OR4A5 Gene
protein-coding GIFtS: 44
GCID: GC11M051411
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|
olfactory receptor, family 4, subfamily A, member 5
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Aliases
for OR4A5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 4, Subfamily A, Member 51 2 | | Olfactory Receptor OR11-1112 3 | | OR11-1112 | | Olfactory Receptor 4A52 | | Seven Transmembrane Helix Receptor2 |
Export aliases for OR4A5 gene to outside databasesPrevious GC identifers: GC11U990551 GC11M051268 GC11M049961 |
Summaries
for OR4A5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR4A5:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR4A5_HUMAN, Q8NH83Function: Odorant receptor (Potential)
Gene Wiki entry for OR4A5
|
Genomic Views
for OR4A5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_035158.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR4A5 gene promoter:
HFH-3 C/EBPbeta AML1a Pax-6 CUTL1 GATA-1 AREB6 FOXI1 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR4A5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR4A5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p11.12 Ensembl cytogenetic band: 11p11.12 HGNC cytogenetic band: 11p11.12OR4A5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M051411: view genomic region
(about GC identifiers)
Start:
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51,411,451 bp from pter |
End:
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51,412,395 bp from pter |
Size:
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945 bases |
Orientation:
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minus strand |
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Proteins
for OR4A5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR4A5_HUMAN, Q8NH83 (See
protein sequence)Recommended Name: Olfactory receptor 4A5 Size: 315 amino acids; 34915 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6IF84Explore the universe of human proteins at neXtProt for OR4A5: NX_Q8NH83
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NH83
HORDE protein sequence for OR4A5
OR4A5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001005272.3
ENSEMBL proteins: ENSP00000367664 Reactome Protein details: Q8NH83
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR4A5 for ontologies About GeneDecksing
OR4A5 Antibody Products:
Assay Products for OR4A5: |
Protein
Domains /
Families
for OR4A5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR4A5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NH83ProtoNet protein and cluster: Q8NH83 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR4A5_HUMAN, Q8NH83Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR4A5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OR4A5_HUMAN, Q8NH83Function: Odorant receptor (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR4A5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR4A5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: OR4A5 (NM_001005272) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR4A5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4A5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4A5 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR4A5 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR4A5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR4A5
1 
Kegg Pathway (Kegg details for OR4A5):
OR4A5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR4A5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/273 Interacting proteins for OR4A5 (ENSP000003676644) via UniProtKB, MINT, STRING, and/or I2D (see all 273)About this table
|
Drugs & Compounds
for OR4A5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR4A5
Search CenterWatch for drugs/clinical trials and news about OR4A5
|
Transcripts
for OR4A5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR4A5 gene: NM_001005272.3 Unigene Cluster for OR4A5: Olfactory receptor, family 4, subfamily A, member 5 Hs.554531 Unigene Representative Sequence: NM_0010052721 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000319760(uc001nhi.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR4A5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR4A5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR4A5 (NM_001005272) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR4A5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4A5 |
Additional cDNA sequence: BC140750.1
GeneLoc Exon Structure
|
Expression
for OR4A5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR4A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAGTCCTT
About this image
See OR4A5 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.554531
SABiosciences Custom PCR Arrays for OR4A5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR4A5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR4A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR4A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR4A5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4A5 |
Orthologs
for OR4A5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OR4A5 (if available)
TreeFam Gene Tree for OR4A5 (if available) |
Paralogs
for OR4A5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR4A5 gene
- OR4A472 OR4C52 OR4S12 OR4X22 OR4A162 OR4C152 OR4C132 OR4C462
- OR4C62 OR4C162 OR4C32 OR4X12 OR4E22 OR4S22 OR4A152 OR4C112
- OR4C122 OR4B12
18/447 SIMAP similar genes for OR4A5 using alignment to 2 protein entries: OR4A5_HUMAN (see all proteins)
(see all similar genes):OR4A8P OR4A16 OR4A15 OR4A47 OR4C15 OR4C46
OR4C12 OR4A4P OR4C13 OR4C3 OR4X1 OR4B1
OR4C5 OR4C6 OR4C11 OR4K17 OR4Q3 OR4S2
OR4A5 for paralogs About GeneDecksing
5/14 Pseudogenes.org Pseudogenes for OR4A5 (see all 14)
PGOHUM00000242245 PGOHUM00000242252 PGOHUM00000242253 PGOHUM00000242669 PGOHUM00000242670
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Genomic Variants
for OR4A5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR4A5 ( 51411451 - 51412395 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for OR4A5
3 CNVs: 53111 8689 48823 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR4A5 |
|
Disorders
/ Diseases
for OR4A5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR4A5 for disorders About GeneDecksing
1  disease for OR4A5: About MalaCardsneuronitis
Export disorders for OR4A5 gene to outside databases
|
Publications
for OR4A5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR4A5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR4A5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for OR4A5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR4A5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR4A5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR4A5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR4A5 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR4A5 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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| | |
About This Section
| Patent Information for OR4A5 gene:
Search GeneIP for patents involving OR4A5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR4A5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR4A5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR4A5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR4A5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR4A5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR4A5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR4A5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR4A5 | | OriGene Custom Protein Services for OR4A5 | | | OriGene Custom Immunoassay Development | | |
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 |  |  |  | |
| | | | Search Tocris compounds for OR4A5 |
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 | | | OR4A5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4A5 |
|  |  |  | | | | ThermoFisher Antibodies for OR4A5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4A5 |
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