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OR2V2 Gene

protein-coding   GIFtS: 45
GCID: GC05P180581

Olfactory Receptor, Family 2, Subfamily V, Member 2


(Previous symbol: OR2V3)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily V, Member 21 2     OST7132
OR2V31 2 3     Olfactory Receptor 2V22
Olfactory Receptor 2V32 3     Olfactory Receptor, Family 2, Subfamily V, Member 32
Olfactory Receptor OR5-32 3     

External Ids:    HGNC: 153411   Entrez Gene: 2856592   Ensembl: ENSG000001826137   UniProtKB: Q96R303   

Export aliases for OR2V2 gene to outside databases

Previous GC identifers: GC13U990069 GC05P180691 GC05P180514


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2V2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2V2 Gene:
OR2V2 (olfactory receptor, family 2, subfamily V, member 2) is a protein-coding gene. Diseases associated with OR2V2 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T35.

UniProtKB/Swiss-Prot: OR2V2_HUMAN, Q96R30
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2V2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2V2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pax-6   Nkx3-1 v1   Evi-1   GATA-1   Max   Nkx3-1 v2   Nkx3-1 v3   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2V2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

OR2V2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2V2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P180581:  view genomic region     (about GC identifiers)

Start:
180,581,943 bp from pter      End:
180,582,887 bp from pter
Size:
945 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR2V2_HUMAN, Q96R30 (See protein sequence)
Recommended Name: Olfactory receptor 2V2  
Size: 315 amino acids; 35339 Da
Secondary accessions: Q6IFL6 Q8NGV1

Explore the universe of human proteins at neXtProt for OR2V2: NX_Q96R30

Explore proteomics data for OR2V2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn6
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR2V2

    See OR2V2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_996763.1  
    ENSEMBL proteins: 
     ENSP00000332185  
    Reactome Protein details: Q96R30

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q96R30

    ProtoNet protein and cluster: Q96R30

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2V2_HUMAN, Q96R30
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR2V2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2V2_HUMAN, Q96R30
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR2V2 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2V2_HUMAN, Q96R30: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR2V2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2V2 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR2V2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2V2):
        Olfactory transduction


    OR2V2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2V2
    Interactions:

        Search GeneGlobe Interaction Network for OR2V2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR2V2 (ENSP000003321854) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10H2ENSP000003060954STRING: ENSP00000306095
    OR10H3ENSP000003071304STRING: ENSP00000307130
    OR10H4ENSP000003188344STRING: ENSP00000318834
    OR11G2ENSP000003499304STRING: ENSP00000349930
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR2V2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR2V2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR2V2 gene: 
    NM_206880.1  

    Unigene Cluster for OR2V2:

    Olfactory receptor, family 2, subfamily V, member 2
    Hs.553681
    Unigene Representative Sequence: NM_206880
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328275(uc011dhj.2)
    miRNA
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    1 AceView cDNA sequence:

    NM_206880 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2V2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR2V2 Expression
    About this image

    OR2V2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2V2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553681
        Custom PCR Arrays for OR2V2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2V2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr13961 , 5 olfactory receptor 13961, 5 85.03(n)1
    82.8(a)1
      11 (29.12 cM)5
    2583341  NM_146337.11  NP_666449.11 
     491127775 


    ENSEMBL Gene Tree for OR2V2 (if available)
    TreeFam Gene Tree for OR2V2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2V2 gene
    OR2T352  OR2V12  OR2M32  OR2T72  OR2M72  OR2T82  OR2M42  OR2T22  
    OR2T122  OR2T272  OR2M52  OR2Z12  OR2T332  OR2AG12  OR2T52  OR2T102  
    OR2M22  OR2T42  OR2T342  OR2T112  OR2T292  OR2T62  OR2T12  OR2AG22  
    OR2T32  
    Selected SIMAP similar genes for OR2V2 using alignment to 1 protein entry:     OR2V2_HUMAN(see all similar genes):
    OR2V1    OR2M4    OR2T2    OR2T35    OR2M3    OR2T11
    OR2T33    OR2T7    OR2T8    OR2AJ1    OR2M5    OR2T12
    OR2Z1    OR2M7    OR2T1    OR2T27    OR2AE1    OR2AK2

    OR2V2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR2V2
    PGOHUM00000242625


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2V2 (see all 169)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007240601,2
    C--180579996(+) GGAGG-/AAAAAG 1 -- us2k10--------
    rs613067411,2
    C,F--180580001(+) GAAAAG/TCGGGG 1 -- us2k17Minor allele frequency- T:0.21WA NA CSA EA 366
    rs1133816061,2
    C,F--180580003(+) AAAGCA/GGGGAA 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1506520581,2
    --180580048(+) CCTGAC/TGGTGC 1 -- us2k10--------
    rs789291821,2
    C,F--180580049(+) CTGACG/AGTGCA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs27709591,2
    C,F,H--180580059(-) CATCCG/AGGCCT 1 -- us2k116Minor allele frequency- A:0.10NS EA CSA WA NA 2337
    rs1446724581,2
    C--180580092(+) AAGGAA/GGCAAA 1 -- us2k10--------
    rs1478797581,2
    --180580109(+) ATAGAA/GCATGA 1 -- us2k10--------
    rs1398374551,2
    --180580167(+) TCAGCC/TGGGTG 1 -- us2k10--------
    rs22596371,2
    C,F,H--180580226(-) CAAGCG/AGAAAA 1 -- us2k19Minor allele frequency- A:0.10NS EA NA WA 798

    HapMap Linkage Disequilibrium report for OR2V2 ( 180581943 - 180582887 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for OR2V2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5163CNV Loss18451855
    nsv830567CNV Loss17160897
    nsv883307CNV Gain21882294
    nsv428133CNV Gain18775914
    dgv735n27CNV Gain19166990
    nsv471062CNV Gain18288195
    nsv883305CNV Gain21882294
    nsv520110CNV Gain19592680
    esv2436663OTHER Inversion19546169
    esv8228OTHER Inversion19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR2V2:    
    About MalaCards
    neuronitis


    OR2V2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OR2V2

    Export disorders for OR2V2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2V2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2V2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285659 HGNC: 15341 AceView: OR2V2 Ensembl:ENSG00000182613 euGenes: HUgn285659
    ECgene: OR2V2 Kegg: 285659 H-InvDB: OR2V2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2V2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2V2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2V2 gene:
    Search GeneIP for patents involving OR2V2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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