OR3A1 Gene
protein-coding GIFtS: 53
GCID: GC17M003194
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|
olfactory receptor, family 3, subfamily A, member 1
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Aliases
for OR3A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 3, Subfamily A, Member 11 2 | | Olfactory Receptor 17-402 3 | | OLFRA031 2 3 | | Olfactory Receptor OR17-152 3 | | OR17-401 2 3 | | OR17-822 | | OR401 2 | | Olfactory Receptor 3A12 |
Export aliases for OR3A1 gene to outside databasesPrevious GC identifers: GC17M003509 GC17M003536 GC17M003145 GC17M003401 GC17M003141 |
Summaries
for OR3A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR3A1:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR3A1_HUMAN, P47881Function: Odorant receptor (Potential)
Gene Wiki entry for OR3A1
|
Genomic Views
for OR3A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR3A1 gene promoter:
Nkx3-1 Nkx3-1 v4 GATA-2 CREB Nkx3-1 v2 PPAR-gamma1 S8 deltaCREB Nkx3-1 v3 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR3A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR3A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3OR3A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M003194: view genomic region
(about GC identifiers)
Start:
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3,194,932 bp from pter |
End:
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3,195,876 bp from pter |
Size:
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945 bases |
Orientation:
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minus strand |
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Proteins
for OR3A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR3A1_HUMAN, P47881 (See
protein sequence)Recommended Name: Olfactory receptor 3A1 Size: 315 amino acids; 34609 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q4VB06 Q6IFM4Explore the universe of human proteins at neXtProt for OR3A1: NX_P47881
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P47881
HORDE protein sequence for OR3A1
OR3A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002541.2
ENSEMBL proteins: ENSP00000313803 Reactome Protein details: P47881
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR3A1 for ontologies About GeneDecksing
OR3A1 Antibody Products:
Assay Products for OR3A1: |
Protein
Domains /
Families
for OR3A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR3A1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P47881ProtoNet protein and cluster: P47881 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR3A1_HUMAN, P47881Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR3A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OR3A1_HUMAN, P47881Function: Odorant receptor (Potential) Genatlas biochemistry entry for OR3A1:olfactory receptor gene family 3,subfamily A,member 1,G protein coupled receptor superfamily,with odorant ligand
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR3A1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR3A1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR3A1 (NM_002550) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR3A1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR3A1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR3A1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for OR3A1:
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Pathways & Interactions
for OR3A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | | | 3 | GPCRs, Other | | | 4 | Class A/1 (Rhodopsin-like receptors) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for OR3A1
4 
Reactome Pathways for OR3A1
1 
Kegg Pathway (Kegg details for OR3A1):
OR3A1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR3A1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/274 Interacting proteins for OR3A1 (P478812, 3 ENSP000003138034) via UniProtKB, MINT, STRING, and/or I2D (see all 274)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
NAS | 8921386 | | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell |
TAS | 8647456 |
OR3A1 for ontologies About GeneDecksing
|
Drugs & Compounds
for OR3A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR3A1
Search CenterWatch for drugs/clinical trials and news about OR3A1
|
Transcripts
for OR3A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR3A1 gene: NM_002550.2 Unigene Cluster for OR3A1: Olfactory receptor, family 3, subfamily A, member 1 Hs.647410 Unigene Representative Sequence: NM_0025501 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000323404(uc002fvh.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR3A1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR3A1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR3A1 (NM_002550) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR3A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR3A1 |
Additional cDNA sequence: BC069414.1 BC096187.3 BC096188.3 BC096189.3 BC096190.1 1 DOTS entry: DT.91929335 2 AceView cDNA sequences: BC069414 NM_002550
GeneLoc Exon Structure
|
Expression
for OR3A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR3A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAACCCAA
About this image
See OR3A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR3A1
SOURCE GeneReport for Unigene cluster: Hs.647410
SABiosciences Custom PCR Arrays for OR3A1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR3A1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR3A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR3A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR3A1 |
Orthologs
for OR3A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OR3A1 (if available)
TreeFam Gene Tree for OR3A1 (if available) |
Paralogs
for OR3A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR3A1 gene
- OR5V12 OR3A22 OR3A32
18/457 SIMAP similar genes for OR3A1 using alignment to 1 protein entry: OR3A1_HUMAN(see all similar genes):OR17-16 OR3A2 OR3A3 OR17-137 OR17-15 OR3A4P
OR5V1 OR1F2P OR5A2 OR5B21 OR5AR1 HSA10
JCG4 OR13G1 OR16-90 OR1C1 OR1F1 OR1J4
OR3A1 for paralogs About GeneDecksing
|
Genomic Variants
for OR3A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR3A1 ( 3194932 - 3195876 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR3A1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR3A1 |
|
Disorders
/ Diseases
for OR3A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR3A1 for disorders About GeneDecksing
1  disease for OR3A1: About MalaCardsneuronitis
Export disorders for OR3A1 gene to outside databases
|
Publications
for OR3A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR3A1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with OR3A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. (PubMed id 8921386)1, 2, 3 Glusman G.... Lancet D. (1996)
- Olfactory receptor-encoding genes and pseudogenes are expressed in humans. (PubMed id 8647456)1, 2, 3 Crowe M.L.... Connerton I.F. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PubMed id 10673334)1, 2 Glusman G.... Lancet D. (2000)
- Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PubMed id 8004088)1, 2 Ben-Arie N.... North M.A. (1994)
- A new concept of olfactory biosensor based on interdigitated microelectrodes and immobilized yeasts expressing the human receptor OR17-40. (PubMed id 17579849)1 Marrakchi M....Pajot-Augy E. (2007)
- Visualizing odorant receptor trafficking in living cells down to the single-molecule level. (PubMed id 16980412)1 Jacquier V....Vogel H. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for OR3A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing OR3A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR3A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR3A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR3A1 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR3A1 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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| | |
About This Section
| Patent Information for OR3A1 gene:
Search GeneIP for patents involving OR3A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR3A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR3A1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR3A1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR3A1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR3A1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR3A1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR3A1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR3A1 | | OriGene Custom Protein Services for OR3A1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR3A1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR3A1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR3A1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR3A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR3A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR3A1 |
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 | | | OR3A1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for OR3A1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR3A1 |
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