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Aliases for OR4A47 Gene

Aliases for OR4A47 Gene

  • Olfactory Receptor Family 4 Subfamily A Member 47 2 3 5
  • Olfactory Receptor OR11-113 3 4
  • Olfactory Receptor, Family 4, Subfamily A, Member 47 2
  • Olfactory Receptor 4A47 3
  • OR11-113 3

External Ids for OR4A47 Gene

Previous GeneCards Identifiers for OR4A47 Gene

  • GC11U900133

Summaries for OR4A47 Gene

Entrez Gene Summary for OR4A47 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4A47 Gene

OR4A47 (Olfactory Receptor Family 4 Subfamily A Member 47) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot for OR4A47 Gene

  • Odorant receptor.

Gene Wiki entry for OR4A47 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4A47 Gene

Genomics for OR4A47 Gene

Regulatory Elements for OR4A47 Gene


Genomic Location for OR4A47 Gene

Chromosome:
11
Start:
48,483,466 bp from pter
End:
48,489,780 bp from pter
Size:
6,315 bases
Orientation:
Plus strand

Genomic View for OR4A47 Gene

Genes around OR4A47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4A47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4A47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4A47 Gene

Proteins for OR4A47 Gene

  • Protein details for OR4A47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IF82-O4A47_HUMAN
    Recommended name:
    Olfactory receptor 4A47
    Protein Accession:
    Q6IF82

    Protein attributes for OR4A47 Gene

    Size:
    309 amino acids
    Molecular mass:
    34760 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4A47 Gene

Post-translational modifications for OR4A47 Gene

  • Glycosylation at Asn 6 and Asn 87
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4A47 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4A47 Gene

Domains & Families for OR4A47 Gene

Gene Families for OR4A47 Gene

Protein Domains for OR4A47 Gene

Suggested Antigen Peptide Sequences for OR4A47 Gene

Graphical View of Domain Structure for InterPro Entry

Q6IF82

UniProtKB/Swiss-Prot:

O4A47_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4A47: view

Function for OR4A47 Gene

Molecular function for OR4A47 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4A47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4A47: view

Phenotypes for OR4A47 Gene

genes like me logo Genes that share phenotypes with OR4A47: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4A47 Gene

Localization for OR4A47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4A47 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4A47 Gene COMPARTMENTS Subcellular localization image for OR4A47 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4A47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4A47: view

Pathways & Interactions for OR4A47 Gene

genes like me logo Genes that share pathways with OR4A47: view

Pathways by source for OR4A47 Gene

Gene Ontology (GO) - Biological Process for OR4A47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4A47: view

No data available for SIGNOR curated interactions for OR4A47 Gene

Transcripts for OR4A47 Gene

mRNA/cDNA for OR4A47 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4A47 Gene

No ASD Table

Relevant External Links for OR4A47 Gene

GeneLoc Exon Structure for
OR4A47
ECgene alternative splicing isoforms for
OR4A47

Expression for OR4A47 Gene

mRNA expression in normal human tissues for OR4A47 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4A47 Gene:

OR4A47

SOURCE GeneReport for Unigene cluster for OR4A47 Gene:

Hs.554532
genes like me logo Genes that share expression patterns with OR4A47: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR4A47 Gene

Orthologs for OR4A47 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4A47 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC745857 34
  • 98.92 (n)
OR4A47 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100683879 34
  • 87.01 (n)
OR4A47 35
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC785969 34
  • 84.31 (n)
-- 35
  • 79 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr720 34
  • 83.22 (n)
mouse
(Mus musculus)
Mammalia Or4a47 55 Olfr1256 34 16 35
  • 83.01 (n)
oppossum
(Monodelphis domestica)
Mammalia OR4A47 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
OneToMany
Species where no ortholog for OR4A47 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4A47 Gene

ENSEMBL:
Gene Tree for OR4A47 (if available)
TreeFam:
Gene Tree for OR4A47 (if available)

Paralogs for OR4A47 Gene

Paralogs for OR4A47 Gene

(455) SIMAP similar genes for OR4A47 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR4A47 Gene

genes like me logo Genes that share paralogs with OR4A47: view

Variants for OR4A47 Gene

Sequence variations from dbSNP and Humsavar for OR4A47 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs112326312 -- 48,489,807(+) GCCAT(A/C)TTCCC downstream-variant-500B
rs113293659 -- 48,487,312(+) AGAAA(A/T)TTAGA upstream-variant-2KB
rs114739604 -- 48,486,821(+) CAGCA(A/C)CAAAA upstream-variant-2KB
rs115159327 -- 48,489,493(+) AAAAG(C/T)CCTCT reference, missense
rs115747493 -- 48,488,396(+) TCCCT(C/T)CCCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4A47 Gene

Variant ID Type Subtype PubMed ID
dgv1111n100 CNV gain 25217958
dgv1112n100 CNV gain 25217958
dgv1113n100 CNV loss 25217958
dgv1114n100 CNV loss 25217958
dgv1780n54 CNV loss 21841781
dgv48e55 CNV loss 17911159
esv2759824 CNV gain+loss 17122850
esv2760610 CNV gain 21179565
esv3579513 CNV loss 25503493
esv3626235 CNV loss 21293372
esv3626241 CNV loss 21293372
esv3626242 CNV gain 21293372
esv3891986 CNV gain 25118596
nsv428253 CNV loss 18775914
nsv467871 CNV gain 19166990
nsv467874 CNV gain 19166990
nsv469953 CNV loss 18288195
nsv469954 CNV gain 18288195
nsv554211 CNV gain 21841781
nsv554220 CNV loss 21841781
nsv554222 CNV loss 21841781
nsv554223 CNV gain 21841781
nsv832144 CNV loss 17160897
nsv975841 CNV duplication 23825009

Variation tolerance for OR4A47 Gene

Residual Variation Intolerance Score: 79.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4A47 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4A47

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4A47 Gene

Disorders for OR4A47 Gene

Relevant External Links for OR4A47

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4A47

No disorders were found for OR4A47 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4A47 Gene

Publications for OR4A47 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PMID: 24144296) Cheng C.Y. … Baird P.N. (Am. J. Hum. Genet. 2013) 3 64
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR4A47 Gene

Sources for OR4A47 Gene

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