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Aliases for OR2W3 Gene

Aliases for OR2W3 Gene

  • Olfactory Receptor Family 2 Subfamily W Member 3 2 3 5
  • Olfactory Receptor OR1-49 3 4
  • Olfactory Receptor 2W8 3 4
  • OR2W3P 3 4
  • OR2W8P 3 4
  • Olfactory Receptor, Family 2, Subfamily W, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily W, Member 8 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily W, Member 3 2
  • Olfactory Receptor 2W3 3
  • OST718 3

External Ids for OR2W3 Gene

Previous HGNC Symbols for OR2W3 Gene

  • OR2W8P
  • OR2W3P

Previous GeneCards Identifiers for OR2W3 Gene

  • GC01U901042
  • GC01P244384
  • GC01P246125
  • GC01P248058
  • GC01P248031

Summaries for OR2W3 Gene

Entrez Gene Summary for OR2W3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2W3 Gene

OR2W3 (Olfactory Receptor Family 2 Subfamily W Member 3) is a Protein Coding gene. Diseases associated with OR2W3 include Retinitis Pigmentosa. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2W1.

UniProtKB/Swiss-Prot for OR2W3 Gene

  • Odorant receptor.

Gene Wiki entry for OR2W3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2W3 Gene

Genomics for OR2W3 Gene

Regulatory Elements for OR2W3 Gene

Enhancers for OR2W3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F247854 1 FANTOM5 ENCODE 4.5 -40.1 -40080 1.5 TBP HDAC1 ATF1 CBX3 ARNT TBL1XR1 CREB3L1 CHAMP1 GATA2 CREM TRIM58 OR2T8 OR13G1 OR2W3 OR11L1
GH01F247905 1.2 Ensembl ENCODE 0.4 +11.2 11214 2.0 HDAC1 PKNOX1 ZBTB40 FOS ZBTB2 POLR2H SMARCA4 PBX2 THRAP3 IKZF1 OR2AJ1 TRIM58 OR2T8 OR2T12 OR2W3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR2W3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2W3 Gene

Chromosome:
1
Start:
247,895,587 bp from pter
End:
247,896,531 bp from pter
Size:
945 bases
Orientation:
Plus strand

Genomic View for OR2W3 Gene

Genes around OR2W3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2W3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2W3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2W3 Gene

Proteins for OR2W3 Gene

  • Protein details for OR2W3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3T1-OR2W3_HUMAN
    Recommended name:
    Olfactory receptor 2W3
    Protein Accession:
    Q7Z3T1
    Secondary Accessions:
    • Q6IF06
    • Q8NG86

    Protein attributes for OR2W3 Gene

    Size:
    314 amino acids
    Molecular mass:
    34789 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2W3 Gene

Post-translational modifications for OR2W3 Gene

Other Protein References for OR2W3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2W3 Gene

Domains & Families for OR2W3 Gene

Gene Families for OR2W3 Gene

Protein Domains for OR2W3 Gene

Suggested Antigen Peptide Sequences for OR2W3 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z3T1

UniProtKB/Swiss-Prot:

OR2W3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2W3: view

Function for OR2W3 Gene

Molecular function for OR2W3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2W3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2W3: view

Phenotypes for OR2W3 Gene

GenomeRNAi human phenotypes for OR2W3:
genes like me logo Genes that share phenotypes with OR2W3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2W3 Gene

Localization for OR2W3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2W3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2W3 Gene COMPARTMENTS Subcellular localization image for OR2W3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2W3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2W3: view

Pathways & Interactions for OR2W3 Gene

genes like me logo Genes that share pathways with OR2W3: view

Pathways by source for OR2W3 Gene

Gene Ontology (GO) - Biological Process for OR2W3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2W3: view

No data available for SIGNOR curated interactions for OR2W3 Gene

Transcripts for OR2W3 Gene

mRNA/cDNA for OR2W3 Gene

(1) REFSEQ mRNAs :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2W3 Gene

No ASD Table

Relevant External Links for OR2W3 Gene

GeneLoc Exon Structure for
OR2W3
ECgene alternative splicing isoforms for
OR2W3

Expression for OR2W3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2W3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR2W3 Gene

This gene is overexpressed in Whole Blood (x29.4).

NURSA nuclear receptor signaling pathways regulating expression of OR2W3 Gene:

OR2W3
genes like me logo Genes that share expression patterns with OR2W3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR2W3 Gene

Orthologs for OR2W3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2W3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR2W3 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 88 (a)
OneToMany
OR2W3 34
  • 84.52 (n)
-- 35
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC100684725 34
  • 85.09 (n)
OR2W3 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or2w3c 55 Olfr322 34 16 35
  • 82.32 (n)
Or2w3b 55 Olfr317 35
  • 80 (a)
OneToMany
Or2w3 55 Olfr179
  • chr11:58,665,537-58,666,541
rat
(Rattus norvegicus)
Mammalia Olr1433 34
  • 82.22 (n)
oppossum
(Monodelphis domestica)
Mammalia OR2W3 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
OneToMany
Species where no ortholog for OR2W3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2W3 Gene

ENSEMBL:
Gene Tree for OR2W3 (if available)
TreeFam:
Gene Tree for OR2W3 (if available)

Paralogs for OR2W3 Gene

Paralogs for OR2W3 Gene

(455) SIMAP similar genes for OR2W3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR2W3 Gene

genes like me logo Genes that share paralogs with OR2W3: view

Variants for OR2W3 Gene

Sequence variations from dbSNP and Humsavar for OR2W3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs189993261 Uncertain significance 247,896,010(+) TCTGC(C/T)GGGGC reference, missense
rs10544204 -- 247,895,032(+) AATTT(-/TAAAA)TTAAA upstream-variant-2KB
rs10732831 -- 247,896,727(+) AGGGT(A/G)GAGTG downstream-variant-500B
rs10888267 -- 247,896,121(+) TCCTG(C/T)GTGAG reference, missense
rs10888268 -- 247,896,554(+) TTCAC(C/T)TCCAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR2W3 Gene

Variant ID Type Subtype PubMed ID
dgv604n100 CNV gain 25217958
dgv605n100 CNV gain 25217958
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
esv2759014 CNV gain+loss 17122850
esv2762235 CNV gain 21179565
esv33129 CNV gain+loss 17666407
esv34503 CNV gain 17911159
esv3589522 CNV gain 21293372
esv3891415 CNV gain 25118596
nsv1008024 CNV gain 25217958
nsv1010087 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv508706 CNV deletion 20534489
nsv515858 CNV gain+loss 19592680
nsv5321 CNV deletion 18451855
nsv549597 CNV gain 21841781
nsv549601 CNV loss 21841781
nsv549602 CNV loss 21841781
nsv549603 CNV loss 21841781

Variation tolerance for OR2W3 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.88; 99.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2W3 Gene

Human Gene Mutation Database (HGMD)
OR2W3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2W3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2W3 Gene

Disorders for OR2W3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR2W3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search OR2W3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OR2W3

Genetic Association Database (GAD)
OR2W3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2W3
genes like me logo Genes that share disorders with OR2W3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR2W3 Gene

Publications for OR2W3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 4 64
  2. Whole-exome sequencing identifies OR2W3 mutation as a cause of autosomal dominant retinitis pigmentosa. (PMID: 25783483) Ma X. … Li Y. (Sci Rep 2015) 3 64
  3. Susceptibility to male infertility: replication study in Japanese men looking for an association with four GWAS-derived loci identified in European men. (PMID: 25847845) Chihara M. … Enomoto T. (J. Assist. Reprod. Genet. 2015) 3 64
  4. Accumulation of rare variants in the arylsulfatase G (ARSG) gene in task-specific dystonia. (PMID: 25825126) Nibbeling E. … Lohmann K. (J. Neurol. 2015) 4 64
  5. Association of single nucleotide polymorphisms in the USF1, GTF2A1L and OR2W3 genes with non-obstructive azoospermia in the Chinese population. (PMID: 25374392) Zhang Y. … Du W.D. (J. Assist. Reprod. Genet. 2014) 3 64

Products for OR2W3 Gene

Sources for OR2W3 Gene

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