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OR2Z1 Gene

protein-coding   GIFtS: 49
GCID: GC19P008841

Olfactory Receptor, Family 2, Subfamily Z, Member 1

(Previous names: olfactory receptor, family 2, subfamily Z, member 2)
(Previous symbol: OR2Z2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily Z, Member 11 2     Olfactory Receptor OR19-42 3
OR2Z21 2 3     OR19-42
Olfactory Receptor, Family 2, Subfamily Z, Member 21 2     Olfactory Receptor 2Z12
Olfactory Receptor 2Z22 3     

External Ids:    HGNC: 153911   Entrez Gene: 2843832   Ensembl: ENSG000001817337   UniProtKB: Q8NG973   

Export aliases for OR2Z1 gene to outside databases

Previous GC identifers: GC19U990261 GC19P008703 GC19P008704


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2Z1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2Z1 Gene:
OR2Z1 (olfactory receptor, family 2, subfamily Z, member 1) is a protein-coding gene. Diseases associated with OR2Z1 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T35.

UniProtKB/Swiss-Prot: OR2Z1_HUMAN, Q8NG97
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2Z1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2Z1 gene promoter:
         E2F-4   E2F-3a   Pax-5   AML1a   MyoD   E2F-2   MEF-2A   IRF-2   E2F-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2Z1 promoter sequence
   Search Chromatin IP Primers for OR2Z1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2Z1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

OR2Z1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2Z1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P008841:  view genomic region     (about GC identifiers)

Start:
8,841,391 bp from pter      End:
8,842,332 bp from pter
Size:
942 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR2Z1_HUMAN, Q8NG97 (See protein sequence)
Recommended Name: Olfactory receptor 2Z1  
Size: 314 amino acids; 34444 Da
Secondary accessions: B9EH50 Q6IFK0 Q96R25

Explore the universe of human proteins at neXtProt for OR2Z1: NX_Q8NG97

Explore proteomics data for OR2Z1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR2Z1

    See OR2Z1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004699.1  
    ENSEMBL proteins: 
     ENSP00000316284  
    Reactome Protein details: Q8NG97

    OR2Z1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NG97

    ProtoNet protein and cluster: Q8NG97

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2Z1_HUMAN, Q8NG97
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR2Z1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2Z1_HUMAN, Q8NG97
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR2Z1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for OR2Z1:
     Increased S DNA content, incre  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR2Z1
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    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2Z1_HUMAN, Q8NG97: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR2Z1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2Z1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR2Z1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2Z1):
        Olfactory transduction


    OR2Z1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2Z1
    Interactions:

        Search GeneGlobe Interaction Network for OR2Z1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR2Z1 (ENSP000003162844) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR4Q3ENSP000003300494STRING: ENSP00000330049
    OR6C2ENSP000003236064STRING: ENSP00000323606
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR2Z1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2Z1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR2Z1 gene: 
    NM_001004699.2  

    Unigene Cluster for OR2Z1:

    Olfactory receptor, family 2, subfamily Z, member 1
    Hs.553675
    Unigene Representative Sequence: BC151149
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000324060(uc010xkg.2)
    miRNA
    Products:
         
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat OR2Z1
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    GenScript: all cDNA clones in your preferred vector: OR2Z1 (NM_001004699)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OR2Z1
      QuantiTect SYBR Green Assays in human, mouse, rat OR2Z1
      QuantiFast Probe-based Assays in human, mouse, rat OR2Z1

    Additional mRNA sequence: 

    BC137046.1 BC151149.1 

    1 AceView cDNA sequence:

    NM_001004699 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2Z1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCTTGCG
    OR2Z1 Expression
    About this image

    OR2Z1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2Z1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553675
        Custom PCR Arrays for OR2Z1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2Z1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2Z1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr3721 , 5 olfactory receptor 3721, 5 74.28(n)1
    74.92(a)1
      8 (34.74 cM)5
    4043151  NM_207555.21  NP_997438.11 
     720576605 


    ENSEMBL Gene Tree for OR2Z1 (if available)
    TreeFam Gene Tree for OR2Z1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2Z1 gene
    OR2T352  OR2V22  OR2V12  OR2M32  OR2T72  OR2M72  OR2T82  OR2M42  
    OR2T22  OR2T122  OR2T272  OR2M52  OR2T332  OR2AG12  OR2T52  OR2T102  
    OR2M22  OR2T42  OR2T342  OR2T112  OR2T292  OR2T62  OR2T12  OR2AG22  
    OR2T32  
    Selected SIMAP similar genes for OR2Z1 using alignment to 1 protein entry:     OR2Z1_HUMAN(see all similar genes):
    OR2V2    OR2AJ1    OR2AG2    OR2T7    OR2AG1    OR2L2
    OR2M7    OR2T1    OR2T12    OR2T27    OR2T33    OR2T35
    OR2T8    OR2V1    OR2AK2    OR2L5    OR2M5    OR2T11

    OR2Z1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2Z1 (see all 160)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs350019281,2
    C--8839452(+) TTTTTT/-AGTGG 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1824848591,2
    --8839452(+) GGGATC/GTTTTT 1 -- us2k10--------
    rs1879998571,2
    --8839505(+) TTAAAA/GCCTTC 1 -- us2k10--------
    rs739243591,2
    C,F--8839549(+) TCCTTA/GTTTGC 1 -- us2k13Minor allele frequency- G:0.26WA CSA 121
    rs1390005461,2
    --8839558(+) GCTTTC/TGGCGC 1 -- us2k10--------
    rs362411,2
    C,F,A,H--8839559(-) GGCGCC/TGAAAG 1 -- us2k120Minor allele frequency- T:0.20NS EA NA WA 2346
    rs1915348201,2
    --8839601(+) TTAACC/TCTTGC 1 -- us2k10--------
    rs1416370721,2
    --8839647(+) ATTTAC/TATTCC 1 -- us2k10--------
    rs1505172081,2
    --8839651(+) ATATTC/TCTGCG 1 -- us2k10--------
    rs1826025541,2
    --8839655(+) TCCTGC/TGTACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR2Z1 ( 8841391 - 8842332 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for OR2Z1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2402CNV Loss18451855
    dgv571n67CNV Gain20364138
    nsv833735CNV Gain+Loss17160897
    nsv833737CNV Gain+Loss17160897
    nsv471705CNV Gain+Loss15918152
    nsv469648CNV Complex16826518
    nsv469747CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR2Z1
    DNA2.0 Custom Variant and Variant Library Synthesis for OR2Z1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR2Z1:    
    About MalaCards
    neuronitis


    OR2Z1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OR2Z1

    Export disorders for OR2Z1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2Z1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2Z1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284383 HGNC: 15391 AceView: OR2Z1 Ensembl:ENSG00000181733 euGenes: HUgn284383
    ECgene: OR2Z1 Kegg: 284383 H-InvDB: OR2Z1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2Z1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2Z1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2Z1 gene:
    Search GeneIP for patents involving OR2Z1

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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