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Aliases for OR4C3 Gene

Aliases for OR4C3 Gene

  • Olfactory Receptor, Family 4, Subfamily C, Member 3 2 3
  • Olfactory Receptor OR11-98 3 4
  • Olfactory Receptor 4C3 3
  • OR11-98 3

External Ids for OR4C3 Gene

Previous GeneCards Identifiers for OR4C3 Gene

  • GC16U990205
  • GC11P048311
  • GC11P048300

Summaries for OR4C3 Gene

Entrez Gene Summary for OR4C3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C3 Gene

OR4C3 (Olfactory Receptor, Family 4, Subfamily C, Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot for OR4C3 Gene

  • Odorant receptor.

Gene Wiki entry for OR4C3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C3 Gene

Genomics for OR4C3 Gene

Regulatory Elements for OR4C3 Gene

Genomic Location for OR4C3 Gene

Start:
48,324,920 bp from pter
End:
48,328,471 bp from pter
Size:
3,552 bases
Orientation:
Plus strand

Genomic View for OR4C3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C3 Gene

Proteins for OR4C3 Gene

  • Protein details for OR4C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH37-OR4C3_HUMAN
    Recommended name:
    Olfactory receptor 4C3
    Protein Accession:
    Q8NH37
    Secondary Accessions:
    • B2RNF2
    • Q6IFB3

    Protein attributes for OR4C3 Gene

    Size:
    302 amino acids
    Molecular mass:
    33726 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI36854.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI36855.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05803.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=DAA04747.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW67868.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR4C3 Gene

Proteomics data for OR4C3 Gene at MOPED

Post-translational modifications for OR4C3 Gene

  • Glycosylation at Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C3 Gene

Domains for OR4C3 Gene

Gene Families for OR4C3 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4C3 Gene

Suggested Antigen Peptide Sequences for OR4C3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH37

UniProtKB/Swiss-Prot:

OR4C3_HUMAN :
  • Q8NH37
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C3: view

Function for OR4C3 Gene

Molecular function for OR4C3 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C3: view

Phenotypes for OR4C3 Gene

GenomeRNAi human phenotypes for OR4C3:
genes like me logo Genes that share phenotypes with OR4C3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4C3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4C3 Gene

Localization for OR4C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4C3 Gene COMPARTMENTS Subcellular localization image for OR4C3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4C3: view

Pathways for OR4C3 Gene

genes like me logo Genes that share pathways with OR4C3: view

Pathways by source for OR4C3 Gene

Interacting Proteins for OR4C3 Gene

Gene Ontology (GO) - Biological Process for OR4C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C3: view

Transcripts for OR4C3 Gene

mRNA/cDNA for OR4C3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4C3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR4C3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C3 Gene

No ASD Table

Relevant External Links for OR4C3 Gene

GeneLoc Exon Structure for
OR4C3
ECgene alternative splicing isoforms for
OR4C3

Expression for OR4C3 Gene

mRNA expression in normal human tissues for OR4C3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR4C3 Gene

SOURCE GeneReport for Unigene cluster for OR4C3 Gene Hs.553656

genes like me logo Genes that share expressions with OR4C3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR4C3 Gene

Orthologs for OR4C3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC744506 35
  • 99.09 (n)
  • 98.18 (a)
cow
(Bos Taurus)
Mammalia LOC526335 35
  • 81.62 (n)
  • 77.74 (a)
OR4C3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 57 (a)
ManyToMany
OR4C3 35
  • 81.78 (n)
  • 80.33 (a)
mouse
(Mus musculus)
Mammalia Olfr1264 36
  • 83 (a)
OneToOne
Olfr140 35
  • 81.44 (n)
  • 78 (a)
Olfr140 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr731 35
  • 80.67 (n)
  • 77.33 (a)
Species with no ortholog for OR4C3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C3 Gene

ENSEMBL:
Gene Tree for OR4C3 (if available)
TreeFam:
Gene Tree for OR4C3 (if available)

Paralogs for OR4C3 Gene

Selected SIMAP similar genes for OR4C3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4C3 Gene

genes like me logo Genes that share paralogs with OR4C3: view

Variants for OR4C3 Gene

Sequence variations from dbSNP and Humsavar for OR4C3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1483115 -- 48,324,141(+) GACAG(A/G)GCATC upstream-variant-2KB
rs4281485 -- 48,323,555(+) AGGCA(C/T)AGGTA upstream-variant-2KB
rs4315071 -- 48,324,440(+) GAGAA(A/G)TAGAG upstream-variant-2KB
rs4362149 -- 48,323,936(+) GGTGA(A/G)TGTTT upstream-variant-2KB
rs4450174 -- 48,323,983(+) AAGAC(C/T)AGAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4C3 Gene

Variant ID Type Subtype PubMed ID
dgv1091n71 CNV Gain 21882294
nsv467871 CNV Gain 19166990
nsv428253 CNV Loss 18775914
nsv467873 CNV Loss 19166990
nsv469953 CNV Loss 18288195
nsv508628 CNV Loss 20534489
dgv366e1 CNV Complex 17122850
esv542 CNV CNV 17122850
dgv1092n71 CNV Loss 21882294
nsv897333 CNV Gain 21882294
dgv48e55 CNV Loss 17911159
esv2744448 CNV Deletion 23290073

Relevant External Links for OR4C3 Gene

HapMap Linkage Disequilibrium report
OR4C3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C3 Gene

Disorders for OR4C3 Gene

No disorders were found for OR4C3 Gene.

No data available for UniProtKB/Swiss-Prot for OR4C3 Gene

Publications for OR4C3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR4C3 Gene

Sources for OR4C3 Gene

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