Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR3A3 Gene

Aliases for OR3A3 Gene

  • Olfactory Receptor Family 3 Subfamily A Member 3 2 3 5
  • Olfactory Receptor, Family 3, Subfamily A, Member 3 2 3
  • Olfactory Receptor OR17-22 3 4
  • Olfactory Receptor 17-201 3 4
  • Olfactory Receptor 3A6 3 4
  • Olfactory Receptor 3A7 3 4
  • Olfactory Receptor 3A8 3 4
  • OR17-201 3 4
  • OR3A8P 3 4
  • OR3A6 3 4
  • OR3A7 3 4
  • Olfactory Receptor, Family 3, Subfamily A, Member 8 Pseudogene 3
  • Olfactory Receptor, Family 3, Subfamily A, Member 6 3
  • Olfactory Receptor, Family 3, Subfamily A, Member 7 3
  • OR17-137 3
  • OR17-16 3

External Ids for OR3A3 Gene

Previous HGNC Symbols for OR3A3 Gene

  • OR3A6
  • OR3A7
  • OR3A8P

Previous GeneCards Identifiers for OR3A3 Gene

  • GC17P003638
  • GC17P003274
  • GC17P003530
  • GC17P003270
  • GC17P003323

Summaries for OR3A3 Gene

Entrez Gene Summary for OR3A3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR3A3 Gene

OR3A3 (Olfactory Receptor Family 3 Subfamily A Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR3A1.

UniProtKB/Swiss-Prot for OR3A3 Gene

  • Odorant receptor.

Gene Wiki entry for OR3A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR3A3 Gene

Genomics for OR3A3 Gene

Regulatory Elements for OR3A3 Gene


Genomic Location for OR3A3 Gene

Chromosome:
17
Start:
3,420,424 bp from pter
End:
3,421,666 bp from pter
Size:
1,243 bases
Orientation:
Plus strand

Genomic View for OR3A3 Gene

Genes around OR3A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR3A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR3A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR3A3 Gene

Proteins for OR3A3 Gene

  • Protein details for OR3A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47888-OR3A3_HUMAN
    Recommended name:
    Olfactory receptor 3A3
    Protein Accession:
    P47888
    Secondary Accessions:
    • Q2VPE4
    • Q6IFM6
    • Q9P1Q4
    • Q9UBE7

    Protein attributes for OR3A3 Gene

    Size:
    321 amino acids
    Molecular mass:
    34963 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI08922.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR3A3 Gene

Proteomics data for OR3A3 Gene at MOPED

Post-translational modifications for OR3A3 Gene

  • Glycosylation at Asn 14
  • Modification sites at PhosphoSitePlus

Other Protein References for OR3A3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR3A3 Gene

Domains & Families for OR3A3 Gene

Gene Families for OR3A3 Gene

Protein Domains for OR3A3 Gene

Suggested Antigen Peptide Sequences for OR3A3 Gene

Graphical View of Domain Structure for InterPro Entry

P47888

UniProtKB/Swiss-Prot:

OR3A3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR3A3: view

Function for OR3A3 Gene

Molecular function for OR3A3 Gene

GENATLAS Biochemistry:
olfactory receptor,family 3,subfamily A,member 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR3A3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR3A3 Gene

Localization for OR3A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR3A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR3A3 Gene COMPARTMENTS Subcellular localization image for OR3A3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR3A3: view

Pathways & Interactions for OR3A3 Gene

genes like me logo Genes that share pathways with OR3A3: view

Pathways by source for OR3A3 Gene

1 KEGG pathway for OR3A3 Gene

Interacting Proteins for OR3A3 Gene

Gene Ontology (GO) - Biological Process for OR3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR3A3: view

No data available for SIGNOR curated interactions for OR3A3 Gene

Drugs & Compounds for OR3A3 Gene

No Compound Related Data Available

Transcripts for OR3A3 Gene

mRNA/cDNA for OR3A3 Gene

(2) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR3A3 Gene

No ASD Table

Relevant External Links for OR3A3 Gene

GeneLoc Exon Structure for
OR3A3
ECgene alternative splicing isoforms for
OR3A3

Expression for OR3A3 Gene

mRNA expression in normal human tissues for OR3A3 Gene

SOURCE GeneReport for Unigene cluster for OR3A3 Gene Hs.532689

genes like me logo Genes that share expression patterns with OR3A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR3A3 Gene

Orthologs for OR3A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR3A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC508980 35
  • 83.49 (n)
  • 81.79 (a)
-- 36
  • 72 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia OR01E11 35
  • 83.12 (n)
  • 81.53 (a)
-- 36
  • 71 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr411 35
  • 81.21 (n)
  • 78.66 (a)
Olfr411 16
Olfr399 36
  • 72 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC454428 35
  • 96.57 (n)
  • 93.77 (a)
OR3A3 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
ManyToMany
Species with no ortholog for OR3A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR3A3 Gene

ENSEMBL:
Gene Tree for OR3A3 (if available)
TreeFam:
Gene Tree for OR3A3 (if available)

Paralogs for OR3A3 Gene

Paralogs for OR3A3 Gene

(458) SIMAP similar genes for OR3A3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR3A3 Gene

genes like me logo Genes that share paralogs with OR3A3: view

Variants for OR3A3 Gene

Sequence variations from dbSNP and Humsavar for OR3A3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs769432 - 3,420,961(+) ACCGA(C/T)TCCTG reference, missense
rs916039 - 3,421,040(-) AAGCC(A/C)AGGAC reference, missense
rs12939997 - 3,421,426(+) TTTTC(A/G)TGACT reference, missense
rs227787 - 3,421,516(-) TCGCT(C/T)CCCCA reference, missense
rs227788 -- 3,420,792(+) AACCT(A/G)TCAGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR3A3 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV Deletion 23128226
nsv907553 CNV Loss 21882294
nsv833341 CNV Loss 17160897
nsv521277 CNV Gain 19592680

Variation tolerance for OR3A3 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.38; 96.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR3A3 Gene

Disorders for OR3A3 Gene

Relevant External Links for OR3A3

Genetic Association Database (GAD)
OR3A3
Human Genome Epidemiology (HuGE) Navigator
OR3A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR3A3

No disorders were found for OR3A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR3A3 Gene

Publications for OR3A3 Gene

  1. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N. … North M.A. (Hum. Mol. Genet. 1994) 2 3 4 67
  2. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3
  5. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for OR3A3 Gene

Sources for OR3A3 Gene

Content