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Aliases for OR2Y1 Gene

Aliases for OR2Y1 Gene

  • Olfactory Receptor Family 2 Subfamily Y Member 1 2 3 5
  • Olfactory Receptor OR5-2 3 4
  • Olfactory Receptor, Family 2, Subfamily Y, Member 1 2
  • Olfactory Receptor 2Y1 3
  • OR5-2 3

External Ids for OR2Y1 Gene

Previous GeneCards Identifiers for OR2Y1 Gene

  • GC05U990148
  • GC05M180277
  • GC05M180098
  • GC05M180166

Summaries for OR2Y1 Gene

Entrez Gene Summary for OR2Y1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2Y1 Gene

OR2Y1 (Olfactory Receptor Family 2 Subfamily Y Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2G3.

UniProtKB/Swiss-Prot for OR2Y1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2Y1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2Y1 Gene

Genomics for OR2Y1 Gene

Regulatory Elements for OR2Y1 Gene

Enhancers for OR2Y1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F180688 1.6 FANTOM5 Ensembl ENCODE 11.4 +50.3 50347 3.3 CTCF KLF1 ZMYM3 MNT RAD21 TEAD3 CBX1 SMARCA4 SCRT2 ZNF600 FLT4 OR2Y1 MGAT1 GC05P180934 GC05P180939 PIR39363 PIR40400
GH05F180784 1.2 Ensembl ENCODE 10.8 -46.8 -46788 5.8 PLRG1 RAD21 RFX5 CHAMP1 ZNF335 ZNF143 ZNF207 EGR2 ZNF263 ZNF654 ZFP62 MGAT1 LOC100996419 OR2V2 OR2Y1 ENSG00000250900 CNOT6 TBC1D9B RN7SKP150 TRIM7
GH05F180790 0.2 ENCODE 10.8 -50.0 -50047 0.2 CTCF RAD51 L3MBTL2 USF2 RAD21 EGR2 MGAT1 OR2V2 OR2Y1 ENSG00000250900 TRIM7 GC05M180785 PIR38467
GH05F181069 0.2 Ensembl 10.2 -330.1 -330082 0.8 TBP HINFP NFYC SP2 ETS1 POLR2A ZBTB33 MLLT1 ZSCAN29 SPI1 OR2Y1 BTNL3 RPL13P10 TRV-CAC1-2
GH05F180350 0.3 FANTOM5 8.9 +389.1 389052 0.3 ZNF316 OR2Y1 GFPT2 PIR49031
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR2Y1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2Y1 Gene

180,739,042 bp from pter
180,740,099 bp from pter
1,058 bases
Minus strand

Genomic View for OR2Y1 Gene

Genes around OR2Y1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2Y1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2Y1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2Y1 Gene

Proteins for OR2Y1 Gene

  • Protein details for OR2Y1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2Y1
    Protein Accession:
    Secondary Accessions:
    • B9EIP1
    • Q6IFB1
    • Q96R16

    Protein attributes for OR2Y1 Gene

    311 amino acids
    Molecular mass:
    34731 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2Y1 Gene

Post-translational modifications for OR2Y1 Gene

  • Glycosylation at Asn 5 and Asn 264
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2Y1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2Y1 Gene

Domains & Families for OR2Y1 Gene

Gene Families for OR2Y1 Gene

Protein Domains for OR2Y1 Gene

Suggested Antigen Peptide Sequences for OR2Y1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2Y1: view

Function for OR2Y1 Gene

Molecular function for OR2Y1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2Y1: view

Phenotypes for OR2Y1 Gene

GenomeRNAi human phenotypes for OR2Y1:
genes like me logo Genes that share phenotypes with OR2Y1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2Y1 Gene

Localization for OR2Y1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2Y1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR2Y1 Gene COMPARTMENTS Subcellular localization image for OR2Y1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2Y1: view

Pathways & Interactions for OR2Y1 Gene

genes like me logo Genes that share pathways with OR2Y1: view

Pathways by source for OR2Y1 Gene

Interacting Proteins for OR2Y1 Gene

Gene Ontology (GO) - Biological Process for OR2Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2Y1: view

No data available for SIGNOR curated interactions for OR2Y1 Gene

Transcripts for OR2Y1 Gene

mRNA/cDNA for OR2Y1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2Y1 Gene

No ASD Table

Relevant External Links for OR2Y1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2Y1 Gene

mRNA expression in normal human tissues for OR2Y1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2Y1 Gene:


SOURCE GeneReport for Unigene cluster for OR2Y1 Gene:

genes like me logo Genes that share expression patterns with OR2Y1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR2Y1 Gene

Orthologs for OR2Y1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2Y1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC471778 34
  • 99.25 (n)
OR2Y1 35
  • 99 (a)
(Mus musculus)
Mammalia Or2y1c 55 Olfr1386 34 16
  • 82.74 (n)
Or2y15 55 Olfr1387 35
  • 79 (a)
Or2y1 55 Olfr1385
  • chr11:49,494,535-49,495,461
Or2y10 55 Olfr1380
  • chr11:49,563,923-49,564,855
Or2y11 55 Olfr1381
  • chr11:49,551,749-49,552,681
Or2y12 55 Olfr1382
  • chr11:49,535,187-49,536,119
Or2y13 55 Olfr1383
  • chr11:49,523,725-49,524,657
Or2y14 55 Olfr1384
  • chr11:49,513,640-49,514,593
Or2y16 55 Olfr1388
  • chr11:49,443,853-49,444,785
Or2y17 55 Olfr1390
  • chr11:49,340,534-49,341,466
Or2y1b 55 Olfr10
  • chr11:49,317,548-49,318,480
Or2y1d 55 Olfr1389
  • chr11:49,430,478-49,431,410
Or2y1e 55 Olfr1391
  • chr11:49,327,413-49,328,345
Or2y1f 55 Olfr1392
  • chr11:49,293,323-49,294,255
Or2y1g 55 Olfr1393
  • chr11:49,280,150-49,281,082
Or2y6 55 Olfr1371
  • chr11:52,213,055-52,213,987
Or2y7 55 Olfr1372
  • chr11:52,155,249-52,156,283
Or2y8 55 Olfr1373
  • chr11:52,144,596-52,145,528
Or2y9-ps 55 Olfr1374-ps1
  • chr11:51,142,532-51,143,464
(Rattus norvegicus)
Mammalia Olr1394 34
  • 81.88 (n)
(Bos Taurus)
Mammalia OR2Y1 35
  • 80 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
-- 35
  • 71 (a)
(Canis familiaris)
Mammalia -- 35
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia OR2Y1 35
  • 54 (a)
Species where no ortholog for OR2Y1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2Y1 Gene

Gene Tree for OR2Y1 (if available)
Gene Tree for OR2Y1 (if available)

Paralogs for OR2Y1 Gene

Paralogs for OR2Y1 Gene

(437) SIMAP similar genes for OR2Y1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2Y1: view

Variants for OR2Y1 Gene

Sequence variations from dbSNP and Humsavar for OR2Y1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10464105 -- 180,739,461(+) GGCCA(C/G)AAACA reference, missense
rs111827481 -- 180,741,005(+) GGTGG(A/G)TCACC upstream-variant-2KB
rs112381287 -- 180,739,499(+) CACAA(A/G)CCAAC reference, missense
rs113199562 -- 180,739,267(+) GAATA(A/G)TTGTG reference, synonymous-codon
rs113971523 -- 180,738,704(+) CATGC(A/G)CGGTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR2Y1 Gene

Variant ID Type Subtype PubMed ID
dgv10242n54 CNV gain 21841781
dgv5849n100 CNV gain 25217958
dgv5850n100 CNV gain 25217958
esv2759399 CNV gain 17122850
esv2762572 CNV gain 21179565
esv3607791 CNV gain 21293372
esv3890776 CNV gain 25118596
nsv1026417 CNV gain 25217958
nsv1034735 CNV gain 25217958
nsv1161322 CNV duplication 26073780
nsv517459 CNV gain 19592680
nsv830565 CNV loss 17160897

Variation tolerance for OR2Y1 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.53; 64.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2Y1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2Y1 Gene

Disorders for OR2Y1 Gene

Relevant External Links for OR2Y1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR2Y1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2Y1 Gene

Publications for OR2Y1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. (PMID: 19851299) Johansson A. … Gyllensten U. (Obesity (Silver Spring) 2010) 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR2Y1 Gene

Sources for OR2Y1 Gene

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