Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR3A2 Gene

Aliases for OR3A2 Gene

  • Olfactory Receptor Family 3 Subfamily A Member 2 2 3 5
  • Olfactory Receptor OR17-14 3 4
  • Olfactory Receptor 17-228 3 4
  • OR17-228 3 4
  • OLFRA04 3 4
  • Olfactory Receptor, Family 3, Subfamily A, Member 2 2
  • Olfactory Receptor 3A2 3
  • OR17-14 3
  • OR228 3

External Ids for OR3A2 Gene

Previous GeneCards Identifiers for OR3A2 Gene

  • GC17U990068
  • GC17M003522
  • GC17M003132
  • GC17M003387
  • GC17M003128

Summaries for OR3A2 Gene

Entrez Gene Summary for OR3A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR3A2 Gene

OR3A2 (Olfactory Receptor Family 3 Subfamily A Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and receptor activity. An important paralog of this gene is OR3A3.

UniProtKB/Swiss-Prot for OR3A2 Gene

  • Odorant receptor.

Gene Wiki entry for OR3A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR3A2 Gene

Genomics for OR3A2 Gene

Regulatory Elements for OR3A2 Gene

Enhancers for OR3A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F002958 1.5 FANTOM5 Ensembl ENCODE 4.5 +318.5 318531 3.0 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 GLIS2 FOS SP5 MXD4 SGSM2 RAP1GAP2 ENSG00000263345 ENSG00000263050 OR3A2 OR1G1 LOC101927911 GC17P002937
GH17F003130 0.3 FANTOM5 16.9 +148.1 148146 0.2 OR3A2 OR1A1 OR1E2 OR1G1 OR1A2 TRPV3 TRPV1 GC17P003146
GH17F003749 1.3 FANTOM5 Ensembl ENCODE 2.8 -471.7 -471717 2.2 HDGF PKNOX1 MAZ BHLHE40 EBF1 TBX21 EP300 ZFHX2 POLR2A IKZF1 GSG2 P2RX5 NCBP3 OR1E2 OR3A2 ATP2A3 ENSG00000262358 ITGAE
GH17F002899 1.2 FANTOM5 Ensembl ENCODE 1.4 +376.8 376796 5.3 KLF1 RFX1 SMARCA4 POLR2A REST FOS ZIC2 EGR2 OR3A2 GC17M002894 GC17M002899
GH17F003631 0.4 FANTOM5 2.4 -352.6 -352557 0.0 SP3 OR1E2 OR1A2 SHPK OR1A1 OR3A2 OR1E1 ENSG00000262304 LOC100422717
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR3A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR3A2 Gene

Chromosome:
17
Start:
3,277,890 bp from pter
End:
3,278,974 bp from pter
Size:
1,085 bases
Orientation:
Minus strand

Genomic View for OR3A2 Gene

Genes around OR3A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR3A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR3A2 Gene

Proteins for OR3A2 Gene

  • Protein details for OR3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47893-OR3A2_HUMAN
    Recommended name:
    Olfactory receptor 3A2
    Protein Accession:
    P47893
    Secondary Accessions:
    • Q6IFM3
    • Q9P1Q3

    Protein attributes for OR3A2 Gene

    Size:
    321 amino acids
    Molecular mass:
    35207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR3A2 Gene

Post-translational modifications for OR3A2 Gene

  • Glycosylation at Asn 14
  • Modification sites at PhosphoSitePlus

Other Protein References for OR3A2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR3A2 Gene

Domains & Families for OR3A2 Gene

Gene Families for OR3A2 Gene

Protein Domains for OR3A2 Gene

Suggested Antigen Peptide Sequences for OR3A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47893

UniProtKB/Swiss-Prot:

OR3A2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR3A2: view

Function for OR3A2 Gene

Molecular function for OR3A2 Gene

GENATLAS Biochemistry:
olfactory receptor gene family 3,subfamily A,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8921386
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR3A2: view
genes like me logo Genes that share phenotypes with OR3A2: view

Animal Model Products

miRNA for OR3A2 Gene

miRTarBase miRNAs that target OR3A2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR3A2 Gene

Localization for OR3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR3A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR3A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8921386
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR3A2: view

Pathways & Interactions for OR3A2 Gene

genes like me logo Genes that share pathways with OR3A2: view

Pathways by source for OR3A2 Gene

1 KEGG pathway for OR3A2 Gene

Gene Ontology (GO) - Biological Process for OR3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8921386
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007606 sensory perception of chemical stimulus TAS 8921386
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR3A2: view

No data available for SIGNOR curated interactions for OR3A2 Gene

Transcripts for OR3A2 Gene

mRNA/cDNA for OR3A2 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR3A2 Gene

Olfactory receptor, family 3, subfamily A, member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR3A2 Gene

No ASD Table

Relevant External Links for OR3A2 Gene

GeneLoc Exon Structure for
OR3A2
ECgene alternative splicing isoforms for
OR3A2

Expression for OR3A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR3A2 Gene

mRNA differential expression in normal tissues according to GTEx for OR3A2 Gene

This gene is overexpressed in Testis (x14.2).

NURSA nuclear receptor signaling pathways regulating expression of OR3A2 Gene:

OR3A2

SOURCE GeneReport for Unigene cluster for OR3A2 Gene:

Hs.647414
genes like me logo Genes that share expression patterns with OR3A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR3A2 Gene

Orthologs for OR3A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR3A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC454427 34
  • 97.61 (n)
OR3A2 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC509526 34
  • 86.62 (n)
-- 35
  • 85 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR3A2 34
  • 83.54 (n)
OR12C10 35
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1512 34
  • 80.94 (n)
mouse
(Mus musculus)
Mammalia Olfr410 34 16
  • 79.59 (n)
Olfr411 35
  • 77 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
ManyToMany
Species where no ortholog for OR3A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR3A2 Gene

ENSEMBL:
Gene Tree for OR3A2 (if available)
TreeFam:
Gene Tree for OR3A2 (if available)

Paralogs for OR3A2 Gene

Paralogs for OR3A2 Gene

(455) SIMAP similar genes for OR3A2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR3A2 Gene

genes like me logo Genes that share paralogs with OR3A2: view

Variants for OR3A2 Gene

Sequence variations from dbSNP and Humsavar for OR3A2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1029368 -- 3,336,083(+) ACTCT(C/T)CTTGC utr-variant-5-prime
rs10451232 -- 3,324,735(+) gagga(C/G)taccc intron-variant
rs10451247 -- 3,322,945(+) tcgtt(G/T)atctg intron-variant
rs10491219 -- 3,345,177(-) GTACC(A/G)ACATC intron-variant
rs10521124 -- 3,307,545(-) CATCT(A/G)ATGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR3A2 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV deletion 23128226
esv3892949 CNV loss 25118596
esv3892950 CNV loss 25118596
nsv1060926 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv457638 CNV gain 19166990
nsv457639 CNV gain 19166990
nsv470570 CNV gain 18288195
nsv574231 CNV gain 21841781
nsv574232 CNV gain 21841781
nsv574233 CNV gain 21841781
nsv574234 CNV gain 21841781
nsv827859 CNV gain 20364138
nsv960398 CNV duplication 23825009

Variation tolerance for OR3A2 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.13; 84.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR3A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR3A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR3A2 Gene

Disorders for OR3A2 Gene

Relevant External Links for OR3A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR3A2

No disorders were found for OR3A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR3A2 Gene

Publications for OR3A2 Gene

  1. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G. … Lancet D. (Genomics 2000) 2 3 4 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. (PMID: 8921386) Glusman G. … Lancet D. (Genomics 1996) 2 3 64
  4. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N. … North M.A. (Hum. Mol. Genet. 1994) 3 4 64
  5. Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. (PMID: 23958962) Gelernter J. … Farrer L. (Mol. Psychiatry 2013) 3 64

Products for OR3A2 Gene

Sources for OR3A2 Gene

Content
Loading form....