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Aliases for OR3A3 Gene

Aliases for OR3A3 Gene

  • Olfactory Receptor Family 3 Subfamily A Member 3 2 3 5
  • Olfactory Receptor OR17-22 3 4
  • Olfactory Receptor 17-201 3 4
  • Olfactory Receptor 3A6 3 4
  • Olfactory Receptor 3A7 3 4
  • Olfactory Receptor 3A8 3 4
  • OR17-201 3 4
  • OR3A8P 3 4
  • OR3A6 3 4
  • OR3A7 3 4
  • Olfactory Receptor, Family 3, Subfamily A, Member 8 Pseudogene 3
  • Olfactory Receptor, Family 3, Subfamily A, Member 3 2
  • Olfactory Receptor, Family 3, Subfamily A, Member 6 3
  • Olfactory Receptor, Family 3, Subfamily A, Member 7 3
  • Olfactory Receptor 3A3 3
  • OR17-137 3
  • OR17-16 3

External Ids for OR3A3 Gene

Previous HGNC Symbols for OR3A3 Gene

  • OR3A6
  • OR3A7
  • OR3A8P

Previous GeneCards Identifiers for OR3A3 Gene

  • GC17P003638
  • GC17P003274
  • GC17P003530
  • GC17P003270
  • GC17P003323

Summaries for OR3A3 Gene

Entrez Gene Summary for OR3A3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR3A3 Gene

OR3A3 (Olfactory Receptor Family 3 Subfamily A Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR3A2.

UniProtKB/Swiss-Prot for OR3A3 Gene

  • Odorant receptor.

Gene Wiki entry for OR3A3 Gene

Additional gene information for OR3A3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR3A3 Gene

Genomics for OR3A3 Gene

Regulatory Elements for OR3A3 Gene

Enhancers for OR3A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H003534 1.2 ENCODE dbSUPER 10.3 +124.5 124470 2 HDGF PKNOX1 ATF1 ARNT SIN3A GLI4 ZNF2 GLIS2 ZNF302 ZNF143 TRPV3 RN7SL608P ZZEF1 ANKFY1 OR1E2 OR3A4P OR1D3P OR1E3 OR1D5 OR1D2
GH17H003386 0.5 FANTOM5 11.6 -25.1 -25059 0 POLR2A SPATA22 ASPA OR3A3 OR1E2 OR3A1 OR3A2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR3A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR3A3 Gene

Chromosome:
17
Start:
3,411,370 bp from pter
End:
3,424,070 bp from pter
Size:
12,701 bases
Orientation:
Plus strand

Genomic View for OR3A3 Gene

Genes around OR3A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR3A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR3A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR3A3 Gene

Proteins for OR3A3 Gene

  • Protein details for OR3A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47888-OR3A3_HUMAN
    Recommended name:
    Olfactory receptor 3A3
    Protein Accession:
    P47888
    Secondary Accessions:
    • Q2VPE4
    • Q6IFM6
    • Q9P1Q4
    • Q9UBE7

    Protein attributes for OR3A3 Gene

    Size:
    321 amino acids
    Molecular mass:
    34963 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI08922.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR3A3 Gene

Post-translational modifications for OR3A3 Gene

  • Glycosylation at posLast=1414
  • Modification sites at PhosphoSitePlus

Other Protein References for OR3A3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR3A3 Gene

Domains & Families for OR3A3 Gene

Gene Families for OR3A3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR3A3 Gene

Suggested Antigen Peptide Sequences for OR3A3 Gene

Graphical View of Domain Structure for InterPro Entry

P47888

UniProtKB/Swiss-Prot:

OR3A3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR3A3: view

Function for OR3A3 Gene

Molecular function for OR3A3 Gene

GENATLAS Biochemistry:
olfactory receptor,family 3,subfamily A,member 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR3A3: view
genes like me logo Genes that share phenotypes with OR3A3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR3A3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR3A3 Gene

Localization for OR3A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR3A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR3A3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR3A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR3A3 Gene

Pathways & Interactions for OR3A3 Gene

genes like me logo Genes that share pathways with OR3A3: view

Pathways by source for OR3A3 Gene

1 KEGG pathway for OR3A3 Gene

Interacting Proteins for OR3A3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000291231%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000367869%0d%0a9606.ENSP00000248572%0d%0a9606.ENSP00000269260%0d%0a9606.ENSP00000248150%0d%0a
Selected Interacting proteins: ENSP00000291231 P47888-OR3A3_HUMAN for OR3A3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 8004088
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR3A3: view

No data available for SIGNOR curated interactions for OR3A3 Gene

Drugs & Compounds for OR3A3 Gene

No Compound Related Data Available

Transcripts for OR3A3 Gene

mRNA/cDNA for OR3A3 Gene

(2) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR3A3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR3A3 Gene

No ASD Table

Relevant External Links for OR3A3 Gene

GeneLoc Exon Structure for
OR3A3
ECgene alternative splicing isoforms for
OR3A3

Expression for OR3A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR3A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR3A3 Gene:

OR3A3

SOURCE GeneReport for Unigene cluster for OR3A3 Gene:

Hs.532689
genes like me logo Genes that share expression patterns with OR3A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR3A3 Gene

Orthologs for OR3A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR3A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC454428 33
  • 96.57 (n)
OR3A3 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC508980 33
  • 83.49 (n)
-- 34
  • 72 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia OR01E11 33
  • 83.12 (n)
-- 34
  • 71 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr411 33 16
  • 81.21 (n)
Olfr399 34
  • 72 (a)
ManyToMany
Or3a10 52 Olfr139
  • chr11:74,044,328-74,045,272
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 44 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
ManyToMany
Species where no ortholog for OR3A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR3A3 Gene

ENSEMBL:
Gene Tree for OR3A3 (if available)
TreeFam:
Gene Tree for OR3A3 (if available)

Paralogs for OR3A3 Gene

Paralogs for OR3A3 Gene

(458) SIMAP similar genes for OR3A3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR3A3 Gene

genes like me logo Genes that share paralogs with OR3A3: view

Variants for OR3A3 Gene

Sequence variations from dbSNP and Humsavar for OR3A3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000128601 -- 3,420,944(+) GACCG(A/C/T)CATGG reference, missense
rs1000442391 -- 3,422,146(+) GCCAG(A/G)AATCA downstream-variant-500B
rs1000452194 -- 3,421,880(+) GCTGG(C/T)AAGAC downstream-variant-500B
rs1002122730 -- 3,420,308(+) TACAC(G/T)TTATT upstream-variant-2KB
rs1003789152 -- 3,419,837(+) CACAC(A/C)ATTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR3A3 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV deletion 23128226
esv3892950 CNV loss 25118596
nsv1055740 CNV gain 25217958
nsv1059413 CNV loss 25217958
nsv1060071 CNV loss 25217958
nsv1065489 CNV gain 25217958
nsv521277 CNV gain 19592680
nsv574232 CNV gain 21841781
nsv574236 CNV gain 21841781
nsv833341 CNV loss 17160897
nsv978351 CNV duplication 23825009

Variation tolerance for OR3A3 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.38; 96.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR3A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR3A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR3A3 Gene

Disorders for OR3A3 Gene

Relevant External Links for OR3A3

Genetic Association Database (GAD)
OR3A3
Human Genome Epidemiology (HuGE) Navigator
OR3A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR3A3

No disorders were found for OR3A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR3A3 Gene

Publications for OR3A3 Gene

  1. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N … Lehrach H (Human molecular genetics 1994) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 60
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 60

Products for OR3A3 Gene

Sources for OR3A3 Gene

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