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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR4A15 Gene

protein-coding   GIFtS: 44
GCID: GC11P055135

Olfactory Receptor, Family 4, Subfamily A, Member 15

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 4, Subfamily A, Member 151 2
Olfactory Receptor OR11-1182 3
OR11-1182
Olfactory Receptor 4A152

External Ids:    HGNC: 151521   Entrez Gene: 813282   Ensembl: ENSG000001819587   UniProtKB: Q8NGL63   

Export aliases for OR4A15 gene to outside databases

Previous GC identifers: GC11U990561 GC11P054892


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR4A15 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4A15 Gene: 
OR4A15 (olfactory receptor, family 4, subfamily A, member 15) is a protein-coding gene. Diseases associated with OR4A15 include systemic lupus erythematosus, and lupus erythematosus, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4C5.

UniProtKB/Swiss-Prot: O4A15_HUMAN, Q8NGL6
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4A15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR4A15 gene promoter:
         Nkx3-1   SRF   Nkx3-1 v4   SRF (504 AA)   Nkx3-1 v1   POU3F2   Nkx3-1 v2   FOXJ2 (long isoform)   Nkx3-1 v3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR4A15 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR4A15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR4A15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11   Ensembl cytogenetic band:  11q11   HGNC cytogenetic band: 11q11

OR4A15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4A15 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P055135:  view genomic region     (about GC identifiers)

Start:
55,135,450 bp from pter      End:
55,136,391 bp from pter
Size:
942 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: O4A15_HUMAN, Q8NGL6 (See protein sequence)
Recommended Name: Olfactory receptor 4A15  
Size: 344 amino acids; 38828 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: It is uncertain whether Met-1 or Met-31 is the initiator
Sequence caution: Sequence=DAA04646.1; Type=Erroneous initiation;
Secondary accessions: Q6IFL4 Q96R65

Explore the universe of human proteins at neXtProt for OR4A15: NX_Q8NGL6

Explore proteomics data for OR4A15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NGL6

  • HORDE protein sequence for OR4A15
    OR4A15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR4A15 Protein Expression
    REFSEQ proteins: NP_001005275.1  
    ENSEMBL proteins: 
     ENSP00000325065  
    Reactome Protein details: Q8NGL6
    Human Recombinant Protein Products for OR4A15: 
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    Cloud-Clone Corp. Proteins for OR4A15 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    OR4A15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGL6

    ProtoNet protein and cluster: Q8NGL6

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O4A15_HUMAN, Q8NGL6
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR4A15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O4A15_HUMAN, Q8NGL6
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR4A15 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OR4A15 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR4A15 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for OR4A15
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR4A15):
        Olfactory transduction


    OR4A15 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR4A15

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OR4A15 (ENSP000003250654) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB2ENSP000002692604STRING: ENSP00000269260
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR4A15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR4A15 (O4A15)

    Search CenterWatch for drugs/clinical trials and news about OR4A15 / O4A15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR4A15 gene: 
    NM_001005275.1  

    Unigene Cluster for OR4A15:

    Olfactory receptor, family 4, subfamily A, member 15
    Hs.554529
    Unigene Representative Sequence: NM_001005275
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000314706(uc010rif.2)
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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                         Customized lentivirus expression plasmids for stable overexpression of OR4A15 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR4A15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR4A15

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR4A15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR4A15 Expression
    About this image


    See OR4A15 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.554529
        SABiosciences Custom PCR Arrays for OR4A15
    Primer
    Products:
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR4A15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4A15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR4A15 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr12391 , 5 olfactory receptor 12391, 5 70.63(n)1
    70.96(a)1
      2 (50.03 cM)5
    2589721  NM_146970.11  NP_667181.11 
     894174945 


    ENSEMBL Gene Tree for OR4A15 (if available)
    TreeFam Gene Tree for OR4A15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR4A15 gene
    OR4C52  OR4S12  OR4A472  OR4X22  OR4A162  OR4C152  OR4C132  OR4C62  
    OR4C462  OR4C162  OR4C32  OR4X12  OR4S22  OR4C112  OR4A52  OR4C122  
    OR4B12  
    18/444 SIMAP similar genes for OR4A15 using alignment to 1 protein entry:     O4A15_HUMAN(see all similar genes):
    OR4A47    OR4A4P    OR4C46    OR4C13    OR4C15    OR4C6
    OR4A5    OR4A16    OR4A8P    OR4C12    OR4C3    OR4C11
    OR4B1    OR4S2    OR4X1    OR4Q3    OR4C16    OR4C5

    OR4A15 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for OR4A15
    PGOHUM00000242246 PGOHUM00000242254 PGOHUM00000242668 PGOHUM00000257881


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/196 SNPs in OR4A15 are shown (see all 196)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs108967021,2
    C,F,A,H--55133458(+) TAGAAG/ACAAGT 1 -- us2k122Minor allele frequency- A:0.43EA NA NS WA CSA 1426
    rs1113665141,2
    C,F--55133504(+) TCCTGG/ATTGAC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs750700461,2
    C,F--55133540(+) GCTCTG/CAACTA 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1862840631,2
    --55133631(+) GTTATC/GTCTTA 1 -- us2k10--------
    rs1137251351,2
    C,F--55133662(+) TTACTC/TTCCCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs761122511,2
    C,F--55133666(+) TCTCCC/TTCTGA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1444147601,2
    --55133717(+) ATAATC/TTCCTG 1 -- us2k10--------
    rs1181365191,2
    C,F--55133732(+) TCACAA/GATGAT 1 -- us2k11Minor allele frequency- G:0.04NA 120
    rs1903085451,2
    --55133778(+) CTAATA/TCAAAC 1 -- us2k10--------
    rs1169874551,2
    C,F--55133779(+) TAATAC/GAAACT 1 -- us2k11Minor allele frequency- G:0.05NA 120

    HapMap Linkage Disequilibrium report for OR4A15 ( 55135450 - 55136391 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for OR4A15:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv998925CNV Deletion20482838
    nsv832153CNV Loss17160897
    dgv68n21CNV Loss19592680
    esv2751031CNV Loss17911159
    nsv825891CNV Loss20364138
    esv2751030CNV Gain17911159
    nsv467886CNV Gain19166990
    nsv524091CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for OR4A15:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    neuronitis


    OR4A15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OR4A15

    Export disorders for OR4A15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR4A15 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR4A15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PubMed id 21408207)1, 4 Chung S.A....Criswell L.A. (2011)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
    3. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
    4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81328 HGNC: 15152 Ensembl:ENSG00000181958 euGenes: HUgn81328 ECgene: OR4A15 Kegg: 81328
    H-InvDB: OR4A15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR4A15 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4A15 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR4A15 gene:
    Search GeneIP for patents involving OR4A15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for OR4A15
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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