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Aliases for OR2T5 Gene

Aliases for OR2T5 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 5 2 3 5
  • Olfactory Receptor, Family 2, Subfamily T, Member 5 2 3
  • Olfactory Receptor OR1-62 3 4
  • OR1-62 3

External Ids for OR2T5 Gene

Previous GeneCards Identifiers for OR2T5 Gene

  • GC01U990403
  • GC01P245550
  • GC01P244977
  • GC01P246718
  • GC01P248651

Summaries for OR2T5 Gene

Entrez Gene Summary for OR2T5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T5 Gene

OR2T5 (Olfactory Receptor Family 2 Subfamily T Member 5) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2T5 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T5 Gene

Genomics for OR2T5 Gene

Regulatory Elements for OR2T5 Gene

Enhancers for OR2T5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR2T5 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2T5 Gene

Chromosome:
1
Start:
248,488,589 bp from pter
End:
248,489,536 bp from pter
Size:
948 bases
Orientation:
Plus strand

Genomic View for OR2T5 Gene

Genes around OR2T5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T5 Gene

Proteins for OR2T5 Gene

  • Protein details for OR2T5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IEZ7-OR2T5_HUMAN
    Recommended name:
    Olfactory receptor 2T5
    Protein Accession:
    Q6IEZ7

    Protein attributes for OR2T5 Gene

    Size:
    315 amino acids
    Molecular mass:
    35595 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T5 Gene

Proteomics data for OR2T5 Gene at MOPED

Post-translational modifications for OR2T5 Gene

  • Glycosylation at Asn 3 and Asn 9
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2T5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T5 Gene

Domains & Families for OR2T5 Gene

Gene Families for OR2T5 Gene

Protein Domains for OR2T5 Gene

Suggested Antigen Peptide Sequences for OR2T5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6IEZ7

UniProtKB/Swiss-Prot:

OR2T5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T5: view

Function for OR2T5 Gene

Molecular function for OR2T5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR2T5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T5 Gene

Localization for OR2T5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2T5 Gene COMPARTMENTS Subcellular localization image for OR2T5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2T5: view

Pathways & Interactions for OR2T5 Gene

genes like me logo Genes that share pathways with OR2T5: view

Pathways by source for OR2T5 Gene

Interacting Proteins for OR2T5 Gene

Gene Ontology (GO) - Biological Process for OR2T5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T5: view

No data available for SIGNOR curated interactions for OR2T5 Gene

Drugs & Compounds for OR2T5 Gene

No Compound Related Data Available

Transcripts for OR2T5 Gene

mRNA/cDNA for OR2T5 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T5 Gene

No ASD Table

Relevant External Links for OR2T5 Gene

GeneLoc Exon Structure for
OR2T5
ECgene alternative splicing isoforms for
OR2T5

Expression for OR2T5 Gene

mRNA expression in normal human tissues for OR2T5 Gene

SOURCE GeneReport for Unigene cluster for OR2T5 Gene Hs.553808

genes like me logo Genes that share expression patterns with OR2T5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR2T5 Gene

Orthologs for OR2T5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC788323 35
  • 85.81 (n)
  • 83.87 (a)
-- 36
  • 82 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC482243 35
  • 84.55 (n)
  • 83.49 (a)
-- 36
  • 80 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC469776 35
  • 97.88 (n)
  • 94.6 (a)
-- 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1424 35
  • 82.73 (n)
  • 80.86 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr224 36
  • 75 (a)
ManyToMany
Olfr325 36
  • 75 (a)
ManyToMany
Olfr328 36
  • 77 (a)
ManyToMany
Olfr330 36
  • 77 (a)
ManyToMany
Olfr331 36
  • 75 (a)
ManyToMany
Species with no ortholog for OR2T5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T5 Gene

ENSEMBL:
Gene Tree for OR2T5 (if available)
TreeFam:
Gene Tree for OR2T5 (if available)

Paralogs for OR2T5 Gene

(452) SIMAP similar genes for OR2T5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR2T5: view

Variants for OR2T5 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2T5 Gene

Variant ID Type Subtype PubMed ID
nsv515858 CNV Gain+Loss 19592680
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
dgv567n71 CNV Gain 21882294
nsv873462 CNV Loss 21882294
dgv20n17 CNV Loss 16327808
essv15752 CNV CNV 17122850
dgv206e1 CNV Complex 17122850
nsv428357 CNV Loss 18775914
esv2750835 CNV Gain 17911159
dgv569n71 CNV Gain+Loss 21882294
dgv570n71 CNV Gain 21882294
nsv873468 CNV Loss 21882294
dgv571n71 CNV Gain 21882294
nsv873474 CNV Gain 21882294
dgv572n71 CNV Gain+Loss 21882294
nsv7193 OTHER Inversion 18451855
dgv573n71 CNV Gain 21882294
dgv207e1 CNV Complex 17122850
nsv873483 CNV Gain+Loss 21882294
nsv873484 CNV Loss 21882294
dgv574n71 CNV Gain 21882294
dgv575n71 CNV Gain 21882294
nsv873494 CNV Loss 21882294
nsv5354 CNV Loss 18451855
nsv821623 CNV Loss 15273396
esv7998 OTHER Inversion 19470904

Variation tolerance for OR2T5 Gene

Gene Damage Index Score: 7.30; 81.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2T5 Gene

HapMap Linkage Disequilibrium report
OR2T5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for OR2T5 Gene

Disorders for OR2T5 Gene

Relevant External Links for OR2T5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2T5

No disorders were found for OR2T5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T5 Gene

Publications for OR2T5 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2T5 Gene

Sources for OR2T5 Gene

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