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Aliases for OR4B1 Gene

Aliases for OR4B1 Gene

  • Olfactory Receptor Family 4 Subfamily B Member 1 2 3 5
  • Olfactory Receptor OR11-106 3 4
  • OST208 3 4
  • Olfactory Receptor, Family 4, Subfamily B, Member 1 2
  • Olfactory Receptor 4B1 3
  • OR11-106 3

External Ids for OR4B1 Gene

Previous GeneCards Identifiers for OR4B1 Gene

  • GC11U990238
  • GC11P048194

Summaries for OR4B1 Gene

Entrez Gene Summary for OR4B1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4B1 Gene

OR4B1 (Olfactory Receptor Family 4 Subfamily B Member 1) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4S2.

UniProtKB/Swiss-Prot for OR4B1 Gene

  • Odorant receptor.

Gene Wiki entry for OR4B1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4B1 Gene

Genomics for OR4B1 Gene

Regulatory Elements for OR4B1 Gene

Enhancers for OR4B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G048103 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -109.6 -109568 7.3 HDGF PKNOX1 ARNT SIN3A FEZF1 BRCA1 ZNF2 YY1 ELK1 ZNF143 NUP160 OR4S1 PTPRJ-AS1 PTPRJ OR4B1 PACSIN3 ACP2 MADD C1QTNF4 OR4X2
GH11G048266 0.3 FANTOM5 32.1 +50.0 49994 0.0 OR4B1 OR4S1 OR4X2 OR4C3 OR4X1
GH11G047869 1.2 FANTOM5 ENCODE dbSUPER 6.2 -347.0 -346988 1.0 TBP PKNOX1 STAT1 TAF1 JUN FEZF1 EP300 PRDM6 JUND NFE2 OR4C3 OR4B1 OR4S1 PTPRJ OR4X2 NUP160 GC11M054020
GH11G047912 2 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -298.0 -297960 13.2 HDGF FOXA2 PKNOX1 CREB3L1 ARNT SIN3A ARID4B FEZF1 YY1 ZNF766 NUP160 FNBP4 ENSG00000270060 PTPRJ C1QTNF4 ENSG00000200090 DDB2 PTPRJ-AS1 MYBPC3 KBTBD4
GH11G047850 0.9 FANTOM5 ENCODE 3.4 -365.7 -365732 2.0 FOSL1 POLR2A EED JUN IKZF1 HMBOX1 ETV6 IKZF2 SPI1 C1QTNF4 MTCH2 OR4S1 OR4B1 OR4X2 OR4C3 NUP160 GC11M054020
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR4B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4B1 Gene

Chromosome:
11
Start:
48,216,792 bp from pter
End:
48,217,762 bp from pter
Size:
971 bases
Orientation:
Plus strand

Genomic View for OR4B1 Gene

Genes around OR4B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4B1 Gene

Proteins for OR4B1 Gene

  • Protein details for OR4B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGF8-OR4B1_HUMAN
    Recommended name:
    Olfactory receptor 4B1
    Protein Accession:
    Q8NGF8
    Secondary Accessions:
    • Q6IF75
    • Q96R64

    Protein attributes for OR4B1 Gene

    Size:
    309 amino acids
    Molecular mass:
    34456 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4B1 Gene

Post-translational modifications for OR4B1 Gene

Other Protein References for OR4B1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4B1 Gene

Domains & Families for OR4B1 Gene

Gene Families for OR4B1 Gene

Protein Domains for OR4B1 Gene

Suggested Antigen Peptide Sequences for OR4B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGF8

UniProtKB/Swiss-Prot:

OR4B1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4B1: view

Function for OR4B1 Gene

Molecular function for OR4B1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4B1: view
genes like me logo Genes that share phenotypes with OR4B1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4B1 Gene

Localization for OR4B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4B1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4B1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4B1: view

Pathways & Interactions for OR4B1 Gene

genes like me logo Genes that share pathways with OR4B1: view

Pathways by source for OR4B1 Gene

Interacting Proteins for OR4B1 Gene

Gene Ontology (GO) - Biological Process for OR4B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4B1: view

No data available for SIGNOR curated interactions for OR4B1 Gene

Drugs & Compounds for OR4B1 Gene

No Compound Related Data Available

Transcripts for OR4B1 Gene

mRNA/cDNA for OR4B1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4B1 Gene

No ASD Table

Relevant External Links for OR4B1 Gene

GeneLoc Exon Structure for
OR4B1
ECgene alternative splicing isoforms for
OR4B1

Expression for OR4B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4B1 Gene

Protein differential expression in normal tissues from HIPED for OR4B1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR4B1 Gene



Protein tissue co-expression partners for OR4B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4B1 Gene:

OR4B1

SOURCE GeneReport for Unigene cluster for OR4B1 Gene:

Hs.553566
genes like me logo Genes that share expression patterns with OR4B1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4B1 Gene

Orthologs for OR4B1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466510 34
  • 98.81 (n)
OR4B1 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR08C02 34 35
  • 86.75 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 85 (a)
OneToMany
LOC532501 34
  • 84.36 (n)
-- 35
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr737 34
  • 81.91 (n)
mouse
(Mus musculus)
Mammalia Or4b1d 55 Olfr32 34 16 35
  • 81.58 (n)
Or4b1b 55 Olfr1272 35
  • 81 (a)
OneToMany
Or4b12 55 Olfr1271 35
  • 79 (a)
OneToMany
Or4b13 55 Olfr142 35
  • 79 (a)
OneToMany
Or4b1 55 Olfr1270
  • chr2:90,149,093-90,150,004
Or4b1c 55 Olfr1273
  • chr2:90,295,966-90,296,859
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia OR4B1 35
  • 73 (a)
OneToOne
Species where no ortholog for OR4B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4B1 Gene

ENSEMBL:
Gene Tree for OR4B1 (if available)
TreeFam:
Gene Tree for OR4B1 (if available)

Paralogs for OR4B1 Gene

Paralogs for OR4B1 Gene

(453) SIMAP similar genes for OR4B1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4B1 Gene

genes like me logo Genes that share paralogs with OR4B1: view

Variants for OR4B1 Gene

Sequence variations from dbSNP and Humsavar for OR4B1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1001004967 -- 48,216,414(+) GAAAA(C/T)GGAGA upstream-variant-2KB
rs1002040993 -- 48,217,349(+) CTCCA(C/G)CCTTT reference, missense
rs1003230748 -- 48,214,868(+) TTTCT(C/T)TGGAC upstream-variant-2KB
rs1004025195 -- 48,217,611(+) ATAAA(C/G)TTGTG reference, missense
rs1004873548 -- 48,215,716(+) GGCCA(C/G)GCCGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4B1 Gene

Variant ID Type Subtype PubMed ID
dgv1111n100 CNV gain 25217958
dgv1112n100 CNV gain 25217958
dgv198e214 CNV gain 21293372
esv3891986 CNV gain 25118596
nsv1041394 CNV gain 25217958
nsv428253 CNV loss 18775914
nsv467871 CNV gain 19166990
nsv467873 CNV loss 19166990
nsv469953 CNV loss 18288195
nsv554211 CNV gain 21841781
nsv554212 CNV loss 21841781

Variation tolerance for OR4B1 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.49; 77.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4B1 Gene

Disorders for OR4B1 Gene

Relevant External Links for OR4B1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4B1

No disorders were found for OR4B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4B1 Gene

Publications for OR4B1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64

Products for OR4B1 Gene

Sources for OR4B1 Gene

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