Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR2T8 Gene

Aliases for OR2T8 Gene

  • Olfactory Receptor, Family 2, Subfamily T, Member 8 2 3
  • OR2T8P 3 4
  • Olfactory Receptor, Family 2, Subfamily T, Member 8 Pseudogene 3
  • Olfactory Receptor 2T8 3

External Ids for OR2T8 Gene

Previous Symbols for OR2T8 Gene

  • OR2T8P

Summaries for OR2T8 Gene

Entrez Gene Summary for OR2T8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T8 Gene

OR2T8 (Olfactory Receptor, Family 2, Subfamily T, Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2T8 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T8 Gene

Genomics for OR2T8 Gene

Genomic Location for OR2T8 Gene

Start:
247,917,661 bp from pter
End:
247,921,956 bp from pter
Size:
4,296 bases
Orientation:
Plus strand

Genomic View for OR2T8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2T8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T8 Gene

Proteins for OR2T8 Gene

  • Protein details for OR2T8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NH00-OR2T8_HUMAN
    Recommended name:
    Olfactory receptor 2T8
    Protein Accession:
    A6NH00
    Secondary Accessions:

    Protein attributes for OR2T8 Gene

    Size:
    312 amino acids
    Molecular mass:
    34659 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T8 Gene

Proteomics data for OR2T8 Gene at MOPED

Post-translational modifications for OR2T8 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn3 and Asn17

Other Protein References for OR2T8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2T8 Gene

Domains for OR2T8 Gene

Gene Families for OR2T8 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2T8 Gene

UniProtKB/Swiss-Prot:

OR2T8_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • A6NH00
genes like me logo Genes that share domains with OR2T8: view

Function for OR2T8 Gene

Molecular function for OR2T8 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T8: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2T8 Gene

Localization for OR2T8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2T8 Gene COMPARTMENTS Subcellular localization image for OR2T8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T8: view

Pathways for OR2T8 Gene

genes like me logo Genes that share pathways with OR2T8: view

Pathways by source for OR2T8 Gene

Interacting Proteins for OR2T8 Gene

Gene Ontology (GO) - Biological Process for OR2T8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T8: view

Transcripts for OR2T8 Gene

mRNA/cDNA for OR2T8 Gene

(7) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T8 Gene

No ASD Table

Relevant External Links for OR2T8 Gene

GeneLoc Exon Structure for
OR2T8
ECgene alternative splicing isoforms for
OR2T8

Expression for OR2T8 Gene

mRNA expression in normal human tissues for OR2T8 Gene

mRNA differential expression in normal tissues according to GTEx for OR2T8 Gene

This gene is overexpressed in Thyroid (7.3).

SOURCE GeneReport for Unigene cluster for OR2T8 Gene Hs.521114

genes like me logo Genes that share expressions with OR2T8: view

Orthologs for OR2T8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC740494 36
  • 98.61 (n)
  • 97.76 (a)
OR2T8 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 75 (a)
ManyToMany
-- 37
  • 71 (a)
ManyToMany
-- 37
  • 75 (a)
ManyToMany
LOC787932 36
  • 82.16 (n)
  • 75 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 78 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr314 36
  • 77.99 (n)
  • 74.36 (a)
Olfr314 16
Olfr314 37
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 56 (a)
OneToMany
Species with no ortholog for OR2T8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T8 Gene

ENSEMBL:
Gene Tree for OR2T8 (if available)
TreeFam:
Gene Tree for OR2T8 (if available)

Paralogs for OR2T8 Gene

Selected SIMAP similar genes for OR2T8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2T8: view

Variants for OR2T8 Gene

Sequence variations from dbSNP and Humsavar for OR2T8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs946704 -- 247,918,954(-) TTTCA(C/G/T)GACAG intron-variant
rs4362017 - 247,921,678(+) TCCTC(G/T)CTGCT reference, missense
rs4523549 -- 247,921,445(+) GATGA(A/C)CCTGT reference, missense
rs4576684 -- 247,918,972(+) TTAAA(A/G)TGATA intron-variant
rs4584426 - 247,921,552(+) GCGAG(A/G)CCCCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR2T8 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV Gain+Loss 17666407
nsv873440 CNV Gain 21882294
dgv204e1 CNV Complex 17122850
esv34503 CNV Gain 17911159
nsv515858 CNV Gain+Loss 19592680
nsv873442 CNV Gain 21882294
dgv205e1 CNV Complex 17122850
nsv873443 CNV Gain 21882294
esv2750832 CNV Gain 17911159

Relevant External Links for OR2T8 Gene

HapMap Linkage Disequilibrium report
OR2T8

Disorders for OR2T8 Gene

No disorders were found for OR2T8 Gene.

No data available for UniProtKB/Swiss-Prot for OR2T8 Gene

Publications for OR2T8 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for OR2T8 Gene

Sources for OR2T8 Gene

Back to Top

Content