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Aliases for OR4C11 Gene

Aliases for OR4C11 Gene

  • Olfactory Receptor, Family 4, Subfamily C, Member 11 2 3
  • Olfactory Receptor OR11-136 3 4
  • OR4C11P 3 4
  • Olfactory Receptor, Family 4, Subfamily C, Member 11 Pseudogene 3
  • Olfactory Receptor 4C11 3
  • OR11-136 3

External Ids for OR4C11 Gene

Previous HGNC Symbols for OR4C11 Gene

  • OR4C11P

Previous GeneCards Identifiers for OR4C11 Gene

  • GC11M055147
  • GC11M055127
  • GC11M055370

Summaries for OR4C11 Gene

Entrez Gene Summary for OR4C11 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C11 Gene

OR4C11 (Olfactory Receptor, Family 4, Subfamily C, Member 11) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot for OR4C11 Gene

  • Odorant receptor.

Gene Wiki entry for OR4C11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C11 Gene

Genomics for OR4C11 Gene

Regulatory Elements for OR4C11 Gene

Genomic Location for OR4C11 Gene

Start:
55,603,354 bp from pter
End:
55,604,398 bp from pter
Size:
1,045 bases
Orientation:
Minus strand

Genomic View for OR4C11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4C11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C11 Gene

Proteins for OR4C11 Gene

  • Protein details for OR4C11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IEV9-OR4CB_HUMAN
    Recommended name:
    Olfactory receptor 4C11
    Protein Accession:
    Q6IEV9
    Secondary Accessions:
    • B9EIL4
    • Q8NGL8

    Protein attributes for OR4C11 Gene

    Size:
    310 amino acids
    Molecular mass:
    35003 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C11 Gene

Proteomics data for OR4C11 Gene at MOPED

Post-translational modifications for OR4C11 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C11 Gene

Domains for OR4C11 Gene

Gene Families for OR4C11 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4C11 Gene

Suggested Antigen Peptide Sequences for OR4C11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IEV9

UniProtKB/Swiss-Prot:

OR4CB_HUMAN :
  • Q6IEV9
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C11: view

Function for OR4C11 Gene

Molecular function for OR4C11 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C11: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4C11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4C11 Gene

Localization for OR4C11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4C11 Gene COMPARTMENTS Subcellular localization image for OR4C11 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4C11: view

Pathways for OR4C11 Gene

genes like me logo Genes that share pathways with OR4C11: view

Pathways by source for OR4C11 Gene

Interacting Proteins for OR4C11 Gene

Gene Ontology (GO) - Biological Process for OR4C11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C11: view

Transcripts for OR4C11 Gene

mRNA/cDNA for OR4C11 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4C11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C11 Gene

No ASD Table

Relevant External Links for OR4C11 Gene

GeneLoc Exon Structure for
OR4C11
ECgene alternative splicing isoforms for
OR4C11

Expression for OR4C11 Gene

mRNA expression in normal human tissues for OR4C11 Gene

Protein differential expression in normal tissues for OR4C11 Gene

This gene is overexpressed in Fetal Liver (45.5) and Fetal heart (23.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR4C11 Gene

SOURCE GeneReport for Unigene cluster for OR4C11 Gene Hs.553620

genes like me logo Genes that share expressions with OR4C11: view

Expression partners for OR4C11 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR4C11 Gene

Orthologs for OR4C11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C11 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC100686060 35
  • 88.35 (n)
  • 90.61 (a)
-- 36
  • 76 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr1206 35
  • 85.45 (n)
  • 88.6 (a)
Olfr1206 16
Olfr1201 36
  • 85 (a)
OneToMany
Olfr1205 36
  • 84 (a)
OneToMany
Olfr1206 36
  • 89 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC466533 35
  • 76.75 (n)
  • 75 (a)
rat
(Rattus norvegicus)
Mammalia Olr660 35
  • 84.15 (n)
  • 89.9 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 69 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
Species with no ortholog for OR4C11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C11 Gene

ENSEMBL:
Gene Tree for OR4C11 (if available)
TreeFam:
Gene Tree for OR4C11 (if available)

Paralogs for OR4C11 Gene

Selected SIMAP similar genes for OR4C11 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4C11 Gene

genes like me logo Genes that share paralogs with OR4C11: view

Variants for OR4C11 Gene

Sequence variations from dbSNP and Humsavar for OR4C11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs491160 - 55,604,352(+) TTCAG(G/T)CACAC missense, reference
rs491375 -- 55,604,440(+) AAATA(A/G)ATTCT upstream-variant-2KB
rs602937 -- 55,606,227(+) ACACA(A/C)AAAAT upstream-variant-2KB
rs682094 -- 55,604,487(+) TTGCA(A/C)CTTTC upstream-variant-2KB
rs2456022 - 55,603,545(+) GGGTG(G/T)TCCAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR4C11 Gene

Variant ID Type Subtype PubMed ID
esv2751030 CNV Gain 17911159
nsv524091 CNV Gain 19592680
nsv467886 CNV Gain 19166990
nsv821668 CNV Loss 15273396
nsv518225 CNV Loss 19592680
dgv376e1 CNV Complex 17122850
esv782 CNV CNV 17122850
dgv12n68 CNV Loss 17160897
dgv377e1 CNV Complex 17122850
nsv428256 CNV Loss 18775914
nsv522846 CNV Gain 19592680
dgv4e49 CNV Loss 18971310
dgv378e1 CNV Complex 17122850
dgv379e1 CNV Complex 17122850
dgv143n27 CNV Loss 19166990
nsv517440 CNV Gain+Loss 19592680
nsv323 CNV Loss 18451855
nsv71 CNV Loss 15895083
nsv437717 CNV Loss 16327808
nsv469957 CNV Gain 18288195
nsv818824 CNV Gain 17921354
dgv144n27 CNV Gain 19166990
dgv145n27 CNV Loss 19166990
dgv146n27 CNV Gain 19166990
nsv508632 CNV Loss 20534489
nsv511485 CNV Gain 21212237
nsv435950 OTHER Inversion 17901297
dgv211e199 CNV Deletion 23128226
nsv443003 CNV Complex 18674749
dgv12n47 CNV Loss 21111241
esv22842 CNV Gain+Loss 19812545
esv2663268 CNV Deletion 23128226
nsv825892 CNV Loss 20364138
dgv217n67 CNV Loss 20364138
nsv8827 CNV Gain+Loss 18304495
esv33874 CNV Gain 17666407
dgv6n14 CNV Loss 18776910
esv2421634 CNV Deletion 20811451
esv29944 CNV Loss 18421352
nsv825895 CNV Loss 20364138
nsv469958 CNV Loss 18288195
dgv147n27 CNV Loss 19166990
dgv9n64 CNV Gain+Loss 17921354
nsv818827 CNV Gain 17921354
dgv10n64 CNV Loss 17921354
dgv11n64 CNV Gain+Loss 17921354
nsv438185 CNV Loss 16468122

Relevant External Links for OR4C11 Gene

HapMap Linkage Disequilibrium report
OR4C11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C11 Gene

Disorders for OR4C11 Gene

No disorders were found for OR4C11 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR4C11 Gene

Publications for OR4C11 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR4C11 Gene

Sources for OR4C11 Gene

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