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Aliases for OR4A8 Gene

Aliases for OR4A8 Gene

  • Olfactory Receptor, Family 4, Subfamily A, Member 8 (Gene/Pseudogene) 2 3
  • Olfactory Receptor, Family 4, Subfamily A, Member 8 Pseudogene 2 3
  • OR4A8P 3 4
  • Olfactory Receptor OR11-110 4
  • Olfactory Receptor 4A8 3

External Ids for OR4A8 Gene

Previous HGNC Symbols for OR4A8 Gene

  • OR4A8P

Summaries for OR4A8 Gene

Entrez Gene Summary for OR4A8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4A8 Gene

OR4A8 (Olfactory Receptor, Family 4, Subfamily A, Member 8 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot for OR4A8 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4A8 Gene

Genomics for OR4A8 Gene

Genomic Location for OR4A8 Gene

Start:
54,682,876 bp from pter
End:
54,683,821 bp from pter
Size:
946 bases
Orientation:
Plus strand

Genomic View for OR4A8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4A8 Gene

No data available for Regulatory Elements for OR4A8 Gene

Proteins for OR4A8 Gene

  • Protein details for OR4A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C604-OR4A8_HUMAN
    Recommended name:
    Olfactory receptor 4A8
    Protein Accession:
    P0C604
    Secondary Accessions:

    Protein attributes for OR4A8 Gene

    Size:
    315 amino acids
    Molecular mass:
    35621 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4A8 Gene

Proteomics data for OR4A8 Gene at MOPED

Post-translational modifications for OR4A8 Gene

No Post-translational modifications

Other Protein References for OR4A8 Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for OR4A8 Gene

Domains for OR4A8 Gene

Gene Families for OR4A8 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4A8 Gene

Graphical View of Domain Structure for InterPro Entry

P0C604

UniProtKB/Swiss-Prot:

OR4A8_HUMAN :
  • P0C604
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4A8: view

No data available for Suggested Antigen Peptide Sequences for OR4A8 Gene

Function for OR4A8 Gene

Molecular function for OR4A8 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4A8: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4A8 Gene

Localization for OR4A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4A8 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR4A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4A8: view

No data available for Subcellular locations from COMPARTMENTS for OR4A8 Gene

Pathways for OR4A8 Gene

genes like me logo Genes that share pathways with OR4A8: view

Pathways by source for OR4A8 Gene

Interacting Proteins for OR4A8 Gene

Gene Ontology (GO) - Biological Process for OR4A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4A8: view

Transcripts for OR4A8 Gene

mRNA/cDNA for OR4A8 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4A8 Gene

No ASD Table

Relevant External Links for OR4A8 Gene

GeneLoc Exon Structure for
OR4A8
ECgene alternative splicing isoforms for
OR4A8

Expression for OR4A8 Gene

mRNA expression in normal human tissues for OR4A8 Gene

genes like me logo Genes that share expressions with OR4A8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR4A8 Gene

Orthologs for OR4A8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4A8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 64 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 66 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr1238 36
  • 70 (a)
ManyToMany
Olfr1240 36
  • 67 (a)
ManyToMany
Olfr1241 36
  • 67 (a)
ManyToMany
Olfr1242 36
  • 65 (a)
ManyToMany
Olfr1243 36
  • 65 (a)
ManyToMany
Olfr1245 36
  • 67 (a)
ManyToMany
Olfr1246 36
  • 66 (a)
ManyToMany
Olfr1247 36
  • 67 (a)
ManyToMany
Olfr1248 36
  • 67 (a)
ManyToMany
Olfr1249 36
  • 65 (a)
ManyToMany
Olfr1250 36
  • 67 (a)
ManyToMany
Olfr1251 36
  • 66 (a)
ManyToMany
Olfr1252 36
  • 67 (a)
ManyToMany
Olfr1253 36
  • 66 (a)
ManyToMany
Olfr1254 36
  • 67 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia OPOR77 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
Species with no ortholog for OR4A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4A8 Gene

ENSEMBL:
Gene Tree for OR4A8 (if available)
TreeFam:
Gene Tree for OR4A8 (if available)

Paralogs for OR4A8 Gene

genes like me logo Genes that share paralogs with OR4A8: view

Variants for OR4A8 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR4A8 Gene

P0C604-OR4A8_HUMAN
A stop codon in the gene coding for this protein at position Arg-136 is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Relevant External Links for OR4A8 Gene

HapMap Linkage Disequilibrium report
OR4A8

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for OR4A8 Gene

Disorders for OR4A8 Gene

No disorders were found for OR4A8 Gene.

No data available for UniProtKB/Swiss-Prot for OR4A8 Gene

Publications for OR4A8 Gene

  1. Population differences in the human functional olfactory repertoire. (PMID: 12644552) Gilad Y. … Lancet D. (Mol. Biol. Evol. 2003) 3 4
  2. Different noses for different people. (PMID: 12730696) Menashe I. … Gilad Y. (Nat. Genet. 2003) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4

Products for OR4A8 Gene

Sources for OR4A8 Gene

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