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OR4A15 Gene

protein-coding   GIFtS: 44
GCID: GC11P055135

Olfactory Receptor, Family 4, Subfamily A, Member 15

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 4, Subfamily A, Member 151 2
Olfactory Receptor OR11-1182 3
OR11-1182
Olfactory Receptor 4A152

External Ids:    HGNC: 151521   Entrez Gene: 813282   Ensembl: ENSG000001819587   UniProtKB: Q8NGL63   

Export aliases for OR4A15 gene to outside databases

Previous GC identifers: GC11U990561 GC11P054892


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR4A15 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4A15 Gene:
OR4A15 (olfactory receptor, family 4, subfamily A, member 15) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4C5.

UniProtKB/Swiss-Prot: O4A15_HUMAN, Q8NGL6
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4A15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR4A15 gene promoter:
         Nkx3-1   SRF   Nkx3-1 v4   SRF (504 AA)   Nkx3-1 v1   POU3F2   Nkx3-1 v2   FOXJ2 (long isoform)   Nkx3-1 v3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR4A15 promoter sequence
   Search Chromatin IP Primers for OR4A15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4A15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11   Ensembl cytogenetic band:  11q11   HGNC cytogenetic band: 11q11

OR4A15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4A15 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P055135:  view genomic region     (about GC identifiers)

Start:
55,135,450 bp from pter      End:
55,136,391 bp from pter
Size:
942 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: O4A15_HUMAN, Q8NGL6 (See protein sequence)
Recommended Name: Olfactory receptor 4A15  
Size: 344 amino acids; 38828 Da
Caution: It is uncertain whether Met-1 or Met-31 is the initiator
Sequence caution: Sequence=DAA04646.1; Type=Erroneous initiation;
Secondary accessions: Q6IFL4 Q96R65

Explore the universe of human proteins at neXtProt for OR4A15: NX_Q8NGL6

Explore proteomics data for OR4A15 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn36, Asn290
  • HORDE protein sequence for OR4A15

    See OR4A15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005275.1  
    ENSEMBL proteins: 
     ENSP00000325065  
    Reactome Protein details: Q8NGL6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGL6

    ProtoNet protein and cluster: Q8NGL6

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O4A15_HUMAN, Q8NGL6
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR4A15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O4A15_HUMAN, Q8NGL6
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR4A15           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O4A15_HUMAN, Q8NGL6: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR4A15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR4A15 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR4A15           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR4A15
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR4A15):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR4A15
    Interactions:

        Search GeneGlobe Interaction Network for OR4A15

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OR4A15 (ENSP000003250654) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB2ENSP000002692604STRING: ENSP00000269260
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR4A15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for OR4A15 (O4A15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR4A15 gene: 
    NM_001005275.1  

    Unigene Cluster for OR4A15:

    Olfactory receptor, family 4, subfamily A, member 15
    Hs.554529
    Unigene Representative Sequence: NM_001005275
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000314706(uc010rif.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR4A15

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    OR4A15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR4A15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.554529
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR4A15 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr12395
    Olfr12341
    olfactory receptor 12395
    olfactory receptor 12341
    82.7(n)1
    83.12(a)1
      2 (50.03 cM)5
    2589751  NM_146973.21  NP_667184.21 
     894174945 


    ENSEMBL Gene Tree for OR4A15 (if available)
    TreeFam Gene Tree for OR4A15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR4A15 gene
    OR4C52  OR4S12  OR4A472  OR4X22  OR4A162  OR4C152  OR4C132  OR4C62  
    OR4C462  OR4C162  OR4C32  OR4X12  OR4S22  OR4C112  OR4A52  OR4C122  
    OR4B12  OR4A8P2  
    Selected SIMAP similar genes for OR4A15 using alignment to 1 protein entry:     O4A15_HUMAN(see all similar genes):
    OR4A47    OR4A4P    OR4C46    OR4C13    OR4C15    OR4C6
    OR4A5    OR4A16    OR4A8P    OR4C12    OR4C3    OR4C11
    OR4B1    OR4S2    OR4X1    OR4Q3    OR4C16    OR4C5

    Find genes that share paralogs with OR4A15           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for OR4A15
    PGOHUM00000242246 PGOHUM00000242254 PGOHUM00000242668 PGOHUM00000257881


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR4A15 (see all 196)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs108967021,2
    C,F,A,H--55133458(+) TAGAAG/ACAAGT 1 -- us2k122Minor allele frequency- A:0.43EA NA NS WA CSA 1426
    rs1113665141,2
    C,F--55133504(+) TCCTGG/ATTGAC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs750700461,2
    C,F--55133540(+) GCTCTG/CAACTA 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1862840631,2
    --55133631(+) GTTATC/GTCTTA 1 -- us2k10--------
    rs1137251351,2
    C,F--55133662(+) TTACTC/TTCCCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs761122511,2
    C,F--55133666(+) TCTCCC/TTCTGA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1444147601,2
    --55133717(+) ATAATC/TTCCTG 1 -- us2k10--------
    rs1181365191,2
    C,F--55133732(+) TCACAA/GATGAT 1 -- us2k11Minor allele frequency- G:0.04NA 120
    rs1903085451,2
    --55133778(+) CTAATA/TCAAAC 1 -- us2k10--------
    rs1169874551,2
    C,F--55133779(+) TAATAC/GAAACT 1 -- us2k11Minor allele frequency- G:0.05NA 120

    HapMap Linkage Disequilibrium report for OR4A15 ( 55135450 - 55136391 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for OR4A15:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv998925CNV Deletion20482838
    nsv832153CNV Loss17160897
    dgv68n21CNV Loss19592680
    esv2751031CNV Loss17911159
    nsv825891CNV Loss20364138
    esv2751030CNV Gain17911159
    nsv467886CNV Gain19166990
    nsv524091CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR4A15           About GenesLikeMe

    Genetic Association Database (GAD): OR4A15

    Export disorders for OR4A15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR4A15 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR4A15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PubMed id 21408207)1, 4 Chung S.A....Criswell L.A. (PLoS Genet. 2011)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81328 HGNC: 15152 Ensembl:ENSG00000181958 euGenes: HUgn81328 ECgene: OR4A15 Kegg: 81328
    H-InvDB: OR4A15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR4A15 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4A15 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR4A15 gene:
    Search GeneIP for patents involving OR4A15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Block miRNA regulation of human, mouse, rat OR4A15 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR4A15
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4A15 Predesigned siRNA for gene silencing in human, mouse, rat OR4A15
     QuantiFast Probe-based Assays in human, mouse, rat OR4A15 QuantiTect SYBR Green Assays in human, mouse, rat OR4A15
     Custom PCR Arrays for OR4A15 Search Chromatin IP Primers for OR4A15
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR4A15
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