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Aliases for OR3A2 Gene

Aliases for OR3A2 Gene

  • Olfactory Receptor Family 3 Subfamily A Member 2 2 3 5
  • Olfactory Receptor OR17-14 3 4
  • Olfactory Receptor 17-228 3 4
  • OR17-228 3 4
  • OLFRA04 3 4
  • Olfactory Receptor, Family 3, Subfamily A, Member 2 2
  • Olfactory Receptor 3A2 3
  • OR17-14 3
  • OR228 3

External Ids for OR3A2 Gene

Previous GeneCards Identifiers for OR3A2 Gene

  • GC17U990068
  • GC17M003522
  • GC17M003132
  • GC17M003387
  • GC17M003128

Summaries for OR3A2 Gene

Entrez Gene Summary for OR3A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR3A2 Gene

OR3A2 (Olfactory Receptor Family 3 Subfamily A Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and receptor activity. An important paralog of this gene is OR3A3.

UniProtKB/Swiss-Prot for OR3A2 Gene

  • Odorant receptor.

Gene Wiki entry for OR3A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR3A2 Gene

Genomics for OR3A2 Gene

Regulatory Elements for OR3A2 Gene

Enhancers for OR3A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around OR3A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR3A2 Gene

Chromosome:
17
Start:
3,277,890 bp from pter
End:
3,278,974 bp from pter
Size:
1,085 bases
Orientation:
Minus strand

Genomic View for OR3A2 Gene

Genes around OR3A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR3A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR3A2 Gene

Proteins for OR3A2 Gene

  • Protein details for OR3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47893-OR3A2_HUMAN
    Recommended name:
    Olfactory receptor 3A2
    Protein Accession:
    P47893
    Secondary Accessions:
    • Q6IFM3
    • Q9P1Q3

    Protein attributes for OR3A2 Gene

    Size:
    321 amino acids
    Molecular mass:
    35207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR3A2 Gene

Post-translational modifications for OR3A2 Gene

  • Glycosylation at Asn 14
  • Modification sites at PhosphoSitePlus

Other Protein References for OR3A2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR3A2 Gene

Domains & Families for OR3A2 Gene

Gene Families for OR3A2 Gene

Protein Domains for OR3A2 Gene

Suggested Antigen Peptide Sequences for OR3A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47893

UniProtKB/Swiss-Prot:

OR3A2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR3A2: view

Function for OR3A2 Gene

Molecular function for OR3A2 Gene

GENATLAS Biochemistry:
olfactory receptor gene family 3,subfamily A,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8921386
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR3A2: view
genes like me logo Genes that share phenotypes with OR3A2: view

Animal Model Products

CRISPR Products

miRNA for OR3A2 Gene

miRTarBase miRNAs that target OR3A2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR3A2 Gene

Localization for OR3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR3A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR3A2 Gene COMPARTMENTS Subcellular localization image for OR3A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8921386
genes like me logo Genes that share ontologies with OR3A2: view

Pathways & Interactions for OR3A2 Gene

genes like me logo Genes that share pathways with OR3A2: view

Pathways by source for OR3A2 Gene

1 KEGG pathway for OR3A2 Gene

Gene Ontology (GO) - Biological Process for OR3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8921386
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007606 sensory perception of chemical stimulus TAS 8921386
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR3A2: view

No data available for SIGNOR curated interactions for OR3A2 Gene

Drugs & Compounds for OR3A2 Gene

No Compound Related Data Available

Transcripts for OR3A2 Gene

mRNA/cDNA for OR3A2 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR3A2 Gene

Olfactory receptor, family 3, subfamily A, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR3A2 Gene

No ASD Table

Relevant External Links for OR3A2 Gene

GeneLoc Exon Structure for
OR3A2
ECgene alternative splicing isoforms for
OR3A2

Expression for OR3A2 Gene

mRNA expression in normal human tissues for OR3A2 Gene

mRNA differential expression in normal tissues according to GTEx for OR3A2 Gene

This gene is overexpressed in Testis (x14.2).

NURSA nuclear receptor signaling pathways regulating expression of OR3A2 Gene:

OR3A2

SOURCE GeneReport for Unigene cluster for OR3A2 Gene:

Hs.647414
genes like me logo Genes that share expression patterns with OR3A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR3A2 Gene

Orthologs for OR3A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR3A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC509526 34
  • 86.62 (n)
  • 85.99 (a)
-- 35
  • 85 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR3A2 34
  • 83.54 (n)
  • 80.19 (a)
OR12C10 35
  • 43 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr410 34
  • 79.59 (n)
  • 77.56 (a)
Olfr410 16
Olfr411 35
  • 77 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC454427 34
  • 97.61 (n)
  • 96.26 (a)
OR3A2 35
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1512 34
  • 80.94 (n)
  • 77.32 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
ManyToMany
Species where no ortholog for OR3A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR3A2 Gene

ENSEMBL:
Gene Tree for OR3A2 (if available)
TreeFam:
Gene Tree for OR3A2 (if available)

Paralogs for OR3A2 Gene

Paralogs for OR3A2 Gene

(455) SIMAP similar genes for OR3A2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR3A2 Gene

genes like me logo Genes that share paralogs with OR3A2: view

Variants for OR3A2 Gene

Sequence variations from dbSNP and Humsavar for OR3A2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs9901356 - 3,278,368(+) TGGGA(C/G)GTCAC reference, missense
rs743610 -- 3,279,102(-) TGGTG(G/T)CATTG upstream-variant-2KB
rs769434 -- 3,278,090(-) AAAGG(A/G)GTTGG reference, synonymous-codon
rs2003789 -- 3,278,990(-) GTTTA(A/T)AATAT upstream-variant-2KB
rs2013809 -- 3,278,261(+) TAGGC(A/G)GTGAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR3A2 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV deletion 23128226
esv3892949 CNV loss 25118596
esv3892950 CNV loss 25118596
nsv1060926 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv457638 CNV gain 19166990
nsv457639 CNV gain 19166990
nsv470570 CNV gain 18288195
nsv574231 CNV gain 21841781
nsv574232 CNV gain 21841781
nsv574233 CNV gain 21841781
nsv574234 CNV gain 21841781
nsv827859 CNV gain 20364138
nsv960398 CNV duplication 23825009

Variation tolerance for OR3A2 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.13; 84.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR3A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR3A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR3A2 Gene

Disorders for OR3A2 Gene

Relevant External Links for OR3A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR3A2

No disorders were found for OR3A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR3A2 Gene

Publications for OR3A2 Gene

  1. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G. … Lancet D. (Genomics 2000) 2 3 4 65
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 65
  3. Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. (PMID: 8921386) Glusman G. … Lancet D. (Genomics 1996) 2 3 65
  4. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N. … North M.A. (Hum. Mol. Genet. 1994) 3 4 65
  5. Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. (PMID: 23958962) Gelernter J. … Farrer L. (Mol. Psychiatry 2013) 3 65

Products for OR3A2 Gene

Sources for OR3A2 Gene

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