Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR2Z1 Gene

Aliases for OR2Z1 Gene

  • Olfactory Receptor Family 2 Subfamily Z Member 1 2 3 5
  • Olfactory Receptor, Family 2, Subfamily Z, Member 2 2 3
  • Olfactory Receptor, Family 2, Subfamily Z, Member 1 2 3
  • Olfactory Receptor OR19-4 3 4
  • Olfactory Receptor 2Z2 3 4
  • OR2Z2 3 4
  • OR19-4 3

External Ids for OR2Z1 Gene

Previous HGNC Symbols for OR2Z1 Gene

  • OR2Z2

Previous GeneCards Identifiers for OR2Z1 Gene

  • GC19U990261
  • GC19P008703
  • GC19P008841

Summaries for OR2Z1 Gene

Entrez Gene Summary for OR2Z1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2Z1 Gene

OR2Z1 (Olfactory Receptor Family 2 Subfamily Z Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2Z1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2Z1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2Z1 Gene

Genomics for OR2Z1 Gene

Regulatory Elements for OR2Z1 Gene


Genomic Location for OR2Z1 Gene

Chromosome:
19
Start:
8,730,954 bp from pter
End:
8,732,009 bp from pter
Size:
1,056 bases
Orientation:
Plus strand

Genomic View for OR2Z1 Gene

Genes around OR2Z1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2Z1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2Z1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2Z1 Gene

Proteins for OR2Z1 Gene

  • Protein details for OR2Z1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG97-OR2Z1_HUMAN
    Recommended name:
    Olfactory receptor 2Z1
    Protein Accession:
    Q8NG97
    Secondary Accessions:
    • B9EH50
    • Q6IFK0
    • Q96R25

    Protein attributes for OR2Z1 Gene

    Size:
    314 amino acids
    Molecular mass:
    34444 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2Z1 Gene

Proteomics data for OR2Z1 Gene at MOPED

Post-translational modifications for OR2Z1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2Z1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

  • Abcam antibodies for OR2Z1
  • Santa Cruz Biotechnology (SCBT) Antibodies for OR2Z1

No data available for DME Specific Peptides for OR2Z1 Gene

Domains & Families for OR2Z1 Gene

Gene Families for OR2Z1 Gene

Protein Domains for OR2Z1 Gene

Suggested Antigen Peptide Sequences for OR2Z1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG97

UniProtKB/Swiss-Prot:

OR2Z1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2Z1: view

Function for OR2Z1 Gene

Molecular function for OR2Z1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR2Z1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2Z1 Gene

Localization for OR2Z1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2Z1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2Z1 Gene COMPARTMENTS Subcellular localization image for OR2Z1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2Z1: view

Pathways & Interactions for OR2Z1 Gene

genes like me logo Genes that share pathways with OR2Z1: view

Pathways by source for OR2Z1 Gene

Interacting Proteins for OR2Z1 Gene

Gene Ontology (GO) - Biological Process for OR2Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2Z1: view

No data available for SIGNOR curated interactions for OR2Z1 Gene

Drugs & Compounds for OR2Z1 Gene

No Compound Related Data Available

Transcripts for OR2Z1 Gene

mRNA/cDNA for OR2Z1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2Z1 Gene

No ASD Table

Relevant External Links for OR2Z1 Gene

GeneLoc Exon Structure for
OR2Z1
ECgene alternative splicing isoforms for
OR2Z1

Expression for OR2Z1 Gene

mRNA expression in normal human tissues for OR2Z1 Gene

SOURCE GeneReport for Unigene cluster for OR2Z1 Gene Hs.553675

genes like me logo Genes that share expression patterns with OR2Z1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR2Z1 Gene

Orthologs for OR2Z1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2Z1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR2Z1 35
  • 85.17 (n)
  • 85.06 (a)
OR2Z1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR2Z1 35
  • 86.5 (n)
  • 87.14 (a)
OR2Z1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr372 35
  • 74.28 (n)
  • 74.92 (a)
Olfr373 16
Olfr373 36
  • 73 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia OR2Z1 35
  • 99.15 (n)
  • 99.04 (a)
OR2Z1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1096 35
  • 77.1 (n)
  • 74.76 (a)
oppossum
(Monodelphis domestica)
Mammalia OR2Z1 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OR2Z1 36
  • 55 (a)
OneToOne
Species with no ortholog for OR2Z1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2Z1 Gene

ENSEMBL:
Gene Tree for OR2Z1 (if available)
TreeFam:
Gene Tree for OR2Z1 (if available)

Paralogs for OR2Z1 Gene

(445) SIMAP similar genes for OR2Z1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2Z1: view

Variants for OR2Z1 Gene

Sequence variations from dbSNP and Humsavar for OR2Z1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs58741481 - 8,731,440(+) TGAGA(A/C/T)GCCAG reference, missense
rs8099865 -- 8,729,294(+) cctgc(G/T)taccc upstream-variant-2KB
rs890848 -- 8,731,601(-) CAGGT(A/G)TCTGC reference, synonymous-codon
rs1078042 -- 8,731,445(+) CGCCA(A/G)GTATG reference, synonymous-codon
rs28442285 -- 8,730,149(+) TGCTC(A/G)TTTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2Z1 Gene

Variant ID Type Subtype PubMed ID
nsv469747 CNV Complex 16826518
nsv471705 CNV Gain+Loss 15918152
nsv833735 CNV Gain+Loss 17160897
nsv469648 CNV Complex 16826518
nsv833737 CNV Gain+Loss 17160897
nsv2402 CNV Loss 18451855
dgv571n67 CNV Gain 20364138

Variation tolerance for OR2Z1 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR2Z1 Gene

Disorders for OR2Z1 Gene

Relevant External Links for OR2Z1

Genetic Association Database (GAD)
OR2Z1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2Z1

No disorders were found for OR2Z1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2Z1 Gene

Publications for OR2Z1 Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2Z1 Gene

Sources for OR2Z1 Gene

Content