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Aliases for OR4A16 Gene

Aliases for OR4A16 Gene

  • Olfactory Receptor Family 4 Subfamily A Member 16 2 3 5
  • Olfactory Receptor OR11-117 3 4
  • Olfactory Receptor, Family 4, Subfamily A, Member 16 2
  • Olfactory Receptor 4A16 3
  • OR11-117 3
  • OR4A16Q 3

External Ids for OR4A16 Gene

Previous GeneCards Identifiers for OR4A16 Gene

  • GC11U990560
  • GC11P054867
  • GC11P055110

Summaries for OR4A16 Gene

Entrez Gene Summary for OR4A16 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4A16 Gene

OR4A16 (Olfactory Receptor Family 4 Subfamily A Member 16) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot for OR4A16 Gene

  • Odorant receptor.

Gene Wiki entry for OR4A16 Gene

Additional gene information for OR4A16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4A16 Gene

Genomics for OR4A16 Gene

Regulatory Elements for OR4A16 Gene

Enhancers for OR4A16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H055430 0.3 FANTOM5 2.9 +106.7 106671 0 OR5D14 OR5D18 OR4C15 OR5L2 OR4C16 OR5D16 OR4C6 OR4S2 OR4A16 OR4C11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR4A16 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR4A16 Gene

Genomic Locations for OR4A16 Gene
20,571 bases
Plus strand

Genomic View for OR4A16 Gene

Genes around OR4A16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4A16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4A16 Gene

Proteins for OR4A16 Gene

  • Protein details for OR4A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4A16
    Protein Accession:
    Secondary Accessions:
    • Q6IFL3

    Protein attributes for OR4A16 Gene

    328 amino acids
    Molecular mass:
    36922 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4A16 Gene

Post-translational modifications for OR4A16 Gene

  • Glycosylation at posLast=66
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4A16 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4A16 Gene

Domains & Families for OR4A16 Gene

Gene Families for OR4A16 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4A16 Gene

Suggested Antigen Peptide Sequences for OR4A16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4A16: view

Function for OR4A16 Gene

Molecular function for OR4A16 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4A16: view

Phenotypes for OR4A16 Gene

genes like me logo Genes that share phenotypes with OR4A16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4A16 Gene

Localization for OR4A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4A16 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4A16 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4A16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4A16 Gene

Pathways & Interactions for OR4A16 Gene

genes like me logo Genes that share pathways with OR4A16: view

Pathways by source for OR4A16 Gene

Interacting Proteins for OR4A16 Gene

Gene Ontology (GO) - Biological Process for OR4A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4A16: view

No data available for SIGNOR curated interactions for OR4A16 Gene

Drugs & Compounds for OR4A16 Gene

No Compound Related Data Available

Transcripts for OR4A16 Gene

mRNA/cDNA for OR4A16 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4A16 Gene

No ASD Table

Relevant External Links for OR4A16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4A16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4A16 Gene

Protein differential expression in normal tissues from HIPED for OR4A16 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR4A16 Gene

Protein tissue co-expression partners for OR4A16 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4A16 Gene:


SOURCE GeneReport for Unigene cluster for OR4A16 Gene:

genes like me logo Genes that share expression patterns with OR4A16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4A16 Gene

Orthologs for OR4A16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4A16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC746859 33
  • 91.57 (n)
OR4A16 34
  • 84 (a)
(Mus musculus)
Mammalia Or4a68 52 Olfr1240 33 16 34
  • 78.7 (n)
Olfr1238 34
  • 73 (a)
Olfr1245 34
  • 71 (a)
Or4a69 52 Olfr1241 34
  • 70 (a)
Olfr1247 34
  • 70 (a)
Olfr1250 34
  • 68 (a)
Olfr1252 34
  • 68 (a)
Olfr1254 34
  • 68 (a)
Olfr1246 34
  • 67 (a)
Olfr1248 34
  • 67 (a)
Olfr1243 34
  • 66 (a)
Olfr1249 34
  • 65 (a)
Olfr1251 34
  • 65 (a)
Olfr1253 34
  • 65 (a)
Olfr1242 34
  • 64 (a)
(Rattus norvegicus)
Mammalia Olr702 33
  • 77.96 (n)
(Monodelphis domestica)
Mammalia OPOR77 34
  • 70 (a)
(Bos Taurus)
Mammalia LOC100294956 33
  • 69.53 (n)
-- 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
Species where no ortholog for OR4A16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4A16 Gene

Gene Tree for OR4A16 (if available)
Gene Tree for OR4A16 (if available)

Paralogs for OR4A16 Gene

Paralogs for OR4A16 Gene

(416) SIMAP similar genes for OR4A16 Gene using alignment to 2 proteins: Pseudogenes for OR4A16 Gene

genes like me logo Genes that share paralogs with OR4A16: view

Variants for OR4A16 Gene

Sequence variations from dbSNP and Humsavar for OR4A16 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000322838 -- 55,341,272(+) ATATG(C/T)TCTTT upstream-variant-2KB
rs1004671147 -- 55,341,793(+) TTACT(C/G)TCACT upstream-variant-2KB
rs1004737102 -- 55,342,834(+) GCTGA(C/T)TGGGG upstream-variant-2KB
rs1005335990 -- 55,344,310(+) GAGAA(C/T)GAATA downstream-variant-500B
rs1006914370 -- 55,344,447(+) AAACA(A/C)AAGCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR4A16 Gene

Variant ID Type Subtype PubMed ID
dgv1164n100 CNV gain 25217958
dgv1166n100 CNV gain 25217958
dgv1168n100 CNV loss 25217958
dgv1169n100 CNV loss 25217958
dgv1865n54 CNV gain 21841781
dgv1905n54 CNV gain 21841781
dgv362e212 CNV gain 25503493
dgv68n21 CNV loss 19592680
nsv972026 CNV duplication 23825009
nsv832153 CNV loss 17160897
nsv825891 CNV loss 20364138
nsv554799 CNV gain 21841781
nsv554798 CNV loss 21841781
nsv524091 CNV gain 19592680
nsv467886 CNV gain 19166990
nsv1053286 CNV loss 25217958
nsv1051199 CNV loss 25217958
nsv1047317 CNV gain 25217958
esv998925 CNV deletion 20482838
esv3892009 CNV gain 25118596
esv3626425 CNV loss 21293372
esv3626424 CNV gain 21293372
esv3626423 CNV loss 21293372
esv2760193 CNV loss 21179565
esv2751030 CNV gain 17911159

Variation tolerance for OR4A16 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.59; 96.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4A16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4A16 Gene

Disorders for OR4A16 Gene

Relevant External Links for OR4A16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR4A16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4A16 Gene

Publications for OR4A16 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR4A16 Gene

Sources for OR4A16 Gene

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