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Aliases for OR4A15 Gene

Aliases for OR4A15 Gene

  • Olfactory Receptor, Family 4, Subfamily A, Member 15 2 3
  • Olfactory Receptor OR11-118 3 4
  • Olfactory Receptor 4A15 3
  • OR11-118 3

External Ids for OR4A15 Gene

Previous GeneCards Identifiers for OR4A15 Gene

  • GC11U990561
  • GC11P054892
  • GC11P055135

Summaries for OR4A15 Gene

Entrez Gene Summary for OR4A15 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4A15 Gene

OR4A15 (Olfactory Receptor, Family 4, Subfamily A, Member 15) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot for OR4A15 Gene

  • Odorant receptor.

Gene Wiki entry for OR4A15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4A15 Gene

Genomics for OR4A15 Gene

Regulatory Elements for OR4A15 Gene

Genomic Location for OR4A15 Gene

Start:
55,367,884 bp from pter
End:
55,368,918 bp from pter
Size:
1,035 bases
Orientation:
Plus strand

Genomic View for OR4A15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4A15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4A15 Gene

Proteins for OR4A15 Gene

  • Protein details for OR4A15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGL6-O4A15_HUMAN
    Recommended name:
    Olfactory receptor 4A15
    Protein Accession:
    Q8NGL6
    Secondary Accessions:
    • Q6IFL4
    • Q96R65

    Protein attributes for OR4A15 Gene

    Size:
    344 amino acids
    Molecular mass:
    38828 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04646.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR4A15 Gene

Proteomics data for OR4A15 Gene at MOPED

Post-translational modifications for OR4A15 Gene

  • Glycosylation at Asn36 and Asn290
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4A15 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4A15 Gene

Domains for OR4A15 Gene

Gene Families for OR4A15 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4A15 Gene

Suggested Antigen Peptide Sequences for OR4A15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGL6

UniProtKB/Swiss-Prot:

O4A15_HUMAN :
  • Q8NGL6
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4A15: view

Function for OR4A15 Gene

Molecular function for OR4A15 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4A15: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4A15

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4A15 Gene

Localization for OR4A15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4A15 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4A15 Gene COMPARTMENTS Subcellular localization image for OR4A15 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4A15: view

Pathways for OR4A15 Gene

genes like me logo Genes that share pathways with OR4A15: view

Pathways by source for OR4A15 Gene

Interacting Proteins for OR4A15 Gene

Gene Ontology (GO) - Biological Process for OR4A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4A15: view

Transcripts for OR4A15 Gene

mRNA/cDNA for OR4A15 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4A15

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR4A15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4A15 Gene

No ASD Table

Relevant External Links for OR4A15 Gene

GeneLoc Exon Structure for
OR4A15
ECgene alternative splicing isoforms for
OR4A15

Expression for OR4A15 Gene

mRNA expression in normal human tissues for OR4A15 Gene

SOURCE GeneReport for Unigene cluster for OR4A15 Gene Hs.554529

genes like me logo Genes that share expressions with OR4A15: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR4A15 Gene

Orthologs for OR4A15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4A15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466527 35
  • 97.97 (n)
  • 96.8 (a)
OR4A15 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 67 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia cOR4C1P 35
  • 84.71 (n)
  • 81.21 (a)
OR4A15 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1234 35
  • 82.7 (n)
  • 83.12 (a)
Olfr1234 36
  • 83 (a)
OneToOne
Olfr1239 16
oppossum
(Monodelphis domestica)
Mammalia OPOR77 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr697 35
  • 84.16 (n)
  • 85.05 (a)
Species with no ortholog for OR4A15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4A15 Gene

ENSEMBL:
Gene Tree for OR4A15 (if available)
TreeFam:
Gene Tree for OR4A15 (if available)

Paralogs for OR4A15 Gene

Selected SIMAP similar genes for OR4A15 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4A15 Gene

genes like me logo Genes that share paralogs with OR4A15: view

Variants for OR4A15 Gene

Sequence variations from dbSNP and Humsavar for OR4A15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1425193 - 55,367,959(-) TGAAG(A/G)TGTTG reference, missense
rs1946333 -- 55,366,899(-) acaca(C/G)acaca upstream-variant-2KB
rs2042592 -- 55,366,677(-) GAAAA(C/T)ATTAG upstream-variant-2KB
rs2113913 -- 55,366,879(-) TTCAT(C/T)TATTA upstream-variant-2KB
rs3056430 -- 55,366,911(-) cacac(-/AC)atata upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4A15 Gene

Variant ID Type Subtype PubMed ID
esv2751030 CNV Gain 17911159
nsv524091 CNV Gain 19592680
nsv832153 CNV Loss 17160897
dgv68n21 CNV Loss 19592680
nsv467886 CNV Gain 19166990
esv998925 CNV Deletion 20482838
nsv825891 CNV Loss 20364138
esv2751031 CNV Loss 17911159

Relevant External Links for OR4A15 Gene

HapMap Linkage Disequilibrium report
OR4A15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4A15 Gene

Disorders for OR4A15 Gene

Relevant External Links for OR4A15

Genetic Association Database (GAD)
OR4A15
genes like me logo Genes that share disorders with OR4A15: view

No data available for UniProtKB/Swiss-Prot for OR4A15 Gene

Publications for OR4A15 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PMID: 21408207) Chung S.A. … Criswell L.A. (PLoS Genet. 2011) 3 48
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for OR4A15 Gene

  • antibodies-online peptides for OR4A15
  • antibodies-online antibodies for OR4A15
  • antibodies-online kits for OR4A15

Sources for OR4A15 Gene

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