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OR4C15 Gene

protein-coding   GIFtS: 44
GCID: GC11P055321

Olfactory Receptor, Family 4, Subfamily C, Member 15

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 4, Subfamily C, Member 151 2
Olfactory Receptor OR11-1272 3
Olfactory Receptor OR11-1342 3
OR11-1272
OR11-1342
Olfactory Receptor 4C152

External Ids:    HGNC: 151711   Entrez Gene: 813092   Ensembl: ENSG000001819397   UniProtKB: Q8NGM13   

Export aliases for OR4C15 gene to outside databases

Previous GC identifers: GC11U990542 GC11P055078


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR4C15 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4C15 Gene:
OR4C15 (olfactory receptor, family 4, subfamily C, member 15) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4C5.

UniProtKB/Swiss-Prot: OR4CF_HUMAN, Q8NGM1
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4C15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR4C15 gene promoter:
         POU2F1   POU2F1b   NCX/Ncx   POU2F1a   FOXD3   POU2F1c   YY1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR4C15 promoter sequence
   Search Chromatin IP Primers for OR4C15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4C15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11   Ensembl cytogenetic band:  11q11   HGNC cytogenetic band: 11q11

OR4C15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4C15 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P055321:  view genomic region     (about GC identifiers)

Start:
55,321,945 bp from pter      End:
55,322,892 bp from pter
Size:
948 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR4CF_HUMAN, Q8NGM1 (See protein sequence)
Recommended Name: Olfactory receptor 4C15  
Size: 316 amino acids; 35667 Da
Sequence caution: Sequence=DAA04717.1; Type=Erroneous initiation; Sequence=DAA04718.1; Type=Erroneous initiation;
Secondary accessions: Q6IFE2

Explore the universe of human proteins at neXtProt for OR4C15: NX_Q8NGM1

Explore proteomics data for OR4C15 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn3
  • HORDE protein sequence for OR4C15

    See OR4C15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001001920.1  
    ENSEMBL proteins: 
     ENSP00000324958  
    Reactome Protein details: Q8NGM1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGM1

    ProtoNet protein and cluster: Q8NGM1

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR4CF_HUMAN, Q8NGM1
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR4C15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR4CF_HUMAN, Q8NGM1
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR4C15           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR4CF_HUMAN, Q8NGM1: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR4C15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR4C15 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR4C15           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR4C15
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR4C15):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR4C15
    Interactions:

        Search GeneGlobe Interaction Network for OR4C15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR4C15 (ENSP000003249584) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR2S2ENSP000003440404STRING: ENSP00000344040
    OR56A1ENSP000003212464STRING: ENSP00000321246
    OR56A4ENSP000003282154STRING: ENSP00000328215
    OR5J2ENSP000003107884STRING: ENSP00000310788
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR4C15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR4C15 (OR4CF)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR4C15 gene: 
    NM_001001920.1  

    Unigene Cluster for OR4C15:

    Olfactory receptor, family 4, subfamily C, member 15
    Hs.589003
    Unigene Representative Sequence: NM_001001920
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000314644(uc010rig.2)
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR4C15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATATTTGTA
    OR4C15 Expression
    About this image

    OR4C15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR4C15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.589003
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR4C15 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr12111 , 5 olfactory receptor 12111, 5 82.96(n)1
    82.96(a)1
      2 (50.03 cM)5
    2580251  NM_001011804.11  NP_001011804.11 
     889293785 


    ENSEMBL Gene Tree for OR4C15 (if available)
    TreeFam Gene Tree for OR4C15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR4C15 gene
    OR4C52  OR4S12  OR4A472  OR4X22  OR4A162  OR4C132  OR4C62  OR4C462  
    OR4C162  OR4C32  OR4X12  OR4S22  OR4A152  OR4C112  OR4A52  OR4C122  
    OR4B12  OR4A8P2  
    Selected SIMAP similar genes for OR4C15 using alignment to 1 protein entry:     OR4CF_HUMAN(see all similar genes):
    OR4C3    OR4C13    OR4C46    OR4A15    OR4A5    OR4C5
    OR4C6    OR4X1    OR4A8P    OR4C12    OR4S2    OR4A4P
    OR4P4    OR4X2    OR4A16    OR4A47    OR4B1    OR4C11

    Find genes that share paralogs with OR4C15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR4C15 (see all 179)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1482911861,2
    --55319793(+) GGGCTC/TGTTCT 1 -- us2k10--------
    rs1404532641,2
    --55319815(+) ATGATC/GTTCTA 1 -- us2k10--------
    rs1890285681,2
    --55319831(+) CTTACC/TGCATC 1 -- us2k10--------
    rs1470574621,2
    C--55319846(+) CTTTTA/GTGTGT 1 -- us2k10--------
    rs1809235351,2
    --55319856(+) TATTGC/TTTTCT 1 -- us2k10--------
    rs1411412021,2
    C--55319858(+) TGCTT-/TATCTTA 1 -- us2k10--------
    rs175813371,2
    C,F,H--55319882(+) TGTATA/GGATAG 1 -- us2k1 tfbs311Minor allele frequency- G:0.05NA NS EA CSA 686
    rs1384162511,2
    --55319884(+) TATAGA/GTAGAC 1 -- us2k10--------
    rs787672201,2
    F--55319887(+) AGATAG/AACATC 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs112301191,2
    C,F--55319908(+) ACTGAA/TGTGGA 1 -- us2k112Minor allele frequency- T:0.18NA WA EA 512

    HapMap Linkage Disequilibrium report for OR4C15 ( 55321945 - 55322892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR4C15 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv12n68CNV Loss17160897
    nsv821668CNV Loss15273396
    nsv518225CNV Loss19592680
    esv2751031CNV Loss17911159
    nsv428256CNV Loss18775914
    esv2751032CNV Loss17911159
    esv2751030CNV Gain17911159
    nsv522846CNV Gain19592680
    nsv467886CNV Gain19166990
    nsv524091CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR4C15 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR4C15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    3. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81309 HGNC: 15171 Ensembl:ENSG00000181939 euGenes: HUgn81309 ECgene: OR4C15 Kegg: 81309
    H-InvDB: OR4C15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR4C15 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4C15 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR4C15 gene:
    Search GeneIP for patents involving OR4C15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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