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OR4C12 Gene

protein-coding   GIFtS: 47
GCID: GC11M050076

Olfactory Receptor, Family 4, Subfamily C, Member 12

  See OR4C12-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 4, Subfamily C, Member 121 2
Olfactory Receptor OR11-2592 3
OR11-2592
Olfactory Receptor 4C122
Seven Transmembrane Helix Receptor2

External Ids:    HGNC: 151681   Entrez Gene: 2830932   Ensembl: ENSG000002219547   UniProtKB: Q96R673   

Export aliases for OR4C12 gene to outside databases

Previous GC identifers: GC11U990545 GC11M049959 GC11M049894


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR4C12 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4C12 Gene:
OR4C12 (olfactory receptor, family 4, subfamily C, member 12) is a protein-coding gene. Diseases associated with OR4C12 include pineoblastoma, and medulloblastoma. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4C5.

UniProtKB/Swiss-Prot: OR4CC_HUMAN, Q96R67
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4C12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR4C12 gene promoter:
         Tal-1   AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   GATA-1   E47   GATA-2   Nkx6-1   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR4C12 promoter sequence
   Search Chromatin IP Primers for OR4C12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4C12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.12   Ensembl cytogenetic band:  11p11.12   HGNC cytogenetic band: 11p11.12

OR4C12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4C12 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M050076:  view genomic region     (about GC identifiers)

Start:
50,003,111 bp from pter      End:
50,004,037 bp from pter
Size:
927 bases      Orientation:
minus strand

1 alternative location:
Chr11-,NW_003571045 140,359-141,421     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR4CC_HUMAN, Q96R67 (See protein sequence)
Recommended Name: Olfactory receptor 4C12  
Size: 309 amino acids; 34491 Da
Secondary accessions: B2RNF0 Q6IF49

Explore the universe of human proteins at neXtProt for OR4C12: NX_Q96R67

Post-translational modifications: 

  • Glycosylation2 at Asn6
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR4C12
    REFSEQ proteins: NP_001005270.2  
    ENSEMBL proteins: 
     ENSP00000334418  
    Reactome Protein details: Q96R67

    OR4C12 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q96R67

    ProtoNet protein and cluster: Q96R67

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR4CC_HUMAN, Q96R67
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR4C12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR4CC_HUMAN, Q96R67
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR4C12           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR4C12
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR4CC_HUMAN, Q96R67: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR4C12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR4C12 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR4C12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR4C12
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR4C12):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR4C12
    Interactions:

        Search GeneGlobe Interaction Network for OR4C12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR4C12 (Q96R673 ENSP000003344184) via UniProtKB, MINT, STRING, and/or I2D (see all 274)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSC22D1Q157143, ENSP000003974354I2D: score=1 STRING: ENSP00000397435
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR4A5ENSP000003676644STRING: ENSP00000367664
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR4C12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR4C12 (OR4CC)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR4C12 gene: 
    NM_001005270.3  

    Unigene Cluster for OR4C12:

    Olfactory receptor, family 4, subfamily C, member 12
    Hs.553669
    Unigene Representative Sequence: NM_001005270
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000335238(uc010ria.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR4C12

    Additional mRNA sequence: 

    BC136850.1 BC136851.1 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR4C12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACTATTCA
    OR4C12 Expression
    About this image

    OR4C12 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.553669
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4C12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR4C12 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr12551 , 5 olfactory receptor 12551, 5 85.31(n)1
    83.22(a)1
      2 (50.13 cM)5
    2589791  NM_146977.21  NP_667188.21 
     898163285 


    ENSEMBL Gene Tree for OR4C12 (if available)
    TreeFam Gene Tree for OR4C12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR4C12 gene
    OR4C52  OR4S12  OR4A472  OR4X22  OR4A162  OR4C152  OR4C132  OR4C62  
    OR4C462  OR4C162  OR4C32  OR4X12  OR4S22  OR4A152  OR4C112  OR4A52  
    OR4B12  OR4A8P2  
    Selected SIMAP similar genes for OR4C12 using alignment to 1 protein entry:     OR4CC_HUMAN(see all similar genes):
    OR4C3    OR4C46    OR4C13    OR4C11    OR4A15    OR4A47
    OR4A16    OR4A4P    OR4A5    OR4C15    OR4C6    OR4C5
    OR4S1    OR4A8P    OR4C16    OR4X2    OR4B1    OR4Q2

    Find genes that share paralogs with OR4C12           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for OR4C12
    PGOHUM00000257820


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR4C12 (see all 92)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1939207801,2
    Cuntested150003964(-) AGTCAC/TGTTTG 2 T M mis10--------
    rs1453319711,2
    --50002533(+) CTCGAC/TATAAT 1 -- ds50010--------
    rs1825026391,2
    --50002576(+) TCGGGA/GAAGCT 1 -- ds50010--------
    rs1887033471,2
    --50002651(+) TCTTGC/TGGCAT 1 -- ds50010--------
    rs1378989371,2
    --50002653(+) TTGCGA/GCATTA 1 -- ds50010--------
    rs20306871,2
    C,F,O,A,H--50002744(-) TGGACC/TCTGGC 1 -- ds500112Minor allele frequency- T:0.43NS EA NA WA 800
    rs1463988031,2
    C--50002941(+) TGACAA/GGAGTG 1 -- ds50010--------
    rs110406951,2
    C--50003025(+) CAGCCC/TCTTGT 1 -- ut311Minor allele frequency- T:0.00NA 2
    rs1928159261,2
    C,F--50003075(+) TACCTA/GTTACC 1 -- ut311Minor allele frequency- G:0.00EU 593
    rs765714621,2
    C--50003092(+) TTGAGC/TGCTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OR4C12 ( 50003111 - 50004037 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for OR4C12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428254CNV Loss18775914
    esv33425CNV Gain17666407
    nsv897491CNV Gain21882294
    nsv467876CNV Gain19166990
    dgv1132n71CNV Gain21882294
    nsv897498CNV Gain21882294
    nsv897496CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR4C12
    DNA2.0 Custom Variant and Variant Library Synthesis for OR4C12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for OR4C12:    
    About MalaCards
    pineoblastoma    medulloblastoma

    2 diseases from the University of Copenhagen DISEASES database for OR4C12:
    Pineoblastoma     Childhood medulloblastoma

    Find genes that share disorders with OR4C12           About GenesLikeMe


    Export disorders for OR4C12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR4C12 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR4C12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283093 HGNC: 15168 Ensembl:ENSG00000221954 euGenes: HUgn283093 ECgene: OR4C12 Kegg: 283093
    H-InvDB: OR4C12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR4C12 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4C12 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR4C12 gene:
    Search GeneIP for patents involving OR4C12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     OriGene Antibodies for OR4C12   OriGene RNAi products in human, mouse, rat for OR4C12  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
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     OriGene Custom Antibody Services for OR4C12   OriGene Custom Protein Services for OR4C12  

     
     
     Block miRNA regulation of human, mouse, rat OR4C12 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR4C12
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4C12 Predesigned siRNA for gene silencing in human, mouse, rat OR4C12
     QuantiFast Probe-based Assays in human, mouse, rat OR4C12 QuantiTect SYBR Green Assays in human, mouse, rat OR4C12
     Custom PCR Arrays for OR4C12 Search Chromatin IP Primers for OR4C12
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OR4C12  Search GeneGlobe Interaction Network for OR4C12
     Regulatory tfbs in OR4C12 promoter
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     Search Tocris compounds for OR4C12 (OR4CC)
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Proteins for OR4C12
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OR4C12
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     SwitchGear Promoter luciferase reporter plasmids for OR4C12
     Search ThermoFisher Antibodies for OR4C12
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4C12
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR4C12
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OR4C12
     LSBio Antibodies in human, mouse, rat for OR4C12
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     Browse compounds at ApexBio
     Search Addgene for plasmids for OR4C12
      Search eBioscience for proteins for OR4C12
      Search eBioscience for elisas for OR4C12
      eBioscience FlowRNA Probe Sets
           
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