OR2T4 Gene
protein-coding GIFtS: 41
GCID: GC01P248524
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olfactory receptor, family 2, subfamily T, member 4
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Aliases
for OR2T4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 2, Subfamily T, Member 41 2 | | OR2T4Q1 2 | | Olfactory Receptor OR1-602 3 | | OR1-602 | | Olfactory Receptor 2T42 |
Export aliases for OR2T4 gene to outside databasesPrevious GC identifers: GC01U990404 GC01P245423 GC01P244850 GC01P246591 |
Summaries
for OR2T4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR2T4:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR2T4_HUMAN, Q8NH00Function: Odorant receptor (Potential)
Gene Wiki entry for OR2T4
|
Genomic Views
for OR2T4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR2T4 gene promoter:
SRF Nkx3-1 Nkx3-1 v4 AML1a Nkx3-1 v1 Nkx3-1 v2 CREB deltaCREB Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR2T4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2T4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44OR2T4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P248524: view genomic region
(about GC identifiers)
Start:
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248,524,937 bp from pter |
End:
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248,525,926 bp from pter |
Size:
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990 bases |
Orientation:
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plus strand |
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Proteins
for OR2T4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR2T4_HUMAN, Q8NH00 (See
protein sequence)Recommended Name: Olfactory receptor 2T4 Size: 348 amino acids; 39414 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: It is uncertain whether Met-1 or Met-29 is the initiator
Sequence caution: Sequence=BAC05842.1; Type=Erroneous initiation;
Secondary accessions: Q6IEZ8Explore the universe of human proteins at neXtProt for OR2T4: NX_Q8NH00
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NH00
HORDE protein sequence for OR2T4
OR2T4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001004696.1
ENSEMBL proteins: ENSP00000355431 Reactome Protein details: Q8NH00
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR2T4 for ontologies About GeneDecksing
OR2T4 Antibody Products:
Assay Products for OR2T4: |
Protein
Domains /
Families
for OR2T4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR2T4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NH00ProtoNet protein and cluster: Q8NH00 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR2T4_HUMAN, Q8NH00Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR2T4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OR2T4_HUMAN, Q8NH00Function: Odorant receptor (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2T4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2T4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR2T4 (NM_001004696) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR2T4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR2T4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR2T4 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR2T4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR2T4
1 
Kegg Pathway (Kegg details for OR2T4):
OR2T4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2T4
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for OR2T4 (ENSP000003554314) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for OR2T4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR2T4
Search CenterWatch for drugs/clinical trials and news about OR2T4
|
Transcripts
for OR2T4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR2T4 gene: NM_001004696.1 Unigene Cluster for OR2T4: Olfactory receptor, family 2, subfamily T, member 4 Hs.553586 Unigene Representative Sequence: NM_0010046961 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000366475(uc001ieh.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2T4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2T4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR2T4 (NM_001004696) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR2T4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR2T4 |
1 AceView cDNA sequence: NM_001004696
GeneLoc Exon Structure
|
Expression
for OR2T4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR2T4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OR2T4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.553586
SABiosciences Custom PCR Arrays for OR2T4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2T4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR2T4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2T4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2T4 |
Orthologs
for OR2T4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OR2T4 (if available)
TreeFam Gene Tree for OR2T4 (if available) |
Paralogs
for OR2T4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR2T4 gene
- OR2V22 OR2T352 OR2AK22 OR2V12 OR2M32 OR2L132 OR2M72 OR2T82
- OR2M42 OR2L22 OR2T22 OR2T122 OR2T52 OR2L52 OR2AE12 OR2Z12
- OR2M52 OR2AG12 OR2T332 OR2T272 OR2T102 OR2M22 OR2AJ12 OR2L32
- OR2T342 OR2T112 OR2T292 OR2T62 OR2L82 OR2T12 OR2AG22 OR2T32
18/438 SIMAP similar genes for OR2T4 using alignment to 1 protein entry: OR2T4_HUMAN(see all similar genes):OR2T29 OR2T5 OR2T10 OR2T11 OR2T3 OR2T34
OR2T7 OR2T2 OR2T27 OR2T35 OR2T33 OR2T12
OR2T6 OR2L2 OR2M2 OR2M3 OR2T8 OR2AJ1
OR2T4 for paralogs About GeneDecksing
|
Genomic Variants
for OR2T4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR2T4 ( 248524937 - 248525926 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for OR2T4
4 CNVs: 8355 8935 3340 8354
1 Indel: 33214 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR2T4 |
|
Disorders
/ Diseases
for OR2T4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR2T4 for disorders About GeneDecksing
1  disease for OR2T4: About MalaCardsneuronitis
Export disorders for OR2T4 gene to outside databases
|
Publications
for OR2T4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR2T4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR2T4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for OR2T4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing OR2T4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR2T4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR2T4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR2T4 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR2T4 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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About This Section
| Patent Information for OR2T4 gene:
Search GeneIP for patents involving OR2T4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR2T4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR2T4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR2T4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2T4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR2T4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2T4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2T4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR2T4 | | OriGene Custom Protein Services for OR2T4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR2T4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR2T4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2T4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR2T4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2T4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2T4 |
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 | | | OR2T4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for OR2T4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR2T4 |
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