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Aliases for OR3A1 Gene

Aliases for OR3A1 Gene

  • Olfactory Receptor Family 3 Subfamily A Member 1 2 3 5
  • Olfactory Receptor OR17-15 3 4
  • Olfactory Receptor 17-40 3 4
  • OLFRA03 3 4
  • OR17-40 3 4
  • Olfactory Receptor, Family 3, Subfamily A, Member 1 2
  • Olfactory Receptor-Like Protein OR17-82 3
  • Olfactory Receptor 3A1 3
  • OR17-82 3
  • OR40 3

External Ids for OR3A1 Gene

Previous GeneCards Identifiers for OR3A1 Gene

  • GC17M003509
  • GC17M003536
  • GC17M003145
  • GC17M003401
  • GC17M003141
  • GC17M003194

Summaries for OR3A1 Gene

Entrez Gene Summary for OR3A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR3A1 Gene

OR3A1 (Olfactory Receptor Family 3 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR3A2.

UniProtKB/Swiss-Prot for OR3A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR3A1 Gene

Additional gene information for OR3A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR3A1 Gene

Genomics for OR3A1 Gene

Regulatory Elements for OR3A1 Gene

Enhancers for OR3A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H003386 0.5 FANTOM5 10.6 -0.1 -103 0.4 POLR2A SPATA22 ASPA OR3A3 OR1E2 OR3A1 OR3A2
GH17H003244 0.2 Ensembl 7 +141.3 141309 0.2 OR3A1 GC17M003252 OR1D4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR3A1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR3A1 Gene

Genomic Locations for OR3A1 Gene
97,892 bases
Minus strand

Genomic View for OR3A1 Gene

Genes around OR3A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR3A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR3A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR3A1 Gene

Proteins for OR3A1 Gene

  • Protein details for OR3A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 3A1
    Protein Accession:
    Secondary Accessions:
    • Q4VB06
    • Q6IFM4

    Protein attributes for OR3A1 Gene

    315 amino acids
    Molecular mass:
    34609 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR3A1 Gene

Post-translational modifications for OR3A1 Gene

  • Glycosylation at Asn8
  • Modification sites at PhosphoSitePlus

Other Protein References for OR3A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR3A1 Gene

Domains & Families for OR3A1 Gene

Gene Families for OR3A1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR3A1 Gene

Suggested Antigen Peptide Sequences for OR3A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR3A1: view

Function for OR3A1 Gene

Molecular function for OR3A1 Gene

GENATLAS Biochemistry:
olfactory receptor gene family 3,subfamily A,member 1,G protein coupled receptor superfamily,with odorant ligand
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with OR3A1: view
genes like me logo Genes that share phenotypes with OR3A1: view

Animal Model Products

CRISPR Products

miRNA for OR3A1 Gene

miRTarBase miRNAs that target OR3A1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR3A1 Gene

Localization for OR3A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR3A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR3A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with OR3A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR3A1 Gene

Pathways & Interactions for OR3A1 Gene

genes like me logo Genes that share pathways with OR3A1: view

Pathways by source for OR3A1 Gene

1 KEGG pathway for OR3A1 Gene

Interacting Proteins for OR3A1 Gene

Gene Ontology (GO) - Biological Process for OR3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,NAS 8921386
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR3A1: view

No data available for SIGNOR curated interactions for OR3A1 Gene

Drugs & Compounds for OR3A1 Gene

No Compound Related Data Available

Transcripts for OR3A1 Gene

mRNA/cDNA for OR3A1 Gene

(3) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR3A1 Gene

No ASD Table

Relevant External Links for OR3A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR3A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR3A1 Gene

mRNA differential expression in normal tissues according to GTEx for OR3A1 Gene

This gene is overexpressed in Testis (x14.3).

NURSA nuclear receptor signaling pathways regulating expression of OR3A1 Gene:


SOURCE GeneReport for Unigene cluster for OR3A1 Gene:

genes like me logo Genes that share expression patterns with OR3A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR3A1 Gene

Orthologs for OR3A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR3A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC468152 33
  • 98.52 (n)
OR3A1 34
  • 98 (a)
(Bos Taurus)
Mammalia OR3A1 33 34
  • 89.07 (n)
(Canis familiaris)
Mammalia LOC491212 33
  • 87.62 (n)
OR3A1 34
  • 84 (a)
(Mus musculus)
Mammalia Or3a1 52 Olfr410 34
  • 85 (a)
Or3a1c 52 Olfr402 33 16 34
  • 83.28 (n)
Or3a1b 52 Olfr401 34
  • 81 (a)
Or3a15-ps 52 Olfr400-ps1
  • chr11:74,110,257-74,110,788
Or3a1d 52 Olfr411
  • chr11:74,346,638-74,347,582
(Rattus norvegicus)
Mammalia Olr1517 33
  • 84.87 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
(Gallus gallus)
Aves -- 34
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 39 (a)
Species where no ortholog for OR3A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR3A1 Gene

Gene Tree for OR3A1 (if available)
Gene Tree for OR3A1 (if available)

Paralogs for OR3A1 Gene

Paralogs for OR3A1 Gene

(456) SIMAP similar genes for OR3A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR3A1: view

Variants for OR3A1 Gene

Sequence variations from dbSNP and Humsavar for OR3A1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000105503 -- 3,336,317(+) AAGTT(A/T)TCTGG intron-variant, upstream-variant-2KB
rs1000109280 -- 3,320,370(+) AGAAG(A/C)TCTTT intron-variant
rs1000363159 -- 3,313,862(+) ATGTT(C/T)AAGCC intron-variant
rs1000392153 -- 3,319,280(+) AGGAC(C/T)AGGCA intron-variant
rs1000477779 -- 3,336,131(+) TCTGT(A/G)GAAAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR3A1 Gene

Variant ID Type Subtype PubMed ID
nsv827859 CNV gain 20364138
nsv574235 CNV loss 21841781
nsv574234 CNV gain 21841781
nsv574233 CNV gain 21841781
nsv574232 CNV gain 21841781
nsv470570 CNV gain 18288195
nsv457639 CNV gain 19166990
nsv457638 CNV gain 19166990
nsv1065489 CNV gain 25217958
nsv1060926 CNV gain 25217958
esv3892950 CNV loss 25118596
esv3892949 CNV loss 25118596
esv3639741 CNV gain 21293372
esv2660206 CNV deletion 23128226

Variation tolerance for OR3A1 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR3A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR3A1 Gene

Disorders for OR3A1 Gene

Relevant External Links for OR3A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR3A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR3A1 Gene

Publications for OR3A1 Gene

  1. Olfactory receptor-encoding genes and pseudogenes are expressed in humans. (PMID: 8647456) Crowe ML … Connerton IF (Gene 1996) 2 3 4 60
  2. Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. (PMID: 8921386) Glusman G … Lancet D (Genomics 1996) 2 3 4 60
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G … Lancet D (Genomics 2000) 3 4 60

Products for OR3A1 Gene

Sources for OR3A1 Gene

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