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Aliases for OR4C15 Gene

Aliases for OR4C15 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 15 2 3 5
  • Olfactory Receptor OR11-127 3 4
  • Olfactory Receptor OR11-134 3 4
  • Olfactory Receptor, Family 4, Subfamily C, Member 15 2
  • Olfactory Receptor 4C15 3
  • OR11-127 3
  • OR11-134 3

External Ids for OR4C15 Gene

Previous GeneCards Identifiers for OR4C15 Gene

  • GC11U990542
  • GC11P055078
  • GC11P055321

Summaries for OR4C15 Gene

Entrez Gene Summary for OR4C15 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C15 Gene

OR4C15 (Olfactory Receptor Family 4 Subfamily C Member 15) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for OR4C15 Gene

  • Odorant receptor.

Gene Wiki entry for OR4C15 Gene

Additional gene information for OR4C15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C15 Gene

Genomics for OR4C15 Gene

GeneHancer (GH) Regulatory Elements for OR4C15 Gene

Promoters and enhancers for OR4C15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I055430 Enhancer 0.2 FANTOM5 15.5 -124.0 -123976 0 GC11P055433 GC11P055434 OR4A10P OR5D14 OR5D18 OR4C15 OR5L2 OR4C16 OR5D16 OR4C6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR4C15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4C15 gene promoter:

Genomic Locations for OR4C15 Gene

Genomic Locations for OR4C15 Gene
chr11:55,554,307-55,555,419
(GRCh38/hg38)
Size:
1,113 bases
Orientation:
Plus strand
chr11:55,321,783-55,322,895
(GRCh37/hg19)

Genomic View for OR4C15 Gene

Genes around OR4C15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C15 Gene

Proteins for OR4C15 Gene

  • Protein details for OR4C15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGM1-OR4CF_HUMAN
    Recommended name:
    Olfactory receptor 4C15
    Protein Accession:
    Q8NGM1
    Secondary Accessions:
    • Q6IFE2

    Protein attributes for OR4C15 Gene

    Size:
    316 amino acids
    Molecular mass:
    35667 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04717.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=DAA04718.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR4C15 Gene

Post-translational modifications for OR4C15 Gene

No Post-translational modifications

Other Protein References for OR4C15 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C15 Gene

Domains & Families for OR4C15 Gene

Gene Families for OR4C15 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4C15 Gene

Suggested Antigen Peptide Sequences for OR4C15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGM1

UniProtKB/Swiss-Prot:

OR4CF_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C15: view

Function for OR4C15 Gene

Molecular function for OR4C15 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4C15 Gene

Gene Ontology (GO) - Molecular Function for OR4C15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C15: view

Phenotypes for OR4C15 Gene

GenomeRNAi human phenotypes for OR4C15:
genes like me logo Genes that share phenotypes with OR4C15: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C15 Gene

Localization for OR4C15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C15 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4C15 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4C15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4C15 Gene

Pathways & Interactions for OR4C15 Gene

genes like me logo Genes that share pathways with OR4C15: view

Pathways by source for OR4C15 Gene

Interacting Proteins for OR4C15 Gene

Gene Ontology (GO) - Biological Process for OR4C15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4C15: view

No data available for SIGNOR curated interactions for OR4C15 Gene

Drugs & Compounds for OR4C15 Gene

No Compound Related Data Available

Transcripts for OR4C15 Gene

mRNA/cDNA for OR4C15 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C15 Gene

No ASD Table

Relevant External Links for OR4C15 Gene

GeneLoc Exon Structure for
OR4C15
ECgene alternative splicing isoforms for
OR4C15

Expression for OR4C15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4C15 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4C15 Gene:

OR4C15

SOURCE GeneReport for Unigene cluster for OR4C15 Gene:

Hs.589003
genes like me logo Genes that share expression patterns with OR4C15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4C15 Gene

Orthologs for OR4C15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466532 33
  • 99.37 (n)
OR4C15 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR4C15 34
  • 85 (a)
OneToOne
LOC100684610 33
  • 65.57 (n)
rat
(Rattus norvegicus)
Mammalia Olr663 33
  • 83.07 (n)
mouse
(Mus musculus)
Mammalia Or4c15 51 Olfr1211 33 16 34
  • 82.96 (n)
Or4c15b 51 Olfr1229 34
  • 80 (a)
OneToMany
Or4c124 51 Olfr1232 34
  • 76 (a)
OneToMany
Or4c107 51 Olfr1212 34
  • 75 (a)
OneToMany
Or4c108 51 Olfr1213 34
  • 74 (a)
OneToMany
Or4c118 51 Olfr1223 34
  • 74 (a)
OneToMany
Or4c117 51 Olfr1222 34
  • 73 (a)
OneToMany
Or4c112 51 Olfr1217 34
  • 72 (a)
OneToMany
Olfr1224-ps1 34
  • 72 (a)
OneToMany
Or4c122 51 Olfr1228 34
  • 72 (a)
OneToMany
Or4c110 51 Olfr1215 34
  • 71 (a)
OneToMany
Or4c114 51 Olfr1219 34
  • 71 (a)
OneToMany
Or4c116 51 Olfr1221 34
  • 71 (a)
OneToMany
Or4c120 51 Olfr1225 34
  • 71 (a)
OneToMany
Or4c121 51 Olfr1226 34
  • 71 (a)
OneToMany
Or4c115 51 Olfr1220 34
  • 70 (a)
OneToMany
Or4c109 51 Olfr1214 34
  • 69 (a)
OneToMany
Or4c111 51 Olfr1216 34
  • 69 (a)
OneToMany
Or4c113 51 Olfr1218 34
  • 68 (a)
OneToMany
Or4ad1-ps 51 Olfr1227-ps1
  • chr2:89,226,816-89,227,731
Or4ad2-ps 51 Olfr1227-ps1a
  • chr2:89,242,859-89,243,773
Or4c119 51 Olfr1224
  • chr2:89,156,241-89,157,173
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
OneToMany
-- 34
  • 73 (a)
OneToMany
-- 34
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 62 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 59 (a)
ManyToMany
Species where no ortholog for OR4C15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C15 Gene

ENSEMBL:
Gene Tree for OR4C15 (if available)
TreeFam:
Gene Tree for OR4C15 (if available)

Paralogs for OR4C15 Gene

(445) SIMAP similar genes for OR4C15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4C15: view

No data available for Paralogs for OR4C15 Gene

Variants for OR4C15 Gene

Sequence variations from dbSNP and Humsavar for OR4C15 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001146427 -- 55,553,463(+) T/A/C upstream_transcript_variant
rs1002589885 -- 55,552,347(+) C/T upstream_transcript_variant
rs1004384397 -- 55,552,333(+) C/T upstream_transcript_variant
rs1005020929 -- 55,552,669(+) C/A upstream_transcript_variant
rs1005378363 -- 55,552,974(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4C15 Gene

Variant ID Type Subtype PubMed ID
dgv1166n100 CNV gain 25217958
dgv1170n100 CNV loss 25217958
dgv1171n100 CNV loss 25217958
dgv1172n100 CNV gain 25217958
dgv12n68 CNV loss 17160897
dgv1905n54 CNV gain 21841781
dgv362e212 CNV gain 25503493
esv2751030 CNV gain 17911159
esv2751031 CNV loss 17911159
esv2751032 CNV loss 17911159
esv2759828 CNV gain+loss 17122850
esv3626425 CNV loss 21293372
esv3626432 CNV loss 21293372
esv3626433 CNV gain 21293372
esv3892009 CNV gain 25118596
nsv1036325 CNV gain 25217958
nsv428256 CNV loss 18775914
nsv467886 CNV gain 19166990
nsv518225 CNV loss 19592680
nsv522846 CNV gain 19592680
nsv524091 CNV gain 19592680
nsv554799 CNV gain 21841781
nsv554801 CNV loss 21841781
nsv821668 CNV loss 15273396

Variation tolerance for OR4C15 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.59; 91.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4C15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4C15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C15 Gene

Disorders for OR4C15 Gene

Additional Disease Information for OR4C15

No disorders were found for OR4C15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C15 Gene

Publications for OR4C15 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58

Products for OR4C15 Gene

Sources for OR4C15 Gene

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