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Aliases for OR4C15 Gene

Aliases for OR4C15 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 15 2 3 5
  • Olfactory Receptor OR11-127 3 4
  • Olfactory Receptor OR11-134 3 4
  • Olfactory Receptor, Family 4, Subfamily C, Member 15 2
  • Olfactory Receptor 4C15 3
  • OR11-127 3
  • OR11-134 3

External Ids for OR4C15 Gene

Previous GeneCards Identifiers for OR4C15 Gene

  • GC11U990542
  • GC11P055078
  • GC11P055321

Summaries for OR4C15 Gene

Entrez Gene Summary for OR4C15 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C15 Gene

OR4C15 (Olfactory Receptor Family 4 Subfamily C Member 15) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4C3.

UniProtKB/Swiss-Prot for OR4C15 Gene

  • Odorant receptor.

Gene Wiki entry for OR4C15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C15 Gene

Genomics for OR4C15 Gene

Regulatory Elements for OR4C15 Gene

Enhancers for OR4C15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G055430 0.3 FANTOM5 15.5 -124.0 -123976 0.0 OR5D14 OR5D18 OR4C15 OR5L2 OR4C16 OR5D16 OR4C6 OR4S2 OR4A16 OR4C11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR4C15 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4C15 Gene

Chromosome:
11
Start:
55,554,307 bp from pter
End:
55,555,419 bp from pter
Size:
1,113 bases
Orientation:
Plus strand

Genomic View for OR4C15 Gene

Genes around OR4C15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C15 Gene

Proteins for OR4C15 Gene

  • Protein details for OR4C15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGM1-OR4CF_HUMAN
    Recommended name:
    Olfactory receptor 4C15
    Protein Accession:
    Q8NGM1
    Secondary Accessions:
    • Q6IFE2

    Protein attributes for OR4C15 Gene

    Size:
    316 amino acids
    Molecular mass:
    35667 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04717.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=DAA04718.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR4C15 Gene

Post-translational modifications for OR4C15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR4C15 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C15 Gene

Domains & Families for OR4C15 Gene

Gene Families for OR4C15 Gene

Protein Domains for OR4C15 Gene

Suggested Antigen Peptide Sequences for OR4C15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGM1

UniProtKB/Swiss-Prot:

OR4CF_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C15: view

Function for OR4C15 Gene

Molecular function for OR4C15 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C15: view

Phenotypes for OR4C15 Gene

GenomeRNAi human phenotypes for OR4C15:
genes like me logo Genes that share phenotypes with OR4C15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C15 Gene

Localization for OR4C15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C15 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4C15 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4C15: view

Pathways & Interactions for OR4C15 Gene

genes like me logo Genes that share pathways with OR4C15: view

Pathways by source for OR4C15 Gene

Interacting Proteins for OR4C15 Gene

Gene Ontology (GO) - Biological Process for OR4C15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4C15: view

No data available for SIGNOR curated interactions for OR4C15 Gene

Drugs & Compounds for OR4C15 Gene

No Compound Related Data Available

Transcripts for OR4C15 Gene

mRNA/cDNA for OR4C15 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C15 Gene

No ASD Table

Relevant External Links for OR4C15 Gene

GeneLoc Exon Structure for
OR4C15
ECgene alternative splicing isoforms for
OR4C15

Expression for OR4C15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4C15 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4C15 Gene:

OR4C15

SOURCE GeneReport for Unigene cluster for OR4C15 Gene:

Hs.589003
genes like me logo Genes that share expression patterns with OR4C15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4C15 Gene

Orthologs for OR4C15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466532 34
  • 99.37 (n)
OR4C15 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR4C15 35
  • 85 (a)
OneToOne
LOC100684610 34
  • 65.57 (n)
rat
(Rattus norvegicus)
Mammalia Olr663 34
  • 83.07 (n)
mouse
(Mus musculus)
Mammalia Or4c15 55 Olfr1211 34 16 35
  • 82.96 (n)
Or4c15b 55 Olfr1229 35
  • 80 (a)
OneToMany
Or4c124 55 Olfr1232 35
  • 76 (a)
OneToMany
Or4c107 55 Olfr1212 35
  • 75 (a)
OneToMany
Or4c108 55 Olfr1213 35
  • 74 (a)
OneToMany
Or4c118 55 Olfr1223 35
  • 74 (a)
OneToMany
Or4c117 55 Olfr1222 35
  • 73 (a)
OneToMany
Or4c112 55 Olfr1217 35
  • 72 (a)
OneToMany
Olfr1224-ps1 35
  • 72 (a)
OneToMany
Or4c122 55 Olfr1228 35
  • 72 (a)
OneToMany
Or4c110 55 Olfr1215 35
  • 71 (a)
OneToMany
Or4c114 55 Olfr1219 35
  • 71 (a)
OneToMany
Or4c116 55 Olfr1221 35
  • 71 (a)
OneToMany
Or4c120 55 Olfr1225 35
  • 71 (a)
OneToMany
Or4c121 55 Olfr1226 35
  • 71 (a)
OneToMany
Or4c115 55 Olfr1220 35
  • 70 (a)
OneToMany
Or4c109 55 Olfr1214 35
  • 69 (a)
OneToMany
Or4c111 55 Olfr1216 35
  • 69 (a)
OneToMany
Or4c113 55 Olfr1218 35
  • 68 (a)
OneToMany
Or4ad1-ps 55 Olfr1227-ps1
  • chr2:89,226,816-89,227,731
Or4ad2-ps 55 Olfr1227-ps1a
  • chr2:89,242,859-89,243,773
Or4c119 55 Olfr1224
  • chr2:89,156,241-89,157,173
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 59 (a)
ManyToMany
Species where no ortholog for OR4C15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C15 Gene

ENSEMBL:
Gene Tree for OR4C15 (if available)
TreeFam:
Gene Tree for OR4C15 (if available)

Paralogs for OR4C15 Gene

(445) SIMAP similar genes for OR4C15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4C15: view

Variants for OR4C15 Gene

Sequence variations from dbSNP and Humsavar for OR4C15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1001146427 -- 55,553,463(+) GTACA(A/T)GCAAG upstream-variant-2KB
rs1002589885 -- 55,552,347(+) CTATG(C/T)TTCTT upstream-variant-2KB
rs1004384397 -- 55,552,333(+) CTCAT(C/T)ATGAT upstream-variant-2KB
rs1005020929 -- 55,552,669(+) ATAAC(A/C)TTATA upstream-variant-2KB
rs1005378363 -- 55,552,974(+) AAATA(C/T)ACACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4C15 Gene

Variant ID Type Subtype PubMed ID
dgv1166n100 CNV gain 25217958
dgv1170n100 CNV loss 25217958
dgv1171n100 CNV loss 25217958
dgv1172n100 CNV gain 25217958
dgv12n68 CNV loss 17160897
dgv1905n54 CNV gain 21841781
dgv362e212 CNV gain 25503493
esv2751030 CNV gain 17911159
esv2751031 CNV loss 17911159
esv2751032 CNV loss 17911159
esv2759828 CNV gain+loss 17122850
esv3626425 CNV loss 21293372
esv3626432 CNV loss 21293372
esv3626433 CNV gain 21293372
esv3892009 CNV gain 25118596
nsv1036325 CNV gain 25217958
nsv428256 CNV loss 18775914
nsv467886 CNV gain 19166990
nsv518225 CNV loss 19592680
nsv522846 CNV gain 19592680
nsv524091 CNV gain 19592680
nsv554799 CNV gain 21841781
nsv554801 CNV loss 21841781
nsv821668 CNV loss 15273396

Variation tolerance for OR4C15 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.59; 91.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4C15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4C15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C15 Gene

Disorders for OR4C15 Gene

Relevant External Links for OR4C15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4C15

No disorders were found for OR4C15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C15 Gene

Publications for OR4C15 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for OR4C15 Gene

Sources for OR4C15 Gene

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