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OR2Y1 Gene

protein-coding   GIFtS: 47
GCID: GC05M180166

Olfactory Receptor, Family 2, Subfamily Y, Member 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily Y, Member 11 2
Olfactory Receptor OR5-22 3
OR5-22
Olfactory Receptor 2Y12

External Ids:    HGNC: 148371   Entrez Gene: 1340832   Ensembl: ENSG000001743397   UniProtKB: Q8NGV03   

Export aliases for OR2Y1 gene to outside databases

Previous GC identifers: GC05U990148 GC05M180277 GC05M180098


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2Y1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2Y1 Gene:
OR2Y1 (olfactory receptor, family 2, subfamily Y, member 1) is a protein-coding gene. Diseases associated with OR2Y1 include spondyloarthropathy, and reactive arthritis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2W1.

UniProtKB/Swiss-Prot: OR2Y1_HUMAN, Q8NGV0
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2Y1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2Y1 gene promoter:
         SRF   TBP   SRF (504 AA)   HNF-4alpha2   C/EBPalpha   HNF-4alpha1   S8   TFIID   HOXA5   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2Y1 promoter sequence
   Search Chromatin IP Primers for OR2Y1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2Y1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

OR2Y1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2Y1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M180166:  view genomic region     (about GC identifiers)

Start:
180,166,126 bp from pter      End:
180,167,058 bp from pter
Size:
933 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR2Y1_HUMAN, Q8NGV0 (See protein sequence)
Recommended Name: Olfactory receptor 2Y1  
Size: 311 amino acids; 34731 Da
Secondary accessions: B9EIP1 Q6IFB1 Q96R16

Explore the universe of human proteins at neXtProt for OR2Y1: NX_Q8NGV0

Explore proteomics data for OR2Y1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn264
  • HORDE protein sequence for OR2Y1

    See OR2Y1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001001657.1  
    ENSEMBL proteins: 
     ENSP00000312403  
    Reactome Protein details: Q8NGV0

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGV0

    ProtoNet protein and cluster: Q8NGV0

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2Y1_HUMAN, Q8NGV0
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR2Y1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2Y1_HUMAN, Q8NGV0
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR2Y1 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2Y1_HUMAN, Q8NGV0: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR2Y1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2Y1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR2Y1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2Y1):
        Olfactory transduction


    OR2Y1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2Y1
    Interactions:

        Search GeneGlobe Interaction Network for OR2Y1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR2Y1 (ENSP000003124034) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10K2ENSP000003242514STRING: ENSP00000324251
    OR10R2ENSP000003571344STRING: ENSP00000357134
    OR2A2ENSP000003862094STRING: ENSP00000386209
    OR2AT4ENSP000003048464STRING: ENSP00000304846
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR2Y1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2Y1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR2Y1 gene: 
    NM_001001657.1  

    Unigene Cluster for OR2Y1:

    Olfactory receptor, family 2, subfamily Y, member 1
    Hs.554719
    Unigene Representative Sequence: BC140756
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000307832(uc003mmf.1)
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      QuantiFast Probe-based Assays in human, mouse, rat OR2Y1

    Additional mRNA sequence: BC140756.1 
    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2Y1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTGCTGAG
    OR2Y1 Expression
    About this image

    OR2Y1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2Y1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.554719
        Custom PCR Arrays for OR2Y1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2Y1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr13855
    Olfr13861
    olfactory receptor 13855
    olfactory receptor 13861
    82.74(n)1
    83.17(a)1
      11 (29.56 cM)5
    2578881  NM_001011741.21  NP_001011741.11 
     494945355 


    ENSEMBL Gene Tree for OR2Y1 (if available)
    TreeFam Gene Tree for OR2Y1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2Y1 gene
    OR2W12  OR2J22  OR2G22  OR2J12  OR2H22  OR2C12  OR2H12  OR2W32  
    OR2J32  OR2G32  OR2C32  OR2G62  
    Selected SIMAP similar genes for OR2Y1 using alignment to 1 protein entry:     OR2Y1_HUMAN(see all similar genes):
    OR2J4P    OR2B8P    OR2G6    OR2J1    OR2J3    OR2C3
    OR2B2    OR2C1    OR2G2    OR2G3    OR2J2    OR2W6P
    OLFR 42A    6M1-16    OR2B3    OR2B6    OR2W3    OR2A12

    OR2Y1 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for OR2Y1 (see all 7)
    PGOHUM00000243555 PGOHUM00000235919 PGOHUM00000245382 PGOHUM00000236861 PGOHUM00000242997


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2Y1 (see all 114)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1139715231,2
    C--180165704(+) CATGCA/GCGGTG 1 -- ds50012Minor allele frequency- G:0.00CSA 2
    rs1391776751,2
    C--180165705(+) TGCGC-/GGGTGG 1 -- ds50010--------
    rs1919908601,2
    --180165705(+) ATGCGC/TGGTGG 1 -- ds50010--------
    rs1840117601,2
    --180165706(+) TGCGCA/GGTGGC 1 -- ds50010--------
    rs77372191,2
    C--180165743(+) GAGGCC/TGAGGC 1 -- ds50018Minor allele frequency- T:0.00NA WA CSA 14
    rs1490933431,2
    C--180165841(+) GGCGTA/GGTGGT 1 -- ds50010--------
    rs1885618561,2
    --180165870(+) CTACTC/TGGGAG 1 -- ds50010--------
    rs1502610631,2
    C--180165976(+) CTGTT-/CTCCCC 1 -- ds50010--------
    rs2016298111,2
    --180165979(+) TTCCC-/GCCCGC 1 -- ds50010--------
    rs20546961,2
    C,F,H--180165983(-) ggtggG/Cggggg 1 -- ds50019Minor allele frequency- C:0.04NS EA NA WA CSA 391

    HapMap Linkage Disequilibrium report for OR2Y1 ( 180166126 - 180167058 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OR2Y1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830565CNV Loss17160897
    nsv517459CNV Gain19592680
    dgv1882e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for OR2Y1:    
    About MalaCards
    spondyloarthropathy    reactive arthritis    arthritis    neuronitis
    obesity


    OR2Y1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OR2Y1

    Export disorders for OR2Y1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2Y1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2Y1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. (PubMed id 19851299)4 Johansson A....Gyllensten U. (Obesity (Silver Spring) 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 134083 HGNC: 14837 Ensembl:ENSG00000174339 euGenes: HUgn134083 ECgene: OR2Y1 Kegg: 134083
    H-InvDB: OR2Y1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2Y1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2Y1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2Y1 gene:
    Search GeneIP for patents involving OR2Y1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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