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Aliases for OR2T4 Gene

Aliases for OR2T4 Gene

  • Olfactory Receptor, Family 2, Subfamily T, Member 4 2 3
  • Olfactory Receptor OR1-60 3 4
  • Olfactory Receptor 2T4 3
  • OR1-60 3
  • OR2T4Q 3

External Ids for OR2T4 Gene

Previous GeneCards Identifiers for OR2T4 Gene

  • GC01U990404
  • GC01P245423
  • GC01P244850
  • GC01P246591
  • GC01P248524

Summaries for OR2T4 Gene

Entrez Gene Summary for OR2T4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T4 Gene

OR2T4 (Olfactory Receptor, Family 2, Subfamily T, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2T4 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T4 Gene

Genomics for OR2T4 Gene

Regulatory Elements for OR2T4 Gene

Genomic Location for OR2T4 Gene

248,361,581 bp from pter
248,362,627 bp from pter
1,047 bases
Plus strand

Genomic View for OR2T4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2T4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T4 Gene

Proteins for OR2T4 Gene

  • Protein details for OR2T4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2T4
    Protein Accession:
    Secondary Accessions:
    • Q6IEZ8

    Protein attributes for OR2T4 Gene

    348 amino acids
    Molecular mass:
    39414 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05842.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2T4 Gene

Proteomics data for OR2T4 Gene at MOPED

Post-translational modifications for OR2T4 Gene

  • Glycosylation at Asn31, Asn37, and Asn218
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2T4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T4 Gene

Domains for OR2T4 Gene

Gene Families for OR2T4 Gene

Protein Domains for OR2T4 Gene

Suggested Antigen Peptide Sequences for OR2T4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T4: view

Function for OR2T4 Gene

Molecular function for OR2T4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2T4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T4 Gene

Localization for OR2T4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR2T4 Gene COMPARTMENTS Subcellular localization image for OR2T4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T4: view

Pathways for OR2T4 Gene

genes like me logo Genes that share pathways with OR2T4: view

Pathways by source for OR2T4 Gene

Interacting Proteins for OR2T4 Gene

Gene Ontology (GO) - Biological Process for OR2T4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T4: view

Transcripts for OR2T4 Gene

mRNA/cDNA for OR2T4 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2T4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T4 Gene

No ASD Table

Relevant External Links for OR2T4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2T4 Gene

mRNA expression in normal human tissues for OR2T4 Gene

SOURCE GeneReport for Unigene cluster for OR2T4 Gene Hs.553586

genes like me logo Genes that share expressions with OR2T4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR2T4 Gene

Orthologs for OR2T4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC615281 35
  • 84.62 (n)
  • 81.09 (a)
-- 36
  • 81 (a)
-- 36
  • 79 (a)
(Canis familiaris)
Mammalia LOC482236 35
  • 84.9 (n)
  • 82.5 (a)
-- 36
  • 80 (a)
-- 36
  • 81 (a)
(Mus musculus)
Mammalia Olfr330 35
  • 83.07 (n)
  • 78.14 (a)
Olfr224 36
  • 75 (a)
Olfr325 36
  • 74 (a)
Olfr328 36
  • 76 (a)
Olfr330 36
  • 77 (a)
Olfr331 36
  • 75 (a)
(Pan troglodytes)
Mammalia LOC469770 35
  • 98.47 (n)
  • 96.55 (a)
OR2T4 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
Species with no ortholog for OR2T4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T4 Gene

Gene Tree for OR2T4 (if available)
Gene Tree for OR2T4 (if available)

Paralogs for OR2T4 Gene

(437) SIMAP similar genes for OR2T4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2T4: view

Variants for OR2T4 Gene

Sequence variations from dbSNP and Humsavar for OR2T4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1538704 -- 248,360,252(+) TTTCC(A/G)TGAAA upstream-variant-2KB
rs1538705 -- 248,360,279(+) GCAAT(A/T)AAGCA upstream-variant-2KB
rs1544175 -- 248,360,960(+) CATGC(A/G)ACTCT upstream-variant-2KB
rs1544176 -- 248,361,346(+) TCATC(A/G)GGAAA upstream-variant-2KB
rs1544177 -- 248,361,381(+) CTTCA(C/G)TACAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2T4 Gene

Variant ID Type Subtype PubMed ID
nsv515858 CNV Gain+Loss 19592680
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
dgv566n71 CNV Gain 21882294
dgv567n71 CNV Gain 21882294
nsv873459 CNV Loss 21882294
nsv873461 CNV Gain 21882294
nsv873462 CNV Loss 21882294
dgv20n17 CNV Loss 16327808
essv15752 CNV CNV 17122850
dgv206e1 CNV Complex 17122850
nsv428357 CNV Loss 18775914
nsv5332 CNV Loss 18451855
esv2750835 CNV Gain 17911159
nsv9125 CNV Gain 18304495
dgv569n71 CNV Gain+Loss 21882294
dgv570n71 CNV Gain 21882294
nsv873468 CNV Loss 21882294
dgv571n71 CNV Gain 21882294
esv2728151 CNV Deletion 23290073
esv2728162 CNV Deletion 23290073

Relevant External Links for OR2T4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T4 Gene

Disorders for OR2T4 Gene

No disorders were found for OR2T4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR2T4 Gene

Publications for OR2T4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for OR2T4 Gene

Sources for OR2T4 Gene

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