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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR4A5 Gene

protein-coding   GIFtS: 43
GCID: GC11M051411

Olfactory Receptor, Family 4, Subfamily A, Member 5

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 4, Subfamily A, Member 51 2
Olfactory Receptor OR11-1112 3
OR11-1112
Olfactory Receptor 4A52
Seven Transmembrane Helix Receptor2

External Ids:    HGNC: 151621   Entrez Gene: 813182   Ensembl: ENSG000002218407   UniProtKB: Q8NH833   

Export aliases for OR4A5 gene to outside databases

Previous GC identifers: GC11U990551 GC11M051268 GC11M049961


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR4A5 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4A5 Gene: 
OR4A5 (olfactory receptor, family 4, subfamily A, member 5) is a protein-coding gene. Diseases associated with OR4A5 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4C5.

UniProtKB/Swiss-Prot: OR4A5_HUMAN, Q8NH83
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4A5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_035158.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR4A5 gene promoter:
         HFH-3   C/EBPbeta   AML1a   Pax-6   CUTL1   GATA-1   AREB6   FOXI1   POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for OR4A5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR4A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.12   Ensembl cytogenetic band:  11p11.12   HGNC cytogenetic band: 11p11.12

OR4A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4A5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M051411:  view genomic region     (about GC identifiers)

Start:
51,411,451 bp from pter      End:
51,412,395 bp from pter
Size:
945 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OR4A5_HUMAN, Q8NH83 (See protein sequence)
Recommended Name: Olfactory receptor 4A5  
Size: 315 amino acids; 34915 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6IF84

Explore the universe of human proteins at neXtProt for OR4A5: NX_Q8NH83

Explore proteomics data for OR4A5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NH83

  • HORDE protein sequence for OR4A5
    OR4A5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR4A5 Protein Expression
    REFSEQ proteins: NP_001005272.3  
    ENSEMBL proteins: 
     ENSP00000367664  
    Reactome Protein details: Q8NH83
    Human Recombinant Protein Products for OR4A5: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OR4A5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    OR4A5 for ontologies           About GeneDecksing



    OR4A5 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for OR4A5 
    Cloud-Clone Corp. CLIAs for OR4A5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NH83

    ProtoNet protein and cluster: Q8NH83

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR4A5_HUMAN, Q8NH83
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR4A5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR4A5_HUMAN, Q8NH83
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR4A5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OR4A5 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR4A5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for OR4A5
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR4A5):
        Olfactory transduction


    OR4A5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR4A5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/273 Interacting proteins for OR4A5 (ENSP000003676644) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR4C12ENSP000003344184STRING: ENSP00000334418
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR4A5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR4A5

    Search CenterWatch for drugs/clinical trials and news about OR4A5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR4A5 gene: 
    NM_001005272.3  

    Unigene Cluster for OR4A5:

    Olfactory receptor, family 4, subfamily A, member 5
    Hs.554531
    Unigene Representative Sequence: NM_001005272
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000319760(uc001nhi.2)
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate OR4A5
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OR4A5
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4A5
    Sirion Biotech Customized lentivirus for stable overexpression of OR4A5 
                         Customized lentivirus expression plasmids for stable overexpression of OR4A5 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR4A5

    Additional mRNA sequence: BC140750.1 
    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR4A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGTCCTT
    OR4A5 Expression
    About this image


    See OR4A5 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.554531
        SABiosciences Custom PCR Arrays for OR4A5
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR4A5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4A5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR4A5 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr12381 , 5 olfactory receptor 12381, 5 80.37(n)1
    75.66(a)1
      2 (50.03 cM)5
    2587861  NM_146790.11  NP_667001.11 
     894061305 


    ENSEMBL Gene Tree for OR4A5 (if available)
    TreeFam Gene Tree for OR4A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR4A5 gene
    OR4C52  OR4S12  OR4A472  OR4X22  OR4A162  OR4C152  OR4C132  OR4C62  
    OR4C462  OR4C162  OR4C32  OR4X12  OR4S22  OR4A152  OR4C112  OR4C122  
    OR4B12  
    18/447 SIMAP similar genes for OR4A5 using alignment to 2 protein entries:     OR4A5_HUMAN (see all proteins) (see all similar genes):
    OR4A8P    OR4A16    OR4A15    OR4A47    OR4C15    OR4C46
    OR4C12    OR4A4P    OR4C13    OR4C3    OR4X1    OR4B1
    OR4C5    OR4C6    OR4C11    OR4K17    OR4Q3    OR4S2

    OR4A5 for paralogs           About GeneDecksing


    5/14 Pseudogenes.org Pseudogenes for OR4A5 (see all 14)
    PGOHUM00000242245 PGOHUM00000242252 PGOHUM00000242253 PGOHUM00000242669 PGOHUM00000242670


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/216 SNPs in OR4A5 are shown (see all 216)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487101821,2
    Cuntested151412108(+) TGGCCA/C/TATGCA 2 I M mis10--------
    rs1876976371,2
    --51410887(+) AGTTAC/TGGATG 1 -- ds50010--------
    rs1923169071,2
    C--51410889(+) TTATGA/GATGTT 1 -- ds50010--------
    rs1437215261,2
    C--51410943(+) ATAAGC/TACCTT 1 -- ds50010--------
    rs112465461,2
    C,F,H--51410966(+) CATAAT/ATCTAA 1 -- ds50016Minor allele frequency- A:0.09NS EA NA 658
    rs745917821,2
    C,F--51410973(+) CTAAGT/ATTCTT 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1419503811,2
    --51410974(+) TAAGAC/TTCTTA 1 -- ds50010--------
    rs1114488081,2
    F--51410992(+) ATATGT/ACTGCA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs112465471,2
    C,F,H--51411038(+) TTCAAA/CGATAT 1 -- ds500112Minor allele frequency- C:0.18NS EA 1938
    rs1459352071,2
    --51411094(+) ACACTA/GAGGGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for OR4A5 ( 51411451 - 51412395 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for OR4A5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832151CNV Loss17160897
    dgv142n27CNV Gain19166990
    nsv897586CNV Gain21882294
    esv2751029CNV Gain17911159
    nsv897582CNV Gain21882294
    dgv1140n71CNV Gain21882294
    nsv516340CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OR4A5:    About MalaCards
    neuronitis    


    OR4A5 for disorders           About GeneDecksing


    Export disorders for OR4A5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR4A5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR4A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
    3. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81318 HGNC: 15162 Ensembl:ENSG00000221840 euGenes: HUgn81318 ECgene: OR4A5 Kegg: 81318
    H-InvDB: OR4A5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR4A5 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4A5 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR4A5 gene:
    Search GeneIP for patents involving OR4A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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