gene

Gene Ontology (GO) - Molecular Function for OR4C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C3: view
genes like me logo Genes that share phenotypes with OR4C3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR4C3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C3 Gene

Localization for OR4C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4C3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR4C3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4C3 Gene

Pathways & Interactions for OR4C3 Gene

genes like me logo Genes that share pathways with OR4C3: view

Pathways by source for OR4C3 Gene

Interacting Proteins for OR4C3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000321419%0d%0a9606.ENSP00000367869%0d%0a9606.ENSP00000248572%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000371594%0d%0a9606.ENSP00000409581%0d%0a
Selected Interacting proteins: ENSP00000321419 Q8NH37-OR4C3_HUMAN for OR4C3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR4C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA,IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4C3: view

No data available for SIGNOR curated interactions for OR4C3 Gene

Drugs & Compounds for OR4C3 Gene

No Compound Related Data Available

Transcripts for OR4C3 Gene

mRNA/cDNA for OR4C3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR4C3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C3 Gene

No ASD Table

Relevant External Links for OR4C3 Gene

GeneLoc Exon Structure for
OR4C3
ECgene alternative splicing isoforms for
OR4C3

Expression for OR4C3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4C3 Gene

Protein differential expression in normal tissues from HIPED for OR4C3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR4C3 Gene



Protein tissue co-expression partners for OR4C3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4C3 Gene:

OR4C3

SOURCE GeneReport for Unigene cluster for OR4C3 Gene:

Hs.553656
genes like me logo Genes that share expression patterns with OR4C3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4C3 Gene

Orthologs for OR4C3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC744506 33
  • 99.09 (n)
mouse
(Mus musculus)
Mammalia Or4c3 52 Olfr1264 34
  • 83 (a)
OneToOne
Or4c57 52 Olfr140 33 16
  • 81.44 (n)
cow
(Bos Taurus)
Mammalia OR4C3 34
  • 82 (a)
OneToOne
LOC526335 33
  • 81.62 (n)
dog
(Canis familiaris)
Mammalia OR4C3 33
  • 81.78 (n)
-- 34
  • 57 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr731 33
  • 80.67 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 57 (a)
ManyToMany
Species where no ortholog for OR4C3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C3 Gene

ENSEMBL:
Gene Tree for OR4C3 (if available)
TreeFam:
Gene Tree for OR4C3 (if available)

Paralogs for OR4C3 Gene

(449) SIMAP similar genes for OR4C3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4C3 Gene

genes like me logo Genes that share paralogs with OR4C3: view

Variants for OR4C3 Gene

Sequence variations from dbSNP and Humsavar for OR4C3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000777353 -- 48,323,287(+) GGAGC(C/T)ATATT upstream-variant-2KB
rs1003292417 -- 48,324,823(+) TGATG(C/T)TAAAG upstream-variant-2KB
rs1003585872 -- 48,324,574(+) CCCAA(A/G)AAGAA upstream-variant-2KB
rs1004143127 -- 48,326,225(+) TGCCC(A/G)GCTAA downstream-variant-500B
rs1005137673 -- 48,325,132(+) ACGGT(G/T)TGTGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR4C3 Gene

Variant ID Type Subtype PubMed ID
dgv1111n100 CNV gain 25217958
dgv1112n100 CNV gain 25217958
dgv198e214 CNV gain 21293372
dgv48e55 CNV loss 17911159
dgv636n106 CNV duplication 24896259
esv2744448 CNV deletion 23290073
esv2759824 CNV gain+loss 17122850
esv2760610 CNV gain 21179565
esv3578682 CNV gain 25503493
esv3891986 CNV gain 25118596
nsv1076376 CNV duplication 25765185
nsv1122614 CNV deletion 24896259
nsv428253 CNV loss 18775914
nsv467871 CNV gain 19166990
nsv467873 CNV loss 19166990
nsv469953 CNV loss 18288195
nsv508628 CNV deletion 20534489
nsv554211 CNV gain 21841781
nsv554212 CNV loss 21841781
nsv951613 CNV duplication 24416366
nsv972008 CNV duplication 23825009

Variation tolerance for OR4C3 Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4C3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4C3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C3 Gene

Disorders for OR4C3 Gene

Relevant External Links for OR4C3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4C3

No disorders were found for OR4C3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C3 Gene

Publications for OR4C3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR4C3 Gene

Sources for OR4C3 Gene

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