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Aliases for OR2T8 Gene

Aliases for OR2T8 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 8 2 3 5
  • OR2T8P 3 4
  • Olfactory Receptor, Family 2, Subfamily T, Member 8 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily T, Member 8 2

External Ids for OR2T8 Gene

Previous HGNC Symbols for OR2T8 Gene

  • OR2T8P

Previous GeneCards Identifiers for OR2T8 Gene

  • GC01U901043
  • GC01P244410
  • GC01P246150
  • GC01P248084

Summaries for OR2T8 Gene

Entrez Gene Summary for OR2T8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T8 Gene

OR2T8 (Olfactory Receptor Family 2 Subfamily T Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2T8 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T8 Gene

Genomics for OR2T8 Gene

Genomic Location for OR2T8 Gene

Chromosome:
1
Start:
247,912,253 bp from pter
End:
247,923,152 bp from pter
Size:
10,900 bases
Orientation:
Plus strand

Genomic View for OR2T8 Gene

Genes around OR2T8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T8 Gene

Proteins for OR2T8 Gene

  • Protein details for OR2T8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NH00-OR2T8_HUMAN
    Recommended name:
    Olfactory receptor 2T8
    Protein Accession:
    A6NH00

    Protein attributes for OR2T8 Gene

    Size:
    312 amino acids
    Molecular mass:
    34659 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T8 Gene

Proteomics data for OR2T8 Gene at MOPED

Post-translational modifications for OR2T8 Gene

  • Glycosylation at Asn 3 and Asn 17
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2T8 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T8 Gene

Domains & Families for OR2T8 Gene

Gene Families for OR2T8 Gene

Protein Domains for OR2T8 Gene

Suggested Antigen Peptide Sequences for OR2T8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NH00

UniProtKB/Swiss-Prot:

OR2T8_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T8: view

Function for OR2T8 Gene

Molecular function for OR2T8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR2T8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T8 Gene

Localization for OR2T8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2T8 Gene COMPARTMENTS Subcellular localization image for OR2T8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2T8: view

Pathways & Interactions for OR2T8 Gene

genes like me logo Genes that share pathways with OR2T8: view

Pathways by source for OR2T8 Gene

Interacting Proteins for OR2T8 Gene

Gene Ontology (GO) - Biological Process for OR2T8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T8: view

No data available for SIGNOR curated interactions for OR2T8 Gene

Drugs & Compounds for OR2T8 Gene

No Compound Related Data Available

Transcripts for OR2T8 Gene

mRNA/cDNA for OR2T8 Gene

(7) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T8 Gene

No ASD Table

Relevant External Links for OR2T8 Gene

GeneLoc Exon Structure for
OR2T8
ECgene alternative splicing isoforms for
OR2T8

Expression for OR2T8 Gene

mRNA expression in normal human tissues for OR2T8 Gene

mRNA differential expression in normal tissues according to GTEx for OR2T8 Gene

This gene is overexpressed in Thyroid (x7.3).

SOURCE GeneReport for Unigene cluster for OR2T8 Gene Hs.521114

genes like me logo Genes that share expression patterns with OR2T8: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR2T8 Gene

Orthologs for OR2T8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC787932 35
  • 82.16 (n)
  • 75 (a)
-- 36
  • 75 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr314 35
  • 77.99 (n)
  • 74.36 (a)
Olfr314 16
Olfr314 36
  • 70 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC740494 35
  • 98.61 (n)
  • 97.76 (a)
OR2T8 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
OneToMany
Species with no ortholog for OR2T8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T8 Gene

ENSEMBL:
Gene Tree for OR2T8 (if available)
TreeFam:
Gene Tree for OR2T8 (if available)

Paralogs for OR2T8 Gene

(457) SIMAP similar genes for OR2T8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2T8: view

Variants for OR2T8 Gene

Sequence variations from dbSNP and Humsavar for OR2T8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11204563 - 247,921,132(+) TGTTT(A/C/G)GCAAT reference, missense
rs11204564 - 247,921,162(+) TTCAC(C/T)GGGAC reference, missense
rs4584426 - 247,921,552(+) GCGAG(A/G)CCCCC reference, missense
VAR_037345 -
rs4362017 - 247,921,678(+) TCCTC(G/T)CTGCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR2T8 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV Gain+Loss 17666407
nsv873440 CNV Gain 21882294
dgv204e1 CNV Complex 17122850
esv34503 CNV Gain 17911159
nsv515858 CNV Gain+Loss 19592680
nsv873442 CNV Gain 21882294
dgv205e1 CNV Complex 17122850
nsv873443 CNV Gain 21882294
esv2750832 CNV Gain 17911159

Variation tolerance for OR2T8 Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 24.92; 99.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2T8 Gene

HapMap Linkage Disequilibrium report
OR2T8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T8 Gene

Disorders for OR2T8 Gene

Relevant External Links for OR2T8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2T8

No disorders were found for OR2T8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T8 Gene

Publications for OR2T8 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 67
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3

Products for OR2T8 Gene

Sources for OR2T8 Gene

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