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OR2T6 Gene

protein-coding   GIFtS: 44
GCID: GC01P248550

Olfactory Receptor, Family 2, Subfamily T, Member 6


(Previous symbols: OR2T6P, OR2T9)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily T, Member 61 2     OST7032 3
OR2T6P1 2 3     Olfactory Receptor 2T62
OR2T91 2 3     Olfactory Receptor, Family 2, Subfamily T, Member 6 Pseudogene2
Olfactory Receptor 2T92 3     Seven Transmembrane Helix Receptor2

External Ids:    HGNC: 150181   Entrez Gene: 2548792   Ensembl: ENSG000001981047   UniProtKB: Q8NHC83   

Export aliases for OR2T6 gene to outside databases

Previous GC identifers: GC01P245449 GC01U901106 GC01P244878 GC01P246617


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2T6 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2T6 Gene:
OR2T6 (olfactory receptor, family 2, subfamily T, member 6) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T35.

UniProtKB/Swiss-Prot: OR2T6_HUMAN, Q8NHC8
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2T6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_167186.2  NT_187518.1  NT_187646.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2T6 gene promoter:
         Tal-1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   LCR-F1   YY1   E47   PPAR-alpha   POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OR2T6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2T6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

OR2T6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2T6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P248550:  view genomic region     (about GC identifiers)

Start:
248,550,910 bp from pter      End:
248,551,833 bp from pter
Size:
924 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR2T6_HUMAN, Q8NHC8 (See protein sequence)
Recommended Name: Olfactory receptor 2T6  
Size: 308 amino acids; 34765 Da
Sequence caution: Sequence=BAC05705.1; Type=Miscellaneous discrepancy; Note=Hybrid of two separate genomic loci;
Secondary accessions: A6NE36

Explore the universe of human proteins at neXtProt for OR2T6: NX_Q8NHC8

Explore proteomics data for OR2T6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR2T6

    See OR2T6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005471.1  
    ENSEMBL proteins: 
     ENSP00000347965  
    Reactome Protein details: Q8NHC8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NHC8

    ProtoNet protein and cluster: Q8NHC8

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2T6_HUMAN, Q8NHC8
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR2T6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2T6_HUMAN, Q8NHC8
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR2T6           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2T6_HUMAN, Q8NHC8: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR2T6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2T6 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR2T6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR2T6
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2T6):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2T6
    Interactions:

        Search GeneGlobe Interaction Network for OR2T6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR2T6 (Q8NHC83 ENSP000003479654) via UniProtKB, MINT, STRING, and/or I2D (see all 274)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10J5ENSP000003344414STRING: ENSP00000334441
    OR2M4ENSP000003066884STRING: ENSP00000306688
    OR2T1ENSP000003554304STRING: ENSP00000355430
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR2T6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2T6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR2T6 gene: 
    NM_001005471.1  

    Unigene Cluster for OR2T6:

    Olfactory receptor, family 2, subfamily T, member 6
    Hs.626884
    Unigene Representative Sequence: NM_001005471
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000355728(uc001iei.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR2T6

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2T6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGTGGTGA
    OR2T6 Expression
    About this image

    OR2T6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2T6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.626884
        Custom PCR Arrays for OR2T6
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2T6 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr7201 , 5 olfactory receptor 7201, 5 82.3(n)1
    81.97(a)1
      14 (7.08 cM)5
    2583871  NM_146392.11  NP_666504.11 
     141751305 


    ENSEMBL Gene Tree for OR2T6 (if available)
    TreeFam Gene Tree for OR2T6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2T6 gene
    OR2T352  OR2V22  OR2V12  OR2M32  OR2T72  OR2M72  OR2T82  OR2M42  
    OR2T22  OR2T122  OR2T272  OR2M52  OR2Z12  OR2T332  OR2AG12  OR2T52  
    OR2T102  OR2M22  OR2T42  OR2T342  OR2T112  OR2T292  OR2T12  OR2AG22  
    OR2T32  
    Selected SIMAP similar genes for OR2T6 using alignment to 1 protein entry:     OR2T6_HUMAN(see all similar genes):
    OR2T1    OR2T7    OR2T2    OR2T27    OR2T11    OR2T35
    OR2T29    OR2T5    OR2T3    OR2T4    OR2AG1    OR2AG2
    OR2AK2    OR2M2    OR2M3    OR2M5    OR2M7    OR2T10

    Find genes that share paralogs with OR2T6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2T6 (see all 142)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs65874641,2
    C,F,A,H--248548916(+) AATAAC/TTCACA 1 -- us2k115Minor allele frequency- T:0.33NS EA NA WA CSA 769
    rs75541501,2
    C,F--248548973(+) TGACAC/TATAAT 1 -- us2k14Minor allele frequency- T:0.36NA WA 124
    rs75135701,2
    C,F--248548974(+) GACACA/GTAATT 1 -- us2k110Minor allele frequency- G:0.41NA WA EA 374
    rs1124934421,2
    C--248549024(+) TTTTTAG/-AGTGT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs65874651,2
    C,F,A,H--248549094(+) TTCGGC/AAAGAT 1 -- us2k120Minor allele frequency- A:0.34NS EA NA WA CSA 2345
    rs741535831,2
    C,F--248549103(+) ATATTG/ATGTGT 1 -- us2k12Minor allele frequency- A:0.05WA 120
    rs1452386381,2
    --248549135(+) ACAAGC/TGCAAC 1 -- us2k10--------
    rs1892681141,2
    --248549136(+) CAAGCA/GCAACA 1 -- us2k10--------
    rs1491726331,2
    --248549191(+) TGCATA/GTGTTA 1 -- us2k10--------
    rs65874661,2
    C,F,A,H--248549219(+) ACAACA/GTCCCG 1 -- us2k122Minor allele frequency- G:0.28NA NS EA WA 2480

    HapMap Linkage Disequilibrium report for OR2T6 ( 248550910 - 248551833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR2T6 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv17e55CNV Loss17911159
    nsv873468CNV Loss21882294
    nsv873462CNV Loss21882294
    dgv20n17CNV Loss16327808
    nsv5332CNV Loss18451855
    nsv428357CNV Loss18775914
    esv2750835CNV Gain17911159
    dgv570n71CNV Gain21882294
    dgv567n71CNV Gain21882294
    dgv571n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2T6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2T6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. An investigation into the human serum &quot;interactome&quot;. (PubMed id 15174051)1 Zhou M....Conrads T.P. (Electrophoresis 2004)
    3. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1 Fuchs T.... Shamir R. (Genomics 2002)
    4. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 254879 HGNC: 15018 Ensembl:ENSG00000198104 euGenes: HUgn254879 ECgene: OR2T6 Kegg: 254879
    H-InvDB: OR2T6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2T6 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2T6 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2T6 gene:
    Search GeneIP for patents involving OR2T6

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OR2T6  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
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     OriGene Custom Antibody Services for OR2T6   OriGene Custom Protein Services for OR2T6  

     
     
     Block miRNA regulation of human, mouse, rat OR2T6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR2T6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2T6 Predesigned siRNA for gene silencing in human, mouse, rat OR2T6
     QuantiFast Probe-based Assays in human, mouse, rat OR2T6 QuantiTect SYBR Green Assays in human, mouse, rat OR2T6
     Custom PCR Arrays for OR2T6 Search Chromatin IP Primers for OR2T6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OR2T6  Search GeneGlobe Interaction Network for OR2T6
     Regulatory tfbs in OR2T6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for OR2T6 GenScript cDNA clones with any tag delivered in your preferred vector for OR2T6
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     Search Tocris compounds for OR2T6
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     Novus Biologicals
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OR2T6
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for OR2T6
     Browse SwitchGear Promoter luciferase reporter plasmids for OR2T6
     Search ThermoFisher Antibodies for OR2T6
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR2T6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR2T6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OR2T6
     LSBio Antibodies in human, mouse, rat for OR2T6
     Browse compounds at ApexBio
     Search Addgene for plasmids for OR2T6
      Search eBioscience for proteins for OR2T6
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      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
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     antibodies-online antibodies for OR2T6 (10 products)
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      Search antibodies-online for proteins for OR2T6
           
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