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Aliases for OR4C16 Gene

Aliases for OR4C16 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 16 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 4, Subfamily C, Member 16 2 3
  • Olfactory Receptor OR11-135 3 4
  • Olfactory Receptor, Family 4, Subfamily C, Member 16 (Gene/Pseudogene) 2
  • Olfactory Receptor 4C16 3
  • OR11-135 3

External Ids for OR4C16 Gene

Previous GeneCards Identifiers for OR4C16 Gene

  • GC11U990541
  • GC11P055115
  • GC11P055096
  • GC11P055340

Summaries for OR4C16 Gene

Entrez Gene Summary for OR4C16 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR4C16 Gene

OR4C16 (Olfactory Receptor Family 4 Subfamily C Member 16 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4C11.

UniProtKB/Swiss-Prot for OR4C16 Gene

  • Odorant receptor.

Gene Wiki entry for OR4C16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C16 Gene

Genomics for OR4C16 Gene

Regulatory Elements for OR4C16 Gene

Enhancers for OR4C16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around OR4C16 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4C16 Gene

Chromosome:
11
Start:
55,572,128 bp from pter
End:
55,573,060 bp from pter
Size:
933 bases
Orientation:
Plus strand

Genomic View for OR4C16 Gene

Genes around OR4C16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C16 Gene

Proteins for OR4C16 Gene

  • Protein details for OR4C16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGL9-OR4CG_HUMAN
    Recommended name:
    Olfactory receptor 4C16
    Protein Accession:
    Q8NGL9
    Secondary Accessions:
    • Q6IEV8

    Protein attributes for OR4C16 Gene

    Size:
    310 amino acids
    Molecular mass:
    34991 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C16 Gene

Post-translational modifications for OR4C16 Gene

  • Glycosylation at Asn 6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C16 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C16 Gene

Domains & Families for OR4C16 Gene

Gene Families for OR4C16 Gene

Protein Domains for OR4C16 Gene

Suggested Antigen Peptide Sequences for OR4C16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGL9

UniProtKB/Swiss-Prot:

OR4CG_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C16: view

Function for OR4C16 Gene

Molecular function for OR4C16 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C16: view

Phenotypes for OR4C16 Gene

genes like me logo Genes that share phenotypes with OR4C16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C16 Gene

Localization for OR4C16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C16 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4C16 Gene COMPARTMENTS Subcellular localization image for OR4C16 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4C16: view

Pathways & Interactions for OR4C16 Gene

genes like me logo Genes that share pathways with OR4C16: view

Pathways by source for OR4C16 Gene

Interacting Proteins for OR4C16 Gene

Gene Ontology (GO) - Biological Process for OR4C16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C16: view

No data available for SIGNOR curated interactions for OR4C16 Gene

Drugs & Compounds for OR4C16 Gene

No Compound Related Data Available

Transcripts for OR4C16 Gene

mRNA/cDNA for OR4C16 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C16 Gene

No ASD Table

Relevant External Links for OR4C16 Gene

GeneLoc Exon Structure for
OR4C16
ECgene alternative splicing isoforms for
OR4C16

Expression for OR4C16 Gene

mRNA expression in normal human tissues for OR4C16 Gene

Protein differential expression in normal tissues from HIPED for OR4C16 Gene

This gene is overexpressed in Liver (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4C16 Gene



Protein tissue co-expression partners for OR4C16 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4C16 Gene:

OR4C16

SOURCE GeneReport for Unigene cluster for OR4C16 Gene:

Hs.553619
genes like me logo Genes that share expression patterns with OR4C16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR4C16 Gene

Orthologs for OR4C16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC532486 34
  • 84.52 (n)
  • 78.39 (a)
dog
(Canis familiaris)
Mammalia LOC100855716 34
  • 85.27 (n)
  • 77.42 (a)
mouse
(Mus musculus)
Mammalia Olfr1209 34
  • 80.97 (n)
  • 76.77 (a)
Olfr1209 16
chimpanzee
(Pan troglodytes)
Mammalia LOC466535 34
  • 98.06 (n)
  • 95.16 (a)
rat
(Rattus norvegicus)
Mammalia Olr662 34
  • 80.32 (n)
  • 75.81 (a)
Species where no ortholog for OR4C16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C16 Gene

ENSEMBL:
Gene Tree for OR4C16 (if available)
TreeFam:
Gene Tree for OR4C16 (if available)

Paralogs for OR4C16 Gene

Paralogs for OR4C16 Gene

(440) SIMAP similar genes for OR4C16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4C16: view

Variants for OR4C16 Gene

Sequence variations from dbSNP and Humsavar for OR4C16 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs557590 - 55,572,353(+) CCATA(A/G)CCCCT reference, missense
rs12800642 - 55,572,200(+) AAATA(A/G/T)TGTTT reference, missense
rs558465 - 55,572,272(-) GCTGG(C/T)CTTGA reference, missense
rs12288690 - 55,572,734(+) GTGGG(A/G/T)CCATT reference, missense
rs559449 - 55,572,903(+) ATGCC(C/T)TGCAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR4C16 Gene

Variant ID Type Subtype PubMed ID
dgv1166n100 CNV gain 25217958
dgv1170n100 CNV loss 25217958
dgv1171n100 CNV loss 25217958
dgv1172n100 CNV gain 25217958
dgv12n68 CNV loss 17160897
dgv143n27 CNV loss 19166990
dgv1905n54 CNV gain 21841781
dgv1906n54 CNV gain+loss 21841781
dgv362e212 CNV gain 25503493
dgv4e49 CNV loss 18971310
esv2751030 CNV gain 17911159
esv2751031 CNV loss 17911159
esv2751032 CNV loss 17911159
esv2759828 CNV gain+loss 17122850
esv3626443 CNV gain 21293372
esv3892009 CNV gain 25118596
nsv1036325 CNV gain 25217958
nsv428256 CNV loss 18775914
nsv467886 CNV gain 19166990
nsv517440 CNV gain+loss 19592680
nsv518225 CNV loss 19592680
nsv522846 CNV gain 19592680
nsv524091 CNV gain 19592680
nsv554799 CNV gain 21841781
nsv554801 CNV loss 21841781
nsv554803 CNV gain 21841781
nsv554805 CNV loss 21841781
nsv821668 CNV loss 15273396

Variation tolerance for OR4C16 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.19; 96.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4C16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4C16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C16 Gene

Disorders for OR4C16 Gene

Relevant External Links for OR4C16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4C16

No disorders were found for OR4C16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C16 Gene

Publications for OR4C16 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 65
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 65
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3 65
  4. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3 65

Products for OR4C16 Gene

Sources for OR4C16 Gene

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