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Aliases for OR2W3 Gene

Aliases for OR2W3 Gene

  • Olfactory Receptor Family 2 Subfamily W Member 3 2 3 5
  • Olfactory Receptor OR1-49 3 4
  • Olfactory Receptor 2W8 3 4
  • OR2W3P 3 4
  • OR2W8P 3 4
  • Olfactory Receptor, Family 2, Subfamily W, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily W, Member 8 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily W, Member 3 2
  • OST718 3

External Ids for OR2W3 Gene

Previous HGNC Symbols for OR2W3 Gene

  • OR2W8P
  • OR2W3P

Previous GeneCards Identifiers for OR2W3 Gene

  • GC01U901042
  • GC01P244384
  • GC01P246125
  • GC01P248058
  • GC01P248031

Summaries for OR2W3 Gene

Entrez Gene Summary for OR2W3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2W3 Gene

OR2W3 (Olfactory Receptor Family 2 Subfamily W Member 3) is a Protein Coding gene. Diseases associated with OR2W3 include retinitis pigmentosa. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2C1.

UniProtKB/Swiss-Prot for OR2W3 Gene

  • Odorant receptor.

Gene Wiki entry for OR2W3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2W3 Gene

Genomics for OR2W3 Gene

Regulatory Elements for OR2W3 Gene

Genomic Location for OR2W3 Gene

247,895,587 bp from pter
247,896,531 bp from pter
945 bases
Plus strand

Genomic View for OR2W3 Gene

Genes around OR2W3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2W3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2W3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2W3 Gene

Proteins for OR2W3 Gene

  • Protein details for OR2W3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2W3
    Protein Accession:
    Secondary Accessions:
    • Q6IF06
    • Q8NG86

    Protein attributes for OR2W3 Gene

    314 amino acids
    Molecular mass:
    34789 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2W3 Gene

Proteomics data for OR2W3 Gene at MOPED

Post-translational modifications for OR2W3 Gene

Other Protein References for OR2W3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2W3 Gene

Domains & Families for OR2W3 Gene

Gene Families for OR2W3 Gene

Protein Domains for OR2W3 Gene

Suggested Antigen Peptide Sequences for OR2W3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2W3: view

Function for OR2W3 Gene

Molecular function for OR2W3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR2W3 Gene

GenomeRNAi human phenotypes for OR2W3:
genes like me logo Genes that share phenotypes with OR2W3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2W3 Gene

Localization for OR2W3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2W3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR2W3 Gene COMPARTMENTS Subcellular localization image for OR2W3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2W3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2W3: view

Pathways & Interactions for OR2W3 Gene

genes like me logo Genes that share pathways with OR2W3: view

Pathways by source for OR2W3 Gene

Interacting Proteins for OR2W3 Gene

Gene Ontology (GO) - Biological Process for OR2W3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2W3: view

No data available for SIGNOR curated interactions for OR2W3 Gene

Drugs & Compounds for OR2W3 Gene

No Compound Related Data Available

Transcripts for OR2W3 Gene

mRNA/cDNA for OR2W3 Gene

(1) REFSEQ mRNAs :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2W3 Gene

No ASD Table

Relevant External Links for OR2W3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2W3 Gene

mRNA expression in normal human tissues for OR2W3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR2W3 Gene

This gene is overexpressed in Whole Blood (x29.4).
genes like me logo Genes that share expression patterns with OR2W3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR2W3 Gene

Orthologs for OR2W3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2W3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR2W3 35
  • 84.52 (n)
  • 89.35 (a)
-- 36
  • 88 (a)
-- 36
  • 84 (a)
(Canis familiaris)
Mammalia LOC100684725 35
  • 85.09 (n)
  • 88.5 (a)
OR2W3 36
  • 85 (a)
(Mus musculus)
Mammalia Olfr322 35
  • 82.32 (n)
  • 84.66 (a)
Olfr322 16
Olfr317 36
  • 80 (a)
Olfr322 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Olr1433 35
  • 82.22 (n)
  • 83.97 (a)
(Monodelphis domestica)
Mammalia OR2W3 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
(Pan troglodytes)
Mammalia OR2W3 36
  • 98 (a)
Species with no ortholog for OR2W3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2W3 Gene

Gene Tree for OR2W3 (if available)
Gene Tree for OR2W3 (if available)

Paralogs for OR2W3 Gene

Paralogs for OR2W3 Gene

(455) SIMAP similar genes for OR2W3 Gene using alignment to 2 proteins: Pseudogenes for OR2W3 Gene

genes like me logo Genes that share paralogs with OR2W3: view

Variants for OR2W3 Gene

Sequence variations from dbSNP and Humsavar for OR2W3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12083024 - 247,896,092(+) CCGCT(C/G)TGGGC reference, missense
rs10888267 - 247,896,121(+) TCCTG(C/T)GTGAG reference, missense
rs12135078 - 247,896,154(+) CCTGC(A/G/T)TCAGC reference, missense
rs12139390 - 247,896,174(+) ATCGA(A/C/T)GGCAC reference, missense
rs11204545 - 247,896,401(+) GGGCA(A/T)GTTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR2W3 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV Gain+Loss 17666407
nsv873440 CNV Gain 21882294
dgv204e1 CNV Complex 17122850
esv34503 CNV Gain 17911159
nsv515858 CNV Gain+Loss 19592680
nsv873442 CNV Gain 21882294
dgv205e1 CNV Complex 17122850
nsv873443 CNV Gain 21882294
nsv5321 CNV Loss 18451855
nsv508706 CNV Loss 20534489

Variation tolerance for OR2W3 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.88; 99.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2W3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2W3 Gene

Disorders for OR2W3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR2W3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search OR2W3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OR2W3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OR2W3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR2W3 Gene

Publications for OR2W3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 4 67
  2. Whole-exome sequencing identifies OR2W3 mutation as a cause of autosomal dominant retinitis pigmentosa. (PMID: 25783483) Ma X. … Li Y. (Sci Rep 2015) 3
  3. Association of single nucleotide polymorphisms in the USF1, GTF2A1L and OR2W3 genes with non-obstructive azoospermia in the Chinese population. (PMID: 25374392) Zhang Y. … Du W.D. (J. Assist. Reprod. Genet. 2014) 3
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2W3 Gene

Sources for OR2W3 Gene

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