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GIFtS
-

OR3A4P Gene

pseudogene GIFtS: 34
GCID: GC17P003228

Olfactory Receptor, Family 3, Subfamily A, Member 4 Pseudogene

(Previous names: olfactory receptor, family 3, subfamily A, member 4)
(Previous symbol: OR3A4)

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 3, Subfamily A, Member 4 Pseudogene¹ ²		OR17-13²
OR3A4¹ ² ³		OR17-16²
OR17-24² ³		OR17-25²
OR3A5P² ³		OR24²
Olfactory Receptor, Family 3, Subfamily A, Member 4¹		OR25²
OLFRA05²		Olfactory Receptor 17-24³
OLFRA06²		Olfactory Receptor 3A5³

External Ids:	HGNC: 15510¹	Entrez Gene: 390756²	Ensembl: ENSG00000180068⁷	UniProtKB: P47883³

Export aliases for OR3A4P gene to outside databases

Previous GC identifers: GC17P003214 GC17P003216 GC17P003222

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR3A4P Gene:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled

receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain

structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G

protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the

genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent

of other organisms. This olfactory receptor gene is transcribed and contains an intact ORF, but it is predicted

to be a pseudogene due to a poorly conserved 7-transmembrane domain structure. (provided by RefSeq, Sep 2008)

GeneCards Summary for OR3A4P Gene:

OR3A4P (olfactory receptor, family 3, subfamily A, member 4 pseudogene) is a pseudogene. Diseases associated with OR3A4P include neuronitis, and among its related super-pathways are Signaling by GPCR and Olfactory transduction.

UniProtKB/Swiss-Prot: OR3A4_HUMAN, P47883

Function: Odorant receptor (Potential)

Gene Wiki entry for OR3A4P (OR3A4) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.2 NT_010718.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for OR3A4P
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR3A4P

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3

OR3A4P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR3A4P gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P003228: view genomic region (about GC identifiers)

Start:	3,213,280 bp from pter	End:	3,215,225 bp from pter
Size:	1,946 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: OR3A4_HUMAN, P47883 (See protein sequence)

Recommended Name: Putative olfactory receptor 3A4

Size: 348 amino acids; 37194 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Caution: Could be the product of a pseudogene

Secondary accessions: Q96R24

Explore the universe of human proteins at neXtProt for OR3A4P: NX_P47883

OR3A4P Protein expression data from MOPED¹, PaxDb² and MAXQB³ : --
Reactome Protein details: P47883
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

OR3: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:

IPR017452 GPCR_Rhodpsn_7TM

IPR000725 Olfact_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P47883

ProtoNet protein and cluster: P47883

UniProtKB/Swiss-Prot: OR3A4_HUMAN, P47883

Similarity: Belongs to the G-protein coupled receptor 1 family

OR3A4P for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: OR3A4_HUMAN, P47883

Function: Odorant receptor (Potential)

Genatlas biochemistry entry for OR3A4P:

olfactory receptor gene family 3,subfamily A,member 4,pseudogene,G protein coupled receptor superfamily

Phenotypes:
1 GenomeRNAi human phenotype for OR3A4P:

Increased HPV18 LCR reporter a

Animal Models:

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About This Section

SuperPaths for OR3A4P About

See pathways by source

SuperPath

Contained pathways About

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.55
	GPCR downstream signaling	0.90

Olfactory transduction

Olfactory Signaling Pathway

0.81

Class A/1 (Rhodopsin-like receptors)

GPCRs, Class A Rhodopsin-like

0.41

GPCRs, Other

GPCRs, Other

Pathways by source See SuperPaths
Show all pathways

2 BioSystems Pathways for OR3A4P

	GPCRs, Other
	GPCRs, Class A Rhodopsin-like

4 Reactome Pathways for OR3A4P

	GPCR downstream signaling
	Olfactory Signaling Pathway
	Signal Transduction
	Signaling by GPCR

OR3A4P for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR3A4P

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
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RefSeq according to Entrez Gene,
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About This Section

REFSEQ mRNAs for OR3A4P gene:

NM_001005334.1

Unigene Cluster for OR3A4P:

Olfactory receptor, family 3, subfamily A, member 4 pseudogene

Hs.632245

Unigene Representative Sequence: BC136875

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000323164 ENST00000574571 ENST00000545655(uc002fvi.2)

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Additional mRNA sequence:

AJ459867.1 BC136874.1 BC136875.1 NR_024128.1

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR3A4P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGCTGTGAAG

About this image

SOURCE GeneReport for Unigene cluster: Hs.632245

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for OR3A4P gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Olfr399⁵	olfactory receptor 399	--		11 (45.73 cM) 74050436

ENSEMBL Gene Tree for OR3A4P (if available)
TreeFam Gene Tree for OR3A4P (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OR3A4P gene

18/437 SIMAP similar genes for OR3A4P using alignment to 1 protein entry: OR3A4_HUMAN(see all similar genes):

OR17-16 OR17-137 OR3A1 OR3A2 OR3A3 OR17-15

OR13G1 OR1C1 OR1F2P OR1J2 OR4Q3 OR2W3

OR6N1 HSA10 LOC441453 OR10G4 OR10G7 OR10R3P

OR3A4P for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs151172647^1,2		--	3211560(+)	`AGTGTC/GAAAAT`	1	--	us2k¹		0	--	--	--	--
rs76402508^1,2	C	--	3211637(+)	`TGCTGG/AGCCGG`	1	--	us2k¹		4		WA CSA NA	241
rs141183846^1,2		--	3211641(+)	`GGGCCA/GGCGGG`	1	--	us2k¹		0	--	--	--	--
rs189020876^1,2		--	3211681(+)	`TTGGCC/TGGGTG`	1	--	us2k¹		0	--	--	--	--
rs146847185^1,2		--	3211695(+)	`CTCATA/CTCAAG`	1	--	us2k¹		0	--	--	--	--
rs139224218^1,2		--	3211702(+)	`CAAGAA/CTCCTC`	1	--	us2k¹		0	--	--	--	--
rs2855678^1,2	C,F,H	--	3211794(-)	`CCCACT/CGGATC`	1	--	us2k¹		6		NS EA WA	532
rs231680^1,2	C,F,A	--	3211814(+)	`CTTCAG/ATGTGC`	1	--	us2k¹		15		EA NA WA	658
rs181457630^1,2		--	3211874(+)	`CTCACA/GGGGAG`	1	--	us2k¹		0	--	--	--	--
rs7214565^1,2	C,F,A,H	--	3211910(+)	`TTAGTC/TCAAAG`	1	--	us2k¹		18		NS EA NA WA	908

HapMap Linkage Disequilibrium report for OR3A4P (3213280 - 3215225 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for OR3A4P: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

2 diseases for OR3A4P: About MalaCards

neuronitis

OR3A4P for disorders About GeneDecksing

Export disorders for OR3A4P gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OR3A4P gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR3A4P)

Utopia: connect your pdf to the dynamic
world of online information

DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)^{1, 2} Fuchs T.... Shamir R. (2002)
Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PubMed id 8004088)^{1, 2} Ben-Arie N.... North M.A. (1994)
Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. (PubMed id 8921386)^{1, 9} Glusman G.... Lancet D. (1996)
A probabilistic classifier for olfactory receptor pseudogenes. (PubMed id 16939646)¹ Menashe I....Lancet D. (2006)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)² Zody M.C.... Nusbaum C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The human olfactory receptor gene family. (PubMed id 14983052)¹ Malnic B.... Buck L.B. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PubMed id 10673334)¹ Glusman G.... Lancet D. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 390756	HGNC: 15510	Ensembl:ENSG00000180068	euGenes: HUgn390756	ECgene: OR3A4P
H-InvDB: OR3A4P

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OR3A4P	Pharmacogenomics, SNPs, Pathways

Intellectual Property for OR3A4P gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OR3A4P gene:
Search GeneIP for patents involving OR3A4P

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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OR3A4P Gene

Olfactory Receptor, Family 3, Subfamily A, Member 4 Pseudogene

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OR3A4P Gene

Olfactory Receptor, Family 3, Subfamily A, Member 4 Pseudogene

Aliasesfor OR3A4P gene

Summariesfor OR3A4P gene

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Aliases
for OR3A4P gene

Summaries
for OR3A4P gene

Genomic Views
for OR3A4P gene

Proteins
for OR3A4P gene

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Families
for OR3A4P gene

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for OR3A4P gene

Pathways & Interactions
for OR3A4P gene

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for OR3A4P gene

Transcripts
for OR3A4P gene

Expression
for OR3A4P gene

Orthologs
for OR3A4P gene

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for OR3A4P gene

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for OR3A4P gene

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for OR3A4P gene

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for OR3A4P gene

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for OR3A4P gene

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