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Aliases for OR2V2 Gene

Aliases for OR2V2 Gene

  • Olfactory Receptor Family 2 Subfamily V Member 2 2 3 5
  • Olfactory Receptor, Family 2, Subfamily V, Member 2 2 3
  • Olfactory Receptor OR5-3 3 4
  • Olfactory Receptor 2V3 3 4
  • OR2V3 3 4
  • Olfactory Receptor, Family 2, Subfamily V, Member 3 3
  • OST713 3

External Ids for OR2V2 Gene

Previous HGNC Symbols for OR2V2 Gene

  • OR2V3

Previous GeneCards Identifiers for OR2V2 Gene

  • GC13U990069
  • GC05P180691
  • GC05P180514
  • GC05P180581

Summaries for OR2V2 Gene

Entrez Gene Summary for OR2V2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2V2 Gene

OR2V2 (Olfactory Receptor Family 2 Subfamily V Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2V2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2V2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2V2 Gene

Genomics for OR2V2 Gene

Regulatory Elements for OR2V2 Gene

Enhancers for OR2V2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR2V2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2V2 Gene

Chromosome:
5
Start:
181,154,943 bp from pter
End:
181,155,890 bp from pter
Size:
948 bases
Orientation:
Plus strand

Genomic View for OR2V2 Gene

Genes around OR2V2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2V2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2V2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2V2 Gene

Proteins for OR2V2 Gene

  • Protein details for OR2V2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R30-OR2V2_HUMAN
    Recommended name:
    Olfactory receptor 2V2
    Protein Accession:
    Q96R30
    Secondary Accessions:
    • Q6IFL6
    • Q8NGV1

    Protein attributes for OR2V2 Gene

    Size:
    315 amino acids
    Molecular mass:
    35339 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2V2 Gene

Proteomics data for OR2V2 Gene at MOPED

Post-translational modifications for OR2V2 Gene

  • Glycosylation at Asn 6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2V2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2V2 Gene

Domains & Families for OR2V2 Gene

Gene Families for OR2V2 Gene

Protein Domains for OR2V2 Gene

Suggested Antigen Peptide Sequences for OR2V2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96R30

UniProtKB/Swiss-Prot:

OR2V2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2V2: view

Function for OR2V2 Gene

Molecular function for OR2V2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR2V2 Gene

genes like me logo Genes that share phenotypes with OR2V2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2V2 Gene

Localization for OR2V2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2V2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2V2 Gene COMPARTMENTS Subcellular localization image for OR2V2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2V2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2V2: view

Pathways & Interactions for OR2V2 Gene

genes like me logo Genes that share pathways with OR2V2: view

Pathways by source for OR2V2 Gene

Interacting Proteins for OR2V2 Gene

Gene Ontology (GO) - Biological Process for OR2V2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2V2: view

No data available for SIGNOR curated interactions for OR2V2 Gene

Drugs & Compounds for OR2V2 Gene

No Compound Related Data Available

Transcripts for OR2V2 Gene

mRNA/cDNA for OR2V2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2V2 Gene

No ASD Table

Relevant External Links for OR2V2 Gene

GeneLoc Exon Structure for
OR2V2
ECgene alternative splicing isoforms for
OR2V2

Expression for OR2V2 Gene

mRNA expression in normal human tissues for OR2V2 Gene

Protein differential expression in normal tissues from HIPED for OR2V2 Gene

This gene is overexpressed in Urine (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2V2 Gene



SOURCE GeneReport for Unigene cluster for OR2V2 Gene Hs.553681

genes like me logo Genes that share expression patterns with OR2V2: view

Protein tissue co-expression partners for OR2V2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR2V2 Gene

Orthologs for OR2V2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2V2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR2V2 35
  • 87.2 (n)
  • 87.3 (a)
-- 36
  • 87 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr1396 35
  • 85.03 (n)
  • 82.8 (a)
Olfr1396 16
Olfr1396 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC471781 35
  • 99.37 (n)
  • 99.05 (a)
OR2V2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1384 35
  • 85.58 (n)
  • 85.26 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 57 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
Species with no ortholog for OR2V2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2V2 Gene

ENSEMBL:
Gene Tree for OR2V2 (if available)
TreeFam:
Gene Tree for OR2V2 (if available)

Paralogs for OR2V2 Gene

(447) SIMAP similar genes for OR2V2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR2V2 Gene

genes like me logo Genes that share paralogs with OR2V2: view

Variants for OR2V2 Gene

Sequence variations from dbSNP and Humsavar for OR2V2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17617270 - 181,155,043(+) TATGG(C/T)GGTCT reference, missense
rs2546423 - 181,155,604(-) GAATG(C/T)GAGCA reference, missense
rs2770958 -- 181,153,462(-) cgatc(C/T)gcctg upstream-variant-2KB
rs2770959 -- 181,153,059(-) CATCC(A/G)GGCCT upstream-variant-2KB
rs6865627 -- 181,154,029(+) TCACT(A/C/T)GCGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2V2 Gene

Variant ID Type Subtype PubMed ID
nsv428133 CNV Gain 18775914
nsv471062 CNV Gain 18288195
dgv735n27 CNV Gain 19166990
nsv883305 CNV Gain 21882294
nsv830567 CNV Loss 17160897
nsv883307 CNV Gain 21882294
esv2436663 OTHER Inversion 19546169
esv8228 OTHER Inversion 19470904
nsv5163 CNV Loss 18451855
nsv520110 CNV Gain 19592680

Variation tolerance for OR2V2 Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR2V2 Gene

Disorders for OR2V2 Gene

Relevant External Links for OR2V2

Genetic Association Database (GAD)
OR2V2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2V2

No disorders were found for OR2V2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2V2 Gene

Publications for OR2V2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3

Products for OR2V2 Gene

Sources for OR2V2 Gene

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