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OR2W1 Gene

protein-coding   GIFtS: 53
GCID: GC06M029011

Olfactory Receptor, Family 2, Subfamily W, Member 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily W, Member 11 2
Olfactory Receptor OR6-132 3
hs6M1-152
Olfactory Receptor 2W12
Hs6M1-153

External Ids:    HGNC: 82811   Entrez Gene: 266922   Ensembl: ENSG000002047047   UniProtKB: Q9Y3N93   

Export aliases for OR2W1 gene to outside databases

Previous GC identifers: GC06M029069 GC06M028782 GC06M029119 GC06Mo28942


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2W1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2W1 Gene:
OR2W1 (olfactory receptor, family 2, subfamily W, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2J2.

UniProtKB/Swiss-Prot: OR2W1_HUMAN, Q9Y3N9
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2W1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  
NT_167248.2  NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2W1 gene promoter:
         Nkx3-1   ER-alpha   RFX1   AML1a   Nkx3-1 v1   NF-kappaB1   NF-kappaB   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2W1 promoter sequence
   Search Chromatin IP Primers for OR2W1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2W1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

OR2W1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2W1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M029011:  view genomic region     (about GC identifiers)

Start:
29,011,993 bp from pter      End:
29,012,952 bp from pter
Size:
960 bases      Orientation:
minus strand

Selected alternative locations (see all 7):
Chr6-,NT_113891.2 530,807-531,769      Chr6-,NT_167245 315,401-316,363      Chr6-,NT_167244 315,432-316,394     
Chr6-,NT_167249 352,868-353,830      Chr6-,NT_167248 315,387-316,349      Chr6-,NT_167246 315,391-316,353     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR2W1_HUMAN, Q9Y3N9 (See protein sequence)
Recommended Name: Olfactory receptor 2W1  
Size: 320 amino acids; 36101 Da
Secondary accessions: B0S7Y5 Q5JNZ1 Q6IEU0 Q96R17 Q9GZL0 Q9GZL1

Explore the universe of human proteins at neXtProt for OR2W1: NX_Q9Y3N9

Explore proteomics data for OR2W1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR2W1

    See OR2W1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112165.1  
    ENSEMBL proteins: 
     ENSP00000366380  
    Reactome Protein details: Q9Y3N9

    OR2W1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for OR2W1

     
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    antibodies-online proteins for OR2W1 (2 products) 

     
    antibodies-online peptides for OR2W1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9Y3N9

    ProtoNet protein and cluster: Q9Y3N9

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2W1_HUMAN, Q9Y3N9
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR2W1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2W1_HUMAN, Q9Y3N9
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR2W1:
    olfactory receptor,family 2,subfamily W,member 1,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR2W1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for OR2W1:
     Increased HPV18 LCR reporter a  Increased circadian rhythm amp 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR2W1
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    miRNA
    Products:
        
    miRTarBase miRNAs that target OR2W1:
    hsa-mir-335-5p (MIRT018723), hsa-mir-26b-5p (MIRT030021)

    Block miRNA regulation of human, mouse, rat OR2W1 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2W1_HUMAN, Q9Y3N9: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR2W1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2W1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    Find genes that share SuperPaths with OR2W1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR2W1
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR2W1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2W1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2W1
    Interactions:

        Search GeneGlobe Interaction Network for OR2W1

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR2W1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2W1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR2W1 gene: 
    NM_030903.3  

    Unigene Cluster for OR2W1:

    Olfactory receptor, family 2, subfamily W, member 1
    Hs.553526  [show with all ESTs]
    Unigene Representative Sequence: NM_001195202
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377175(uc003nlw.2)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat OR2W1
      QuantiFast Probe-based Assays in human, mouse, rat OR2W1

    Additional mRNA sequence: 

    BC103870.1 BC103871.1 BC103872.1 

    2 DOTS entries:

    DT.99934552  DT.121312075 

    2 AceView cDNA sequences:

    NM_030903 AJ459865 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2W1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGATGCCC
    OR2W1 Expression
    About this image

    OR2W1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2W1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553526
        Custom PCR Arrays for OR2W1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2W1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2W1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr2631 , 5 olfactory receptor 2631, 5 85.49(n)1
    85.8(a)1
      13 (7.65 cM)5
    183411  NM_010984.11  NP_035114.11 
     211327775 


    ENSEMBL Gene Tree for OR2W1 (if available)
    TreeFam Gene Tree for OR2W1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2W1 gene
    OR2J22  OR2G22  OR2J12  OR2H22  OR2C12  OR2H12  OR2Y12  OR2W32  
    OR2J32  OR2G32  OR2C32  OR2G62  
    Selected SIMAP similar genes for OR2W1 using alignment to 1 protein entry:     OR2W1_HUMAN(see all similar genes):
    OR2W6P    OR2W3    OR2G6    OR2C3    6M1-16    OR2B8P
    OLFR 42A    OR2G2    OR2G3    OR2J1    OR2J3    OR2B11
    OR2B3    OR2C1    OR2H1    OR2H2    OR2J2    OR2B2

    Find genes that share paralogs with OR2W1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for OR2W1 (see all 18)
    PGOHUM00000245297 PGOHUM00000243110 PGOHUM00000243115 PGOHUM00000260121 PGOHUM00000243533


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for OR2W1    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357715651,2,4
    ----see VAR_0109542 mis40--------
    rs348920061,2,4
    ----see VAR_0109532 mis40--------

    HapMap Linkage Disequilibrium report for OR2W1 ( 29011993 - 29012952 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR2W1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830622CNV Gain17160897
    nsv830623CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR2W1
    DNA2.0 Custom Variant and Variant Library Synthesis for OR2W1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR2W1           About GenesLikeMe

    Genetic Association Database (GAD): OR2W1
    Human Genome Epidemiology (HuGE) Navigator: OR2W1 (2 documents)

    Export disorders for OR2W1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2W1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2W1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    6. Common variation contributes to the genetic architecture of social communication traits. (PubMed id 24047820)1 St Pourcain B....Smith G.D. (Mol Autism 2013)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26692 HGNC: 8281 AceView: OR2W1 Ensembl:ENSG00000204704 euGenes: HUgn26692
    ECgene: OR2W1 Kegg: 26692 H-InvDB: OR2W1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2W1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2W1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2W1 gene:
    Search GeneIP for patents involving OR2W1

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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