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OR2T4 Gene

protein-coding   GIFtS: 41
GCID: GC01P248524

Olfactory Receptor, Family 2, Subfamily T, Member 4

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily T, Member 41 2
Olfactory Receptor OR1-602 3
OR1-602
OR2T4Q2
Olfactory Receptor 2T42

External Ids:    HGNC: 150161   Entrez Gene: 1270742   Ensembl: ENSG000001969447   UniProtKB: Q8NH003   

Export aliases for OR2T4 gene to outside databases

Previous GC identifers: GC01U990404 GC01P245423 GC01P244850 GC01P246591


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2T4 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2T4 Gene:
OR2T4 (olfactory receptor, family 2, subfamily T, member 4) is a protein-coding gene. Diseases associated with OR2T4 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T35.

UniProtKB/Swiss-Prot: OR2T4_HUMAN, Q8NH00
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2T4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  NT_187518.1  NT_187646.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2T4 gene promoter:
         SRF   Nkx3-1   Nkx3-1 v4   AML1a   Nkx3-1 v1   Nkx3-1 v2   CREB   deltaCREB   Nkx3-1 v3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2T4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

OR2T4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2T4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P248524:  view genomic region     (about GC identifiers)

Start:
248,524,937 bp from pter      End:
248,525,926 bp from pter
Size:
990 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OR2T4_HUMAN, Q8NH00 (See protein sequence)
Recommended Name: Olfactory receptor 2T4  
Size: 348 amino acids; 39414 Da
Caution: It is uncertain whether Met-1 or Met-29 is the initiator
Sequence caution: Sequence=BAC05842.1; Type=Erroneous initiation;
Secondary accessions: Q6IEZ8

Explore the universe of human proteins at neXtProt for OR2T4: NX_Q8NH00

Explore proteomics data for OR2T4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn31, Asn37, Asn218
  • HORDE protein sequence for OR2T4

    See OR2T4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004696.1  
    ENSEMBL proteins: 
     ENSP00000355431  
    Reactome Protein details: Q8NH00

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NH00

    ProtoNet protein and cluster: Q8NH00

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2T4_HUMAN, Q8NH00
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR2T4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2T4_HUMAN, Q8NH00
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR2T4 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2T4_HUMAN, Q8NH00: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR2T4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2T4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR2T4
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2T4):
        Olfactory transduction


    OR2T4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2T4
    Interactions:

        Search GeneGlobe Interaction Network for OR2T4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OR2T4 (ENSP000003554314) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB2ENSP000002692604STRING: ENSP00000269260
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR2T4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for OR2T4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR2T4 gene: 
    NM_001004696.1  

    Unigene Cluster for OR2T4:

    Olfactory receptor, family 2, subfamily T, member 4
    Hs.553586
    Unigene Representative Sequence: NM_001004696
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000366475(uc001ieh.1)
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    1 AceView cDNA sequence:

    NM_001004696 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2T4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR2T4 Expression
    About this image

    OR2T4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2T4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553586
        Custom PCR Arrays for OR2T4
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2T4 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr3301 olfactory receptor 330 83.07(n)
    78.14(a)
      258879  NM_146879.2  NP_667090.1 


    ENSEMBL Gene Tree for OR2T4 (if available)
    TreeFam Gene Tree for OR2T4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2T4 gene
    OR2T352  OR2V22  OR2V12  OR2M32  OR2T72  OR2M72  OR2T82  OR2M42  
    OR2T22  OR2T122  OR2T272  OR2M52  OR2Z12  OR2T332  OR2AG12  OR2T52  
    OR2T102  OR2M22  OR2T342  OR2T112  OR2T292  OR2T62  OR2T12  OR2AG22  
    OR2T32  
    Selected SIMAP similar genes for OR2T4 using alignment to 1 protein entry:     OR2T4_HUMAN(see all similar genes):
    OR2T29    OR2T5    OR2T10    OR2T11    OR2T3    OR2T34
    OR2T7    OR2T2    OR2T27    OR2T35    OR2T33    OR2T12
    OR2T6    OR2L2    OR2M2    OR2M3    OR2T8    OR2AJ1

    OR2T4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2T4 (see all 157)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446611131,2
    C,Funtested1248524894(+) AACATC/TACCTG 2 I syn12Minor allele frequency- T:0.00NA EU 5805
    rs2009151401,2
    Cuntested1248524967(+) ATCCAA/GTGGCC 2 M V mis10--------
    rs75412161,2
    C,F,A,H--248522896(+) TCAGCG/ATGGCT 1 -- us2k127Minor allele frequency- A:0.29NS EA NA WA 2912
    rs1847088141,2
    --248522966(+) CATCCC/TGCACT 1 -- us2k10--------
    rs1155306641,2
    C,F--248523132(+) GACTGT/GATGAT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs61437291,2
    C,F--248523158(+) TTCCCT/AGAAAA 1 -- us2k13Minor allele frequency- A:0.39NA 142
    rs287198331,2
    C,F--248523159(+) TTCCCT/AGAAAA 1 -- us2k112Minor allele frequency- A:0.39NA WA CSA EA 376
    rs1889158551,2
    --248523195(+) ATAAAC/TACTAA 1 -- us2k10--------
    rs584944191,2
    --248523199(+) ATACTA/GAAATT 1 -- us2k10--------
    rs15569671,2
    C,F--248523223(+) GAAATC/TGAAAA 1 -- us2k118Minor allele frequency- T:0.37NS NA WA EA 610

    HapMap Linkage Disequilibrium report for OR2T4 ( 248524937 - 248525926 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR2T4 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728151CNV Deletion23290073
    esv2728162CNV Deletion23290073
    nsv873459CNV Loss21882294
    dgv17e55CNV Loss17911159
    nsv873468CNV Loss21882294
    nsv873462CNV Loss21882294
    dgv20n17CNV Loss16327808
    nsv5332CNV Loss18451855
    nsv428357CNV Loss18775914
    esv2750835CNV Gain17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR2T4:    About MalaCards
    neuronitis


    OR2T4 for disorders           About GeneDecksing


    Export disorders for OR2T4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2T4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2T4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 127074 HGNC: 15016 AceView: OR2T4 Ensembl:ENSG00000196944 euGenes: HUgn127074
    ECgene: OR2T4 Kegg: 127074 H-InvDB: OR2T4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2T4 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2T4 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2T4 gene:
    Search GeneIP for patents involving OR2T4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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