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Aliases for OR4C13 Gene

Aliases for OR4C13 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 13 2 3 5
  • Olfactory Receptor, Family 4, Subfamily C, Member 13 2
  • Olfactory Receptor OR11-260 4

External Ids for OR4C13 Gene

Previous GeneCards Identifiers for OR4C13 Gene

  • GC11U990544
  • GC11P049930

Summaries for OR4C13 Gene

Entrez Gene Summary for OR4C13 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C13 Gene

OR4C13 (Olfactory Receptor Family 4 Subfamily C Member 13) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4C46.

UniProtKB/Swiss-Prot for OR4C13 Gene

  • Odorant receptor.

Gene Wiki entry for OR4C13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C13 Gene

Genomics for OR4C13 Gene

Regulatory Elements for OR4C13 Gene


Genomic Location for OR4C13 Gene

Chromosome:
11
Start:
49,952,391 bp from pter
End:
49,953,419 bp from pter
Size:
1,029 bases
Orientation:
Plus strand

Genomic View for OR4C13 Gene

Genes around OR4C13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C13 Gene

Proteins for OR4C13 Gene

  • Protein details for OR4C13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGP0-OR4CD_HUMAN
    Recommended name:
    Olfactory receptor 4C13
    Protein Accession:
    Q8NGP0
    Secondary Accessions:
    • A6NJJ3
    • B9EH30
    • Q6IF48
    • Q96R68

    Protein attributes for OR4C13 Gene

    Size:
    309 amino acids
    Molecular mass:
    34582 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C13 Gene

Post-translational modifications for OR4C13 Gene

  • Glycosylation at Asn 6 and Asn 87
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C13 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C13 Gene

Domains & Families for OR4C13 Gene

Gene Families for OR4C13 Gene

Protein Domains for OR4C13 Gene

Suggested Antigen Peptide Sequences for OR4C13 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NGP0

UniProtKB/Swiss-Prot:

OR4CD_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C13: view

Function for OR4C13 Gene

Molecular function for OR4C13 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C13: view

Phenotypes for OR4C13 Gene

genes like me logo Genes that share phenotypes with OR4C13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C13 Gene

Localization for OR4C13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C13 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4C13 Gene COMPARTMENTS Subcellular localization image for OR4C13 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4C13: view

Pathways & Interactions for OR4C13 Gene

genes like me logo Genes that share pathways with OR4C13: view

Pathways by source for OR4C13 Gene

Interacting Proteins for OR4C13 Gene

Gene Ontology (GO) - Biological Process for OR4C13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C13: view

No data available for SIGNOR curated interactions for OR4C13 Gene

Drugs & Compounds for OR4C13 Gene

No Compound Related Data Available

Transcripts for OR4C13 Gene

mRNA/cDNA for OR4C13 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C13 Gene

No ASD Table

Relevant External Links for OR4C13 Gene

GeneLoc Exon Structure for
OR4C13
ECgene alternative splicing isoforms for
OR4C13

Expression for OR4C13 Gene

mRNA expression in normal human tissues for OR4C13 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4C13 Gene



NURSA nuclear receptor signaling pathways regulating expression of OR4C13 Gene:

OR4C13

SOURCE GeneReport for Unigene cluster for OR4C13 Gene:

Hs.553668
genes like me logo Genes that share expression patterns with OR4C13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR4C13 Gene

Orthologs for OR4C13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC515790 34
  • 80.89 (n)
  • 72.64 (a)
-- 35
  • 76 (a)
ManyToMany
-- 35
  • 76 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC483566 34
  • 84.25 (n)
  • 78.64 (a)
-- 35
  • 82 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr1257 34
  • 80.8 (n)
  • 78.64 (a)
Olfr1257 16
Olfr1202 35
  • 74 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC746422 34
  • 98.38 (n)
  • 96.76 (a)
OR4C13 35
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr722 34
  • 80.69 (n)
  • 79.55 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
ManyToMany
-- 35
  • 76 (a)
ManyToMany
-- 35
  • 77 (a)
ManyToMany
Species where no ortholog for OR4C13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C13 Gene

ENSEMBL:
Gene Tree for OR4C13 (if available)
TreeFam:
Gene Tree for OR4C13 (if available)

Paralogs for OR4C13 Gene

Paralogs for OR4C13 Gene

(446) SIMAP similar genes for OR4C13 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4C13 Gene

genes like me logo Genes that share paralogs with OR4C13: view

Variants for OR4C13 Gene

Sequence variations from dbSNP and Humsavar for OR4C13 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs28378220 - 49,952,427(+) CATGG(C/T)GAATA reference, missense
rs28662375 - 49,952,819(+) CCACC(A/G)TCATG reference, missense
rs1996982 -- 49,951,067(+) ACTTT(G/T)CAGAA upstream-variant-2KB
rs34040136 -- 49,951,822(+) GCACT(A/G)TTATT upstream-variant-2KB
rs34884838 -- 49,951,336(+) TTACA(-/C)ACAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4C13 Gene

Variant ID Type Subtype PubMed ID
dgv1128n100 CNV gain 25217958
dgv1130n100 CNV gain 25217958
dgv1813n54 CNV gain 21841781
esv2760533 CNV gain+loss 21179565
esv33425 CNV gain 17666407
esv3626326 CNV gain 21293372
esv3892002 CNV gain 25118596
nsv1048074 CNV gain 25217958
nsv467876 CNV gain 19166990
nsv554394 CNV loss 21841781
nsv983016 CNV duplication 23825009

Variation tolerance for OR4C13 Gene

Residual Variation Intolerance Score: 90.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4C13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4C13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C13 Gene

Disorders for OR4C13 Gene

Relevant External Links for OR4C13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4C13

No disorders were found for OR4C13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C13 Gene

Publications for OR4C13 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 65
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 65
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for OR4C13 Gene

Sources for OR4C13 Gene

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