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Aliases for OR4C12 Gene

Aliases for OR4C12 Gene

  • Olfactory Receptor, Family 4, Subfamily C, Member 12 2 3
  • Olfactory Receptor OR11-259 3 4
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor 4C12 3
  • OR11-259 3

External Ids for OR4C12 Gene

Previous GeneCards Identifiers for OR4C12 Gene

  • GC11U990545
  • GC11M049959
  • GC11M049894
  • GC11M050076

Summaries for OR4C12 Gene

Entrez Gene Summary for OR4C12 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C12 Gene

OR4C12 (Olfactory Receptor, Family 4, Subfamily C, Member 12) is a Protein Coding gene. Diseases associated with OR4C12 include pineoblastoma and medulloblastoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot for OR4C12 Gene

  • Odorant receptor.

Gene Wiki entry for OR4C12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C12 Gene

Genomics for OR4C12 Gene

Regulatory Elements for OR4C12 Gene

Genomic Location for OR4C12 Gene

Start:
49,981,473 bp from pter
End:
49,982,535 bp from pter
Size:
1,063 bases
Orientation:
Minus strand

Genomic View for OR4C12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4C12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C12 Gene

Proteins for OR4C12 Gene

  • Protein details for OR4C12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R67-OR4CC_HUMAN
    Recommended name:
    Olfactory receptor 4C12
    Protein Accession:
    Q96R67
    Secondary Accessions:
    • B2RNF0
    • Q6IF49

    Protein attributes for OR4C12 Gene

    Size:
    309 amino acids
    Molecular mass:
    34491 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C12 Gene

Proteomics data for OR4C12 Gene at MOPED

Post-translational modifications for OR4C12 Gene

  • Glycosylation at Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C12 Gene

Domains for OR4C12 Gene

Gene Families for OR4C12 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4C12 Gene

Suggested Antigen Peptide Sequences for OR4C12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96R67

UniProtKB/Swiss-Prot:

OR4CC_HUMAN :
  • Q96R67
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C12: view

Function for OR4C12 Gene

Molecular function for OR4C12 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C12: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4C12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4C12 Gene

Localization for OR4C12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C12 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4C12 Gene COMPARTMENTS Subcellular localization image for OR4C12 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4C12: view

Pathways for OR4C12 Gene

genes like me logo Genes that share pathways with OR4C12: view

Pathways by source for OR4C12 Gene

Gene Ontology (GO) - Biological Process for OR4C12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C12: view

Transcripts for OR4C12 Gene

mRNA/cDNA for OR4C12 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4C12

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR4C12
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C12 Gene

No ASD Table

Relevant External Links for OR4C12 Gene

GeneLoc Exon Structure for
OR4C12
ECgene alternative splicing isoforms for
OR4C12

Expression for OR4C12 Gene

mRNA expression in normal human tissues for OR4C12 Gene

SOURCE GeneReport for Unigene cluster for OR4C12 Gene Hs.553669

genes like me logo Genes that share expressions with OR4C12: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR4C12 Gene

Orthologs for OR4C12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466885 35
  • 99.14 (n)
  • 98.06 (a)
OR4C12 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
OR4C12 35
  • 85.87 (n)
  • 82.2 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
OR4C12 35
  • 87.38 (n)
  • 84.47 (a)
mouse
(Mus musculus)
Mammalia Olfr1255 35
  • 85.31 (n)
  • 83.22 (a)
Olfr1255 16
Olfr1255 36
  • 81 (a)
OneToMany
Olfr1259 36
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia OR4C12 36
  • 71 (a)
OneToOne
Species with no ortholog for OR4C12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C12 Gene

ENSEMBL:
Gene Tree for OR4C12 (if available)
TreeFam:
Gene Tree for OR4C12 (if available)

Paralogs for OR4C12 Gene

Selected SIMAP similar genes for OR4C12 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4C12 Gene

genes like me logo Genes that share paralogs with OR4C12: view

Variants for OR4C12 Gene

Sequence variations from dbSNP and Humsavar for OR4C12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1851867 -- 49,983,973(-) AGCAC(C/T)GGGCT upstream-variant-2KB
rs1851868 -- 49,983,848(-) ATACC(C/T)CCATG upstream-variant-2KB
rs2030687 -- 49,981,208(-) TGGAC(C/T)CTGGC downstream-variant-500B
rs4598671 - 49,981,655(-) ATCCC(G/T)TGGTC reference, missense
rs11040695 -- 49,981,489(+) CAGCC(C/T)CTTGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OR4C12 Gene

Variant ID Type Subtype PubMed ID
nsv897491 CNV Gain 21882294
esv33425 CNV Gain 17666407
nsv467876 CNV Gain 19166990
nsv897496 CNV Gain 21882294
dgv1132n71 CNV Gain 21882294
nsv897498 CNV Gain 21882294
nsv428254 CNV Loss 18775914

Relevant External Links for OR4C12 Gene

HapMap Linkage Disequilibrium report
OR4C12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C12 Gene

Disorders for OR4C12 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for OR4C12 Gene including...

Search for OR4C12 Gene in MalaCards »

(2) University of Copenhagen DISEASES for OR4C12 Gene

genes like me logo Genes that share disorders with OR4C12: view

No data available for UniProtKB/Swiss-Prot for OR4C12 Gene

Publications for OR4C12 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR4C12 Gene

  • antibodies-online peptides for OR4C12
  • antibodies-online antibodies for OR4C12
  • antibodies-online kits for OR4C12

Sources for OR4C12 Gene

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