Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR4C16 Gene

Aliases for OR4C16 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 16 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 4, Subfamily C, Member 16 2 3
  • Olfactory Receptor OR11-135 3 4
  • Olfactory Receptor, Family 4, Subfamily C, Member 16 (Gene/Pseudogene) 2
  • OR11-135 3

External Ids for OR4C16 Gene

Previous GeneCards Identifiers for OR4C16 Gene

  • GC11U990541
  • GC11P055115
  • GC11P055096
  • GC11P055340

Summaries for OR4C16 Gene

Entrez Gene Summary for OR4C16 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR4C16 Gene

OR4C16 (Olfactory Receptor Family 4 Subfamily C Member 16 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4X2.

UniProtKB/Swiss-Prot for OR4C16 Gene

  • Odorant receptor.

Gene Wiki entry for OR4C16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C16 Gene

Genomics for OR4C16 Gene

Regulatory Elements for OR4C16 Gene

Genomic Location for OR4C16 Gene

55,572,128 bp from pter
55,573,060 bp from pter
933 bases
Plus strand

Genomic View for OR4C16 Gene

Genes around OR4C16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C16 Gene

Proteins for OR4C16 Gene

  • Protein details for OR4C16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4C16
    Protein Accession:
    Secondary Accessions:
    • Q6IEV8

    Protein attributes for OR4C16 Gene

    310 amino acids
    Molecular mass:
    34991 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C16 Gene

Proteomics data for OR4C16 Gene at MOPED

Post-translational modifications for OR4C16 Gene

  • Glycosylation at Asn 6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C16 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C16 Gene

Domains & Families for OR4C16 Gene

Gene Families for OR4C16 Gene

Protein Domains for OR4C16 Gene

Suggested Antigen Peptide Sequences for OR4C16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C16: view

Function for OR4C16 Gene

Molecular function for OR4C16 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C16: view

Phenotypes for OR4C16 Gene

genes like me logo Genes that share phenotypes with OR4C16: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C16 Gene

Localization for OR4C16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C16 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR4C16 Gene COMPARTMENTS Subcellular localization image for OR4C16 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR4C16: view

Pathways & Interactions for OR4C16 Gene

genes like me logo Genes that share pathways with OR4C16: view

Pathways by source for OR4C16 Gene

Interacting Proteins for OR4C16 Gene

Gene Ontology (GO) - Biological Process for OR4C16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C16: view

No data available for SIGNOR curated interactions for OR4C16 Gene

Drugs & Compounds for OR4C16 Gene

No Compound Related Data Available

Transcripts for OR4C16 Gene

mRNA/cDNA for OR4C16 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C16 Gene

No ASD Table

Relevant External Links for OR4C16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4C16 Gene

mRNA expression in normal human tissues for OR4C16 Gene

Protein differential expression in normal tissues from HIPED for OR4C16 Gene

This gene is overexpressed in Liver (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR4C16 Gene

SOURCE GeneReport for Unigene cluster for OR4C16 Gene Hs.553619

genes like me logo Genes that share expression patterns with OR4C16: view

Protein tissue co-expression partners for OR4C16 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR4C16 Gene

Orthologs for OR4C16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC532486 35
  • 84.52 (n)
  • 78.39 (a)
-- 36
  • 77 (a)
-- 36
  • 78 (a)
-- 36
  • 53 (a)
(Canis familiaris)
Mammalia LOC100855716 35
  • 85.27 (n)
  • 77.42 (a)
-- 36
  • 78 (a)
-- 36
  • 78 (a)
-- 36
  • 78 (a)
-- 36
  • 77 (a)
(Mus musculus)
Mammalia Olfr1209 35
  • 80.97 (n)
  • 76.77 (a)
Olfr1209 16
Olfr1195 36
  • 74 (a)
Olfr1199 36
  • 76 (a)
Olfr1209 36
  • 77 (a)
(Pan troglodytes)
Mammalia LOC466535 35
  • 98.06 (n)
  • 95.16 (a)
OR4C16 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Olr662 35
  • 80.32 (n)
  • 75.81 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
-- 36
  • 64 (a)
-- 36
  • 63 (a)
-- 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
-- 36
  • 60 (a)
-- 36
  • 60 (a)
Species with no ortholog for OR4C16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C16 Gene

Gene Tree for OR4C16 (if available)
Gene Tree for OR4C16 (if available)

Paralogs for OR4C16 Gene

Paralogs for OR4C16 Gene

(440) SIMAP similar genes for OR4C16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4C16: view

Variants for OR4C16 Gene

Sequence variations from dbSNP and Humsavar for OR4C16 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs557590 - 55,572,353(+) CCATA(A/G)CCCCT reference, missense
rs12800642 - 55,572,200(+) AAATA(A/G/T)TGTTT reference, missense
rs558465 - 55,572,272(-) GCTGG(C/T)CTTGA reference, missense
rs12288690 - 55,572,734(+) GTGGG(A/G/T)CCATT reference, missense
rs559449 - 55,572,903(+) ATGCC(C/T)TGCAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR4C16 Gene

Variant ID Type Subtype PubMed ID
esv2751030 CNV Gain 17911159
nsv524091 CNV Gain 19592680
nsv467886 CNV Gain 19166990
esv2751031 CNV Loss 17911159
nsv821668 CNV Loss 15273396
nsv518225 CNV Loss 19592680
dgv376e1 CNV Complex 17122850
esv782 CNV CNV 17122850
dgv12n68 CNV Loss 17160897
esv2751032 CNV Loss 17911159
dgv377e1 CNV Complex 17122850
nsv428256 CNV Loss 18775914
nsv522846 CNV Gain 19592680
dgv4e49 CNV Loss 18971310
dgv378e1 CNV Complex 17122850
dgv379e1 CNV Complex 17122850
dgv143n27 CNV Loss 19166990
nsv517440 CNV Gain+Loss 19592680

Variation tolerance for OR4C16 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.19; 96.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4C16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C16 Gene

Disorders for OR4C16 Gene

Relevant External Links for OR4C16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR4C16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C16 Gene

Publications for OR4C16 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 67
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3
  3. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for OR4C16 Gene

Sources for OR4C16 Gene

Back to Top