Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR4C11 Gene

Aliases for OR4C11 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 11 2 3 5
  • Olfactory Receptor OR11-136 3 4
  • OR4C11P 3 4
  • Olfactory Receptor, Family 4, Subfamily C, Member 11 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily C, Member 11 2
  • Olfactory Receptor 4C11 3
  • OR11-136 3

External Ids for OR4C11 Gene

Previous HGNC Symbols for OR4C11 Gene

  • OR4C11P

Previous GeneCards Identifiers for OR4C11 Gene

  • GC11M055147
  • GC11M055127
  • GC11M055370

Summaries for OR4C11 Gene

Entrez Gene Summary for OR4C11 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C11 Gene

OR4C11 (Olfactory Receptor Family 4 Subfamily C Member 11) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4C16.

UniProtKB/Swiss-Prot for OR4C11 Gene

  • Odorant receptor.

Gene Wiki entry for OR4C11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C11 Gene

Genomics for OR4C11 Gene

Regulatory Elements for OR4C11 Gene

Enhancers for OR4C11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G055430 0.3 FANTOM5 2 +174.1 174067 0.0 OR5D14 OR5D18 OR4C15 OR5L2 OR4C16 OR5D16 OR4C6 OR4S2 OR4A16 OR4C11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR4C11 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4C11 Gene

Chromosome:
11
Start:
55,603,354 bp from pter
End:
55,604,398 bp from pter
Size:
1,045 bases
Orientation:
Minus strand

Genomic View for OR4C11 Gene

Genes around OR4C11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C11 Gene

Proteins for OR4C11 Gene

  • Protein details for OR4C11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IEV9-OR4CB_HUMAN
    Recommended name:
    Olfactory receptor 4C11
    Protein Accession:
    Q6IEV9
    Secondary Accessions:
    • B9EIL4
    • Q8NGL8

    Protein attributes for OR4C11 Gene

    Size:
    310 amino acids
    Molecular mass:
    35003 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C11 Gene

Post-translational modifications for OR4C11 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C11 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C11 Gene

Domains & Families for OR4C11 Gene

Gene Families for OR4C11 Gene

Protein Domains for OR4C11 Gene

Suggested Antigen Peptide Sequences for OR4C11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IEV9

UniProtKB/Swiss-Prot:

OR4CB_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C11: view

Function for OR4C11 Gene

Molecular function for OR4C11 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C11: view
genes like me logo Genes that share phenotypes with OR4C11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C11 Gene

Localization for OR4C11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4C11 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4C11: view

Pathways & Interactions for OR4C11 Gene

genes like me logo Genes that share pathways with OR4C11: view

Pathways by source for OR4C11 Gene

Interacting Proteins for OR4C11 Gene

Gene Ontology (GO) - Biological Process for OR4C11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4C11: view

No data available for SIGNOR curated interactions for OR4C11 Gene

Transcripts for OR4C11 Gene

mRNA/cDNA for OR4C11 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C11 Gene

No ASD Table

Relevant External Links for OR4C11 Gene

GeneLoc Exon Structure for
OR4C11
ECgene alternative splicing isoforms for
OR4C11

Expression for OR4C11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4C11 Gene

Protein differential expression in normal tissues from HIPED for OR4C11 Gene

This gene is overexpressed in Fetal Liver (45.5) and Fetal heart (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR4C11 Gene



Protein tissue co-expression partners for OR4C11 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4C11 Gene:

OR4C11

SOURCE GeneReport for Unigene cluster for OR4C11 Gene:

Hs.553620
genes like me logo Genes that share expression patterns with OR4C11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4C11 Gene

Orthologs for OR4C11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C11 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC100686060 34
  • 88.35 (n)
-- 35
  • 76 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Or4c11 55 Olfr1206 34 16 35
  • 85.45 (n)
Or4c11b 55 Olfr1201 35
  • 85 (a)
OneToMany
Or4c11c 55 Olfr1205 35
  • 84 (a)
OneToMany
Or4c100 55 Olfr1186
  • chr2:88,525,585-88,526,493
Or4c31 55 Olfr1183
  • chr2:88,461,342-88,462,250
Or4c99 55 Olfr1185
  • chr2:88,499,087-88,499,995
rat
(Rattus norvegicus)
Mammalia Olr660 34
  • 84.15 (n)
chimpanzee
(Pan troglodytes)
Mammalia LOC466533 34
  • 76.75 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
ManyToMany
-- 35
  • 73 (a)
ManyToMany
-- 35
  • 72 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
Species where no ortholog for OR4C11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C11 Gene

ENSEMBL:
Gene Tree for OR4C11 (if available)
TreeFam:
Gene Tree for OR4C11 (if available)

Paralogs for OR4C11 Gene

Paralogs for OR4C11 Gene

(440) SIMAP similar genes for OR4C11 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4C11 Gene

genes like me logo Genes that share paralogs with OR4C11: view

Variants for OR4C11 Gene

Sequence variations from dbSNP and Humsavar for OR4C11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1001894142 -- 55,605,212(+) TCCAA(A/C)GTTAA upstream-variant-2KB
rs1002346667 -- 55,604,622(+) TCTAG(C/G)CTGGA upstream-variant-2KB
rs1006745101 -- 55,603,508(+) CTGCA(C/T)TCCTC reference, missense
rs1006798859 -- 55,603,001(+) GTTGT(G/T)ATGTG downstream-variant-500B
rs1013174263 -- 55,604,570(+) ATTTA(C/T)CAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4C11 Gene

Variant ID Type Subtype PubMed ID
dgv10n64 CNV loss 17921354
dgv1170n100 CNV loss 25217958
dgv1172n100 CNV gain 25217958
dgv1173n100 CNV gain 25217958
dgv1174n100 CNV gain 25217958
dgv1175n100 CNV loss 25217958
dgv1176n100 CNV gain 25217958
dgv1177n100 CNV gain+loss 25217958
dgv1178n100 CNV gain+loss 25217958
dgv1179n100 CNV loss 25217958
dgv11n64 CNV gain+loss 17921354
dgv12n47 CNV loss 21111241
dgv12n68 CNV loss 17160897
dgv143n27 CNV loss 19166990
dgv144n27 CNV gain 19166990
dgv145n27 CNV loss 19166990
dgv146n27 CNV gain 19166990
dgv147n27 CNV loss 19166990
dgv1905n54 CNV gain 21841781
dgv1906n54 CNV gain+loss 21841781
dgv1907n54 CNV loss 21841781
dgv1908n54 CNV gain 21841781
dgv1909n54 CNV loss 21841781
dgv1910n54 CNV loss 21841781
dgv1911n54 CNV loss 21841781
dgv1912n54 CNV gain+loss 21841781
dgv1913n54 CNV gain+loss 21841781
dgv1914n54 CNV loss 21841781
dgv1915n54 CNV gain+loss 21841781
dgv1916n54 CNV loss 21841781
dgv1917n54 CNV loss 21841781
dgv1918n54 CNV loss 21841781
dgv1919n54 CNV gain+loss 21841781
dgv211e199 CNV deletion 23128226
dgv217n67 CNV loss 20364138
dgv362e212 CNV gain 25503493
dgv368e212 CNV loss 25503493
dgv369e212 CNV gain 25503493
dgv48n111 CNV deletion 26073780
dgv4e49 CNV loss 18971310
dgv6n14 CNV loss 18776910
dgv9n64 CNV gain+loss 17921354
esv22842 CNV gain+loss 19812545
esv2421634 CNV deletion 20811451
esv2663268 CNV deletion 23128226
esv2751030 CNV gain 17911159
esv2759828 CNV gain+loss 17122850
esv2760216 CNV loss 21179565
esv2760311 CNV gain+loss 21179565
esv29944 CNV loss 18421352
esv3380977 OTHER inversion 20981092
esv33874 CNV gain 17666407
esv3626445 CNV loss 21293372
esv3626446 CNV gain 21293372
esv3892006 CNV gain+loss 25118596
esv3892007 CNV loss 25118596
esv3892008 CNV loss 25118596
esv3892009 CNV gain 25118596
nsv1036325 CNV gain 25217958
nsv1037763 CNV gain 25217958
nsv1045375 CNV gain 25217958
nsv1045911 CNV gain+loss 25217958
nsv1143540 CNV deletion 24896259
nsv1159879 CNV deletion 26073780
nsv323 CNV deletion 18451855
nsv428256 CNV loss 18775914
nsv435950 OTHER inversion 17901297
nsv437717 CNV loss 16327808
nsv438185 CNV loss 16468122
nsv443003 CNV deletion 18674749
nsv467886 CNV gain 19166990
nsv469957 CNV gain 18288195
nsv469958 CNV loss 18288195
nsv508632 CNV deletion 20534489
nsv511485 CNV gain 21212237
nsv517440 CNV gain+loss 19592680
nsv518225 CNV loss 19592680
nsv522846 CNV gain 19592680
nsv524091 CNV gain 19592680
nsv554799 CNV gain 21841781
nsv554801 CNV loss 21841781
nsv554803 CNV gain 21841781
nsv554805 CNV loss 21841781
nsv554809 CNV gain 21841781
nsv554815 CNV loss 21841781
nsv554819 CNV gain 21841781
nsv71 CNV deletion 15895083
nsv818824 CNV gain 17921354
nsv818827 CNV gain 17921354
nsv821668 CNV loss 15273396
nsv825892 CNV loss 20364138
nsv825895 CNV loss 20364138
nsv8827 CNV gain+loss 18304495
nsv952449 CNV deletion 24416366
nsv972950 CNV deletion 23825009

Variation tolerance for OR4C11 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.23; 88.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4C11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4C11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C11 Gene

Disorders for OR4C11 Gene

Relevant External Links for OR4C11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4C11

No disorders were found for OR4C11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C11 Gene

Publications for OR4C11 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR4C11 Gene

Sources for OR4C11 Gene

Content
Loading form....