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OR2W5 Gene

pseudogene   GIFtS: 38
GCID: GC01P247654

Olfactory Receptor, Family 2, Subfamily W, Member 5


(Previous symbol: OR2W5P)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily W, Member 51 2
OR2W5P1 2 3
OST7222
Olfactory Receptor 2W52
Olfactory Receptor, Family 2, Subfamily W, Member 5 Pseudogene2
Putative Olfactory Receptor 2W52

External Ids:    HGNC: 154241   Entrez Gene: 4419322   Ensembl: ENSG000002036647   UniProtKB: A6NFC93   

Export aliases for OR2W5 gene to outside databases

Previous GC identifers: GC01P244595 GC01P243960 GC01P245721


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2W5 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. This olfactory receptor gene has a coding sequence that is comparable in length to other
olfactory receptor genes, but it should be noted that a frameshift is present in the 3' coding region that
disrupts the 7-transmembrane domain structure in the protein. It is unclear if the protein can function as an
olfactory receptor or if an alternate function is served. For this reason, this gene has also been interpreted to
be a pseudogene. (provided by RefSeq, Jan 2010)

GeneCards Summary for OR2W5 Gene:
OR2W5 (olfactory receptor, family 2, subfamily W, member 5) is a pseudogene. Diseases associated with OR2W5 include lymphoblastic leukemia, and neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot: OR2W5_HUMAN, A6NFC9
Function: Odorant receptor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2W5 gene promoter:
         POU2F1   GATA-3   POU2F1a   HSF1short   HSF1 (long)   Evi-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OR2W5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2W5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

OR2W5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2W5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P247654:  view genomic region     (about GC identifiers)

Start:
247,654,430 bp from pter      End:
247,655,389 bp from pter
Size:
960 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OR2W5_HUMAN, A6NFC9 (See protein sequence)
Recommended Name: Putative olfactory receptor 2W5  
Size: 320 amino acids; 35528 Da
Caution: Could be the product of a pseudogene
Secondary accessions: B9EH85

Explore the universe of human proteins at neXtProt for OR2W5: NX_A6NFC9

Explore proteomics data for OR2W5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR2W5

    See OR2W5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004698.1  Reactome Protein details: A6NFC9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry A6NFC9

    ProtoNet protein and cluster: A6NFC9

    UniProtKB/Swiss-Prot: OR2W5_HUMAN, A6NFC9
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR2W5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2W5_HUMAN, A6NFC9
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR2W5 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2W5_HUMAN, A6NFC9: Cell membrane; Multi-pass membrane protein

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR2W5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2W5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR2W5
        Olfactory Signaling Pathway



    OR2W5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2W5
    Interactions:

        Search GeneGlobe Interaction Network for OR2W5

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2W5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR2W5 gene: 
    NM_001004698.2  

    Unigene Cluster for OR2W5:

    Olfactory receptor, family 2, subfamily W, member 5
    Hs.591526  [show with all ESTs]
    Unigene Representative Sequence: NM_001004698
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522351 ENST00000366492 ENST00000530852(uc001icz.2)
    miRNA
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    hsa-miR-489
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    Additional mRNA sequence: 

    BC137203.1 BC137204.1 

    1 DOTS entry:

    DT.433357 

    9 AceView cDNA sequences:

    BC025398 BC034790 AK130400 BG717366 BG773026 R60641 R60587 H12141 
    H11629 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2W5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAACTTC
    OR2W5 Expression
    About this image

    OR2W5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2W5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591526
        Custom PCR Arrays for OR2W5
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for OR2W5 (if available)
    TreeFam Gene Tree for OR2W5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2W5 gene
    Selected SIMAP similar genes for OR2W5 using alignment to 1 protein entry:     OR2W5_HUMAN(see all similar genes):
    OR2W6P    OLFR 42A    6M1-16    OR2G6    OR2H1    OR2H2
    OR2W1    OR2W3    OLFR 42B    OR2C1    OR2H5P    OR2Y1
    OR2B3    OR2B8P    OR2G3    OR2J1    OR2J3    OR2J4P

    OR2W5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2W5 (see all 113)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115875071,2
    C,F,H--247652371(+) AAGCAT/CTGGCT 1 -- us2k15Minor allele frequency- C:0.12NA CSA WA EA 362
    rs1929002021,2
    --247652394(+) TCTCTA/GTTATT 1 -- us2k10--------
    rs115875171,2
    H--247652463(+) TGCTGA/TGATGA 1 -- us2k10--------
    rs1849705361,2
    --247652591(+) TGGCAC/TTGTTA 1 -- us2k10--------
    rs107545631,2
    C,F,A,H--247652603(+) ATCCTG/TTTCAG 1 -- us2k130Minor allele frequency- T:0.18NS EA NA WA CSA 2780
    rs120929411,2
    C,F--247652621(+) AGAGAA/GCCATT 1 -- us2k14Minor allele frequency- G:0.25NA WA 124
    rs1490447371,2
    --247652689(+) AATCAA/GCCCAA 1 -- us2k10--------
    rs1457428111,2
    C--247652708(+) TTGGCA/GTCTAA 1 -- us2k10--------
    rs1898643241,2
    --247652837(+) AAATGC/TGAGAA 1 -- us2k10--------
    rs1161363631,2
    C,F--247652839(+) ATGTGA/GGAAGA 1 -- us2k11Minor allele frequency- G:0.02NA 120

    HapMap Linkage Disequilibrium report for OR2W5 ( 247654430 - 247655389 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OR2W5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675635CNV Deletion23128226
    esv2727818CNV Deletion23290073
    nsv827764CNV Loss20364138
    dgv115n67CNV Loss20364138
    esv33129CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for OR2W5:    About MalaCards
    lymphoblastic leukemia    neuronitis    leukemia


    OR2W5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OR2W5

    Export disorders for OR2W5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2W5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2W5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 3 Fuchs T.... Shamir R. (Genomics 2002)
    4. New gene functions in megakaryopoiesis and platelet formation. (PubMed id 22139419)4 Gieger C....Soranzo N. (Nature 2011)
    5. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PubMed id 19684603)4 Trevino L.R.... Relling M.V. (Nat. Genet. 2009)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 441932 HGNC: 15424 AceView: OR2W5 Ensembl:ENSG00000203664 euGenes: HUgn441932
    ECgene: OR2W5 H-InvDB: OR2W5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2W5 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2W5 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2W5 gene:
    Search GeneIP for patents involving OR2W5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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